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KIF4A

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KIF4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIF4A, KIF4, KIF4G1, MRX100, kinesin family member 4A, XLID100
External IDsOMIM: 300521; MGI: 108389; HomoloGene: 69022; GeneCards: KIF4A; OMA:KIF4A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012310

NM_008446

RefSeq (protein)

NP_036442

NP_032472

Location (UCSC)Chr X: 70.29 – 70.42 MbChr X: 99.67 – 99.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.[5][6]

Function

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Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[6]

Interactions

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KIF4A has been shown to interact with HMG20B[7] and DNMT3B.[8]

Clinical significance

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NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV).[9] KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090889Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034311Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–42. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.
  6. ^ a b "Entrez Gene: KIF4A kinesin family member 4A".
  7. ^ Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
  8. ^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
  9. ^ Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife. 1: e00049. doi:10.7554/eLife.00049. PMC 3485615. PMID 23150796.
  10. ^ Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al. (March 2022). "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro". PLOS Pathogens. 18 (3): e1009983. doi:10.1371/journal.ppat.1009983. PMC 8970526. PMID 35312737.

Further reading

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