Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:52, 24 November 2007 (UTC)
[edit]Proteins without matches (13)
[edit]Proteins with a High Potential Match (7)
[edit]Redirected Proteins (4)
[edit]Manual Inspection (Page not found) (11)
[edit]
Protein Status Grid - Date: 23:52, 24 November 2007 (UTC)
[edit]Vebose Log - Date: 23:52, 24 November 2007 (UTC)
[edit]- INFO: Beginning work on CCR10... {November 24, 2007 3:37:51 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:38:24 PM PST}
- CREATED: Created new protein page: CCR10 {November 24, 2007 3:38:33 PM PST}
- INFO: Beginning work on DARC... {November 24, 2007 3:30:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:30:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Duffy blood group, chemokine receptor
| HGNCid = 4035
| Symbol = DARC
| AltSymbols =; CCBP1; CD234; Dfy; FY; GPD
| OMIM = 110700
| ECnumber =
| Homologene = 48067
| MGIid = 1097689
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004950 |text = chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2532
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002027
| Hs_RefseqmRNA = NM_002036
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13349
| Mm_Ensembl = ENSMUSG00000037872
| Mm_RefseqmRNA = NM_010045
| Mm_RefseqProtein = NP_034175
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 175168621
| Mm_GenLoc_end = 175170348
| Mm_Uniprot = Q53ZP8
}}
}}
'''Duffy blood group, chemokine receptor''', also known as '''DARC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DARC Duffy blood group, chemokine receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2532| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pogo AO, Chaudhuri A |title=Duffy and receptors for P. vivax and chemotactic peptides. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=2 |issue= 4 |pages= 269-76 |year= 1996 |pmid= 8542025 |doi= }}
*{{cite journal | author=Pruenster M, Rot A |title=Throwing light on DARC. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 6 |pages= 1005-8 |year= 2007 |pmid= 17073738 |doi= 10.1042/BST0341005 }}
*{{cite journal | author=Raeymaekers P, Van Broeckhoven C, Backhovens H, ''et al.'' |title=The Duffy blood group is linked to the alpha-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1. |journal=Hum. Genet. |volume=78 |issue= 1 |pages= 76-8 |year= 1988 |pmid= 2892777 |doi= }}
*{{cite journal | author=Lu ZH, Wang ZX, Horuk R, ''et al.'' |title=The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26239-45 |year= 1995 |pmid= 7592830 |doi= }}
*{{cite journal | author=Tournamille C, Colin Y, Cartron JP, Le Van Kim C |title=Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. |journal=Nat. Genet. |volume=10 |issue= 2 |pages= 224-8 |year= 1995 |pmid= 7663520 |doi= 10.1038/ng0695-224 }}
*{{cite journal | author=Horuk R, Chitnis CE, Darbonne WC, ''et al.'' |title=A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor. |journal=Science |volume=261 |issue= 5125 |pages= 1182-4 |year= 1993 |pmid= 7689250 |doi= }}
*{{cite journal | author=Tournamille C, Le Van Kim C, Gane P, ''et al.'' |title=Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism. |journal=Hum. Genet. |volume=95 |issue= 4 |pages= 407-10 |year= 1995 |pmid= 7705836 |doi= }}
*{{cite journal | author=Iwamoto S, Omi T, Kajii E, Ikemoto S |title=Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. |journal=Blood |volume=85 |issue= 3 |pages= 622-6 |year= 1995 |pmid= 7833467 |doi= }}
*{{cite journal | author=Chaudhuri A, Polyakova J, Zbrzezna V, ''et al.'' |title=Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10793-7 |year= 1993 |pmid= 8248172 |doi= }}
*{{cite journal | author=Horuk R, Martin AW, Wang Z, ''et al.'' |title=Expression of chemokine receptors by subsets of neurons in the central nervous system. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2882-90 |year= 1997 |pmid= 9058825 |doi= }}
*{{cite journal | author=Tournamille C, Le Van Kim C, Gane P, ''et al.'' |title=Close association of the first and fourth extracellular domains of the Duffy antigen/receptor for chemokines by a disulfide bond is required for ligand binding. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16274-80 |year= 1997 |pmid= 9195930 |doi= }}
*{{cite journal | author=Tournamille C, Le Van Kim C, Gane P, ''et al.'' |title=Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. |journal=Blood |volume=92 |issue= 6 |pages= 2147-56 |year= 1998 |pmid= 9731074 |doi= }}
*{{cite journal | author=Parasol N, Reid M, Rios M, ''et al.'' |title=A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype. |journal=Blood |volume=92 |issue= 7 |pages= 2237-43 |year= 1998 |pmid= 9746760 |doi= }}
*{{cite journal | author=Olsson ML, Smythe JS, Hansson C, ''et al.'' |title=The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein. |journal=Br. J. Haematol. |volume=103 |issue= 4 |pages= 1184-91 |year= 1999 |pmid= 9886340 |doi= }}
*{{cite journal | author=Lachgar A, Jaureguiberry G, Le Buenac H, ''et al.'' |title=Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC). |journal=Biomed. Pharmacother. |volume=52 |issue= 10 |pages= 436-9 |year= 1999 |pmid= 9921412 |doi= }}
*{{cite journal | author=Zimmerman PA, Woolley I, Masinde GL, ''et al.'' |title=Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13973-7 |year= 2000 |pmid= 10570183 |doi= }}
*{{cite journal | author=Woolley IJ, Kalayjian R, Valdez H, ''et al.'' |title=HIV nephropathy and the Duffy antigen/receptor for Chemokines in African Americans. |journal=J. Nephrol. |volume=14 |issue= 5 |pages= 384-7 |year= 2002 |pmid= 11730271 |doi= }}
*{{cite journal | author=Hamblin MT, Thompson EE, Di Rienzo A |title=Complex signatures of natural selection at the Duffy blood group locus. |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 369-83 |year= 2002 |pmid= 11753822 |doi= }}
*{{cite journal | author=Patterson AM, Siddall H, Chamberlain G, ''et al.'' |title=Expression of the duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium. |journal=J. Pathol. |volume=197 |issue= 1 |pages= 108-16 |year= 2002 |pmid= 12081195 |doi= 10.1002/path.1100 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F2RL2... {November 24, 2007 3:26:41 PM PST}
- REDIRECT: Protein Redirected to: F2RL2 {November 24, 2007 3:27:01 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:27:03 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 3:27:03 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:27:03 PM PST}
- UPDATED: Updated protein page: F2RL2 {November 24, 2007 3:27:09 PM PST}
- INFO: Beginning work on FPR1... {November 24, 2007 3:27:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:27:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Formyl peptide receptor 1
| HGNCid = 3826
| Symbol = FPR1
| AltSymbols =; FMLP; FPR
| OMIM = 136537
| ECnumber =
| Homologene = 20466
| MGIid = 107443
| GeneAtlas_image1 = PBB_GE_FPR1_205119_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FPR1_205118_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004982 |text = N-formyl peptide receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007263 |text = nitric oxide mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2357
