Nomegestrol acetate/estradiol

Nomegestrol acetate/estradiol
	Estradiol (top) and; nomegestrol acetate (bottom)
Combination of
Nomegestrol acetate	Progestogen
Estradiol	Estrogen
Clinical data
Trade names	Zoely
Other names	NOMAC-E2, NOMAC/E2, MK-8175A
AHFS/Drugs.com	UK Drug Information
Routes of; administration	By mouth
Drug class	Estrogen; Progestogen
ATC code	G03AA14 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only); EU: Rx-only;
Identifiers
CAS Number	853244-42-5;
PubChem CID	9895694;
KEGG	D10856;

Nomegestrol acetate/estradiol (NOMAC-E2), sold under the brand names Naemis and Zoely among others, is a fixed-dose combination medication of nomegestrol acetate, a progestogen, and estradiol, an estrogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy in women.^[3] It is taken by mouth.

Research

Estradiol-containing birth control pills like NOMAC-E2 may have a lower risk of venous thromboembolism than birth control pills containing ethinylestradiol.^[4] This is being studied in the case of NOMAC-E2.^[4]^[5]

^ "Zoely 2.5 mg/1.5 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 20 July 2020. Retrieved 9 June 2021.
^ "Zoely EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 9 June 2021.
^ Yang LP, Plosker GL (October 2012). "Nomegestrol acetate/estradiol: in oral contraception". Drugs. 72 (14): 1917–28. doi:10.2165/11208180-000000000-00000. PMID 22950535. S2CID 44335732.
^ ^a ^b Douxfils J, Morimont L, Bouvy C (October 2020). "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost. 46 (8): 872–886. doi:10.1055/s-0040-1714140. PMID 33080636. S2CID 224821517.
^ "Results from large-scale real-world safety study for oral combination contraception pill, Zoely (NOMAC-E2), submitted to European Medicines Agency". Theramex (Press release). 27 April 2021. Retrieved 9 June 2021.

"Estradiol mixture with nomegestrol acetate". Drug Information Portal. U.S. National Library of Medicine.

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