User:ProteinBoxBot/PBB Log Wiki 9-17-07 B Rerun

Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 07:48, 9 October 2007 (UTC)

Redirected Proteins (44)

SERPINE1	CDKN1B	FYN	NR3C1	CASP8
MMP2	MDM2	RET	RELA	ITGB3
SOD1	PSEN1	BAX	CDC2	ATM
NOS3	MAPK3	MYC	ICAM1	TLR4
HLA-DRB1	CCL2	HBB	CCR5	CCND1
ESR2	ABCB1	PRKCD	LCK	PRKACA
GRB2	HLA-A	F2	IFNG	CXCR4
RAC1	LEP	TERT	JAK2	JUN
EP300	VWF	CSNK2A1	INSR

Manual Inspection (Page not found) (6)

HBA1	CREBBP	SNCA	SP1	PTEN
ADIPOQ

Updated (44)

SERPINE1	CDKN1B	FYN	NR3C1	CASP8
MMP2	MDM2	RET	RELA	ITGB3
SOD1	PSEN1	BAX	CDC2	ATM
NOS3	MAPK3	MYC	ICAM1	TLR4
HLA-DRB1	CCL2	HBB	CCR5	CCND1
ESR2	ABCB1	PRKCD	LCK	PRKACA
GRB2	HLA-A	F2	IFNG	CXCR4
RAC1	LEP	TERT	JAK2	JUN
EP300	VWF	CSNK2A1	INSR

Protein Status Grid - Date: 07:48, 9 October 2007 (UTC)

