Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:33, 24 November 2007 (UTC)
[edit]Proteins without matches (14)
[edit]Proteins with a High Potential Match (4)
[edit]Redirected Proteins (7)
[edit]Manual Inspection (Page not found) (10)
[edit]Updated with Warning (1)
[edit]
Protein Status Grid - Date: 23:33, 24 November 2007 (UTC)
[edit]Vebose Log - Date: 23:33, 24 November 2007 (UTC)
[edit]- INFO: Beginning work on CCBP2... {November 24, 2007 3:07:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:08:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine binding protein 2
| HGNCid = 1565
| Symbol = CCBP2
| AltSymbols =; CCR10; CCR9; CMKBR9; D6; MGC126678; MGC138250; hD6
| OMIM = 602648
| ECnumber =
| Homologene = 992
| MGIid = 1891697
| GeneAtlas_image1 = PBB_GE_CCBP2_206887_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}} {{GNF_GO|id=GO:0016494 |text = C-X-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1238
| Hs_Ensembl = ENSG00000144648
| Hs_RefseqProtein = NP_001287
| Hs_RefseqmRNA = NM_001296
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 42836115
| Hs_GenLoc_end = 42883778
| Hs_Uniprot = O00590
| Mm_EntrezGene = 59289
| Mm_Ensembl = ENSMUSG00000044534
| Mm_RefseqmRNA = NM_021609
| Mm_RefseqProtein = NP_067622
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 121747162
| Mm_GenLoc_end = 121759762
| Mm_Uniprot = Q2V6T2
}}
}}
'''Chemokine binding protein 2''', also known as '''CCBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCBP2 chemokine binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.<ref name="entrez">{{cite web | title = Entrez Gene: CCBP2 chemokine binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ |title=Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. |journal=J. Biol. Chem. |volume=272 |issue= 19 |pages= 12495-504 |year= 1997 |pmid= 9139699 |doi= }}
*{{cite journal | author=Bonini JA, Martin SK, Dralyuk F, ''et al.'' |title=Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1249-56 |year= 1997 |pmid= 9364936 |doi= }}
*{{cite journal | author=Nibbs RJ, Wylie SM, Yang J, ''et al.'' |title=Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32078-83 |year= 1998 |pmid= 9405404 |doi= }}
*{{cite journal | author=Nibbs RJ, Yang J, Landau NR, ''et al.'' |title=LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17478-83 |year= 1999 |pmid= 10364178 |doi= }}
*{{cite journal | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265-8 |year= 2000 |pmid= 10702689 |doi= }}
*{{cite journal | author=Gosling J, Dairaghi DJ, Wang Y, ''et al.'' |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851-6 |year= 2000 |pmid= 10706668 |doi= }}
*{{cite journal | author=Jarmin DI, Rits M, Bota D, ''et al.'' |title=Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3460-4 |year= 2000 |pmid= 10725696 |doi= }}
*{{cite journal | author=Homey B, Wang W, Soto H, ''et al.'' |title=Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). |journal=J. Immunol. |volume=164 |issue= 7 |pages= 3465-70 |year= 2000 |pmid= 10725697 |doi= }}
*{{cite journal | author=Wang W, Soto H, Oldham ER, ''et al.'' |title=Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22313-23 |year= 2000 |pmid= 10781587 |doi= 10.1074/jbc.M001461200 }}
*{{cite journal | author=Nibbs RJ, Kriehuber E, Ponath PD, ''et al.'' |title=The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 867-77 |year= 2001 |pmid= 11238036 |doi= }}
*{{cite journal | author=Homey B, Alenius H, Müller A, ''et al.'' |title=CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. |journal=Nat. Med. |volume=8 |issue= 2 |pages= 157-65 |year= 2002 |pmid= 11821900 |doi= 10.1038/nm0202-157 }}
*{{cite journal | author=Soler D, Humphreys TL, Spinola SM, Campbell JJ |title=CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. |journal=Blood |volume=101 |issue= 5 |pages= 1677-82 |year= 2003 |pmid= 12406880 |doi= 10.1182/blood-2002-07-2348 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Fra AM, Locati M, Otero K, ''et al.'' |title=Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. |journal=J. Immunol. |volume=170 |issue= 5 |pages= 2279-82 |year= 2003 |pmid= 12594248 |doi= }}
*{{cite journal | author=Kunkel EJ, Kim CH, Lazarus NH, ''et al.'' |title=CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. |journal=J. Clin. Invest. |volume=111 |issue= 7 |pages= 1001-10 |year= 2003 |pmid= 12671049 |doi= }}
*{{cite journal | author=Galliera E, Jala VR, Trent JO, ''et al.'' |title=beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. |journal=J. Biol. Chem. |volume=279 |issue= 24 |pages= 25590-7 |year= 2004 |pmid= 15084596 |doi= 10.1074/jbc.M400363200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Neil SJ, Aasa-Chapman MM, Clapham PR, ''et al.'' |title=The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. |journal=J. Virol. |volume=79 |issue= 15 |pages= 9618-24 |year= 2005 |pmid= 16014924 |doi= 10.1128/JVI.79.15.9618-9624.2005 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CELSR2... {November 24, 2007 3:21:29 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:22:35 PM PST}
- CREATED: Created new protein page: CELSR2 {November 24, 2007 3:22:43 PM PST}
- INFO: Beginning work on CELSR3... {November 24, 2007 3:20:56 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:21:22 PM PST}
- CREATED: Created new protein page: CELSR3 {November 24, 2007 3:21:29 PM PST}
- INFO: Beginning work on CMKLR1... {November 24, 2007 3:08:25 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:09:24 PM PST}
- CREATED: Created new protein page: CMKLR1 {November 24, 2007 3:09:31 PM PST}
- INFO: Beginning work on CNR1... {November 24, 2007 3:10:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:10:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cannabinoid receptor 1 (brain)
| HGNCid = 2159
| Symbol = CNR1
| AltSymbols =; CANN6; CB-R; CB1; CB1A; CB1K5; CNR
| OMIM = 114610
| ECnumber =
| Homologene = 7273
| MGIid = 104615
| GeneAtlas_image1 = PBB_GE_CNR1_208243_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CNR1_213436_at_tn.png
