ORG-20599

ORG-20599
Names
	IUPAC name (2β,3α,5β)-21-chloro-3-hydroxy-2-morpholin-4-ylpregnan-20-one
	Other names 2-chloro-1-[(2S,3S,5S,10S,13S)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Identifiers
CAS Number	156685-94-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	8025739;
PubChem CID	9850026;
CompTox Dashboard (EPA)	DTXSID30349651 ;
	InChI InChI=1S/C25H40ClNO3/c1-24-8-7-19-17(18(24)5-6-20(24)23(29)15-26)4-3-16-13-22(28)21(14-25(16,19)2)27-9-11-30-12-10-27/h16-22,28H,3-15H2,1-2H3/t16-,17-,18-,19-,20+,21-,22-,24-,25-/m0/s1 Key: NZFNABGZEQPYBX-PMBZPZLSSA-N; InChI=1/C25H40ClNO3/c1-24-8-7-19-17(18(24)5-6-20(24)23(29)15-26)4-3-16-13-22(28)21(14-25(16,19)2)27-9-11-30-12-10-27/h16-22,28H,3-15H2,1-2H3/t16-,17-,18-,19-,20+,21-,22-,24-,25-/m0/s1 Key: NZFNABGZEQPYBX-PMBZPZLSBZ;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CCl)CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C;
Properties
Chemical formula	C25H40ClNO3
Molar mass	438.04 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

ORG-20599 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABA_A receptor positive allosteric modulator and, at higher concentrations, agonist.^[1]^[2] It was developed for use as an anaesthetic agent but was never marketed for this purpose, although it is still used in scientific research.^[3]^[4]

Chemistry

^ Hill-Venning C, Peters JA, Callachan H, Lambert JJ, Gemmell DK, Anderson A, Byford A, Hamilton N, Hill DR, Marshall RJ, Campbell AC. The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 1996;35(9-10):1209-22. PMID 9014136
^ Anderson A, Boyd AC, Byford A, Campbell AC, Gemmell DK, Hamilton NM, Hill DR, Hill-Venning C, Lambert JJ, Maidment MS, May V, Marshall RJ, Peters JA, Rees DC, Stevenson D, Sundaram H. Anesthetic activity of novel water-soluble 2 beta-morpholinyl steroids and their modulatory effects at GABAA receptors. Journal of Medicinal Chemistry. 1997 May 23;40(11):1668-81. PMID 9171876
^ Visser SA, Gladdines WW, van der Graaf PH, Peletier LA, Danhof M. Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo. Journal of Pharmacology and Experimental Therapeutics. 2002 Nov;303(2):616-26. PMID 12388643
^ Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ. The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors. British Journal of Anaesthesia. 2004 May;92(5):704-11. PMID 15033889

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