| Hs_Ensembl = ENSG00000171051
| Hs_RefseqProtein = NP_002020
| Hs_RefseqmRNA = NM_002029
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 56940237
| Hs_GenLoc_end = 56946912
| Hs_Uniprot = P21462
| Mm_EntrezGene = 14293
| Mm_Ensembl = ENSMUSG00000045551
| Mm_RefseqmRNA = NM_013521
| Mm_RefseqProtein = NP_038549
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 17581087
| Mm_GenLoc_end = 17588557
| Mm_Uniprot = Q3UV01
}}
}}
'''Formyl peptide receptor 1''', also known as '''FPR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FPR1 formyl peptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2357| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Graves V, Gabig T, McCarthy L, ''et al.'' |title=Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils. |journal=Blood |volume=80 |issue= 3 |pages= 776-87 |year= 1992 |pmid= 1322204 |doi= }}
*{{cite journal | author=Murphy PM, Ozçelik T, Kenney RT, ''et al.'' |title=A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7637-43 |year= 1992 |pmid= 1373134 |doi= }}
*{{cite journal | author=Perez HD, Holmes R, Kelly E, ''et al.'' |title=Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression. |journal=Biochemistry |volume=31 |issue= 46 |pages= 11595-9 |year= 1992 |pmid= 1445895 |doi= }}
*{{cite journal | author=Bao L, Gerard NP, Eddy RL, ''et al.'' |title=Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. |journal=Genomics |volume=13 |issue= 2 |pages= 437-40 |year= 1992 |pmid= 1612600 |doi= }}
*{{cite journal | author=Murphy PM, McDermott D |title=Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. |journal=J. Biol. Chem. |volume=266 |issue= 19 |pages= 12560-7 |year= 1991 |pmid= 1712023 |doi= }}
*{{cite journal | author=Boulay F, Tardif M, Brouchon L, Vignais P |title=Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=168 |issue= 3 |pages= 1103-9 |year= 1990 |pmid= 2161213 |doi= }}
*{{cite journal | author=Boulay F, Tardif M, Brouchon L, Vignais P |title=The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. |journal=Biochemistry |volume=29 |issue= 50 |pages= 11123-33 |year= 1991 |pmid= 2176894 |doi= }}
*{{cite journal | author=Wahl SM, Allen JB, Gartner S, ''et al.'' |title=HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes. |journal=J. Immunol. |volume=142 |issue= 10 |pages= 3553-9 |year= 1989 |pmid= 2541200 |doi= }}
*{{cite journal | author=Jesaitis AJ, Naemura JR, Painter RG, ''et al.'' |title=Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes. |journal=Biochim. Biophys. Acta |volume=719 |issue= 3 |pages= 556-68 |year= 1983 |pmid= 6129903 |doi= }}
*{{cite journal | author=Prossnitz ER, Kim CM, Benovic JL, Ye RD |title=Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. |journal=J. Biol. Chem. |volume=270 |issue= 3 |pages= 1130-7 |year= 1995 |pmid= 7836371 |doi= }}
*{{cite journal | author=Klotz KN, Jesaitis AJ |title=Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization. |journal=Biochem. Pharmacol. |volume=48 |issue= 6 |pages= 1297-300 |year= 1994 |pmid= 7945424 |doi= }}
*{{cite journal | author=Bommakanti RK, Dratz EA, Siemsen DW, Jesaitis AJ |title=Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity. |journal=Biochim. Biophys. Acta |volume=1209 |issue= 1 |pages= 69-76 |year= 1994 |pmid= 7947984 |doi= }}
*{{cite journal | author=Murphy PM, Tiffany HL, McDermott D, Ahuja SK |title=Sequence and organization of the human N-formyl peptide receptor-encoding gene. |journal=Gene |volume=133 |issue= 2 |pages= 285-90 |year= 1993 |pmid= 8224916 |doi= }}
*{{cite journal | author=Jesaitis AJ, Erickson RW, Klotz KN, ''et al.'' |title=Functional molecular complexes of human N-formyl chemoattractant receptors and actin. |journal=J. Immunol. |volume=151 |issue= 10 |pages= 5653-65 |year= 1993 |pmid= 8228254 |doi= }}
*{{cite journal | author=Särndahl E, Bokoch GM, Boulay F, ''et al.'' |title=Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15267-71 |year= 1996 |pmid= 8663057 |doi= }}
*{{cite journal | author=Maestes DC, Potter RM, Prossnitz ER |title=Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29791-5 |year= 1999 |pmid= 10514456 |doi= }}
*{{cite journal | author=Liang TS, Wang JM, Murphy PM, Gao JL |title=Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 2 |pages= 331-5 |year= 2000 |pmid= 10753626 |doi= 10.1006/bbrc.2000.2416 }}
*{{cite journal | author=Luu NT, Rainger GE, Nash GB |title=Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5961-9 |year= 2000 |pmid= 10820279 |doi= }}
*{{cite journal | author=Bennett TA, Maestas DC, Prossnitz ER |title=Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24590-4 |year= 2000 |pmid= 10823817 |doi= 10.1074/jbc.C000314200 }}
*{{cite journal | author=Ayala JM, Goyal S, Liverton NJ, ''et al.'' |title=Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway. |journal=J. Leukoc. Biol. |volume=67 |issue= 6 |pages= 869-75 |year= 2000 |pmid= 10857861 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FPRL1... {November 24, 2007 3:27:42 PM PST}
- REDIRECT: Protein Redirected to: FPRL1 {November 24, 2007 3:27:58 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:28:01 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:28:01 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:28:01 PM PST}
- UPDATED: Updated protein page: FPRL1 {November 24, 2007 3:28:06 PM PST}
- INFO: Beginning work on FPRL2... {November 24, 2007 3:28:06 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:28:56 PM PST}
- CREATED: Created new protein page: FPRL2 {November 24, 2007 3:29:03 PM PST}
- INFO: Beginning work on FSHR... {November 24, 2007 3:29:03 PM PST}
- SEARCH REDIRECT: Control Box Found: FSH-receptor {November 24, 2007 3:30:02 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:30:03 PM PST}
- SKIP SUMMARY: Skipping Summary, No Errors. {November 24, 2007 3:30:03 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 24, 2007 3:30:03 PM PST}
- UPDATED: Updated protein page: FSH-receptor {November 24, 2007 3:30:11 PM PST}
- INFO: Beginning work on FZD2... {November 24, 2007 3:30:36 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:31:15 PM PST}
- CREATED: Created new protein page: FZD2 {November 24, 2007 3:31:23 PM PST}
- INFO: Beginning work on GABBR1... {November 24, 2007 3:31:23 PM PST}
- REDIRECT: Protein Redirected to: GABBR1 {November 24, 2007 3:31:49 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:31:50 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:31:50 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:31:50 PM PST}
- UPDATED: Updated protein page: GABBR1 {November 24, 2007 3:31:55 PM PST}
- INFO: Beginning work on GALR1... {November 24, 2007 3:31:55 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:32:31 PM PST}
- CREATED: Created new protein page: GALR1 {November 24, 2007 3:32:38 PM PST}
- INFO: Beginning work on GCGR... {November 24, 2007 3:32:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:32:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glucagon receptor
| HGNCid = 4192
| Symbol = GCGR
| AltSymbols =; GGR; MGC138246
| OMIM = 138033
| ECnumber =
| Homologene = 131
