KRT23

KRT23
Identifiers
Aliases	KRT23, CK23, HAIK1, K23, keratin 23
External IDs	OMIM: 606194; MGI: 2148866; HomoloGene: 9172; GeneCards: KRT23; OMA:KRT23 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,937,646 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,383,963 bp
RNA expression pattern
	Top expressed in
	placenta; ; skin of leg; ; skin of abdomen; ; olfactory zone of nasal mucosa; ; salivary gland; ; minor salivary glands; ; blood; ; islet of Langerhans; ; tonsil; ; right uterine tube;
	Top expressed in
	otic placode; ; esophagus; ; epithelium of stomach; ; lip; ; submandibular gland; ; skin of back; ; saccule; ; parotid gland; ; mucous cell of stomach; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; cytosol;
Biological process	keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	25984
	94179
	ENSG00000108244; ENSG00000263309
	ENSMUSG00000006777
	Q9C075
	Q99PS0
	NM_001282433; NM_015515; NM_173213
	NM_033373
	NP_001269362; NP_056330
	NP_203537
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.^[7]

References

^ ^a ^b ^c ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "KRT23 keratin 23 [ Homo sapiens (human) ]".

Suzuki A, Ji G, Numabe Y, et al. (2004). "Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese". Biochem. Biophys. Res. Commun. 317 (3): 887–92. doi:10.1016/j.bbrc.2004.03.126. PMID 15081423.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tolstonog GV, Sabasch M, Traub P (2002). "Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function". DNA Cell Biol. 21 (3): 213–39. doi:10.1089/10445490252925459. PMID 12015898.
Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell Sci. 114 (Pt 14): 2569–75. doi:10.1242/jcs.114.14.2569. PMID 11683385.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11135429-5] Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-7] "KRT23 keratin 23 [ Homo sapiens (human) ]".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading