TEP1

TEP1
Identifiers
Aliases	TEP1, TLP1, TP1, TROVE1, VAULT2, p240, telomerase associated protein 1
External IDs	OMIM: 601686; MGI: 109573; HomoloGene: 5157; GeneCards: TEP1; OMA:TEP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,413,501 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,108,017 bp
RNA expression pattern
	Top expressed in
	monocyte; ; mucosa of transverse colon; ; jejunal mucosa; ; epithelium of colon; ; rectum; ; granulocyte; ; duodenum; ; spleen; ; lymph node; ; tonsil;
	Top expressed in
	duodenum; ; intestinal villus; ; Ileal epithelium; ; jejunum; ; large intestine; ; colon; ; crypt of lieberkuhn of small intestine; ; stroma of bone marrow; ; Paneth cell; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATP binding; p53 binding; nucleotide binding; enzyme binding; telomerase RNA binding; telomerase activity; RNA binding;
Cellular component	telomere; telomerase holoenzyme complex; nucleus; cytoplasm; nuclear matrix; chromosome; U5 snRNP; precatalytic spliceosome; catalytic step 2 spliceosome; ribonucleoprotein complex;
Biological process	telomere maintenance via recombination; RNA-dependent DNA biosynthetic process; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	7011
	21745
	ENSG00000129566
	ENSMUSG00000006281
	Q99973
	P97499
	NM_007110; NM_001319035
	NM_009351
	NP_001305964; NP_009041
	NP_033377
	Wikidata
View/Edit Human	View/Edit Mouse

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.^[5]^[6]

Function

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.^[6] It is also a minor vault protein.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129566 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006281 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (November 1997). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.
^ ^a ^b "Entrez Gene: TEP1 telomerase-associated protein 1".

Joly EC, Tremblay E, Tanguay RM, Wu Y, Bibor-Hardy V (October 1994). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". Journal of Cell Science. 107 ( Pt 10) (10): 2851–9. doi:10.1242/jcs.107.10.2851. PMID 7876352.
Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (February 1997). "A mammalian telomerase-associated protein". Science. 275 (5302): 973–7. doi:10.1126/science.275.5302.973. PMID 9020079. S2CID 21631570.
Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO (December 1997). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes & Development. 11 (23): 3109–15. doi:10.1101/gad.11.23.3109. PMC 316744. PMID 9389643.
Li H, Zhao L, Yang Z, Funder JW, Liu JP (December 1998). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". The Journal of Biological Chemistry. 273 (50): 33436–42. doi:10.1074/jbc.273.50.33436. PMID 9837921.
Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (November 1999). "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
Li H, Cao Y, Berndt MC, Funder JW, Liu JP (November 1999). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.
Koyanagi Y, Kobayashi D, Yajima T, Asanuma K, Kimura T, Sato T, Kida T, Yagihashi A, Kameshima H, Watanabe N (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Research. 20 (2A): 773–8. PMID 10810353.
Beattie TL, Zhou W, Robinson MO, Harrington L (October 2000). "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding". Molecular Biology of the Cell. 11 (10): 3329–40. doi:10.1091/mbc.11.10.3329. PMC 14995. PMID 11029039.
Zhang RG, Zhang RP, Wang XW, Xie H (March 2002). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Research. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.
Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ (July 2002). "Differential regulation of telomerase activity by six telomerase subunits". European Journal of Biochemistry. 269 (14): 3442–50. doi:10.1046/j.1432-1033.2002.03025.x. PMID 12135483.
Zhou JH, Zhang HM, Chen Q, Han DD, Pei F, Zhang LS, Yang DT (August 2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World Journal of Gastroenterology. 9 (8): 1808–14. doi:10.3748/wjg.v9.i8.1808. PMC 4611549. PMID 12918126.
Li C, Wu MY, Liang YR, Wu XY (November 2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World Journal of Gastroenterology. 9 (11): 2395–9. doi:10.3748/wjg.v9.i11.2395. PMC 4656508. PMID 14606063.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129566 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006281 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9403057-5] Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (November 1997). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.

[entrez-6] "Entrez Gene: TEP1 telomerase-associated protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

Function

References

Further reading