HUGO Symbol	Action Summary	Target page(s)	WP Symbol Search
SERPINE1	Updated	Other Pages: serpin peptidase inhibitor (No Data); SERPINE1 (No Data); PAI (DisAmbig); Pai (DisAmbig); PAI-1 (Redirect -> Plasminogen activator inhibitor-1); Pai-1 (No Data); PAI1 (Redirect -> Plasminogen activator inhibitor-1); Pai1 (No Data); PLANH1 (No Data); Planh1 (No Data); Plasminogen activator inhibitor-1 (Good Codes Found);	[1]
CDKN1B	Updated	Other Pages: cyclin-dependent kinase inhibitor 1B (No Data); CDKN1B (Good Codes Found); CDKN4 (No Data); Cdkn4 (No Data); KIP1 (No Data); Kip1 (No Data); P27KIP1 (No Data); P27kip1 (No Data);	[2]
FYN	Updated	Other Pages: FYN oncogene related to SRC (No Data); FYN (Good Codes Found); MGC45350 (No Data); Mgc45350 (No Data); SLK (DisAmbig); Slk (No Data); SYN (DisAmbig); Syn (Redirect -> SYN);	[3]
NR3C1	Updated	Other Pages: nuclear receptor subfamily 3 (No Data); NR3C1 (Redirect -> Glucocorticoid receptor); GCCR (No Data); Gccr (No Data); GCR (DisAmbig); Gcr (No Data); GR (DisAmbig); Gr (Redirect -> GR); GRL (DisAmbig); Grl (No Data); Glucocorticoid receptor (Good Codes Found);	[4]
CASP8	Updated	Other Pages: caspase 8 (Good Codes Found); CASP8 (No Data); CAP4 (No Data); Cap4 (No Data); FLICE (No Data); Flice (No Data); MACH (No Data); Mach (DisAmbig); MCH5 (No Data); Mch5 (No Data); MGC78473 (No Data); Mgc78473 (No Data);	[5]
MMP2	Updated	Other Pages: matrix metallopeptidase 2 (No Data); MMP2 (Good Codes Found); CLG4 (No Data); Clg4 (No Data); CLG4A (No Data); Clg4a (No Data); MMP-II (No Data); Mmp-ii (No Data); MONA (No Data); Mona (DisAmbig); TBE-1 (No Data); Tbe-1 (No Data);	[6]
MDM2	Updated	Other Pages: Mdm2 (Good Codes Found); MDM2 (Redirect -> Mdm2); HDMX (No Data); Hdmx (No Data); MGC71221 (No Data); Mgc71221 (No Data); hdm2 (No Data); Hdm2 (No Data);	[7]
RET	Updated	Other Pages: ret proto-oncogene (Redirect -> RET proto-oncogene); RET (DisAmbig); PTC (DisAmbig); Ptc (No Data); CDHF12 (No Data); Cdhf12 (No Data); HSCR1 (No Data); Hscr1 (No Data); MEN2A (No Data); Men2a (No Data); MEN2B (No Data); Men2b (No Data); MTC1 (No Data); Mtc1 (No Data); RET-ELE1 (No Data); Ret-ele1 (No Data); RET51 (No Data); Ret51 (No Data); RET proto-oncogene (Good Codes Found);	[8]
RELA	Updated	Other Pages: v-rel reticuloendotheliosis viral oncogene homolog A (No Data); RELA (Good Codes Found); MGC131774 (No Data); Mgc131774 (No Data); NFKB3 (No Data); Nfkb3 (No Data);	[9]
HBA1	Manual Inspection (Page not found)	Other Pages: hemoglobin (Protein Template); HBA1 (Good Codes Found); CD31 (Protein Template); Cd31 (No Data); MGC126895 (No Data); Mgc126895 (No Data); MGC126897 (No Data); Mgc126897 (No Data); HBA1 (Good Codes Found); Hba1 (No Data);	[10]
ITGB3	Updated	Other Pages: integrin (Unknown Data); ITGB3 (No Data); CD61 (Good Codes Found); Cd61 (No Data); GP3A (No Data); Gp3a (No Data); GPIIIa (No Data); Gpiiia (No Data);	[11]
SOD1	Updated	Other Pages: superoxide dismutase 1 (No Data); SOD1 (Good Codes Found); ALS (DisAmbig); Als (Unknown Data); ALS1 (No Data); Als1 (No Data); IPOA (Redirect -> International Peace Operations Association); Ipoa (No Data); SOD (Redirect -> Sod (disambiguation)); Sod (Unknown Data); homodimer (Redirect -> dimer); Homodimer (Redirect -> dimer); International Peace Operations Association (Unknown Data); Sod (disambiguation) (DisAmbig); dimer (Unknown Data);	[12]
PSEN1	Updated	Other Pages: presenilin 1 (No Data); PSEN1 (Good Codes Found); FAD (Unknown Data); Fad (Redirect -> Fads and trends); AD3 (No Data); Ad3 (No Data); PS1 (DisAmbig); Ps1 (Redirect -> PS1); S182 (No Data); S182 (No Data); Fads and trends (Unknown Data);	[13]
BAX	Updated	Other Pages: BCL2-associated X protein (Redirect -> Bcl-2-associated X protein); BAX (DisAmbig); Bax zeta (No Data); Bax zeta (No Data); Bcl-2-associated X protein (Good Codes Found);	[14]
CDC2	Updated	Other Pages: cell division cycle 2 (No Data); CDC2 (Good Codes Found); CDC28A (No Data); Cdc28a (No Data); CDK1 (No Data); Cdk1 (No Data); DKFZp686L20222 (No Data); Dkfzp686l20222 (No Data); MGC111195 (No Data); Mgc111195 (No Data);	[15]
ATM	Updated	Other Pages: ataxia telangiectasia mutated (Good Codes Found); ATM (DisAmbig); AT1 (No Data); At1 (No Data); ATD (No Data); Atd (No Data); ATA (DisAmbig); Ata (Redirect -> ATA); ATC (DisAmbig); Atc (Redirect -> ATC); ATDC (Redirect -> Advanced Technology Development Center); Atdc (No Data); ATE (Redirect -> ate); Ate (Unknown Data); DKFZp781A0353 (No Data); Dkfzp781a0353 (No Data); MGC74674 (No Data); Mgc74674 (No Data); TEL1 (No Data); Tel1 (No Data); TELO1 (No Data); Telo1 (No Data); Advanced Technology Development Center (Unknown Data); ate (Unknown Data);	[16]
NOS3	Updated	Other Pages: nitric oxide synthase 3 (No Data); NOS3 (Good Codes Found); ECNOS (No Data); Ecnos (No Data); NOS III (No Data); Nos iii (No Data); eNOS (No Data); Enos (DisAmbig);	[17]
MAPK3	Updated	Other Pages: mitogen-activated protein kinase 3 (Redirect -> Extracellular signal-regulated kinases); MAPK3 (Good Codes Found); ERK1 (No Data); Erk1 (No Data); HS44KDAP (No Data); Hs44kdap (No Data); HUMKER1A (No Data); Humker1a (No Data); MGC20180 (No Data); Mgc20180 (No Data); P44ERK1 (No Data); P44erk1 (No Data); P44MAPK (No Data); P44mapk (No Data); PRKM3 (No Data); Prkm3 (No Data); Extracellular signal-regulated kinases (Protein Template);	[18]
MYC	Updated	Other Pages: v-myc myelocytomatosis viral oncogene homolog (No Data); MYC (Redirect -> Myc); c-Myc (No Data); C-myc (Redirect -> Myc); Myc (Good Codes Found);	[19]
ICAM1	Updated	Other Pages: intercellular adhesion molecule 1 (No Data); ICAM1 (Redirect -> ICAM-1); BB2 (DisAmbig); Bb2 (No Data); CD54 (Redirect -> ICAM-1); Cd54 (No Data); P3.58 (No Data); P3.58 (No Data); ICAM-1 (Good Codes Found);	[20]
TLR4	Updated	Other Pages: toll-like receptor 4 (No Data); TLR4 (Redirect -> TLR 4); CD284 (No Data); Cd284 (No Data); TOLL (No Data); Toll (DisAmbig); hToll (No Data); Htoll (No Data); TLR 4 (Good Codes Found);	[21]
HLA-DRB1	Updated	Other Pages: major histocompatibility complex (Unknown Data); HLA-DRB1 (Good Codes Found); DRB1 (No Data); Drb1 (No Data); HLA DRB1 (No Data); Hla drb1 (No Data); HLA-DR1B (No Data); Hla-dr1b (No Data);	[22]
CCL2	Updated	Other Pages: chemokine ligand 2 (No Data); CCL2 (Good Codes Found); GDCF-2 (No Data); Gdcf-2 (No Data); GDCF-2 HC11 (No Data); Gdcf-2 hc11 (No Data); HC11 (No Data); Hc11 (No Data); HSMCR30 (No Data); Hsmcr30 (No Data); MCAF (No Data); Mcaf (No Data); MCP-1 (Redirect -> CCL2); Mcp-1 (Redirect -> CCL2); MCP1 (No Data); Mcp1 (No Data); MGC9434 (No Data); Mgc9434 (No Data); SCYA2 (No Data); Scya2 (No Data); SMC-CF (No Data); Smc-cf (No Data);	[23]
CREBBP	Manual Inspection (Page not found)	Other Pages: CREB binding protein (Good Codes Found); CREBBP (Redirect -> CREB_binding_protein); CBP (DisAmbig); Cbp (No Data); RSTS (DisAmbig); Rsts (Redirect -> RSTS); RTS (DisAmbig); Rts (Redirect -> RTS); CREB_binding_protein (Good Codes Found);	[24]
HBB	Updated	Other Pages: hemoglobin (Protein Template); HBB (Redirect -> Human β-globin locus); CD113t-C (No Data); Cd113t-c (No Data); HBD (No Data); Hbd (No Data); Human β-globin locus (Good Codes Found);	[25]
CCR5	Updated	Other Pages: chemokine receptor 5 (No Data); CCR5 (Good Codes Found); CC-CKR-5 (No Data); Cc-ckr-5 (No Data); CCCKR5 (No Data); Ccckr5 (No Data); CD195 (No Data); Cd195 (No Data); CKR-5 (No Data); Ckr-5 (No Data); CKR5 (Redirect -> Lumsden (Metz) Airport); Ckr5 (No Data); CMKBR5 (No Data); Cmkbr5 (No Data); Lumsden (Metz) Airport (Unknown Data);	[26]
CCND1	Updated	Other Pages: cyclin D1 (Good Codes Found); CCND1 (Redirect -> cyclin D1); BCL1 (No Data); Bcl1 (No Data); D11S287E (No Data); D11s287e (No Data); PRAD1 (No Data); Prad1 (No Data); U21B31 (No Data); U21b31 (No Data);	[27]
ESR2	Updated	Other Pages: estrogen receptor 2 (No Data); ESR2 (Good Codes Found); ER-BETA (No Data); Er-beta (No Data); ESR-BETA (No Data); Esr-beta (No Data); ESRB (Redirect -> Entertainment_Software_Rating_Board); Esrb (No Data); ESTRB (No Data); Estrb (No Data); Erb (DisAmbig); Erb (DisAmbig); NR3A2 (No Data); Nr3a2 (No Data); Entertainment_Software_Rating_Board (Unknown Data);	[28]
SNCA	Manual Inspection (Page not found)	Other Pages: synuclein (Protein Template); SNCA (Redirect -> Alpha-synuclein); PD1 (No Data); Pd1 (Redirect -> The Princess Diaries (film)); MGC110988 (No Data); Mgc110988 (No Data); NACP (DisAmbig); Nacp (No Data); PARK1 (No Data); Park1 (No Data); PARK4 (No Data); Park4 (No Data); Alpha-synuclein (Unknown Data); The Princess Diaries (film) (Unknown Data);	[29]
ABCB1	Updated	Other Pages: ATP-binding cassette (Redirect -> ATP-binding cassette transporter); ABCB1 (Redirect -> p-glycoprotein); ABC20 (No Data); Abc20 (No Data); CD243 (No Data); Cd243 (No Data); CLCS (No Data); Clcs (No Data); GP170 (No Data); Gp170 (No Data); MDR1 (No Data); Mdr1 (Protein Template); MGC163296 (No Data); Mgc163296 (No Data); P-gp (No Data); P-gp (No Data); PGY1 (No Data); Pgy1 (No Data); ATP-binding cassette transporter (Unknown Data); p-glycoprotein (Good Codes Found);	[30]
PRKCD	Updated	Other Pages: protein kinase C (Unknown Data); PRKCD (Good Codes Found); MAY1 (No Data); May1 (No Data); MGC49908 (No Data); Mgc49908 (No Data); nPKC-delta (No Data); Npkc-delta (No Data);	[31]
LCK	Updated	Other Pages: lymphocyte-specific protein tyrosine kinase (Redirect -> Lck); LCK (DisAmbig); YT16 (No Data); Yt16 (No Data); p56lck (No Data); P56lck (No Data); pp58lck (No Data); Pp58lck (No Data); Lck (Good Codes Found);	[32]
PRKACA	Updated	Other Pages: protein kinase (Unknown Data); PRKACA (Good Codes Found); MGC102831 (No Data); Mgc102831 (No Data); MGC48865 (No Data); Mgc48865 (No Data); PKACA (No Data); Pkaca (No Data);	[33]
GRB2	Updated	Other Pages: growth factor receptor-bound protein 2 (Redirect -> Grb2); GRB2 (Redirect -> Grb2); ASH (Redirect -> Ash); Ash (DisAmbig); EGFRBP-GRB2 (No Data); Egfrbp-grb2 (No Data); Grb3-3 (No Data); Grb3-3 (No Data); MST084 (No Data); Mst084 (No Data); MSTP084 (No Data); Mstp084 (No Data); Grb2 (Good Codes Found);	[34]
HLA-A	Updated	Other Pages: major histocompatibility complex (Unknown Data); HLA-A (Good Codes Found);	[35]
F2	Updated	Other Pages: coagulation factor II (Redirect -> thrombin); F2 (DisAmbig); PT (DisAmbig); Pt (Redirect -> PT); thrombin (Good Codes Found);	[36]
IFNG	Updated	Other Pages: interferon (Unknown Data); IFNG (Redirect -> interferon-gamma); IFG (DisAmbig); Ifg (No Data); IFI (Unknown Data); Ifi (No Data); interferon-gamma (Good Codes Found);	[37]
CXCR4	Updated	Other Pages: chemokine receptor 4 (No Data); CXCR4 (Good Codes Found); NPYR (No Data); Npyr (No Data); CD184 (Redirect -> CXCR4); Cd184 (No Data); D2S201E (No Data); D2s201e (No Data); FB22 (No Data); Fb22 (No Data); HM89 (No Data); Hm89 (No Data); HSY3RR (No Data); Hsy3rr (No Data); LAP3 (No Data); Lap3 (No Data); LCR1 (No Data); Lcr1 (No Data); LESTR (No Data); Lestr (No Data); NPY3R (No Data); Npy3r (No Data); NPYRL (No Data); Npyrl (No Data); NPYY3R (No Data); Npyy3r (No Data); WHIM (DisAmbig); Whim (DisAmbig);	[38]
RAC1	Updated	Other Pages: ras-related C3 botulinum toxin substrate 1 (No Data); RAC1 (Good Codes Found); MGC111543 (No Data); Mgc111543 (No Data); MIG5 (No Data); Mig5 (No Data); TC-25 (No Data); Tc-25 (No Data); p21-Rac1 (No Data); P21-rac1 (No Data);	[39]
SP1	Manual Inspection (Page not found)	Other Pages: Sp1 transcription factor (Redirect -> Sp1); SP1 (DisAmbig); Sp1 (Unknown Data);	[40]
PTEN	Manual Inspection (Page not found)	Other Pages: phosphatase and tensin homolog (Redirect -> PTEN (gene)); PTEN (DisAmbig); BZS (No Data); Bzs (No Data); MGC11227 (No Data); Mgc11227 (No Data); MHAM (No Data); Mham (No Data); MMAC1 (No Data); Mmac1 (No Data); PTEN1 (No Data); Pten1 (No Data); TEP1 (No Data); Tep1 (No Data); PTEN (gene) (Unknown Data);	[41]
LEP	Updated	Other Pages: leptin (Good Codes Found); LEP (Redirect -> Large Electron-Positron Collider); OB (DisAmbig); Ob (Unknown Data); OBS (DisAmbig); Obs (No Data); Large Electron-Positron Collider (Unknown Data);	[42]
TERT	Updated	Other Pages: telomerase reverse transcriptase (Good Codes Found); TERT (Unknown Data); EST2 (No Data); Est2 (No Data); TCS1 (No Data); Tcs1 (No Data); TP2 (No Data); Tp2 (No Data); TRT (DisAmbig); Trt (No Data); hEST2 (No Data); Hest2 (No Data);	[43]
JAK2	Updated	Other Pages: Janus kinase 2 (Good Codes Found); JAK2 (Redirect -> Janus kinase); Janus kinase (Unknown Data);	[44]
JUN	Updated	Other Pages: jun oncogene (No Data); JUN (Unknown Data); AP1 (No Data); Ap1 (No Data); c-Jun (Redirect -> C-jun); C-jun (Good Codes Found);	[45]
EP300	Updated	Other Pages: E1A binding protein p300 (No Data); EP300 (Good Codes Found); p300 (DisAmbig); P300 (DisAmbig);	[46]
VWF	Updated	Other Pages: von Willebrand factor (Good Codes Found); VWF (Redirect -> von Willebrand factor); F8VWF (No Data); F8vwf (No Data); VWD (Redirect -> Von Willebrand disease); Vwd (No Data); Von Willebrand disease (Unknown Data);	[47]
CSNK2A1	Updated	Other Pages: casein kinase 2 (Protein Template); CSNK2A1 (Good Codes Found); CK2A1 (No Data); Ck2a1 (No Data); CKII (No Data); Ckii (No Data); CKII alpha (No Data); Ckii alpha (No Data);	[48]
ADIPOQ	Manual Inspection (Page not found)	Other Pages: adiponectin (Good Codes Found); ADIPOQ (No Data); ACDC (Redirect -> AC/DC); Acdc (Redirect -> AC/DC); ACRP30 (No Data); Acrp30 (No Data); APM-1 (No Data); Apm-1 (No Data); APM1 (No Data); Apm1 (No Data); GBP28 (No Data); Gbp28 (No Data); adiponectin (Good Codes Found); Adiponectin (Good Codes Found); AC/DC (Unknown Data);	[49]
INSR	Updated	Other Pages: insulin receptor (Good Codes Found); INSR (No Data); CD220 (No Data); Cd220 (No Data); HHF5 (No Data); Hhf5 (No Data);	[50]

Vebose Log - Date: 07:48, 9 October 2007 (UTC)

ABCB1

INFO: Beginning work on ABCB1... {October 9, 2007 12:33:06 AM PDT}
SEARCH REDIRECT: Control Box Found: p-glycoprotein {October 9, 2007 12:33:46 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:33:48 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:33:48 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:33:48 AM PDT}
UPDATED: Updated protein page: p-glycoprotein {October 9, 2007 12:33:55 AM PDT}

ADIPOQ

INFO: Beginning work on ADIPOQ... {October 9, 2007 12:44:39 AM PDT}
SEARCH: Multiple Conflicting Pages. Need Resolution. {October 9, 2007 12:45:05 AM PDT}
AMBIGUITY: More than one potential page found for updating, adiponectin adiponectin Adiponectin {October 9, 2007 12:45:05 AM PDT}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = {{PDB2|1c28}}, {{PDB2|1c3h}}
 | Name = Adiponectin, C1Q and collagen domain containing
 | HGNCid = 13633
 | Symbol = ADIPOQ
 | AltSymbols =; ACDC; ACRP30; APM-1; APM1; GBP28; adiponectin
 | OMIM = 605441
 | ECnumber =  
 | Homologene = 3525
 | MGIid = 106675
 | GeneAtlas_image1 = PBB_GE_ADIPOQ_207175_at_tn.png
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | DateOfBotUpdate = ~~~~~
 | Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} 
 | Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006635 |text = fatty acid beta-oxidation}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0009749 |text = response to glucose stimulus}} {{GNF_GO|id=GO:0042593 |text = glucose homeostasis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045721 |text = negative regulation of gluconeogenesis}} {{GNF_GO|id=GO:0045923 |text = positive regulation of fatty acid metabolic process}} {{GNF_GO|id=GO:0046326 |text = positive regulation of glucose import}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9370
    | Hs_Ensembl = ENSG00000181092
    | Hs_RefseqProtein = NP_004788
    | Hs_RefseqmRNA = NM_004797
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 188043157
    | Hs_GenLoc_end = 188058944
    | Hs_Uniprot = Q15848
    | Mm_EntrezGene = 11450
    | Mm_Ensembl = ENSMUSG00000022878
    | Mm_RefseqmRNA = NM_009605
    | Mm_RefseqProtein = NP_033735
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 23061870
    | Mm_GenLoc_end = 23073302
    | Mm_Uniprot = Q6GTX4
  }}
}}
'''Adiponectin, C1Q and collagen domain containing''', also known as '''ADIPOQ''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes.<ref>{{cite web | title = Entrez Gene: ADIPOQ adiponectin, C1Q and collagen domain containing| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9370| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ukkola O, Santaniemi M |title=Adiponectin: a link between excess adiposity and associated comorbidities? |journal=J. Mol. Med. |volume=80 |issue= 11 |pages= 696-702 |year= 2003 |pmid= 12436346 |doi= 10.1007/s00109-002-0378-7 }}
*{{cite journal  | author=Díez JJ, Iglesias P |title=The role of the novel adipocyte-derived hormone adiponectin in human disease. |journal=Eur. J. Endocrinol. |volume=148 |issue= 3 |pages= 293-300 |year= 2003 |pmid= 12611609 |doi=  }}
*{{cite journal  | author=Vasseur F, Leprêtre F, Lacquemant C, Froguel P |title=The genetics of adiponectin. |journal=Curr. Diab. Rep. |volume=3 |issue= 2 |pages= 151-8 |year= 2003 |pmid= 12728641 |doi=  }}
*{{cite journal  | author=Matsuzawa Y, Funahashi T, Kihara S, Shimomura I |title=Adiponectin and metabolic syndrome. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 1 |pages= 29-33 |year= 2004 |pmid= 14551151 |doi= 10.1161/01.ATV.0000099786.99623.EF }}
*{{cite journal  | author=Nedvídková J, Smitka K, Kopský V, Hainer V |title=Adiponectin, an adipocyte-derived protein. |journal=Physiological research / Academia Scientiarum Bohemoslovaca |volume=54 |issue= 2 |pages= 133-40 |year= 2006 |pmid= 15544426 |doi=  }}
*{{cite journal  | author=Hug C, Lodish HF |title=The role of the adipocyte hormone adiponectin in cardiovascular disease. |journal=Current opinion in pharmacology |volume=5 |issue= 2 |pages= 129-34 |year= 2005 |pmid= 15780820 |doi= 10.1016/j.coph.2005.01.001 }}
*{{cite journal  | author=Hara K, Yamauchi T, Kadowaki T |title=Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans. |journal=Curr. Diab. Rep. |volume=5 |issue= 2 |pages= 136-40 |year= 2005 |pmid= 15794918 |doi=  }}
*{{cite journal  | author=Menzaghi C, Trischitta V, Doria A |title=Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. |journal=Diabetes |volume=56 |issue= 5 |pages= 1198-209 |year= 2007 |pmid= 17303804 |doi= 10.2337/db06-0506 }}
*{{cite journal  | author=Lara-Castro C, Fu Y, Chung BH, Garvey WT |title=Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 263-70 |year= 2007 |pmid= 17495599 |doi= 10.1097/MOL.0b013e32814a645f }}
}}
{{refend}}

{{protein-stub}}

ATM

INFO: Beginning work on ATM... {October 9, 2007 12:12:08 AM PDT}
SEARCH REDIRECT: Control Box Found: ataxia telangiectasia mutated {October 9, 2007 12:12:44 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:12:47 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:12:47 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:12:47 AM PDT}
UPDATED: Updated protein page: ataxia telangiectasia mutated {October 9, 2007 12:12:56 AM PDT}

BAX

INFO: Beginning work on BAX... {October 9, 2007 12:12:56 AM PDT}
SEARCH REDIRECT: Control Box Found: Bcl-2-associated X protein {October 9, 2007 12:13:25 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:13:26 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:13:26 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:13:26 AM PDT}
UPDATED: Updated protein page: Bcl-2-associated X protein {October 9, 2007 12:13:35 AM PDT}

CASP8

INFO: Beginning work on CASP8... {October 9, 2007 12:14:11 AM PDT}
SEARCH REDIRECT: Control Box Found: caspase 8 {October 9, 2007 12:14:38 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=caspase 8>caspase 8</a> {October 9, 2007 12:14:45 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:14:52 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:14:52 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:14:52 AM PDT}
UPDATED: Updated protein page: caspase 8 {October 9, 2007 12:14:58 AM PDT}

CCL2

INFO: Beginning work on CCL2... {October 9, 2007 12:39:06 AM PDT}
SEARCH REDIRECT: Control Box Found: CCL2 {October 9, 2007 12:39:45 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=CCL2>CCL2</a> {October 9, 2007 12:39:52 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:40:00 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:40:00 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:40:00 AM PDT}
UPDATED: Updated protein page: CCL2 {October 9, 2007 12:40:05 AM PDT}

CCND1

INFO: Beginning work on CCND1... {October 9, 2007 12:13:35 AM PDT}
SEARCH REDIRECT: Control Box Found: cyclin D1 {October 9, 2007 12:14:03 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:14:06 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:14:06 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:14:06 AM PDT}
UPDATED: Updated protein page: cyclin D1 {October 9, 2007 12:14:11 AM PDT}

CCR5

INFO: Beginning work on CCR5... {October 9, 2007 12:16:08 AM PDT}
SEARCH REDIRECT: Control Box Found: CCR5 {October 9, 2007 12:16:31 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:16:34 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:16:34 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:16:34 AM PDT}
UPDATED: Updated protein page: CCR5 {October 9, 2007 12:16:41 AM PDT}

CDC2

INFO: Beginning work on CDC2... {October 9, 2007 12:14:58 AM PDT}
SEARCH REDIRECT: Control Box Found: CDC2 {October 9, 2007 12:15:32 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:15:34 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:15:34 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:15:34 AM PDT}
UPDATED: Updated protein page: CDC2 {October 9, 2007 12:15:40 AM PDT}

CDKN1B

INFO: Beginning work on CDKN1B... {October 9, 2007 12:15:40 AM PDT}
SEARCH REDIRECT: Control Box Found: CDKN1B {October 9, 2007 12:16:02 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:16:03 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:16:03 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:16:03 AM PDT}
UPDATED: Updated protein page: CDKN1B {October 9, 2007 12:16:08 AM PDT}

CREBBP

INFO: Beginning work on CREBBP... {October 9, 2007 12:16:41 AM PDT}
SEARCH: Multiple Conflicting Pages. Need Resolution. {October 9, 2007 12:17:08 AM PDT}
AMBIGUITY: More than one potential page found for updating, CREB binding protein CREB_binding_protein {October 9, 2007 12:17:08 AM PDT}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = {{PDB2|1f81}}, {{PDB2|1jjs}}, {{PDB2|1jsp}}, {{PDB2|1kbh}}, {{PDB2|1kdx}}, {{PDB2|1l3e}}, {{PDB2|1l8c}}, {{PDB2|1liq}}, {{PDB2|1p4q}}, {{PDB2|1r8u}}, {{PDB2|1sb0}}, {{PDB2|1tot}}, {{PDB2|1u2n}}, {{PDB2|1zoq}}, {{PDB2|2agh}}, {{PDB2|2c52}}, {{PDB2|2d82}}
 | Name = CREB binding protein (Rubinstein-Taybi syndrome)
 | HGNCid = 2348
 | Symbol = CREBBP
 | AltSymbols =; CBP; RSTS; RTS
 | OMIM = 600140
 | ECnumber =  
 | Homologene = 68393
 | MGIid = 1098280
 | GeneAtlas_image1 = PBB_GE_CREBBP_202160_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CREBBP_211808_s_at_tn.png
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | DateOfBotUpdate = ~~~~~
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016407 |text = acetyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0051577 |text = MyoD binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016573 |text = histone acetylation}} {{GNF_GO|id=GO:0042592 |text = homeostatic process}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1387
    | Hs_Ensembl = ENSG00000005339
    | Hs_RefseqProtein = NP_001073315
    | Hs_RefseqmRNA = NM_001079846
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 3716572
    | Hs_GenLoc_end = 3870723
    | Hs_Uniprot = Q92793
    | Mm_EntrezGene = 12914
    | Mm_Ensembl = ENSMUSG00000022521
    | Mm_RefseqmRNA = NM_001025432
    | Mm_RefseqProtein = NP_001020603
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 3999276
    | Mm_GenLoc_end = 4128632
    | Mm_Uniprot = P45481
  }}
}}
'''CREB binding protein (Rubinstein-Taybi syndrome)''', also known as '''CREBBP''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Goldman PS, Tran VK, Goodman RH |title=The multifunctional role of the co-activator CBP in transcriptional regulation. |journal=Recent Prog. Horm. Res. |volume=52 |issue=  |pages= 103-19; discussion 119-20 |year= 1997 |pmid= 9238849 |doi=  }}
*{{cite journal  | author=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175-81 |year= 2002 |pmid= 11547919 |doi=  }}
*{{cite journal  | author=Matt T |title=Transcriptional control of the inflammatory response: a role for the CREB-binding protein (CBP). |journal=Acta Med. Austriaca |volume=29 |issue= 3 |pages= 77-9 |year= 2002 |pmid= 12168567 |doi=  }}
*{{cite journal  | author=Combes R, Balls M, Bansil L, ''et al.'' |title=An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). |journal=Alternatives to laboratory animals : ATLA |volume=30 |issue= 4 |pages= 365-406 |year= 2002 |pmid= 12234245 |doi=  }}
*{{cite journal  | author=Minghetti L, Visentin S, Patrizio M, ''et al.'' |title=Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions. |journal=Neurochem. Res. |volume=29 |issue= 5 |pages= 965-78 |year= 2004 |pmid= 15139295 |doi=  }}
*{{cite journal  | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal  | author=Greene WC, Chen LF |title=Regulation of NF-kappaB action by reversible acetylation. |journal=Novartis Found. Symp. |volume=259 |issue=  |pages= 208-17; discussion 218-25 |year= 2004 |pmid= 15171256 |doi=  }}
*{{cite journal  | author=Liou LY, Herrmann CH, Rice AP |title=HIV-1 infection and regulation of Tat function in macrophages. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 9 |pages= 1767-75 |year= 2005 |pmid= 15183343 |doi= 10.1016/j.biocel.2004.02.018 }}
*{{cite journal  | author=Pugliese A, Vidotto V, Beltramo T, ''et al.'' |title=A review of HIV-1 Tat protein biological effects. |journal=Cell Biochem. Funct. |volume=23 |issue= 4 |pages= 223-7 |year= 2005 |pmid= 15473004 |doi= 10.1002/cbf.1147 }}
*{{cite journal  | author=Bannwarth S, Gatignol A |title=HIV-1 TAR RNA: the target of molecular interactions between the virus and its host. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 61-71 |year= 2005 |pmid= 15638724 |doi=  }}
*{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
*{{cite journal  | author=Gibellini D, Vitone F, Schiavone P, Re MC |title=HIV-1 tat protein and cell proliferation and survival: a brief review. |journal=New Microbiol. |volume=28 |issue= 2 |pages= 95-109 |year= 2005 |pmid= 16035254 |doi=  }}
*{{cite journal  | author=Hetzer C, Dormeyer W, Schnölzer M, Ott M |title=Decoding Tat: the biology of HIV Tat posttranslational modifications. |journal=Microbes Infect. |volume=7 |issue= 13 |pages= 1364-9 |year= 2006 |pmid= 16046164 |doi= 10.1016/j.micinf.2005.06.003 }}
*{{cite journal  | author=Peruzzi F |title=The multiple functions of HIV-1 Tat: proliferation versus apoptosis. |journal=Front. Biosci. |volume=11 |issue=  |pages= 708-17 |year= 2006 |pmid= 16146763 |doi=  }}
}}
{{refend}}

{{protein-stub}}

CSNK2A1

INFO: Beginning work on CSNK2A1... {October 9, 2007 12:17:08 AM PDT}
SEARCH REDIRECT: Control Box Found: CSNK2A1 {October 9, 2007 12:17:39 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=CSNK2A1>CSNK2A1</a> {October 9, 2007 12:17:47 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:17:54 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:17:54 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:17:54 AM PDT}
UPDATED: Updated protein page: CSNK2A1 {October 9, 2007 12:17:59 AM PDT}

CXCR4

INFO: Beginning work on CXCR4... {October 9, 2007 12:43:41 AM PDT}
SEARCH REDIRECT: Control Box Found: CXCR4 {October 9, 2007 12:44:29 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:44:31 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:44:31 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:44:31 AM PDT}
UPDATED: Updated protein page: CXCR4 {October 9, 2007 12:44:39 AM PDT}

EP300

INFO: Beginning work on EP300... {October 9, 2007 12:17:59 AM PDT}
SEARCH REDIRECT: Control Box Found: EP300 {October 9, 2007 12:18:17 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=EP300>EP300</a> {October 9, 2007 12:18:25 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:18:32 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:18:32 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:18:32 AM PDT}
UPDATED: Updated protein page: EP300 {October 9, 2007 12:18:38 AM PDT}

ESR2

INFO: Beginning work on ESR2... {October 9, 2007 12:18:38 AM PDT}
SEARCH REDIRECT: Control Box Found: ESR2 {October 9, 2007 12:19:17 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=ESR2>ESR2</a> {October 9, 2007 12:19:25 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:19:32 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:19:32 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:19:32 AM PDT}
UPDATED: Updated protein page: ESR2 {October 9, 2007 12:19:40 AM PDT}

F2

INFO: Beginning work on F2... {October 9, 2007 12:19:40 AM PDT}
SEARCH REDIRECT: Control Box Found: thrombin {October 9, 2007 12:19:58 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:19:59 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:19:59 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:19:59 AM PDT}
UPDATED: Updated protein page: thrombin {October 9, 2007 12:20:12 AM PDT}

