KRT33B

KRT33B
Identifiers
Aliases	KRT33B, HA3II, Ha-3II, K33B, KRTHA3A, KRTHA3B, hHa3-II, keratin 33B
External IDs	OMIM: 602762; MGI: 1919138; HomoloGene: 136754; GeneCards: KRT33B; OMA:KRT33B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,369,813 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,907,038 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; anterior cingulate cortex; ; skin of abdomen; ; skin of leg; ; Brodmann area 9; ; right lung; ; mucosa of esophagus; ; right frontal lobe; ; vagina; ; hippocampus proper;
	Top expressed in
	lip; ; hair follicle; ; skin of back; ; dermis; ; skin of external ear; ; skin of abdomen; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; conjunctival fornix; ; diencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	extracellular exosome; intermediate filament; extracellular space; cytosol;
Biological process	hair cycle; human ageing; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3884
	71888
	ENSG00000263012; ENSG00000131738
	ENSMUSG00000035592
	Q14525
	Q8K0Y2
	NM_002279
	NM_027983
	NP_002270
	NP_082259
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II hair keratin to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A and KRT33B (this gene).^[7]

References

^ ^a ^b ^c ENSG00000131738 GRCh38: Ensembl release 89: ENSG00000263012, ENSG00000131738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656. S2CID 24487602.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT33B keratin 33B".

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000131738 GRCh38: Ensembl release 89: ENSG00000263012, ENSG00000131738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7565656-5] Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656. S2CID 24487602.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-7] "Entrez Gene: KRT33B keratin 33B".

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References

Further reading