| MGIid = 99572
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004967 |text = glucagon receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2642
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000151
| Hs_RefseqmRNA = NM_000160
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14527
| Mm_Ensembl = ENSMUSG00000025127
| Mm_RefseqmRNA = NM_008101
| Mm_RefseqProtein = NP_032127
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 120346886
| Mm_GenLoc_end = 120355073
| Mm_Uniprot = Q3UN81
}}
}}
'''Glucagon receptor''', also known as '''GCGR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GCGR glucagon receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2642| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The physiologic effects of glucagon (GCG; MIM 138030) are mediated through the glucagon receptor, a member of the superfamily of receptors characterized by a 7-transmembrane domain structure and by their coupling via GTP-binding proteins (G proteins) to adenyl cyclase.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GCGR glucagon receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2642| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Levey GS, Weiss SR, Ruiz E |title=Characterization of the glucagon receptor in a pheochromocytoma. |journal=J. Clin. Endocrinol. Metab. |volume=40 |issue= 4 |pages= 720-3 |year= 1975 |pmid= 165216 |doi= }}
*{{cite journal | author=Nakamura S, Rodbell M |title=Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 7150-4 |year= 1991 |pmid= 1908089 |doi= }}
*{{cite journal | author=Horuk R, Wright DE |title=Partial purification and characterization of the glucagon receptor. |journal=FEBS Lett. |volume=155 |issue= 2 |pages= 213-7 |year= 1983 |pmid= 6303843 |doi= }}
*{{cite journal | author=MacNeil DJ, Occi JL, Hey PJ, ''et al.'' |title=Cloning and expression of a human glucagon receptor. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 1 |pages= 328-34 |year= 1994 |pmid= 7507321 |doi= 10.1006/bbrc.1994.1046 }}
*{{cite journal | author=Fujisawa T, Ikegami H, Yamato E, ''et al.'' |title=A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. |journal=Diabetologia |volume=38 |issue= 8 |pages= 983-5 |year= 1995 |pmid= 7589886 |doi= }}
*{{cite journal | author=Hager J, Hansen L, Vaisse C, ''et al.'' |title=A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. |journal=Nat. Genet. |volume=9 |issue= 3 |pages= 299-304 |year= 1995 |pmid= 7773293 |doi= 10.1038/ng0395-299 }}
*{{cite journal | author=Menzel S, Stoffel M, Espinosa R, ''et al.'' |title=Localization of the glucagon receptor gene to human chromosome band 17q25. |journal=Genomics |volume=20 |issue= 2 |pages= 327-8 |year= 1994 |pmid= 8020989 |doi= 10.1006/geno.1994.1179 }}
*{{cite journal | author=Lok S, Kuijper JL, Jelinek LJ, ''et al.'' |title=The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization. |journal=Gene |volume=140 |issue= 2 |pages= 203-9 |year= 1994 |pmid= 8144028 |doi= }}
*{{cite journal | author=Unson CG, Macdonald D, Merrifield RB |title=The role of histidine-1 in glucagon action. |journal=Arch. Biochem. Biophys. |volume=300 |issue= 2 |pages= 747-50 |year= 1993 |pmid= 8382034 |doi= 10.1006/abbi.1993.1103 }}
*{{cite journal | author=Chambers SM, Morris BJ |title=Glucagon receptor gene mutation in essential hypertension. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 122 |year= 1996 |pmid= 8563746 |doi= 10.1038/ng0296-122 }}
*{{cite journal | author=Yamato E, Ikegami H, Takekawa K, ''et al.'' |title=Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1). |journal=Horm. Metab. Res. |volume=29 |issue= 2 |pages= 56-9 |year= 1997 |pmid= 9105899 |doi= }}
*{{cite journal | author=Strazzullo P, Iacone R, Siani A, ''et al.'' |title=Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. |journal=J. Mol. Med. |volume=79 |issue= 10 |pages= 574-80 |year= 2001 |pmid= 11692154 |doi= 10.1007/s001090100257 }}
*{{cite journal | author=Shiota D, Kasamatsu T, Dib SA, ''et al.'' |title=Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus. |journal=Pancreas |volume=24 |issue= 4 |pages= 386-90 |year= 2002 |pmid= 11961492 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Runge S, Gram C, Brauner-Osborne H, ''et al.'' |title=Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28005-10 |year= 2003 |pmid= 12724331 |doi= 10.1074/jbc.M301085200 }}
*{{cite journal | author=Hassel S, Eichner A, Yakymovych M, ''et al.'' |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346-58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Mortensen OH, Dichmann DS, Abrahamsen N, ''et al.'' |title=Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha. |journal=Gene |volume=393 |issue= 1-2 |pages= 127-36 |year= 2007 |pmid= 17374560 |doi= 10.1016/j.gene.2007.01.023 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GHRHR... {November 24, 2007 3:33:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:33:43 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth hormone releasing hormone receptor
| HGNCid = 4266
| Symbol = GHRHR
| AltSymbols =; GHRFR; GHRHRpsv; GRFR
| OMIM = 139191
| ECnumber =
| Homologene = 640
| MGIid = 95710
| GeneAtlas_image1 = PBB_GE_GHRHR_207825_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GHRHR_211544_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GHRHR_211545_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004999 |text = vasoactive intestinal polypeptide receptor activity}} {{GNF_GO|id=GO:0016520 |text = growth hormone-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2692
| Hs_Ensembl = ENSG00000106128
| Hs_RefseqProtein = NP_000814
| Hs_RefseqmRNA = NM_000823
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 30970161
| Hs_GenLoc_end = 30990114
| Hs_Uniprot = Q02643
| Mm_EntrezGene = 14602
| Mm_Ensembl = ENSMUSG00000004654
| Mm_RefseqmRNA = NM_001003685
| Mm_RefseqProtein = NP_001003685
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 55305921
| Mm_GenLoc_end = 55318108
| Mm_Uniprot = Q0VB62
}}
}}
'''Growth hormone releasing hormone receptor''', also known as '''GHRHR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GHRHR growth hormone releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2692| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, expressed in the pituitary, encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.<ref name="entrez">{{cite web | title = Entrez Gene: GHRHR growth hormone releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2692| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gaylinn BD |title=Molecular and cell biology of the growth hormone-releasing hormone receptor. |journal=Growth Horm. IGF Res. |volume=9 Suppl A |issue= |pages= 37-44 |year= 1999 |pmid= 10429879 |doi= }}
*{{cite journal | author=Lin-Su K, Wajnrajch MP |title=Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor. |journal=Reviews in endocrine & metabolic disorders |volume=3 |issue= 4 |pages= 313-23 |year= 2003 |pmid= 12424433 |doi= }}
*{{cite journal | author=Mayo KE |title=Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. |journal=Mol. Endocrinol. |volume=6 |issue= 10 |pages= 1734-44 |year= 1992 |pmid= 1333056 |doi= }}