FYN

INFO: Beginning work on FYN... {October 9, 2007 12:20:12 AM PDT}
SEARCH REDIRECT: Control Box Found: FYN {October 9, 2007 12:20:36 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=FYN>FYN</a> {October 9, 2007 12:20:44 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:20:51 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:20:51 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:20:51 AM PDT}
UPDATED: Updated protein page: FYN {October 9, 2007 12:21:01 AM PDT}

GRB2

INFO: Beginning work on GRB2... {October 9, 2007 12:21:01 AM PDT}
SEARCH REDIRECT: Control Box Found: Grb2 {October 9, 2007 12:21:30 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Grb2>Grb2</a> {October 9, 2007 12:21:37 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:21:45 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:21:45 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:21:45 AM PDT}
UPDATED: Updated protein page: Grb2 {October 9, 2007 12:21:51 AM PDT}

HBA1

INFO: Beginning work on HBA1... {October 9, 2007 12:22:37 AM PDT}
SEARCH: Multiple Conflicting Pages. Need Resolution. {October 9, 2007 12:22:58 AM PDT}
AMBIGUITY: More than one potential page found for updating, HBA1 HBA1 {October 9, 2007 12:22:58 AM PDT}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = {{PDB2|1a00}}, {{PDB2|1a01}}, {{PDB2|1a0u}}, {{PDB2|1a0z}}, {{PDB2|1a3n}}, {{PDB2|1a3o}}, {{PDB2|1a9w}}, {{PDB2|1abw}}, {{PDB2|1aby}}, {{PDB2|1aj9}}, {{PDB2|1b86}}, {{PDB2|1bab}}, {{PDB2|1bbb}}, {{PDB2|1bij}}, {{PDB2|1buw}}, {{PDB2|1bz0}}, {{PDB2|1bz1}}, {{PDB2|1bzz}}, {{PDB2|1c7b}}, {{PDB2|1c7c}}, {{PDB2|1c7d}}, {{PDB2|1cls}}, {{PDB2|1cmy}}, {{PDB2|1coh}}, {{PDB2|1dke}}, {{PDB2|1dxt}}, {{PDB2|1dxu}}, {{PDB2|1dxv}}, {{PDB2|1fdh}}, {{PDB2|1fn3}}, {{PDB2|1g9v}}, {{PDB2|1gbu}}, {{PDB2|1gbv}}, {{PDB2|1gli}}, {{PDB2|1gzx}}, {{PDB2|1hab}}, {{PDB2|1hac}}, {{PDB2|1hba}}, {{PDB2|1hbb}}, {{PDB2|1hbs}}, {{PDB2|1hco}}, {{PDB2|1hdb}}, {{PDB2|1hga}}, {{PDB2|1hgb}}, {{PDB2|1hgc}}, {{PDB2|1hho}}, {{PDB2|1ird}}, {{PDB2|1j3y}}, {{PDB2|1j3z}}, {{PDB2|1j40}}, {{PDB2|1j41}}, {{PDB2|1j7s}}, {{PDB2|1j7w}}, {{PDB2|1j7y}}, {{PDB2|1jy7}}, {{PDB2|1k0y}}, {{PDB2|1k1k}}, {{PDB2|1kd2}}, {{PDB2|1lfl}}, {{PDB2|1lfq}}, {{PDB2|1lft}}, {{PDB2|1lfv}}, {{PDB2|1lfy}}, {{PDB2|1lfz}}, {{PDB2|1ljw}}, {{PDB2|1m9p}}, {{PDB2|1mko}}, {{PDB2|1nej}}, {{PDB2|1nih}}, {{PDB2|1nqp}}, {{PDB2|1o1i}}, {{PDB2|1o1j}}, {{PDB2|1o1k}}, {{PDB2|1o1l}}, {{PDB2|1o1m}}, {{PDB2|1o1n}}, {{PDB2|1o1o}}, {{PDB2|1o1p}}, {{PDB2|1qi8}}, {{PDB2|1qsh}}, {{PDB2|1qsi}}, {{PDB2|1qxd}}, {{PDB2|1qxe}}, {{PDB2|1r1x}}, {{PDB2|1r1y}}, {{PDB2|1rps}}, {{PDB2|1rq3}}, {{PDB2|1rq4}}, {{PDB2|1rqa}}, {{PDB2|1rvw}}, {{PDB2|1sdk}}, {{PDB2|1sdl}}, {{PDB2|1shr}}, {{PDB2|1si4}}, {{PDB2|1thb}}, {{PDB2|1uiw}}, {{PDB2|1vwt}}, {{PDB2|1xxt}}, {{PDB2|1xy0}}, {{PDB2|1xye}}, {{PDB2|1xz2}}, {{PDB2|1xz4}}, {{PDB2|1xz5}}, {{PDB2|1xz7}}, {{PDB2|1xzu}}, {{PDB2|1xzv}}, {{PDB2|1y01}}, {{PDB2|1y09}}, {{PDB2|1y0a}}, {{PDB2|1y0c}}, {{PDB2|1y0d}}, {{PDB2|1y0t}}, {{PDB2|1y0w}}, {{PDB2|1y22}}, {{PDB2|1y2z}}, {{PDB2|1y31}}, {{PDB2|1y35}}, {{PDB2|1y45}}, {{PDB2|1y46}}, {{PDB2|1y4b}}, {{PDB2|1y4f}}, {{PDB2|1y4g}}, {{PDB2|1y4p}}, {{PDB2|1y4q}}, {{PDB2|1y4r}}, {{PDB2|1y4v}}, {{PDB2|1y5f}}, {{PDB2|1y5j}}, {{PDB2|1y5k}}, {{PDB2|1y7c}}, {{PDB2|1y7d}}, {{PDB2|1y7g}}, {{PDB2|1y7z}}, {{PDB2|1y83}}, {{PDB2|1y85}}, {{PDB2|1y8w}}, {{PDB2|1ydz}}, {{PDB2|1ye0}}, {{PDB2|1ye1}}, {{PDB2|1ye2}}, {{PDB2|1yen}}, {{PDB2|1yeo}}, {{PDB2|1yeq}}, {{PDB2|1yeu}}, {{PDB2|1yev}}, {{PDB2|1yff}}, {{PDB2|1yg5}}, {{PDB2|1ygd}}, {{PDB2|1ygf}}, {{PDB2|1yh9}}, {{PDB2|1yhe}}, {{PDB2|1yhr}}, {{PDB2|1yie}}, {{PDB2|1yih}}, {{PDB2|1yvq}}, {{PDB2|1yvt}}, {{PDB2|1yzi}}, {{PDB2|1z8u}}, {{PDB2|2d5z}}, {{PDB2|2d60}}, {{PDB2|2dn1}}, {{PDB2|2dn2}}, {{PDB2|2dn3}}, {{PDB2|2h35}}, {{PDB2|2hbc}}, {{PDB2|2hbd}}, {{PDB2|2hbe}}, {{PDB2|2hbf}}, {{PDB2|2hbs}}, {{PDB2|2hco}}, {{PDB2|2hhb}}, {{PDB2|2hhd}}, {{PDB2|2hhe}}, {{PDB2|3hhb}}, {{PDB2|4hhb}}, {{PDB2|6hbw}}
 | Name = Hemoglobin, alpha 1
 | HGNCid = 4823
 | Symbol = HBA1
 | AltSymbols =; CD31; MGC126895; MGC126897; HBA1
 | OMIM = 141800
 | ECnumber =  
 | Homologene = 469
 | MGIid = 96015
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | DateOfBotUpdate = ~~~~~
 | Function = {{GNF_GO|id=GO:0005344 |text = oxygen transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005833 |text = hemoglobin complex}} 
 | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015671 |text = oxygen transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3039
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_000549
    | Hs_RefseqmRNA = NM_000558
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 15122
    | Mm_Ensembl = ENSMUSG00000069917
    | Mm_RefseqmRNA = NM_008218
    | Mm_RefseqProtein = NP_032244
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 32196489
    | Mm_GenLoc_end = 32197310
    | Mm_Uniprot = Q61287
  }}
}}
'''Hemoglobin, alpha 1''', also known as '''HBA1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.<ref>{{cite web | title = Entrez Gene: HBA1 hemoglobin, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3039| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Schillirò G, Russo-Mancuso G, Dibenedetto SP, ''et al.'' |title=Six rare hemoglobin variants found in Sicily. |journal=Hemoglobin |volume=15 |issue= 5 |pages= 431-7 |year= 1992 |pmid= 1802885 |doi=  }}
*{{cite journal  | author=Higgs DR, Vickers MA, Wilkie AO, ''et al.'' |title=A review of the molecular genetics of the human alpha-globin gene cluster. |journal=Blood |volume=73 |issue= 5 |pages= 1081-104 |year= 1989 |pmid= 2649166 |doi=  }}
*{{cite journal  | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165-96 |year= 1995 |pmid= 7555018 |doi=  }}
*{{cite journal  | author=Yalçin A, Avcu F, Beyan C, ''et al.'' |title=A case of HB J-Meerut (or Hb J-Birmingham) [alpha 120(H3)Ala-->Glu] |journal=Hemoglobin |volume=18 |issue= 6 |pages= 433-5 |year= 1995 |pmid= 7713747 |doi=  }}
*{{cite journal  | author=Turbpaiboon C, Svasti S, Sawangareetakul P, ''et al.'' |title=Hb Siam [alpha15(A13)Gly-->Arg (alpha1) (GGT-->CGT)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect. |journal=Hemoglobin |volume=26 |issue= 1 |pages= 77-81 |year= 2002 |pmid= 11939517 |doi=  }}
}}
{{refend}}