| GeneAtlas_image3 = PBB_GE_CNR1_207940_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004949 |text = cannabinoid receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1268
| Hs_Ensembl = ENSG00000118432
| Hs_RefseqProtein = NP_057167
| Hs_RefseqmRNA = NM_016083
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 88906302
| Hs_GenLoc_end = 88932385
| Hs_Uniprot = P21554
| Mm_EntrezGene = 12801
| Mm_Ensembl = ENSMUSG00000044288
| Mm_RefseqmRNA = NM_007726
| Mm_RefseqProtein = NP_031752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 34253206
| Mm_GenLoc_end = 34277444
| Mm_Uniprot = Q99NU3
}}
}}
'''Cannabinoid receptor 1 (brain)''', also known as '''CNR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CNR1 cannabinoid receptor 1 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1268| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CNR1 cannabinoid receptor 1 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1268| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oddi S, Spagnuolo P, Bari M, ''et al.'' |title=Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis. |journal=Int. Rev. Neurobiol. |volume=82 |issue= |pages= 327-37 |year= 2007 |pmid= 17678969 |doi= 10.1016/S0074-7742(07)82017-4 }}
*{{cite journal | author=Gérard CM, Mollereau C, Vassart G, Parmentier M |title=Molecular cloning of a human cannabinoid receptor which is also expressed in testis. |journal=Biochem. J. |volume=279 ( Pt 1) |issue= |pages= 129-34 |year= 1991 |pmid= 1718258 |doi= }}
*{{cite journal | author=Hoehe MR, Caenazzo L, Martinez MM, ''et al.'' |title=Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15. |journal=New Biol. |volume=3 |issue= 9 |pages= 880-5 |year= 1991 |pmid= 1931832 |doi= }}
*{{cite journal | author=Matsuda LA, Lolait SJ, Brownstein MJ, ''et al.'' |title=Structure of a cannabinoid receptor and functional expression of the cloned cDNA. |journal=Nature |volume=346 |issue= 6284 |pages= 561-4 |year= 1990 |pmid= 2165569 |doi= 10.1038/346561a0 }}
*{{cite journal | author=Gérard C, Mollereau C, Vassart G, Parmentier M |title=Nucleotide sequence of a human cannabinoid receptor cDNA. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7142 |year= 1991 |pmid= 2263478 |doi= }}
*{{cite journal | author=Shire D, Carillon C, Kaghad M, ''et al.'' |title=An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3726-31 |year= 1995 |pmid= 7876112 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Kenney SP, Kekuda R, Prasad PD, ''et al.'' |title=Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta. |journal=Am. J. Obstet. Gynecol. |volume=181 |issue= 2 |pages= 491-7 |year= 1999 |pmid= 10454705 |doi= }}
*{{cite journal | author=Porcella A, Maxia C, Gessa GL, Pani L |title=The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. |journal=Eur. J. Neurosci. |volume=12 |issue= 3 |pages= 1123-7 |year= 2000 |pmid= 10762343 |doi= }}
*{{cite journal | author=Mukhopadhyay S, Howlett AC |title=CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. |journal=Eur. J. Biochem. |volume=268 |issue= 3 |pages= 499-505 |year= 2001 |pmid= 11168387 |doi= }}
*{{cite journal | author=Murphy WJ, Eizirik E, Johnson WE, ''et al.'' |title=Molecular phylogenetics and the origins of placental mammals. |journal=Nature |volume=409 |issue= 6820 |pages= 614-8 |year= 2001 |pmid= 11214319 |doi= 10.1038/35054550 }}
*{{cite journal | author=Nong L, Newton C, Friedman H, Klein TW |title=CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. |journal=Adv. Exp. Med. Biol. |volume=493 |issue= |pages= 229-33 |year= 2002 |pmid= 11727770 |doi= }}
*{{cite journal | author=Leroy S, Griffon N, Bourdel MC, ''et al.'' |title=Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. |journal=Am. J. Med. Genet. |volume=105 |issue= 8 |pages= 749-52 |year= 2002 |pmid= 11803524 |doi= }}
*{{cite journal | author=Schmidt LG, Samochowiec J, Finckh U, ''et al.'' |title=Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. |journal=Drug and alcohol dependence |volume=65 |issue= 3 |pages= 221-4 |year= 2002 |pmid= 11841893 |doi= }}
*{{cite journal | author=Lastres-Becker I, Cebeira M, de Ceballos ML, ''et al.'' |title=Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets. |journal=Eur. J. Neurosci. |volume=14 |issue= 11 |pages= 1827-32 |year= 2002 |pmid= 11860478 |doi= }}
*{{cite journal | author=Petrelli A, Gilestro GF, Lanzardo S, ''et al.'' |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. |journal=Nature |volume=416 |issue= 6877 |pages= 187-90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a }}
*{{cite journal | author=Huang SM, Bisogno T, Trevisani M, ''et al.'' |title=An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8400-5 |year= 2002 |pmid= 12060783 |doi= 10.1073/pnas.122196999 }}
*{{cite journal | author=Ujike H, Takaki M, Nakata K, ''et al.'' |title=CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia. |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 515-8 |year= 2002 |pmid= 12082570 |doi= 10.1038/sj.mp.4001029 }}
*{{cite journal | author=Ho BY, Current L, Drewett JG |title=Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16). |journal=FEBS Lett. |volume=522 |issue= 1-3 |pages= 130-4 |year= 2002 |pmid= 12095632 |doi= }}
*{{cite journal | author=Matias I, Pochard P, Orlando P, ''et al.'' |title=Presence and regulation of the endocannabinoid system in human dendritic cells. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3771-8 |year= 2002 |pmid= 12153574 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CNR2... {November 24, 2007 3:10:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:11:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cannabinoid receptor 2 (macrophage)
| HGNCid = 2160
| Symbol = CNR2
| AltSymbols =; CB2; CX5
| OMIM = 605051
| ECnumber =
| Homologene = 1389
| MGIid = 104650
| GeneAtlas_image1 = PBB_GE_CNR2_206586_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004949 |text = cannabinoid receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1269
| Hs_Ensembl = ENSG00000188822
| Hs_RefseqProtein = NP_001832
| Hs_RefseqmRNA = NM_001841
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 24069603
| Hs_GenLoc_end = 24112439
| Hs_Uniprot = P34972
| Mm_EntrezGene = 12802
| Mm_Ensembl = ENSMUSG00000062585
| Mm_RefseqmRNA = NM_009924
| Mm_RefseqProtein = NP_034054
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 135167470
| Mm_GenLoc_end = 135192284
| Mm_Uniprot = Q544H5
}}
}}
'''Cannabinoid receptor 2 (macrophage)''', also known as '''CNR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CNR2 cannabinoid receptor 2 (macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1269| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.<ref name="entrez">{{cite web | title = Entrez Gene: CNR2 cannabinoid receptor 2 (macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1269| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Oddi S, Spagnuolo P, Bari M, ''et al.'' |title=Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis. |journal=Int. Rev. Neurobiol. |volume=82 |issue= |pages= 327-37 |year= 2007 |pmid= 17678969 |doi= 10.1016/S0074-7742(07)82017-4 }}
*{{cite journal | author=Galiègue S, Mary S, Marchand J, ''et al.'' |title=Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. |journal=Eur. J. Biochem. |volume=232 |issue= 1 |pages= 54-61 |year= 1995 |pmid= 7556170 |doi= }}
*{{cite journal | author=Munro S, Thomas KL, Abu-Shaar M |title=Molecular characterization of a peripheral receptor for cannabinoids. |journal=Nature |volume=365 |issue= 6441 |pages= 61-5 |year= 1993 |pmid= 7689702 |doi= 10.1038/365061a0 }}
*{{cite journal | author=Shire D, Calandra B, Rinaldi-Carmona M, ''et al.'' |title=Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 2 |pages= 132-6 |year= 1996 |pmid= 8679694 |doi= }}
*{{cite journal | author=Tao Q, McAllister SD, Andreassi J, ''et al.'' |title=Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. |journal=Mol. Pharmacol. |volume=55 |issue= 3 |pages= 605-13 |year= 1999 |pmid= 10051546 |doi= }}
*{{cite journal | author=Nong L, Newton C, Friedman H, Klein TW |title=CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. |journal=Adv. Exp. Med. Biol. |volume=493 |issue= |pages= 229-33 |year= 2002 |pmid= 11727770 |doi= }}
*{{cite journal | author=Ho BY, Current L, Drewett JG |title=Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16). |journal=FEBS Lett. |volume=522 |issue= 1-3 |pages= 130-4 |year= 2002 |pmid= 12095632 |doi= }}
*{{cite journal | author=Matias I, Pochard P, Orlando P, ''et al.'' |title=Presence and regulation of the endocannabinoid system in human dendritic cells. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3771-8 |year= 2002 |pmid= 12153574 |doi= }}
*{{cite journal | author=Song ZH, Feng W |title=Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 290-4 |year= 2002 |pmid= 12417328 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Casanova ML, Blázquez C, Martínez-Palacio J, ''et al.'' |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. |journal=J. Clin. Invest. |volume=111 |issue= 1 |pages= 43-50 |year= 2003 |pmid= 12511587 |doi= }}
*{{cite journal | author=Feng W, Song ZH |title=Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor. |journal=Biochem. Pharmacol. |volume=65 |issue= 7 |pages= 1077-85 |year= 2003 |pmid= 12663043 |doi= }}
*{{cite journal | author=Kishimoto S, Gokoh M, Oka S, ''et al.'' |title=2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24469-75 |year= 2003 |pmid= 12711605 |doi= 10.1074/jbc.M301359200 }}
*{{cite journal | author=Jorda MA, Rayman N, Valk P, ''et al.'' |title=Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. |journal=Ann. N. Y. Acad. Sci. |volume=996 |issue= |pages= 10-6 |year= 2003 |pmid= 12799277 |doi= }}
*{{cite journal | author=Benito C, Núñez E, Tolón RM, ''et al.'' |title=Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. |journal=J. Neurosci. |volume=23 |issue= 35 |pages= 11136-41 |year= 2003 |pmid= 14657172 |doi= }}
*{{cite journal | author=Rayman N, Lam KH, Laman JD, ''et al.'' |title=Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status. |journal=J. Immunol. |volume=172 |issue= 4 |pages= 2111-7 |year= 2004 |pmid= 14764676 |doi= }}
*{{cite journal | author=Rao GK, Zhang W, Kaminski NE |title=Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells. |journal=J. Leukoc. Biol. |volume=75 |issue= 5 |pages= 884-92 |year= 2004 |pmid= 14966196 |doi= 10.1189/jlb.1203638 }}
*{{cite journal | author=Alberich Jordà M, Rayman N, Tas M, ''et al.'' |title=The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner. |journal=Blood |volume=104 |issue= 2 |pages= 526-34 |year= 2004 |pmid= 15039279 |doi= 10.1182/blood-2003-12-4357 }}
*{{cite journal | author=Núñez E, Benito C, Pazos MR, ''et al.'' |title=Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. |journal=Synapse |volume=53 |issue= 4 |pages= 208-13 |year= 2004 |pmid= 15266552 |doi= 10.1002/syn.20050 }}
*{{cite journal | author=Gokoh M, Kishimoto S, Oka S, ''et al.'' |title=2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. |journal=Biochem. J. |volume=386 |issue= Pt 3 |pages= 583-9 |year= 2005 |pmid= 15456404 |doi= 10.1042/BJ20041163 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRHR1... {November 24, 2007 3:12:00 PM PST}
- REDIRECT: Protein Redirected to: CRHR1 {November 24, 2007 3:12:19 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:12:21 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:12:21 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:12:21 PM PST}
- UPDATED: Updated protein page: CRHR1 {November 24, 2007 3:12:27 PM PST}
- INFO: Beginning work on CRHR2... {November 24, 2007 3:12:27 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:13:22 PM PST}
- CREATED: Created new protein page: CRHR2 {November 24, 2007 3:13:30 PM PST}
- INFO: Beginning work on CX3CR1... {November 24, 2007 3:13:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:14:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-X3-C motif) receptor 1
| HGNCid = 2558
| Symbol = CX3CR1
| AltSymbols =; CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28
| OMIM = 601470
| ECnumber =
| Homologene = 20350
| MGIid = 1333815
| GeneAtlas_image1 = PBB_GE_CX3CR1_205898_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0016494 |text = C-X-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1524
| Hs_Ensembl = ENSG00000168329
| Hs_RefseqProtein = NP_001328
| Hs_RefseqmRNA = NM_001337
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 39279989
| Hs_GenLoc_end = 39298190
| Hs_Uniprot = P49238
| Mm_EntrezGene = 13051
| Mm_Ensembl = ENSMUSG00000052336
| Mm_RefseqmRNA = XM_983192
| Mm_RefseqProtein = XP_988286
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 119750314
| Mm_GenLoc_end = 119916981
| Mm_Uniprot = Q543X3
}}
}}
'''Chemokine (C-X3-C motif) receptor 1''', also known as '''CX3CR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CX3CR1 chemokine (C-X3-C motif) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1524| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Robertson MJ |title=Role of chemokines in the biology of natural killer cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 173-83 |year= 2002 |pmid= 11818437 |doi= }}
*{{cite journal | author=Raport CJ, Schweickart VL, Eddy RL, ''et al.'' |title=The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. |journal=Gene |volume=163 |issue= 2 |pages= 295-9 |year= 1995 |pmid= 7590284 |doi= }}
*{{cite journal | author=Combadiere C, Ahuja SK, Murphy PM |title=Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. |journal=DNA Cell Biol. |volume=14 |issue= 8 |pages= 673-80 |year= 1995 |pmid= 7646814 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Imai T, Hieshima K, Haskell C, ''et al.'' |title=Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. |journal=Cell |volume=91 |issue= 4 |pages= 521-30 |year= 1997 |pmid= 9390561 |doi= }}
*{{cite journal | author=Combadiere C, Salzwedel K, Smith ED, ''et al.'' |title=Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 23799-804 |year= 1998 |pmid= 9726990 |doi= }}
*{{cite journal | author=Mizoue LS, Bazan JF, Johnson EC, Handel TM |title=Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. |journal=Biochemistry |volume=38 |issue= 5 |pages= 1402-14 |year= 1999 |pmid= 9931005 |doi= 10.1021/bi9820614 }}
*{{cite journal | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265-8 |year= 2000 |pmid= 10702689 |doi= }}
*{{cite journal | author=Faure S, Meyer L, Costagliola D, ''et al.'' |title=Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. |journal=Science |volume=287 |issue= 5461 |pages= 2274-7 |year= 2000 |pmid= 10731151 |doi= }}
*{{cite journal | author=Yoneda O, Imai T, Goda S, ''et al.'' |title=Fractalkine-mediated endothelial cell injury by NK cells. |journal=J. Immunol. |volume=164 |issue= 8 |pages= 4055-62 |year= 2000 |pmid= 10754298 |doi= }}
*{{cite journal | author=Meucci O, Fatatis A, Simen AA, Miller RJ |title=Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 8075-80 |year= 2000 |pmid= 10869418 |doi= 10.1073/pnas.090017497 }}
*{{cite journal | author=Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C, ''et al.'' |title=Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2355-61 |year= 2000 |pmid= 10940926 |doi= }}
*{{cite journal | author=Moatti D, Faure S, Fumeron F, ''et al.'' |title=Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. |journal=Blood |volume=97 |issue= 7 |pages= 1925-8 |year= 2001 |pmid= 11264153 |doi= }}
*{{cite journal | author=Foussat A, Bouchet-Delbos L, Berrebi D, ''et al.'' |title=Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients. |journal=Blood |volume=98 |issue= 6 |pages= 1678-86 |year= 2001 |pmid= 11535497 |doi= }}
*{{cite journal | author=Dichmann S, Herouy Y, Purlis D, ''et al.'' |title=Fractalkine induces chemotaxis and actin polymerization in human dendritic cells. |journal=Inflamm. Res. |volume=50 |issue= 11 |pages= 529-33 |year= 2002 |pmid= 11766992 |doi= }}
*{{cite journal | author=Brand S, Sakaguchi T, Gu X, ''et al.'' |title=Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. |journal=Gastroenterology |volume=122 |issue= 1 |pages= 166-77 |year= 2002 |pmid= 11781291 |doi= }}
*{{cite journal | author=Utaipat U, Duerr A, Rudolph DL, ''et al.'' |title=Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives. |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11804551 |doi= 10.1089/088922202753394664 }}
*{{cite journal | author=Fong AM, Alam SM, Imai T, ''et al.'' |title=CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19418-23 |year= 2002 |pmid= 11909868 |doi= 10.1074/jbc.M201396200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DRD1... {November 24, 2007 3:14:03 PM PST}
- REDIRECT: Protein Redirected to: DRD1 {November 24, 2007 3:14:18 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:14:20 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:14:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:14:20 PM PST}
- UPDATED: Updated protein page: DRD1 {November 24, 2007 3:14:26 PM PST}
- INFO: Beginning work on DRD2... {November 24, 2007 3:14:26 PM PST}
- SEARCH REDIRECT: Control Box Found: DRD2 {November 24, 2007 3:14:50 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:14:54 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:14:54 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:14:54 PM PST}
- UPDATED: Updated protein page: DRD2 {November 24, 2007 3:15:00 PM PST}
- INFO: Beginning work on DRD3... {November 24, 2007 3:15:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:15:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dopamine receptor D3
| HGNCid = 3024
| Symbol = DRD3
| AltSymbols =; D3DR; ETM1; FET1; MGC149204; MGC149205
| OMIM = 126451
| ECnumber =
| Homologene = 623
| MGIid = 94925
| GeneAtlas_image1 = PBB_GE_DRD3_211625_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DRD3_214559_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004952 |text = dopamine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007212 |text = dopamine receptor signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007610 |text = behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1814
| Hs_Ensembl = ENSG00000151577
| Hs_RefseqProtein = NP_000787
| Hs_RefseqmRNA = NM_000796
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 115330247
| Hs_GenLoc_end = 115380446
| Hs_Uniprot = P35462
| Mm_EntrezGene = 13490
| Mm_Ensembl = ENSMUSG00000022705
| Mm_RefseqmRNA = NM_007877
| Mm_RefseqProtein = NP_031903
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 43681574
| Mm_GenLoc_end = 43742171
| Mm_Uniprot = Q0VEC4
}}
}}
'''Dopamine receptor D3''', also known as '''DRD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DRD3 dopamine receptor D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1814| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).<ref name="entrez">{{cite web | title = Entrez Gene: DRD3 dopamine receptor D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1814| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Missale C, Nash SR, Robinson SW, ''et al.'' |title=Dopamine receptors: from structure to function. |journal=Physiol. Rev. |volume=78 |issue= 1 |pages= 189-225 |year= 1998 |pmid= 9457173 |doi= }}
*{{cite journal | author=Sidhu A, Niznik HB |title=Coupling of dopamine receptor subtypes to multiple and diverse G proteins. |journal=Int. J. Dev. Neurosci. |volume=18 |issue= 7 |pages= 669-77 |year= 2000 |pmid= 10978845 |doi= }}
*{{cite journal | author=Le Coniat M, Sokoloff P, Hillion J, ''et al.'' |title=Chromosomal localization of the human D3 dopamine receptor gene. |journal=Hum. Genet. |volume=87 |issue= 5 |pages= 618-20 |year= 1991 |pmid= 1916765 |doi= }}
*{{cite journal | author=Sokoloff P, Giros B, Martres MP, ''et al.'' |title=Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. |journal=Nature |volume=347 |issue= 6289 |pages= 146-51 |year= 1990 |pmid= 1975644 |doi= 10.1038/347146a0 }}
*{{cite journal | author=Giros B, Martres MP, Sokoloff P, Schwartz JC |title=[Gene cloning of human dopaminergic D3 receptor and identification of its chromosome] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=311 |issue= 13 |pages= 501-8 |year= 1991 |pmid= 2129115 |doi= }}
*{{cite journal | author=Liu K, Bergson C, Levenson R, Schmauss C |title=On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 29220-6 |year= 1994 |pmid= 7961889 |doi= }}
*{{cite journal | author=Schmauss C, Haroutunian V, Davis KL, Davidson M |title=Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8942-6 |year= 1993 |pmid= 8415635 |doi= }}
*{{cite journal | author=Griffon N, Crocq MA, Pilon C, ''et al.'' |title=Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia. |journal=Am. J. Med. Genet. |volume=67 |issue= 1 |pages= 63-70 |year= 1996 |pmid= 8678117 |doi= 10.1002/(SICI)1096-8628(19960216)67:1<63::AID-AJMG11>3.0.CO;2-N }}
*{{cite journal | author=Staley JK, Mash DC |title=Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities. |journal=J. Neurosci. |volume=16 |issue= 19 |pages= 6100-6 |year= 1996 |pmid= 8815892 |doi= }}
*{{cite journal | author=Chen CH, Liu MY, Wei FC, ''et al.'' |title=Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. |journal=Am. J. Med. Genet. |volume=74 |issue= 1 |pages= 40-3 |year= 1997 |pmid= 9034004 |doi= }}
*{{cite journal | author=Gulcher JR, Jónsson P, Kong A, ''et al.'' |title=Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. |journal=Nat. Genet. |volume=17 |issue= 1 |pages= 84-7 |year= 1997 |pmid= 9288103 |doi= 10.1038/ng0997-84 }}
*{{cite journal | author=Oldenhof J, Vickery R, Anafi M, ''et al.'' |title=SH3 binding domains in the dopamine D4 receptor. |journal=Biochemistry |volume=37 |issue= 45 |pages= 15726-36 |year= 1998 |pmid= 9843378 |doi= 10.1021/bi981634+ }}
*{{cite journal | author=Cargill M, Altshuler D, Ireland J, ''et al.'' |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231-8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
*{{cite journal | author=Pilla M, Perachon S, Sautel F, ''et al.'' |title=Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. |journal=Nature |volume=400 |issue= 6742 |pages= 371-5 |year= 1999 |pmid= 10432116 |doi= 10.1038/22560 }}
*{{cite journal | author=Ilani T, Ben-Shachar D, Strous RD, ''et al.'' |title=A peripheral marker for schizophrenia: Increased levels of D3 dopamine receptor mRNA in blood lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 625-8 |year= 2001 |pmid= 11149951 |doi= 10.1073/pnas.021535398 }}
*{{cite journal | author=Lin R, Karpa K, Kabbani N, ''et al.'' |title=Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 9 |pages= 5258-63 |year= 2001 |pmid= 11320256 |doi= 10.1073/pnas.011538198 }}
*{{cite journal | author=Oldenhof J, Ray A, Vickery R, Van Tol HH |title=SH3 ligands in the dopamine D3 receptor. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 411-6 |year= 2001 |pmid= 11384839 |doi= }}
*{{cite journal | author=Soma M, Nakayama K, Rahmutula D, ''et al.'' |title=Ser9Gly polymorphism in the dopamine D3 receptor gene is not associated with essential hypertension in the Japanese. |journal=Med. Sci. Monit. |volume=8 |issue= 1 |pages= CR1-4 |year= 2002 |pmid= 11796958 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DRD4... {November 24, 2007 3:15:31 PM PST}
- SEARCH REDIRECT: Control Box Found: D4DR {November 24, 2007 3:15:49 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:15:52 PM PST}
- SKIP SUMMARY: Skipping Summary, No Errors. {November 24, 2007 3:15:52 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 24, 2007 3:15:52 PM PST}
- UPDATED: Warning while updating page: Could not find summary box. Could not find citation box. {November 24, 2007 3:15:57 PM PST}
- UPDATED: Updated protein page (with warnings): D4DR {November 24, 2007 3:15:57 PM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dopamine receptor D4
| HGNCid = 3025
| Symbol = DRD4
| AltSymbols =; D4DR
| OMIM = 126452
| ECnumber =
| Homologene = 20215
| MGIid = 94926
| GeneAtlas_image1 = PBB_GE_DRD4_208215_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004952 |text = dopamine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007212 |text = dopamine receptor signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1815
| Hs_Ensembl = ENSG00000069696
| Hs_RefseqProtein = NP_000788
| Hs_RefseqmRNA = NM_000797
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 627305
| Hs_GenLoc_end = 630703
| Hs_Uniprot =
| Mm_EntrezGene = 13491
| Mm_Ensembl = ENSMUSG00000025496
| Mm_RefseqmRNA = NM_007878
| Mm_RefseqProtein = NP_031904
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 141143350
| Mm_GenLoc_end = 141147783
| Mm_Uniprot = Q7TT80
}}
}}
'''Dopamine receptor D4''', also known as '''DRD4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DRD4 dopamine receptor D4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1815| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.<ref name="entrez">{{cite web | title = Entrez Gene: DRD4 dopamine receptor D4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1815| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Van Tol HH, Wu CM, Guan HC, ''et al.'' |title=Multiple dopamine D4 receptor variants in the human population. |journal=Nature |volume=358 |issue= 6382 |pages= 149-52 |year= 1992 |pmid= 1319557 |doi= 10.1038/358149a0 }}
*{{cite journal | author=Gelernter J, Kennedy JL, van Tol HH, ''et al.'' |title=The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. |journal=Genomics |volume=13 |issue= 1 |pages= 208-10 |year= 1992 |pmid= 1349574 |doi= }}
*{{cite journal | author=Livingstone CD, Strange PG, Naylor LH |title=Molecular modelling of D2-like dopamine receptors. |journal=Biochem. J. |volume=287 ( Pt 1) |issue= |pages= 277-82 |year= 1992 |pmid= 1358063 |doi= }}
*{{cite journal | author=Van Tol HH, Bunzow JR, Guan HC, ''et al.'' |title=Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. |journal=Nature |volume=350 |issue= 6319 |pages= 610-4 |year= 1991 |pmid= 1840645 |doi= 10.1038/350610a0 }}
*{{cite journal | author=Seeman P, Ulpian C, Chouinard G, ''et al.'' |title=Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia. |journal=Am. J. Med. Genet. |volume=54 |issue= 4 |pages= 384-90 |year= 1995 |pmid= 7726213 |doi= 10.1002/ajmg.1320540419 }}
*{{cite journal | author=Nöthen MM, Cichon S, Hemmer S, ''et al.'' |title=Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. |journal=Hum. Mol. Genet. |volume=3 |issue= 12 |pages= 2207-12 |year= 1995 |pmid= 7881421 |doi= }}
*{{cite journal | author=Seeman P, Guan HC, Van Tol HH |title=Dopamine D4 receptors elevated in schizophrenia. |journal=Nature |volume=365 |issue= 6445 |pages= 441-5 |year= 1993 |pmid= 8413587 |doi= 10.1038/365441a0 }}
*{{cite journal | author=Ebstein RP, Novick O, Umansky R, ''et al.'' |title=Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. |journal=Nat. Genet. |volume=12 |issue= 1 |pages= 78-80 |year= 1996 |pmid= 8528256 |doi= 10.1038/ng0196-78 }}
*{{cite journal | author=Liu IS, Seeman P, Sanyal S, ''et al.'' |title=Dopamine D4 receptor variant in Africans, D4valine194glycine, is insensitive to dopamine and clozapine: report of a homozygous individual. |journal=Am. J. Med. Genet. |volume=61 |issue= 3 |pages= 277-82 |year= 1996 |pmid= 8741875 |doi= 10.1002/(SICI)1096-8628(19960122)61:3<277::AID-AJMG14>3.0.CO;2-Q }}
*{{cite journal | author=Cichon S, Nöthen MM, Catalano M, ''et al.'' |title=Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene. |journal=Psychiatr. Genet. |volume=5 |issue= 3 |pages= 97-103 |year= 1996 |pmid= 8746407 |doi= }}
*{{cite journal | author=LaHoste GJ, Swanson JM, Wigal SB, ''et al.'' |title=Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. |journal=Mol. Psychiatry |volume=1 |issue= 2 |pages= 121-4 |year= 1997 |pmid= 9118321 |doi= }}
*{{cite journal | author=Oldenhof J, Vickery R, Anafi M, ''et al.'' |title=SH3 binding domains in the dopamine D4 receptor. |journal=Biochemistry |volume=37 |issue= 45 |pages= 15726-36 |year= 1998 |pmid= 9843378 |doi= 10.1021/bi981634+ }}
*{{cite journal | author=Serretti A, Macciardi F, Cusin C, ''et al.'' |title=No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. |journal=Am. J. Med. Genet. |volume=88 |issue= 1 |pages= 44-9 |year= 1999 |pmid= 10050966 |doi= }}
*{{cite journal | author=Ding YC, Chi HC, Grady DL, ''et al.'' |title=Evidence of positive selection acting at the human dopamine receptor D4 gene locus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 309-14 |year= 2002 |pmid= 11756666 |doi= 10.1073/pnas.012464099 }}
*{{cite journal | author=Jönsson EG, Ivo R, Gustavsson JP, ''et al.'' |title=No association between dopamine D4 receptor gene variants and novelty seeking. |journal=Mol. Psychiatry |volume=7 |issue= 1 |pages= 18-20 |year= 2002 |pmid= 11803441 |doi= 10.1038/sj/mp/4000950 }}
*{{cite journal | author=Lakatos K, Nemoda Z, Toth I, ''et al.'' |title=Further evidence for the role of the dopamine D4 receptor (DRD4) gene in attachment disorganization: interaction of the exon III 48-bp repeat and the -521 C/T promoter polymorphisms. |journal=Mol. Psychiatry |volume=7 |issue= 1 |pages= 27-31 |year= 2002 |pmid= 11803443 |doi= 10.1038/sj/mp/4000986 }}
*{{cite journal | author=Tsai SJ, Cheng CY, Shu LR, ''et al.'' |title=No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males. |journal=Psychiatr. Genet. |volume=12 |issue= 1 |pages= 29-33 |year= 2002 |pmid= 11901357 |doi= }}
*{{cite journal | author=Hutchison KE, McGeary J, Smolen A, ''et al.'' |title=The DRD4 VNTR polymorphism moderates craving after alcohol consumption. |journal=Health psychology : official journal of the Division of Health Psychology, American Psychological Association |volume=21 |issue= 2 |pages= 139-46 |year= 2002 |pmid= 11950104 |doi= }}
*{{cite journal | author=Mill JS, Caspi A, McClay J, ''et al.'' |title=The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study. |journal=Mol. Psychiatry |volume=7 |issue= 4 |pages= 383-91 |year= 2002 |pmid= 11986982 |doi= 10.1038/sj.mp.4000984 }}
*{{cite journal | author=Serretti A, Cristina S, Lilli R, ''et al.'' |title=Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. |journal=Am. J. Med. Genet. |volume=114 |issue= 4 |pages= 361-9 |year= 2002 |pmid= 11992558 |doi= 10.1002/ajmg.10356 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DRD5... {November 24, 2007 3:15:57 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:16:37 PM PST}
- CREATED: Created new protein page: DRD5 {November 24, 2007 3:16:45 PM PST}
- INFO: Beginning work on EBI2... {November 24, 2007 3:16:45 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:17:17 PM PST}
- CREATED: Created new protein page: EBI2 {November 24, 2007 3:17:23 PM PST}
- INFO: Beginning work on EDG1... {November 24, 2007 3:17:23 PM PST}
- REDIRECT: Protein Redirected to: EDG1 {November 24, 2007 3:17:43 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:17:45 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:17:45 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:17:45 PM PST}
- UPDATED: Updated protein page: EDG1 {November 24, 2007 3:17:52 PM PST}
- INFO: Beginning work on EDG2... {November 24, 2007 3:17:52 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:19:18 PM PST}
- CREATED: Created new protein page: EDG2 {November 24, 2007 3:19:25 PM PST}
- INFO: Beginning work on EDG3... {November 24, 2007 3:19:26 PM PST}
- CREATE: Found no pages, creating new page. {November 24, 2007 3:19:54 PM PST}
- CREATED: Created new protein page: EDG3 {November 24, 2007 3:20:02 PM PST}
- INFO: Beginning work on EDNRA... {November 24, 2007 3:20:02 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:20:29 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin receptor type A
| HGNCid = 3179
| Symbol = EDNRA
| AltSymbols =; ETA; ETRA
| OMIM = 131243
| ECnumber =
| Homologene = 1478
| MGIid = 105923
| GeneAtlas_image1 = PBB_GE_EDNRA_204464_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EDNRA_204463_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_EDNRA_216235_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001599 |text = endothelin-A receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0014032 |text = neural crest cell development}} {{GNF_GO|id=GO:0015758 |text = glucose transport}} {{GNF_GO|id=GO:0030818 |text = negative regulation of cAMP biosynthetic process}} {{GNF_GO|id=GO:0042310 |text = vasoconstriction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1909
| Hs_Ensembl = ENSG00000151617
| Hs_RefseqProtein = NP_001948
| Hs_RefseqmRNA = NM_001957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 148621575
| Hs_GenLoc_end = 148685555
| Hs_Uniprot = P25101
| Mm_EntrezGene = 13617
| Mm_Ensembl = ENSMUSG00000031616
| Mm_RefseqmRNA = NM_010332
| Mm_RefseqProtein = NP_034462
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 80559103
| Mm_GenLoc_end = 80620420
| Mm_Uniprot = Q61614
}}
}}
'''Endothelin receptor type A''', also known as '''EDNRA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EDNRA endothelin receptor type A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1909| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Arai H, Nakao K, Hosoda K, ''et al.'' |title=[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells] |journal=Jpn. Circ. J. |volume=56 Suppl 5 |issue= |pages= 1303-7 |year= 1993 |pmid= 1291713 |doi= }}
*{{cite journal | author=Hosoda K, Nakao K, Tamura N, ''et al.'' |title=Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor. |journal=J. Biol. Chem. |volume=267 |issue= 26 |pages= 18797-804 |year= 1992 |pmid= 1326535 |doi= }}
*{{cite journal | author=Hayzer DJ, Rose PM, Lynch JS, ''et al.'' |title=Cloning and expression of a human endothelin receptor: subtype A. |journal=Am. J. Med. Sci. |volume=304 |issue= 4 |pages= 231-8 |year= 1992 |pmid= 1415318 |doi= }}
*{{cite journal | author=Hosoda K, Nakao K, Hiroshi-Arai, ''et al.'' |title=Cloning and expression of human endothelin-1 receptor cDNA. |journal=FEBS Lett. |volume=287 |issue= 1-2 |pages= 23-6 |year= 1991 |pmid= 1652463 |doi= }}
*{{cite journal | author=Cyr C, Huebner K, Druck T, Kris R |title=Cloning and chromosomal localization of a human endothelin ETA receptor. |journal=Biochem. Biophys. Res. Commun. |volume=181 |issue= 1 |pages= 184-90 |year= 1992 |pmid= 1659806 |doi= }}
*{{cite journal | author=Adachi M, Yang YY, Furuichi Y, Miyamoto C |title=Cloning and characterization of cDNA encoding human A-type endothelin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 3 |pages= 1265-72 |year= 1991 |pmid= 1719979 |doi= }}
*{{cite journal | author=Lin HY, Kaji EH, Winkel GK, ''et al.'' |title=Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 8 |pages= 3185-9 |year= 1991 |pmid= 1849646 |doi= }}
*{{cite journal | author=Takigawa M, Sakurai T, Kasuya Y, ''et al.'' |title=Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors. |journal=Eur. J. Biochem. |volume=228 |issue= 1 |pages= 102-8 |year= 1995 |pmid= 7882989 |doi= }}
*{{cite journal | author=Kobayashi S, Tang R, Wang B, ''et al.'' |title=Binding and functional properties of endothelin receptor subtypes in the human prostate. |journal=Mol. Pharmacol. |volume=45 |issue= 2 |pages= 306-11 |year= 1994 |pmid= 8114678 |doi= }}
*{{cite journal | author=Yang H, Tabuchi H, Furuichi Y, Miyamoto C |title=Molecular characterization of the 5'-flanking region of human genomic ETA gene. |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 2 |pages= 332-9 |year= 1993 |pmid= 8427579 |doi= 10.1006/bbrc.1993.1052 }}
*{{cite journal | author=Elshourbagy NA, Korman DR, Wu HL, ''et al.'' |title=Molecular characterization and regulation of the human endothelin receptors. |journal=J. Biol. Chem. |volume=268 |issue= 6 |pages= 3873-9 |year= 1993 |pmid= 8440682 |doi= }}
*{{cite journal | author=Miyamoto Y, Yoshimasa T, Arai H, ''et al.'' |title=Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts. |journal=Biochem. J. |volume=313 ( Pt 3) |issue= |pages= 795-801 |year= 1996 |pmid= 8611157 |doi= }}
*{{cite journal | author=Horstmeyer A, Cramer H, Sauer T, ''et al.'' |title=Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20811-9 |year= 1996 |pmid= 8702836 |doi= }}
*{{cite journal | author=Freedman NJ, Ament AS, Oppermann M, ''et al.'' |title=Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17734-43 |year= 1997 |pmid= 9211925 |doi= }}