*{{cite journal | author=Squire J, Zhou A, Hassel BA, ''et al.'' |title=Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25. |journal=Genomics |volume=19 |issue= 1 |pages= 174-5 |year= 1994 |pmid= 7514564 |doi= 10.1006/geno.1994.1033 }}
*{{cite journal | author=Hashimoto K, Koga M, Motomura T, ''et al.'' |title=Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 10 |pages= 2933-9 |year= 1995 |pmid= 7559877 |doi= }}
*{{cite journal | author=Tang J, Lagacé G, Castagné J, Collu R |title=Identification of human growth hormone-releasing hormone receptor splicing variants. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 8 |pages= 2381-7 |year= 1995 |pmid= 7629234 |doi= }}
*{{cite journal | author=Gaylinn BD, Harrison JK, Zysk JR, ''et al.'' |title=Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. |journal=Mol. Endocrinol. |volume=7 |issue= 1 |pages= 77-84 |year= 1993 |pmid= 7680413 |doi= }}
*{{cite journal | author=Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO |title=Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization. |journal=Genomics |volume=19 |issue= 1 |pages= 193-5 |year= 1994 |pmid= 8188233 |doi= 10.1006/geno.1994.1045 }}
*{{cite journal | author=Wajnrajch MP, Gertner JM, Harbison MD, ''et al.'' |title=Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. |journal=Nat. Genet. |volume=12 |issue= 1 |pages= 88-90 |year= 1996 |pmid= 8528260 |doi= 10.1038/ng0196-88 }}
*{{cite journal | author=Netchine I, Talon P, Dastot F, ''et al.'' |title=Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 2 |pages= 432-6 |year= 1998 |pmid= 9467553 |doi= }}
*{{cite journal | author=Petersenn S, Rasch AC, Heyens M, Schulte HM |title=Structure and regulation of the human growth hormone-releasing hormone receptor gene. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 233-47 |year= 1998 |pmid= 9482665 |doi= }}
*{{cite journal | author=Maheshwari HG, Silverman BL, Dupuis J, Baumann G |title=Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 11 |pages= 4065-74 |year= 1998 |pmid= 9814493 |doi= }}
*{{cite journal | author=Salvatori R, Hayashida CY, Aguiar-Oliveira MH, ''et al.'' |title=Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 917-23 |year= 1999 |pmid= 10084571 |doi= }}
*{{cite journal | author=Morel G, Gallego R, Boulanger L, ''et al.'' |title=Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries. |journal=Neuroendocrinology |volume=70 |issue= 2 |pages= 128-36 |year= 2000 |pmid= 10461027 |doi= }}
*{{cite journal | author=Rekasi Z, Czompoly T, Schally AV, Halmos G |title=Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10561-6 |year= 2000 |pmid= 10962031 |doi= 10.1073/pnas.180313297 }}
*{{cite journal | author=Salvatori R, Fan X, Phillips JA, ''et al.'' |title=Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 1 |pages= 273-9 |year= 2001 |pmid= 11232012 |doi= }}
*{{cite journal | author=Kiaris H, Schally AV, Busto R, ''et al.'' |title=Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 196-200 |year= 2002 |pmid= 11773624 |doi= 10.1073/pnas.012590999 }}
*{{cite journal | author=Salvatori R, Fan X, Mullis PE, ''et al.'' |title=Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site. |journal=Mol. Endocrinol. |volume=16 |issue= 3 |pages= 450-8 |year= 2002 |pmid= 11875102 |doi= }}
*{{cite journal | author=Plonowski A, Schally AV, Busto R, ''et al.'' |title=Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers. |journal=Peptides |volume=23 |issue= 6 |pages= 1127-33 |year= 2003 |pmid= 12126741 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GHSR... {November 24, 2007 3:33:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:34:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth hormone secretagogue receptor
| HGNCid = 4267
| Symbol = GHSR
| AltSymbols =;
| OMIM = 601898
| ECnumber =
| Homologene = 57161
| MGIid = 2441906
| GeneAtlas_image1 = PBB_GE_GHSR_221360_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001616 |text = growth hormone secretagogue receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016520 |text = growth hormone-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008343 |text = adult feeding behavior}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}} {{GNF_GO|id=GO:0030252 |text = growth hormone secretion}} {{GNF_GO|id=GO:0032100 |text = positive regulation of appetite}} {{GNF_GO|id=GO:0040018 |text = positive regulation of body size}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2693
| Hs_Ensembl = ENSG00000121853
| Hs_RefseqProtein = NP_004113
| Hs_RefseqmRNA = NM_004122
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 173645645
| Hs_GenLoc_end = 173648897
| Hs_Uniprot = Q92847
| Mm_EntrezGene = 208188
| Mm_Ensembl = ENSMUSG00000051136
| Mm_RefseqmRNA = NM_177330
| Mm_RefseqProtein = NP_796304
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 27562424
| Mm_GenLoc_end = 27569083
| Mm_Uniprot = Q0VBE5
}}
}}
'''Growth hormone secretagogue receptor''', also known as '''GHSR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GHSR growth hormone secretagogue receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2693| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a.<ref name="entrez">{{cite web | title = Entrez Gene: GHSR growth hormone secretagogue receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2693| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith RG, Leonard R, Bailey AR, ''et al.'' |title=Growth hormone secretagogue receptor family members and ligands. |journal=Endocrine |volume=14 |issue= 1 |pages= 9-14 |year= 2001 |pmid= 11322507 |doi= }}
*{{cite journal | author=Petersenn S |title=Structure and regulation of the growth hormone secretagogue receptor. |journal=Minerva Endocrinol. |volume=27 |issue= 4 |pages= 243-56 |year= 2003 |pmid= 12511847 |doi= }}
*{{cite journal | author=Holst B, Schwartz TW |title=Ghrelin receptor mutations--too little height and too much hunger. |journal=J. Clin. Invest. |volume=116 |issue= 3 |pages= 637-41 |year= 2006 |pmid= 16511600 |doi= 10.1172/JCI27999 }}
*{{cite journal | author=Nogueiras R, Perez-Tilve D, Wortley KE, Tschöp M |title=Growth hormone secretagogue (ghrelin-) receptors--a complex drug target for the regulation of body weight. |journal=CNS & neurological disorders drug targets |volume=5 |issue= 3 |pages= 335-43 |year= 2006 |pmid= 16787234 |doi= }}
*{{cite journal | author=Engbaek K |title=[Giardia lamblia and other intestinal parasites in children in day-institutions. Incidence and significance] |journal=Ugeskr. Laeg. |volume=140 |issue= 1 |pages= 14-7 |year= 1978 |pmid= 601898 |doi= }}
*{{cite journal | author=Howard AD, Feighner SD, Cully DF, ''et al.'' |title=A receptor in pituitary and hypothalamus that functions in growth hormone release. |journal=Science |volume=273 |issue= 5277 |pages= 974-7 |year= 1996 |pmid= 8688086 |doi= }}
*{{cite journal | author=McKee KK, Palyha OC, Feighner SD, ''et al.'' |title=Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. |journal=Mol. Endocrinol. |volume=11 |issue= 4 |pages= 415-23 |year= 1997 |pmid= 9092793 |doi= }}