{{protein-stub}}

HBB

INFO: Beginning work on HBB... {October 9, 2007 12:22:58 AM PDT}
SEARCH REDIRECT: Control Box Found: Human β-globin locus {October 9, 2007 12:23:15 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Human β-globin locus>Human β-globin locus</a> {October 9, 2007 12:23:23 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:23:30 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:23:30 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:23:30 AM PDT}
UPDATED: Updated protein page: Human β-globin locus {October 9, 2007 12:23:37 AM PDT}

HLA-A

INFO: Beginning work on HLA-A... {October 9, 2007 12:23:37 AM PDT}
SEARCH REDIRECT: Control Box Found: HLA-A {October 9, 2007 12:23:50 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:23:51 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:23:51 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:23:51 AM PDT}
UPDATED: Updated protein page: HLA-A {October 9, 2007 12:23:58 AM PDT}

HLA-DRB1

INFO: Beginning work on HLA-DRB1... {October 9, 2007 12:23:58 AM PDT}
SEARCH REDIRECT: Control Box Found: HLA-DRB1 {October 9, 2007 12:24:23 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=HLA-DRB1>HLA-DRB1</a> {October 9, 2007 12:24:31 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:24:39 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:24:39 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:24:39 AM PDT}
UPDATED: Updated protein page: HLA-DRB1 {October 9, 2007 12:24:44 AM PDT}

ICAM1

INFO: Beginning work on ICAM1... {October 9, 2007 12:24:44 AM PDT}
SEARCH REDIRECT: Control Box Found: ICAM-1 {October 9, 2007 12:25:11 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=ICAM-1>ICAM-1</a> {October 9, 2007 12:25:18 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:25:26 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:25:26 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:25:26 AM PDT}
UPDATED: Updated protein page: ICAM-1 {October 9, 2007 12:25:32 AM PDT}

IFNG

INFO: Beginning work on IFNG... {October 9, 2007 12:25:32 AM PDT}
SEARCH REDIRECT: Control Box Found: interferon-gamma {October 9, 2007 12:25:52 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:25:54 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:25:54 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:25:54 AM PDT}
UPDATED: Updated protein page: interferon-gamma {October 9, 2007 12:26:02 AM PDT}

INSR

INFO: Beginning work on INSR... {October 9, 2007 12:26:03 AM PDT}
SEARCH REDIRECT: Control Box Found: insulin receptor {October 9, 2007 12:26:23 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=insulin receptor>insulin receptor</a> {October 9, 2007 12:26:30 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:26:37 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:26:37 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:26:37 AM PDT}
UPDATED: Updated protein page: insulin receptor {October 9, 2007 12:26:44 AM PDT}

ITGB3

INFO: Beginning work on ITGB3... {October 9, 2007 12:26:44 AM PDT}
SEARCH REDIRECT: Control Box Found: CD61 {October 9, 2007 12:27:07 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=CD61>CD61</a> {October 9, 2007 12:27:15 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:27:22 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:27:22 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:27:22 AM PDT}
UPDATED: Updated protein page: CD61 {October 9, 2007 12:27:29 AM PDT}

JAK2

INFO: Beginning work on JAK2... {October 9, 2007 12:27:29 AM PDT}
SEARCH REDIRECT: Control Box Found: Janus kinase 2 {October 9, 2007 12:27:40 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Janus kinase 2>Janus kinase 2</a> {October 9, 2007 12:27:48 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:27:55 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:27:55 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:27:55 AM PDT}
UPDATED: Updated protein page: Janus kinase 2 {October 9, 2007 12:28:01 AM PDT}

JUN

INFO: Beginning work on JUN... {October 9, 2007 12:28:01 AM PDT}
SEARCH REDIRECT: Control Box Found: C-jun {October 9, 2007 12:28:25 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=C-jun>C-jun</a> {October 9, 2007 12:28:32 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:28:39 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:28:39 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:28:39 AM PDT}
UPDATED: Updated protein page: C-jun {October 9, 2007 12:28:46 AM PDT}

LCK

INFO: Beginning work on LCK... {October 9, 2007 12:28:46 AM PDT}
SEARCH REDIRECT: Control Box Found: Lck {October 9, 2007 12:29:08 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:29:09 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:29:09 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:29:09 AM PDT}
UPDATED: Updated protein page: Lck {October 9, 2007 12:29:15 AM PDT}

LEP

INFO: Beginning work on LEP... {October 9, 2007 12:29:15 AM PDT}
SEARCH REDIRECT: Control Box Found: leptin {October 9, 2007 12:29:36 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:29:37 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:29:37 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:29:37 AM PDT}
UPDATED: Updated protein page: leptin {October 9, 2007 12:29:45 AM PDT}

MAPK3

INFO: Beginning work on MAPK3... {October 9, 2007 12:35:17 AM PDT}
SEARCH REDIRECT: Control Box Found: MAPK3 {October 9, 2007 12:35:52 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:35:55 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:35:55 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:35:55 AM PDT}
UPDATED: Updated protein page: MAPK3 {October 9, 2007 12:36:00 AM PDT}

MDM2

INFO: Beginning work on MDM2... {October 9, 2007 12:29:45 AM PDT}
SEARCH REDIRECT: Control Box Found: Mdm2 {October 9, 2007 12:30:17 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:30:19 AM PDT}
SKIP SUMMARY: Skipping Summary, No Errors. {October 9, 2007 12:30:19 AM PDT}
SKIP CITATIONS: Skipping Citations, No Errors. {October 9, 2007 12:30:19 AM PDT}
UPDATED: Updated protein page: Mdm2 {October 9, 2007 12:30:25 AM PDT}

MMP2

INFO: Beginning work on MMP2... {October 9, 2007 12:30:25 AM PDT}
SEARCH REDIRECT: Control Box Found: MMP2 {October 9, 2007 12:30:49 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=MMP2>MMP2</a> {October 9, 2007 12:30:57 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:31:05 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:31:05 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:31:05 AM PDT}
UPDATED: Updated protein page: MMP2 {October 9, 2007 12:31:13 AM PDT}

MYC

INFO: Beginning work on MYC... {October 9, 2007 12:31:13 AM PDT}
SEARCH REDIRECT: Control Box Found: Myc {October 9, 2007 12:31:27 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Myc>Myc</a> {October 9, 2007 12:31:34 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:31:42 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:31:42 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:31:42 AM PDT}
UPDATED: Updated protein page: Myc {October 9, 2007 12:31:48 AM PDT}

NOS3

INFO: Beginning work on NOS3... {October 9, 2007 12:31:48 AM PDT}
SEARCH REDIRECT: Control Box Found: NOS3 {October 9, 2007 12:32:09 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=NOS3>NOS3</a> {October 9, 2007 12:32:17 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:32:24 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:32:24 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:32:24 AM PDT}
UPDATED: Updated protein page: NOS3 {October 9, 2007 12:32:31 AM PDT}

NR3C1

INFO: Beginning work on NR3C1... {October 9, 2007 12:21:52 AM PDT}
SEARCH REDIRECT: Control Box Found: Glucocorticoid receptor {October 9, 2007 12:22:27 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:22:29 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:22:29 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:22:29 AM PDT}
UPDATED: Updated protein page: Glucocorticoid receptor {October 9, 2007 12:22:37 AM PDT}

PRKACA

INFO: Beginning work on PRKACA... {October 9, 2007 12:33:55 AM PDT}
SEARCH REDIRECT: Control Box Found: PRKACA {October 9, 2007 12:34:18 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=PRKACA>PRKACA</a> {October 9, 2007 12:34:25 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:34:33 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:34:33 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:34:33 AM PDT}
UPDATED: Updated protein page: PRKACA {October 9, 2007 12:34:38 AM PDT}

PRKCD

INFO: Beginning work on PRKCD... {October 9, 2007 12:34:38 AM PDT}
SEARCH REDIRECT: Control Box Found: PRKCD {October 9, 2007 12:34:57 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=PRKCD>PRKCD</a> {October 9, 2007 12:35:05 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:35:12 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:35:12 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:35:12 AM PDT}
UPDATED: Updated protein page: PRKCD {October 9, 2007 12:35:17 AM PDT}

PSEN1

INFO: Beginning work on PSEN1... {October 9, 2007 12:36:00 AM PDT}
SEARCH REDIRECT: Control Box Found: PSEN1 {October 9, 2007 12:36:27 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:36:30 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:36:30 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:36:30 AM PDT}
UPDATED: Updated protein page: PSEN1 {October 9, 2007 12:36:36 AM PDT}

