Margot Kalinke was Protestant by faith. She was expelled from Poland in 1925. From 1937 to 1952 she was managing director of a Angestelltenkrankenkasse ("Employee Health Insurance Company") in Hanover. In 1946 she became a founder of the Verband Weiblicher Angestellter (VWA, "Association of Women Employees") having been active in a predecessor organisation since 1933. From 1949 until her death, she was chair of the VWA. From 1953 to 1974, she was director of the Office of Private Health Insurance. She belonged briefly to the Executive Board of the Bundesversicherungsanstalt für Angestellte ("Federal Insuranceoffice for Employees") and in the 1950s, was a member of the Advisory Council for Reorganisation of Social Services at the office of the Ministry of Labour.
From 1946 to 1949, Kalinke was a member of the Lower Saxony State Parliament. In 1947 and 1948, she was also a member of the Zonenbeirat ("Area Advisory Board").
From 1949 to 1953, and then from 1955 until 1972, she was a member of the German Bundestag, winning the election in the Celle constituency in 1957. Together with Ernst August Farke she represented the Arbeitnehmerflügel ("Worker's Wing") of the German Party in parliament. From 1955 to 1957 she was deputy chair of the Bundestag Committee for Public Welfare. From 1957 until her exit from the party on 1 June 1960, she was vice chair of the German Party.
She joined the Christian Democratic Union on 20 September 1960, and from 1969 to 1971 she was Landesvorsitzende ("State President") of the women's union in Lower Saxony.
Unlike most women in her party, Margot Kalinke opposed the "Stitch Ruling" (pertaining to the rights of the husband in marital disputes). Together with Elisabeth Schwarzhaupt she orchestrated support for an opposition amendment to her own party's bill. The Gesetz über die Gleichstellung von Mann und Frau auf dem Gebiet des bürgerlichen Rechts ("Law of Equality between Man and Woman in Civil Law") was enacted on 18 June 1957 without the Stitch Clause.
Dorls (from 13 December 1950 WAV-Gast, from 17 January 1951 WAV, from 26 September 1951 Non-attached, am 23 October 1952 Mandatsaberkennung)
Frommhold (from 7 September 1949 Nationale Rechte, from 5 October 1950 Non-attached (DRP), from 26 March 1952 DP-Gast, from 11 February 1953 Non-attached)
Miessner (from 5 October 1950 FDP-Gast, from 20 December 1950 FDP)
Rößler (from 15 September 1949 Nationale Rechte, from 6 September 1950 Non-attached, from 13 December 1950 WAV-Gast, from 17 January 1951 WAV, from 26 September 1951 Non-attached, until 21 February 1952)
Thadden (from 15 September 1949 Nationale Rechte; 1950 DRP, from 20 April 1950 Non-attached)
Ott (Non-attached, from 4 May 1950 WAV-Gast, from 13 October 1950 BHE/DG, from 21 March 1952 Non-attached, from 26 March 1952 DP/DPB-Gast, from 26 June 1952 Non-attached)
Berg (from 27 June 1955, from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Blank (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Blücher (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Euler (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Fassbender (from 18 November 1955 DP, from 14 March 1957 DP/FVP)
Hübner (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Manteuffel (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Neumayer (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Preiß (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Preusker (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Schäfer (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Schneider (from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Bender (from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)
Eckhardt (from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)
Finck (from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)
Haasler (from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)
Körner (from 12 July 1955 Non-attached, from 14 July 1955 FDP, from 23 February 1956 Non-attached, from 15 March 1956 Demokratische Arbeitsgemeinschaft (DA), from 26 June 1956 FVP, from 14 March 1957 DP/FVP)
Kraft (from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)
Oberländer (from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)
Samwer (from 15 October 1953, from 12 July 1955 Non-attached, from 14 July 1955 Group Kraft/Oberländer, from 15 July 1955 Guest of CDU/CSU-Fraktion, from 20 March 1956 CDU/CSU)