*{{cite journal | author=Kaji H, Tai S, Okimura Y, ''et al.'' |title=Cloning and characterization of the 5'-flanking region of the human growth hormone secretagogue receptor gene. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 33885-8 |year= 1999 |pmid= 9852035 |doi= }}
*{{cite journal | author=Kojima M, Hosoda H, Date Y, ''et al.'' |title=Ghrelin is a growth-hormone-releasing acylated peptide from stomach. |journal=Nature |volume=402 |issue= 6762 |pages= 656-60 |year= 2000 |pmid= 10604470 |doi= 10.1038/45230 }}
*{{cite journal | author=Deghenghi R, Papotti M, Ghigo E, Muccioli G |title=Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. |journal=J. Endocrinol. Invest. |volume=24 |issue= 1 |pages= RC1-3 |year= 2001 |pmid= 11227737 |doi= }}
*{{cite journal | author=Tannenbaum GS, Bowers CY |title=Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin. |journal=Endocrine |volume=14 |issue= 1 |pages= 21-7 |year= 2001 |pmid= 11322498 |doi= }}
*{{cite journal | author=Petersenn S, Rasch AC, Penshorn M, ''et al.'' |title=Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor. |journal=Endocrinology |volume=142 |issue= 6 |pages= 2649-59 |year= 2001 |pmid= 11356716 |doi= }}
*{{cite journal | author=Shuto Y, Shibasaki T, Otagiri A, ''et al.'' |title=Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. |journal=J. Clin. Invest. |volume=109 |issue= 11 |pages= 1429-36 |year= 2002 |pmid= 12045256 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gaytan F, Barreiro ML, Chopin LK, ''et al.'' |title=Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 2 |pages= 879-87 |year= 2003 |pmid= 12574228 |doi= }}
*{{cite journal | author=Dass NB, Munonyara M, Bassil AK, ''et al.'' |title=Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. |journal=Neuroscience |volume=120 |issue= 2 |pages= 443-53 |year= 2003 |pmid= 12890514 |doi= }}
*{{cite journal | author=Lall S, Balthasar N, Carmignac D, ''et al.'' |title=Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons. |journal=Endocrinology |volume=145 |issue= 4 |pages= 1602-11 |year= 2004 |pmid= 14701677 |doi= 10.1210/en.2003-1509 }}
*{{cite journal | author=Wang HJ, Geller F, Dempfle A, ''et al.'' |title=Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 1 |pages= 157-62 |year= 2004 |pmid= 14715843 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GIPR... {November 24, 2007 3:34:03 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:34:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gastric inhibitory polypeptide receptor
| HGNCid = 4271
| Symbol = GIPR
| AltSymbols =; MGC126722
| OMIM = 137241
| ECnumber =
| Homologene = 20081
| MGIid = 1352753
| GeneAtlas_image1 = PBB_GE_GIPR_208105_at_tn.png
| Function = {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0016519 |text = gastric inhibitory peptide receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2696
| Hs_Ensembl = ENSG00000010310
| Hs_RefseqProtein = NP_000155
| Hs_RefseqmRNA = NM_000164
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 50863342
| Hs_GenLoc_end = 50877544
| Hs_Uniprot = P48546
| Mm_EntrezGene = 381853
| Mm_Ensembl = ENSMUSG00000030406
| Mm_RefseqmRNA = XM_133238
| Mm_RefseqProtein = XP_133238
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 18321065
| Mm_GenLoc_end = 18323191
| Mm_Uniprot =
}}
}}
'''Gastric inhibitory polypeptide receptor''', also known as '''GIPR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GIPR gastric inhibitory polypeptide receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2696| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Gastric inhibitory polypeptide (GIP; MIM 137240), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GIPR gastric inhibitory polypeptide receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2696| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yamada Y, Seino Y |title=Physiology of GIP--a lesson from GIP receptor knockout mice. |journal=Horm. Metab. Res. |volume=36 |issue= 11-12 |pages= 771-4 |year= 2005 |pmid= 15655707 |doi= 10.1055/s-2004-826162 }}
*{{cite journal | author=Stoffel M, Fernald AA, Le Beau MM, Bell GI |title=Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. |journal=Genomics |volume=28 |issue= 3 |pages= 607-9 |year= 1996 |pmid= 7490109 |doi= 10.1006/geno.1995.1203 }}
*{{cite journal | author=Gremlich S, Porret A, Hani EH, ''et al.'' |title=Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor. |journal=Diabetes |volume=44 |issue= 10 |pages= 1202-8 |year= 1995 |pmid= 7556958 |doi= }}
*{{cite journal | author=Volz A, Göke R, Lankat-Buttgereit B, ''et al.'' |title=Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma. |journal=FEBS Lett. |volume=373 |issue= 1 |pages= 23-9 |year= 1995 |pmid= 7589426 |doi= }}
*{{cite journal | author=Usdin TB, Mezey E, Button DC, ''et al.'' |title=Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. |journal=Endocrinology |volume=133 |issue= 6 |pages= 2861-70 |year= 1994 |pmid= 8243312 |doi= }}
*{{cite journal | author=Yamada Y, Hayami T, Nakamura K, ''et al.'' |title=Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. |journal=Genomics |volume=29 |issue= 3 |pages= 773-6 |year= 1996 |pmid= 8575774 |doi= 10.1006/geno.1995.9937 }}
*{{cite journal | author=Gallwitz B, Witt M, Morys-Wortmann C, ''et al.'' |title=GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1. |journal=Regul. Pept. |volume=63 |issue= 1 |pages= 17-22 |year= 1997 |pmid= 8795084 |doi= }}
*{{cite journal | author=N'Diaye N, Tremblay J, Hamet P, ''et al.'' |title=Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 8 |pages= 2781-5 |year= 1998 |pmid= 9709947 |doi= }}
*{{cite journal | author=Tseng CC, Zhang XY |title=Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling. |journal=Endocrinology |volume=141 |issue= 3 |pages= 947-52 |year= 2000 |pmid= 10698169 |doi= }}
*{{cite journal | author=Bollag RJ, Zhong Q, Phillips P, ''et al.'' |title=Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors. |journal=Endocrinology |volume=141 |issue= 3 |pages= 1228-35 |year= 2000 |pmid= 10698200 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Baldacchino V, Oble S, Hamet P, ''et al.'' |title=Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene. |journal=Endocr. Res. |volume=28 |issue= 4 |pages= 577 |year= 2003 |pmid= 12530665 |doi= }}
*{{cite journal | author=Antonini SR, N'Diaye N, Hamet P, ''et al.'' |title=Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS). |journal=Endocr. Res. |volume=28 |issue= 4 |pages= 755-6 |year= 2003 |pmid= 12530694 |doi= }}
*{{cite journal | author=Manhart S, Hinke SA, McIntosh CH, ''et al.'' |title=Structure-function analysis of a series of novel GIP analogues containing different helical length linkers. |journal=Biochemistry |volume=42 |issue= 10 |pages= 3081-8 |year= 2003 |pmid= 12627975 |doi= 10.1021/bi026868e }}