PTEN

INFO: Beginning work on PTEN... {October 9, 2007 12:36:36 AM PDT}
AMBIGUITY: Did not locate an acceptable page to update. {October 9, 2007 12:37:04 AM PDT}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = {{PDB2|1d5r}}
 | Name = Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
 | HGNCid = 9588
 | Symbol = PTEN
 | AltSymbols =; BZS; MGC11227; MHAM; MMAC1; PTEN1; TEP1
 | OMIM = 601728
 | ECnumber =  
 | Homologene = 265
 | MGIid = 109583
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | DateOfBotUpdate = ~~~~~
 | Function = {{GNF_GO|id=GO:0004438 |text = phosphatidylinositol-3-phosphatase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008138 |text = protein tyrosine/serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016314 |text = phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0051717 |text = inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity}} {{GNF_GO|id=GO:0051800 |text = phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0031647 |text = regulation of protein stability}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0046855 |text = inositol phosphate dephosphorylation}} {{GNF_GO|id=GO:0046856 |text = phosphoinositide dephosphorylation}} {{GNF_GO|id=GO:0051895 |text = negative regulation of focal adhesion formation}} {{GNF_GO|id=GO:0051898 |text = negative regulation of protein kinase B signaling cascade}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5728
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_000305
    | Hs_RefseqmRNA = NM_000314
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 19211
    | Mm_Ensembl = ENSMUSG00000013663
    | Mm_RefseqmRNA = NM_008960
    | Mm_RefseqProtein = NP_032986
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 32823574
    | Mm_GenLoc_end = 32892157
    | Mm_Uniprot = Q3UFB0
  }}
}}
'''Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)''', also known as '''PTEN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.<ref>{{cite web | title = Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5728| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Waite KA, Eng C |title=Protean PTEN: form and function. |journal=Am. J. Hum. Genet. |volume=70 |issue= 4 |pages= 829-44 |year= 2002 |pmid= 11875759 |doi=  }}
*{{cite journal  | author=Knobbe CB, Merlo A, Reifenberger G |title=Pten signaling in gliomas. |journal=Neuro-oncology |volume=4 |issue= 3 |pages= 196-211 |year= 2002 |pmid= 12084351 |doi=  }}
*{{cite journal  | author=Eng C |title=Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis. |journal=Ann. N. Y. Acad. Sci. |volume=968 |issue=  |pages= 213-21 |year= 2002 |pmid= 12119278 |doi=  }}
*{{cite journal  | author=Backman S, Stambolic V, Mak T |title=PTEN function in mammalian cell size regulation. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 5 |pages= 516-22 |year= 2002 |pmid= 12367630 |doi=  }}
*{{cite journal  | author=Wishart MJ, Dixon JE |title=PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. |journal=Trends Cell Biol. |volume=12 |issue= 12 |pages= 579-85 |year= 2003 |pmid= 12495846 |doi=  }}
*{{cite journal  | author=Deocampo ND, Huang H, Tindall DJ |title=The role of PTEN in the progression and survival of prostate cancer. |journal=Minerva Endocrinol. |volume=28 |issue= 2 |pages= 145-53 |year= 2003 |pmid= 12717346 |doi=  }}
*{{cite journal  | author=Downes CP, Walker S, McConnachie G, ''et al.'' |title=Acute regulation of the tumour suppressor phosphatase, PTEN, by anionic lipids and reactive oxygen species. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 338-42 |year= 2004 |pmid= 15046604 |doi= 10.1042/ }}
*{{cite journal  | author=Maehama T, Okahara F, Kanaho Y |title=The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 2 |pages= 343-7 |year= 2004 |pmid= 15046605 |doi= 10.1042/ }}
*{{cite journal  | author=Parsons R |title=Human cancer, PTEN and the PI-3 kinase pathway. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 2 |pages= 171-6 |year= 2004 |pmid= 15209376 |doi=  }}
*{{cite journal  | author=Steelman LS, Bertrand FE, McCubrey JA |title=The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. |journal=Expert Opin. Ther. Targets |volume=8 |issue= 6 |pages= 537-50 |year= 2005 |pmid= 15584861 |doi= 10.1517/14728222.8.6.537 }}
*{{cite journal  | author=Mulholland DJ, Dedhar S, Wu H, Nelson CC |title=PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. |journal=Oncogene |volume=25 |issue= 3 |pages= 329-37 |year= 2006 |pmid= 16421604 |doi= 10.1038/sj.onc.1209020 }}
*{{cite journal  | author=Vazquez F, Devreotes P |title=Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1523-7 |year= 2006 |pmid= 16861931 |doi=  }}
*{{cite journal  | author=Mellinghoff IK, Cloughesy TF, Mischel PS |title=PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. |journal=Clin. Cancer Res. |volume=13 |issue= 2 Pt 1 |pages= 378-81 |year= 2007 |pmid= 17255257 |doi= 10.1158/1078-0432.CCR-06-1992 }}
*{{cite journal  | author=Shen MM, Abate-Shen C |title=Pten inactivation and the emergence of androgen-independent prostate cancer. |journal=Cancer Res. |volume=67 |issue= 14 |pages= 6535-8 |year= 2007 |pmid= 17638861 |doi= 10.1158/0008-5472.CAN-07-1271 }}
}}
{{refend}}

{{protein-stub}}

RAC1

INFO: Beginning work on RAC1... {October 9, 2007 12:37:04 AM PDT}
SEARCH REDIRECT: Control Box Found: RAC1 {October 9, 2007 12:37:32 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:37:33 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:37:33 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:37:33 AM PDT}
UPDATED: Updated protein page: RAC1 {October 9, 2007 12:37:39 AM PDT}

RELA

INFO: Beginning work on RELA... {October 9, 2007 12:37:39 AM PDT}
SEARCH REDIRECT: Control Box Found: RELA {October 9, 2007 12:38:01 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:38:02 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:38:02 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:38:02 AM PDT}
UPDATED: Updated protein page: RELA {October 9, 2007 12:38:07 AM PDT}

RET

INFO: Beginning work on RET... {October 9, 2007 12:38:07 AM PDT}
SEARCH REDIRECT: Control Box Found: RET proto-oncogene {October 9, 2007 12:38:43 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=RET proto-oncogene>RET proto-oncogene</a> {October 9, 2007 12:38:51 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:38:58 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:38:58 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:38:58 AM PDT}
UPDATED: Updated protein page: RET proto-oncogene {October 9, 2007 12:39:06 AM PDT}

SERPINE1

INFO: Beginning work on SERPINE1... {October 9, 2007 12:32:31 AM PDT}
SEARCH REDIRECT: Control Box Found: Plasminogen activator inhibitor-1 {October 9, 2007 12:32:58 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:32:59 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:32:59 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:32:59 AM PDT}
UPDATED: Updated protein page: Plasminogen activator inhibitor-1 {October 9, 2007 12:33:06 AM PDT}

