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MYO18B

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MYO18B
Identifiers
AliasesMYO18B, KFS4, myosin XVIIIB
External IDsOMIM: 607295; MGI: 1921626; HomoloGene: 53435; GeneCards: MYO18B; OMA:MYO18B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032608
NM_001318245

NM_028901

RefSeq (protein)

NP_001305174
NP_115997

n/a

Location (UCSC)Chr 22: 25.74 – 26.03 MbChr 5: 112.84 – 113.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.[5][6][7]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133454Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072720Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. Bibcode:2002PNAS...9912269N. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.
  6. ^ Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.
  7. ^ a b "Entrez Gene: MYO18B myosin XVIIIB".

Further reading

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