*{{cite journal | author=Ding KH, Zhong Q, Isales CM |title=Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 2 |pages= E390-6 |year= 2003 |pmid= 12721154 |doi= 10.1152/ajpendo.00509.2002 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Hansotia T, Baggio LL, Delmeire D, ''et al.'' |title=Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. |journal=Diabetes |volume=53 |issue= 5 |pages= 1326-35 |year= 2004 |pmid= 15111503 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Baldacchino V, Oble S, Hamet P, ''et al.'' |title=The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter. |journal=Endocr. Res. |volume=30 |issue= 4 |pages= 805-6 |year= 2005 |pmid= 15666829 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GLP1R... {November 24, 2007 3:34:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:36:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glucagon-like peptide 1 receptor
| HGNCid = 4324
| Symbol = GLP1R
| AltSymbols =; MGC138331
| OMIM = 138032
| ECnumber =
| Homologene = 1558
| MGIid = 99571
| GeneAtlas_image1 = PBB_GE_GLP1R_208401_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GLP1R_208390_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GLP1R_208391_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004967 |text = glucagon receptor activity}} {{GNF_GO|id=GO:0008528 |text = peptide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0019933 |text = cAMP-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2740
| Hs_Ensembl = ENSG00000112164
| Hs_RefseqProtein = NP_002053
| Hs_RefseqmRNA = NM_002062
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 39124552
| Hs_GenLoc_end = 39163497
| Hs_Uniprot = P43220
| Mm_EntrezGene = 14652
| Mm_Ensembl = ENSMUSG00000024027
| Mm_RefseqmRNA = XM_001000702
| Mm_RefseqProtein = XP_001000702
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30628889
| Mm_GenLoc_end = 30663545
| Mm_Uniprot = Q104P0
}}
}}
'''Glucagon-like peptide 1 receptor''', also known as '''GLP1R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GLP1R glucagon-like peptide 1 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2740| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=van Eyll B, Lankat-Buttgereit B, Bode HP, ''et al.'' |title=Signal transduction of the GLP-1-receptor cloned from a human insulinoma. |journal=FEBS Lett. |volume=348 |issue= 1 |pages= 7-13 |year= 1994 |pmid= 7517895 |doi= }}
*{{cite journal | author=Gromada J, Rorsman P, Dissing S, Wulff BS |title=Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release. |journal=FEBS Lett. |volume=373 |issue= 2 |pages= 182-6 |year= 1995 |pmid= 7589461 |doi= }}
*{{cite journal | author=Wei Y, Mojsov S |title=Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. |journal=FEBS Lett. |volume=358 |issue= 3 |pages= 219-24 |year= 1995 |pmid= 7843404 |doi= }}
*{{cite journal | author=Lankat-Buttgereit B, Göke R, Stöckmann F, ''et al.'' |title=Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes. |journal=Digestion |volume=55 |issue= 1 |pages= 29-33 |year= 1994 |pmid= 8112494 |doi= }}
*{{cite journal | author=Graziano MP, Hey PJ, Borkowski D, ''et al.'' |title=Cloning and functional expression of a human glucagon-like peptide-1 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 1 |pages= 141-6 |year= 1993 |pmid= 8216285 |doi= 10.1006/bbrc.1993.2226 }}
*{{cite journal | author=Stoffel M, Espinosa R, Le Beau MM, Bell GI |title=Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6. |journal=Diabetes |volume=42 |issue= 8 |pages= 1215-8 |year= 1993 |pmid= 8392011 |doi= }}
*{{cite journal | author=Dillon JS, Tanizawa Y, Wheeler MB, ''et al.'' |title=Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. |journal=Endocrinology |volume=133 |issue= 4 |pages= 1907-10 |year= 1993 |pmid= 8404634 |doi= }}
*{{cite journal | author=Thorens B, Porret A, Bühler L, ''et al.'' |title=Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. |journal=Diabetes |volume=42 |issue= 11 |pages= 1678-82 |year= 1993 |pmid= 8405712 |doi= }}
*{{cite journal | author=Lankat-Buttgereit B, Göke B |title=Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene. |journal=Peptides |volume=18 |issue= 5 |pages= 617-24 |year= 1997 |pmid= 9213353 |doi= }}
*{{cite journal | author=Frimurer TM, Bywater RP |title=Structure of the integral membrane domain of the GLP1 receptor. |journal=Proteins |volume=35 |issue= 4 |pages= 375-86 |year= 1999 |pmid= 10382665 |doi= }}
*{{cite journal | author=Huypens P, Ling Z, Pipeleers D, Schuit F |title=Glucagon receptors on human islet cells contribute to glucose competence of insulin release. |journal=Diabetologia |volume=43 |issue= 8 |pages= 1012-9 |year= 2001 |pmid= 10990079 |doi= }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Xiao Q, Jeng W, Wheeler MB |title=Characterization of glucagon-like peptide-1 receptor-binding determinants. |journal=J. Mol. Endocrinol. |volume=25 |issue= 3 |pages= 321-35 |year= 2001 |pmid= 11116211 |doi= }}
*{{cite journal | author=Bazarsuren A, Grauschopf U, Wozny M, ''et al.'' |title=In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor. |journal=Biophys. Chem. |volume=96 |issue= 2-3 |pages= 305-18 |year= 2003 |pmid= 12034449 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Tokuyama Y, Matsui K, Egashira T, ''et al.'' |title=Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. |journal=Diabetes Res. Clin. Pract. |volume=66 |issue= 1 |pages= 63-9 |year= 2005 |pmid= 15364163 |doi= 10.1016/j.diabres.2004.02.004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Jorgensen R, Martini L, Schwartz TW, Elling CE |title=Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype. |journal=Mol. Endocrinol. |volume=19 |issue= 3 |pages= 812-23 |year= 2005 |pmid= 15528268 |doi= 10.1210/me.2004-0312 }}
*{{cite journal | author=Mahon MJ, Shimada M |title=Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 803-7 |year= 2005 |pmid= 15670850 |doi= 10.1016/j.febslet.2004.12.056 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GNRHR... {November 24, 2007 3:36:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:37:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gonadotropin-releasing hormone receptor
| HGNCid = 4421
| Symbol = GNRHR
| AltSymbols =; GNRHR1; GRHR; LHRHR; LRHR
| OMIM = 138850
| ECnumber =
| Homologene = 350
| MGIid = 95790
| GeneAtlas_image1 = PBB_GE_GNRHR_216341_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNRHR_211522_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNRHR_211523_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004968 |text = gonadotropin-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2798
| Hs_Ensembl = ENSG00000109163
| Hs_RefseqProtein = NP_000397
| Hs_RefseqmRNA = NM_000406
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 68285701
| Hs_GenLoc_end = 68304399
| Hs_Uniprot = P30968
| Mm_EntrezGene = 14715
| Mm_Ensembl = ENSMUSG00000029255
| Mm_RefseqmRNA = NM_010323
| Mm_RefseqProtein = NP_034453
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 87256547
| Mm_GenLoc_end = 87272431
| Mm_Uniprot = Q01776
}}
}}
'''Gonadotropin-releasing hormone receptor''', also known as '''GNRHR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Michel U, Farnworth P, Findlay JK |title=Follistatins: more than follicle-stimulating hormone suppressing proteins. |journal=Mol. Cell. Endocrinol. |volume=91 |issue= 1-2 |pages= 1-11 |year= 1993 |pmid= 8472841 |doi= }}