SNCA

INFO: Beginning work on SNCA... {October 9, 2007 12:40:05 AM PDT}
AMBIGUITY: Did not locate an acceptable page to update. {October 9, 2007 12:40:37 AM PDT}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = {{PDB2|1xq8}}
 | Name = Synuclein, alpha (non A4 component of amyloid precursor)
 | HGNCid = 11138
 | Symbol = SNCA
 | AltSymbols =; PD1; MGC110988; NACP; PARK1; PARK4
 | OMIM = 163890
 | ECnumber =  
 | Homologene = 293
 | MGIid = 1277151
 | GeneAtlas_image1 = PBB_GE_SNCA_204466_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_SNCA_204467_s_at_tn.png
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | DateOfBotUpdate = ~~~~~
 | Function = {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} 
 | Process = {{GNF_GO|id=GO:0001956 |text = positive regulation of neurotransmitter secretion}} {{GNF_GO|id=GO:0001963 |text = synaptic transmission, dopaminergic}} {{GNF_GO|id=GO:0006644 |text = phospholipid metabolic process}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0040012 |text = regulation of locomotion}} {{GNF_GO|id=GO:0042416 |text = dopamine biosynthetic process}} {{GNF_GO|id=GO:0042493 |text = response to drug}} {{GNF_GO|id=GO:0048169 |text = regulation of long-term neuronal synaptic plasticity}} {{GNF_GO|id=GO:0048489 |text = synaptic vesicle transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6622
    | Hs_Ensembl = ENSG00000145335
    | Hs_RefseqProtein = NP_000336
    | Hs_RefseqmRNA = NM_000345
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 90866479
    | Hs_GenLoc_end = 90978470
    | Hs_Uniprot = P37840
    | Mm_EntrezGene = 20617
    | Mm_Ensembl = ENSMUSG00000025889
    | Mm_RefseqmRNA = NM_001042451
    | Mm_RefseqProtein = NP_001035916
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 60661224
    | Mm_GenLoc_end = 60759433
    | Mm_Uniprot = Q3U130
  }}
}}
'''Synuclein, alpha (non A4 component of amyloid precursor)''', also known as '''SNCA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.<ref>{{cite web | title = Entrez Gene: SNCA synuclein, alpha (non A4 component of amyloid precursor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6622| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lavedan C |title=The synuclein family. |journal=Genome Res. |volume=8 |issue= 9 |pages= 871-80 |year= 1998 |pmid= 9750188 |doi=  }}
*{{cite journal  | author=Ozawa T, Wakabayashi K, Oyanagi K |title=[Recent progress in the research of multiple system atrophy with special references to alpha-synuclein and suprachiasmatic nucleus] |journal=No To Shinkei |volume=54 |issue= 2 |pages= 111-7 |year= 2002 |pmid= 11889756 |doi=  }}
*{{cite journal  | author=Cole NB, Murphy DD |title=The cell biology of alpha-synuclein: a sticky problem? |journal=Neuromolecular Med. |volume=1 |issue= 2 |pages= 95-109 |year= 2002 |pmid= 12025860 |doi=  }}
*{{cite journal  | author=Iwatsubo T |title=[alpha-synuclein and Parkinson's disease] |journal=Seikagaku |volume=74 |issue= 6 |pages= 477-82 |year= 2002 |pmid= 12138709 |doi=  }}
*{{cite journal  | author=Trojanowski JQ, Lee VM |title=Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses. |journal=Neurotoxicology |volume=23 |issue= 4-5 |pages= 457-60 |year= 2002 |pmid= 12428717 |doi=  }}
*{{cite journal  | author=Alves da Costa C |title=Recent advances on alpha-synuclein cell biology: functions and dysfunctions. |journal=Curr. Mol. Med. |volume=3 |issue= 1 |pages= 17-24 |year= 2003 |pmid= 12558071 |doi=  }}
*{{cite journal  | author=Di Rosa G, Puzzo D, Sant'Angelo A, ''et al.'' |title=Alpha-synuclein: between synaptic function and dysfunction. |journal=Histol. Histopathol. |volume=18 |issue= 4 |pages= 1257-66 |year= 2004 |pmid= 12973692 |doi=  }}
*{{cite journal  | author=Baptista MJ, Cookson MR, Miller DW |title=Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 1 |pages= 63-72 |year= 2004 |pmid= 14987449 |doi= 10.1177/1073858403260392 }}
*{{cite journal  | author=Kim S, Seo JH, Suh YH |title=Alpha-synuclein, Parkinson's disease, and Alzheimer's disease. |journal=Parkinsonism Relat. Disord. |volume=10 Suppl 1 |issue=  |pages= S9-13 |year= 2004 |pmid= 15109581 |doi= 10.1016/j.parkreldis.2003.11.005 }}
*{{cite journal  | author=Sidhu A, Wersinger C, Vernier P |title=alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. |journal=FEBS Lett. |volume=565 |issue= 1-3 |pages= 1-5 |year= 2004 |pmid= 15135042 |doi= 10.1016/j.febslet.2004.03.063 }}
*{{cite journal  | author=Vekrellis K, Rideout HJ, Stefanis L |title=Neurobiology of alpha-synuclein. |journal=Mol. Neurobiol. |volume=30 |issue= 1 |pages= 1-21 |year= 2004 |pmid= 15247485 |doi=  }}
*{{cite journal  | author=Chiba-Falek O, Nussbaum RL |title=Regulation of alpha-synuclein expression: implications for Parkinson's disease. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=68 |issue=  |pages= 409-15 |year= 2004 |pmid= 15338643 |doi=  }}
*{{cite journal  | author=Pankratz N, Foroud T |title=Genetics of Parkinson disease. |journal=NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics |volume=1 |issue= 2 |pages= 235-42 |year= 2005 |pmid= 15717024 |doi=  }}
*{{cite journal  | author=Singleton AB |title=Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin. |journal=Trends Neurosci. |volume=28 |issue= 8 |pages= 416-21 |year= 2005 |pmid= 15955578 |doi= 10.1016/j.tins.2005.05.009 }}
*{{cite journal  | author=Lee HG, Zhu X, Takeda A, ''et al.'' |title=Emerging evidence for the neuroprotective role of alpha-synuclein. |journal=Exp. Neurol. |volume=200 |issue= 1 |pages= 1-7 |year= 2006 |pmid= 16780837 |doi= 10.1016/j.expneurol.2006.04.024 }}
*{{cite journal  | author=Giorgi FS, Bandettini di Poggio A, Battaglia G, ''et al.'' |title=A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinson's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 70 |pages= 105-9 |year= 2006 |pmid= 17017516 |doi=  }}
}}
{{refend}}

{{protein-stub}}

SOD1

INFO: Beginning work on SOD1... {October 9, 2007 12:40:37 AM PDT}
SEARCH REDIRECT: Control Box Found: SOD1 {October 9, 2007 12:41:05 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=SOD1>SOD1</a> {October 9, 2007 12:41:12 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:41:19 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:41:19 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:41:19 AM PDT}
UPDATED: Updated protein page: SOD1 {October 9, 2007 12:41:25 AM PDT}

SP1

INFO: Beginning work on SP1... {October 9, 2007 12:41:25 AM PDT}
AMBIGUITY: Did not locate an acceptable page to update. {October 9, 2007 12:41:49 AM PDT}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = {{PDB2|1sp1}}, {{PDB2|1sp2}}, {{PDB2|1va1}}, {{PDB2|1va2}}, {{PDB2|1va3}}
 | Name = Sp1 transcription factor
 | HGNCid = 11205
 | Symbol = SP1
 | AltSymbols =; 
 | OMIM = 189906
 | ECnumber =  
 | Homologene = 8276
 | MGIid = 98372
 | GeneAtlas_image1 = PBB_GE_SP1_214732_at_tn.png
 <!-- The Following entry is a time stamp of the last bot update.  It is typically hidden data -->
 | DateOfBotUpdate = ~~~~~
 | Function = {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045817 |text = positive regulation of global transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6667
    | Hs_Ensembl = ENSG00000185591
    | Hs_RefseqProtein = NP_612482
    | Hs_RefseqmRNA = NM_138473
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 52060246
    | Hs_GenLoc_end = 52096488
    | Hs_Uniprot = P08047
    | Mm_EntrezGene = 20683
    | Mm_Ensembl = ENSMUSG00000001280
    | Mm_RefseqmRNA = NM_013672
    | Mm_RefseqProtein = NP_038700
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 102234414
    | Mm_GenLoc_end = 102260419
    | Mm_Uniprot = O89090
  }}
}}
'''Sp1 transcription factor''', also known as '''SP1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Tseng L, Gao J, Mazella J, ''et al.'' |title=Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium. |journal=Ann. N. Y. Acad. Sci. |volume=828 |issue=  |pages= 27-37 |year= 1997 |pmid= 9329821 |doi=  }}
*{{cite journal  | author=Dyson N |title=The regulation of E2F by pRB-family proteins. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2245-62 |year= 1998 |pmid= 9694791 |doi=  }}
*{{cite journal  | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401-14 |year= 2003 |pmid= 12943729 |doi=  }}
*{{cite journal  | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal  | author=Seelamgari A, Maddukuri A, Berro R, ''et al.'' |title=Role of viral regulatory and accessory proteins in HIV-1 replication. |journal=Front. Biosci. |volume=9 |issue=  |pages= 2388-413 |year= 2006 |pmid= 15353294 |doi=  }}
*{{cite journal  | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
}}
{{refend}}

{{protein-stub}}

TERT

INFO: Beginning work on TERT... {October 9, 2007 12:41:49 AM PDT}
SEARCH REDIRECT: Control Box Found: telomerase reverse transcriptase {October 9, 2007 12:42:11 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:42:13 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:42:13 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:42:13 AM PDT}
UPDATED: Updated protein page: telomerase reverse transcriptase {October 9, 2007 12:42:18 AM PDT}

TLR4

INFO: Beginning work on TLR4... {October 9, 2007 12:42:18 AM PDT}
SEARCH REDIRECT: Control Box Found: TLR 4 {October 9, 2007 12:42:45 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:42:48 AM PDT}
UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:42:48 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:42:48 AM PDT}
UPDATED: Updated protein page: TLR 4 {October 9, 2007 12:42:57 AM PDT}

VWF

INFO: Beginning work on VWF... {October 9, 2007 12:42:57 AM PDT}
SEARCH REDIRECT: Control Box Found: von Willebrand factor {October 9, 2007 12:43:20 AM PDT}
UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=von Willebrand factor>von Willebrand factor</a> {October 9, 2007 12:43:28 AM PDT}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:43:35 AM PDT}
SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:43:35 AM PDT}
UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:43:35 AM PDT}
UPDATED: Updated protein page: von Willebrand factor {October 9, 2007 12:43:41 AM PDT}

end log.

Log file for Protein Box Bot

Protein Status Quick Log - Date: 07:48, 9 October 2007 (UTC)

Conflict: Ambiguous Proteins (3)

Proteins without matches (2)

Proteins with a High Potential Match (1)

Redirected Proteins (44)

Manual Inspection (Page not found) (6)

Updated (44)

Protein Status Grid - Date: 07:48, 9 October 2007 (UTC)

Vebose Log - Date: 07:48, 9 October 2007 (UTC)