*{{cite journal | author=Flanagan CA, Millar RP, Illing N |title=Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions. |journal=Rev. Reprod. |volume=2 |issue= 2 |pages= 113-20 |year= 1998 |pmid= 9414473 |doi= }}
*{{cite journal | author=Limonta P, Moretti RM, Marelli MM, Motta M |title=The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. |journal=Frontiers in neuroendocrinology |volume=24 |issue= 4 |pages= 279-95 |year= 2004 |pmid= 14726258 |doi= }}
*{{cite journal | author=Bédécarrats GY, Kaiser UB |title=Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. |journal=Semin. Reprod. Med. |volume=25 |issue= 5 |pages= 368-78 |year= 2007 |pmid= 17710733 |doi= 10.1055/s-2007-984743 }}
*{{cite journal | author=Kakar SS, Musgrove LC, Devor DC, ''et al.'' |title=Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 1 |pages= 289-95 |year= 1992 |pmid= 1333190 |doi= }}
*{{cite journal | author=Kakar SS, Grizzle WE, Neill JD |title=The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. |journal=Mol. Cell. Endocrinol. |volume=106 |issue= 1-2 |pages= 145-9 |year= 1995 |pmid= 7534732 |doi= }}
*{{cite journal | author=Leung PC, Squire J, Peng C, ''et al.'' |title=Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization. |journal=Mamm. Genome |volume=6 |issue= 4 |pages= 309-10 |year= 1995 |pmid= 7613048 |doi= }}
*{{cite journal | author=Fan NC, Peng C, Krisinger J, Leung PC |title=The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals. |journal=Mol. Cell. Endocrinol. |volume=107 |issue= 2 |pages= R1-8 |year= 1995 |pmid= 7768323 |doi= }}
*{{cite journal | author=Fan NC, Jeung EB, Peng C, ''et al.'' |title=The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment. |journal=Mol. Cell. Endocrinol. |volume=103 |issue= 1-2 |pages= R1-6 |year= 1994 |pmid= 7958384 |doi= }}
*{{cite journal | author=Chi L, Zhou W, Prikhozhan A, ''et al.'' |title=Cloning and characterization of the human GnRH receptor. |journal=Mol. Cell. Endocrinol. |volume=91 |issue= 1-2 |pages= R1-6 |year= 1993 |pmid= 8386108 |doi= }}
*{{cite journal | author=Grosse R, Schöneberg T, Schultz G, Gudermann T |title=Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. |journal=Mol. Endocrinol. |volume=11 |issue= 9 |pages= 1305-18 |year= 1997 |pmid= 9259321 |doi= }}
*{{cite journal | author=Kakar SS |title=Molecular structure of the human gonadotropin-releasing hormone receptor gene. |journal=Eur. J. Endocrinol. |volume=137 |issue= 2 |pages= 183-92 |year= 1997 |pmid= 9272108 |doi= }}
*{{cite journal | author=de Roux N, Young J, Misrahi M, ''et al.'' |title=A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. |journal=N. Engl. J. Med. |volume=337 |issue= 22 |pages= 1597-602 |year= 1997 |pmid= 9371856 |doi= }}
*{{cite journal | author=Layman LC, Cohen DP, Jin M, ''et al.'' |title=Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. |journal=Nat. Genet. |volume=18 |issue= 1 |pages= 14-5 |year= 1998 |pmid= 9425890 |doi= 10.1038/ng0198-14 }}
*{{cite journal | author=de Roux N, Young J, Brailly-Tabard S, ''et al.'' |title=The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 2 |pages= 567-72 |year= 1999 |pmid= 10022417 |doi= }}
*{{cite journal | author=Caron P, Chauvin S, Christin-Maitre S, ''et al.'' |title=Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 990-6 |year= 1999 |pmid= 10084584 |doi= }}
*{{cite journal | author=Kottler ML, Bergametti F, Carrë MC, ''et al.'' |title=Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene. |journal=Eur. J. Endocrinol. |volume=140 |issue= 6 |pages= 561-9 |year= 1999 |pmid= 10366411 |doi= }}
*{{cite journal | author=Pralong FP, Gomez F, Castillo E, ''et al.'' |title=Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 10 |pages= 3811-6 |year= 1999 |pmid= 10523035 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR1... {November 24, 2007 3:37:04 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:37:44 PM PST}
- CREATED: Created new protein page: GPR1 {November 24, 2007 3:37:51 PM PST}
- INFO: Beginning work on GPR3... {November 24, 2007 3:38:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:39:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 3
| HGNCid = 4484
| Symbol = GPR3
| AltSymbols =; ACCA
| OMIM = 600241
| ECnumber =
| Homologene = 31303
| MGIid = 101908
| GeneAtlas_image1 = PBB_GE_GPR3_214613_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007189 |text = G-protein signaling, adenylate cyclase activating pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2827
| Hs_Ensembl = ENSG00000181773
| Hs_RefseqProtein = NP_005272
| Hs_RefseqmRNA = NM_005281
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 27591735
| Hs_GenLoc_end = 27594905
| Hs_Uniprot = P46089
| Mm_EntrezGene = 14748
| Mm_Ensembl = ENSMUSG00000049649
| Mm_RefseqmRNA = NM_008154
| Mm_RefseqProtein = NP_032180
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 132481412
| Mm_GenLoc_end = 132484583
| Mm_Uniprot = Q3USD4
}}
}}
'''G protein-coupled receptor 3''', also known as '''GPR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR3 G protein-coupled receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2827| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eggerickx D, Denef JF, Labbe O, ''et al.'' |title=Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. |journal=Biochem. J. |volume=309 ( Pt 3) |issue= |pages= 837-43 |year= 1995 |pmid= 7639700 |doi= }}
*{{cite journal | author=Iismaa TP, Kiefer J, Liu ML, ''et al.'' |title=Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system. |journal=Genomics |volume=24 |issue= 2 |pages= 391-4 |year= 1995 |pmid= 7698767 |doi= 10.1006/geno.1994.1635 }}
*{{cite journal | author=Heiber M, Docherty JM, Shah G, ''et al.'' |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25-35 |year= 1995 |pmid= 7832990 |doi= }}
*{{cite journal | author=Marchese A, Docherty JM, Nguyen T, ''et al.'' |title=Cloning of human genes encoding novel G protein-coupled receptors. |journal=Genomics |volume=23 |issue= 3 |pages= 609-18 |year= 1995 |pmid= 7851889 |doi= 10.1006/geno.1994.1549 }}
*{{cite journal | author=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |journal=Genomics |volume=28 |issue= 2 |pages= 347-9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Uhlenbrock K, Huber J, Ardati A, ''et al.'' |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75-84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR4... {November 24, 2007 3:39:36 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:40:25 PM PST}
- CREATED: Created new protein page: GPR4 {November 24, 2007 3:40:33 PM PST}
- INFO: Beginning work on GPR6... {November 24, 2007 3:41:10 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:41:44 PM PST}
- CREATED: Created new protein page: GPR6 {November 24, 2007 3:41:51 PM PST}
- INFO: Beginning work on NPBWR1... {November 24, 2007 3:41:51 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:42:10 PM PST}
- CREATED: Created new protein page: NPBWR1 {November 24, 2007 3:42:17 PM PST}
- INFO: Beginning work on NPBWR2... {November 24, 2007 3:42:17 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:42:50 PM PST}
- CREATED: Created new protein page: NPBWR2 {November 24, 2007 3:42:57 PM PST}
- INFO: Beginning work on OPN1MW... {November 24, 2007 3:32:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:33:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
| HGNCid = 4206
| Symbol = OPN1MW
| AltSymbols =; CBBM; CBD; GCP
| OMIM = 303800
| ECnumber =
| Homologene = 88332
| MGIid =
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0009881 |text = photoreceptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2652
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000504
| Hs_RefseqmRNA = NM_000513
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)''', also known as '''OPN1MW''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPN1MW opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2652| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Applebury ML, Hargrave PA |title=Molecular biology of the visual pigments. |journal=Vision Res. |volume=26 |issue= 12 |pages= 1881-95 |year= 1987 |pmid= 3303660 |doi= }}
*{{cite journal | author=Winderickx J, Sanocki E, Lindsey DT, ''et al.'' |title=Defective colour vision associated with a missense mutation in the human green visual pigment gene. |journal=Nat. Genet. |volume=1 |issue= 4 |pages= 251-6 |year= 1993 |pmid= 1302020 |doi= 10.1038/ng0792-251 }}
*{{cite journal | author=Neitz J, Neitz M, Jacobs GH |title=Analysis of fusion gene and encoded photopigment of colour-blind humans. |journal=Nature |volume=342 |issue= 6250 |pages= 679-82 |year= 1990 |pmid= 2574415 |doi= 10.1038/342679a0 }}
*{{cite journal | author=Nathans J, Thomas D, Hogness DS |title=Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. |journal=Science |volume=232 |issue= 4747 |pages= 193-202 |year= 1986 |pmid= 2937147 |doi= }}
*{{cite journal | author=Li ZY, Kljavin IJ, Milam AH |title=Rod photoreceptor neurite sprouting in retinitis pigmentosa. |journal=J. Neurosci. |volume=15 |issue= 8 |pages= 5429-38 |year= 1995 |pmid= 7643192 |doi= }}
*{{cite journal | author=Ladekjaer-Mikkelsen AS, Rosenberg T, Jørgensen AL |title=A new mechanism in blue cone monochromatism. |journal=Hum. Genet. |volume=98 |issue= 4 |pages= 403-8 |year= 1996 |pmid= 8792812 |doi= }}
*{{cite journal | author=Ferreira PA, Nakayama TA, Pak WL, Travis GH |title=Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. |journal=Nature |volume=383 |issue= 6601 |pages= 637-40 |year= 1996 |pmid= 8857542 |doi= 10.1038/383637a0 }}
*{{cite journal | author=Vissers PM, Bovee-Geurts PH, Portier MD, ''et al.'' |title=Large-scale production and purification of the human green cone pigment: characterization of late photo-intermediates. |journal=Biochem. J. |volume=330 ( Pt 3) |issue= |pages= 1201-8 |year= 1998 |pmid= 9494086 |doi= }}
*{{cite journal | author=Bernstein SL, Wong P |title=Regional expression of disease-related genes in human and monkey retina. |journal=Mol. Vis. |volume=4 |issue= |pages= 24 |year= 1998 |pmid= 9815288 |doi= }}
*{{cite journal | author=Hayashi T, Motulsky AG, Deeb SS |title=Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype. |journal=Nat. Genet. |volume=22 |issue= 1 |pages= 90-3 |year= 1999 |pmid= 10319869 |doi= 10.1038/8798 }}
*{{cite journal | author=Ueyama H, Kuwayama S, Imai H, ''et al.'' |title=Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 205-9 |year= 2002 |pmid= 12051694 |doi= 10.1016/S0006-291X(02)00458-8 }}
*{{cite journal | author=Zhu X, Brown B, Li A, ''et al.'' |title=GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina. |journal=J. Neurosci. |volume=23 |issue= 14 |pages= 6152-60 |year= 2003 |pmid= 12853434 |doi= }}
*{{cite journal | author=Bonilha VL, Hollyfield JG, Grover S, Fishman GA |title=Abnormal distribution of red/green cone opsins in a patient with an autosomal dominant cone dystrophy. |journal=Ophthalmic Genet. |volume=26 |issue= 2 |pages= 69-76 |year= 2005 |pmid= 16020309 |doi= 10.1080/13816810590968041 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on XCR1... {November 24, 2007 3:40:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:41:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C motif) receptor 1
| HGNCid = 1625
| Symbol = XCR1
| AltSymbols =; CCXCR1; GPR5
| OMIM = 600552
| ECnumber =
| Homologene = 21095
| MGIid = 1346338
| GeneAtlas_image1 = PBB_GE_XCR1_221468_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004950 |text = chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2829
| Hs_Ensembl = ENSG00000173578
| Hs_RefseqProtein = NP_001019815
| Hs_RefseqmRNA = NM_001024644
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 46037295
| Hs_GenLoc_end = 46043983
| Hs_Uniprot = P46094
| Mm_EntrezGene = 23832
| Mm_Ensembl = ENSMUSG00000060509
| Mm_RefseqmRNA = NM_011798
| Mm_RefseqProtein = NP_035928
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 123701016
| Mm_GenLoc_end = 123710826
| Mm_Uniprot = Q544D8
}}
}}
'''Chemokine (C motif) receptor 1''', also known as '''XCR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: XCR1 chemokine (C motif) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2829| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: XCR1 chemokine (C motif) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2829| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Maghazachi AA |title=Intracellular signalling pathways induced by chemokines in natural killer cells. |journal=Cell. Signal. |volume=11 |issue= 6 |pages= 385-90 |year= 1999 |pmid= 10400311 |doi= }}
*{{cite journal | author=Gao JL, Kuhns DB, Tiffany HL, ''et al.'' |title=Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. |journal=J. Exp. Med. |volume=177 |issue= 5 |pages= 1421-7 |year= 1993 |pmid= 7683036 |doi= }}
*{{cite journal | author=Heiber M, Docherty JM, Shah G, ''et al.'' |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25-35 |year= 1995 |pmid= 7832990 |doi= }}
*{{cite journal | author=Yoshida T, Imai T, Kakizaki M, ''et al.'' |title=Identification of single C motif-1/lymphotactin receptor XCR1. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16551-4 |year= 1998 |pmid= 9632725 |doi= }}
*{{cite journal | author=Shan L, Qiao X, Oldham E, ''et al.'' |title=Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 3 |pages= 938-41 |year= 2000 |pmid= 10679309 |doi= 10.1006/bbrc.2000.2235 }}
*{{cite journal | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265-8 |year= 2000 |pmid= 10702689 |doi= }}
*{{cite journal | author=Kurt RA, Bauck M, Harma S, ''et al.'' |title=Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. |journal=Cell. Immunol. |volume=209 |issue= 2 |pages= 83-8 |year= 2001 |pmid= 11446740 |doi= 10.1006/cimm.2001.1790 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Shinkai H, Morozumi T, Toki D, ''et al.'' |title=Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1. |journal=Gene |volume=349 |issue= |pages= 55-66 |year= 2005 |pmid= 15777643 |doi= 10.1016/j.gene.2004.10.017 }}
*{{cite journal | author=Lüttichau HR, Johnsen AH, Jurlander J, ''et al.'' |title=Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3. |journal=J. Biol. Chem. |volume=282 |issue= 24 |pages= 17794-805 |year= 2007 |pmid= 17403668 |doi= 10.1074/jbc.M702001200 }}
}}
{{refend}}
{{protein-stub}}
end log.