*{{cite journal | author=Bourgeois C, Robert B, Rebourcet R, ''et al.'' |title=Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 9 |pages= 3116-23 |year= 1997 |pmid= 9284755 |doi= }}
*{{cite journal | author=Mao XQ, Gao PS, Roberts MH, ''et al.'' |title=Variants of endothelin-1 and its receptors in atopic asthma. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 259-62 |year= 1999 |pmid= 10448102 |doi= 10.1006/bbrc.1999.1158 }}
*{{cite journal | author=Maggi M, Barni T, Fantoni G, ''et al.'' |title=Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 4 |pages= 1658-65 |year= 2000 |pmid= 10770212 |doi= }}
*{{cite journal | author=Shraga-Levine Z, Sokolovsky M |title=Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 3 |pages= 305-17 |year= 2000 |pmid= 10789830 |doi= }}
*{{cite journal | author=Lee HJ, Chun M, Kandror KV |title=Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 16597-600 |year= 2001 |pmid= 11262386 |doi= 10.1074/jbc.C000909200 }}
*{{cite journal | author=Paasche JD, Attramadal T, Sandberg C, ''et al.'' |title=Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 34041-50 |year= 2001 |pmid= 11382773 |doi= 10.1074/jbc.M103243200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EDNRB... {November 24, 2007 3:20:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:20:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin receptor type B
| HGNCid = 3180
| Symbol = EDNRB
| AltSymbols =; ABCDS; ETB; ETRB; HSCR; HSCR2
| OMIM = 131244
| ECnumber =
| Homologene = 89
| MGIid = 102720
| GeneAtlas_image1 = PBB_GE_EDNRB_204271_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EDNRB_204273_at_tn.png
| GeneAtlas_image3 = PBB_GE_EDNRB_206701_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001600 |text = endothelin-B receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0001755 |text = neural crest cell migration}} {{GNF_GO|id=GO:0006885 |text = regulation of pH}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0007497 |text = posterior midgut development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0030318 |text = melanocyte differentiation}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1910
| Hs_Ensembl = ENSG00000136160
| Hs_RefseqProtein = NP_000106
| Hs_RefseqmRNA = NM_000115
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 77367617
| Hs_GenLoc_end = 77391904
| Hs_Uniprot = P24530
| Mm_EntrezGene = 13618
| Mm_Ensembl = ENSMUSG00000022122
| Mm_RefseqmRNA = NM_007904
| Mm_RefseqProtein = NP_031930
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 102700304
| Mm_GenLoc_end = 102729852
| Mm_Uniprot = Q8K1V9
}}
}}
'''Endothelin receptor type B''', also known as '''EDNRB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EDNRB endothelin receptor type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1910| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. A splice variant, named SVR, has been described; the sequence of the ETB-SVR receptor is identical to ETRB except for the intracellular C-terminal domain. While both splice variants bind ET1, they exhibit different responses upon binding which suggests that they may be functionally distinct.<ref name="entrez">{{cite web | title = Entrez Gene: EDNRB endothelin receptor type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1910| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hofstra RM, Osinga J, Buys CH |title=Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 4 |pages= 180-5 |year= 1998 |pmid= 9359036 |doi= }}
*{{cite journal | author=Haendler B, Hechler U, Schleuning WD |title=Molecular cloning of human endothelin (ET) receptors ETA and ETB. |journal=J. Cardiovasc. Pharmacol. |volume=20 Suppl 12 |issue= |pages= S1-4 |year= 1993 |pmid= 1282938 |doi= }}
*{{cite journal | author=Arai H, Nakao K, Hosoda K, ''et al.'' |title=[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells] |journal=Jpn. Circ. J. |volume=56 Suppl 5 |issue= |pages= 1303-7 |year= 1993 |pmid= 1291713 |doi= }}
*{{cite journal | author=Ogawa Y, Nakao K, Arai H, ''et al.'' |title=Molecular cloning of a non-isopeptide-selective human endothelin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 1 |pages= 248-55 |year= 1991 |pmid= 1648908 |doi= }}
*{{cite journal | author=Cyr C, Huebner K, Druck T, Kris R |title=Cloning and chromosomal localization of a human endothelin ETA receptor. |journal=Biochem. Biophys. Res. Commun. |volume=181 |issue= 1 |pages= 184-90 |year= 1992 |pmid= 1659806 |doi= }}
*{{cite journal | author=Nakamuta M, Takayanagi R, Sakai Y, ''et al.'' |title=Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=177 |issue= 1 |pages= 34-9 |year= 1991 |pmid= 1710450 |doi= }}
*{{cite journal | author=Sakamoto A, Yanagisawa M, Sakurai T, ''et al.'' |title=Cloning and functional expression of human cDNA for the ETB endothelin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 2 |pages= 656-63 |year= 1991 |pmid= 1713452 |doi= }}
*{{cite journal | author=Vane J |title=Endothelins come home to roost. |journal=Nature |volume=348 |issue= 6303 |pages= 673 |year= 1991 |pmid= 2175394 |doi= 10.1038/348673a0 }}
*{{cite journal | author=Puffenberger EG, Kauffman ER, Bolk S, ''et al.'' |title=Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. |journal=Hum. Mol. Genet. |volume=3 |issue= 8 |pages= 1217-25 |year= 1995 |pmid= 7987295 |doi= }}
*{{cite journal | author=Puffenberger EG, Hosoda K, Washington SS, ''et al.'' |title=A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. |journal=Cell |volume=79 |issue= 7 |pages= 1257-66 |year= 1995 |pmid= 8001158 |doi= }}
*{{cite journal | author=Baynash AG, Hosoda K, Giaid A, ''et al.'' |title=Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. |journal=Cell |volume=79 |issue= 7 |pages= 1277-85 |year= 1995 |pmid= 8001160 |doi= }}
*{{cite journal | author=Arai H, Nakao K, Takaya K, ''et al.'' |title=The human endothelin-B receptor gene. Structural organization and chromosomal assignment. |journal=J. Biol. Chem. |volume=268 |issue= 5 |pages= 3463-70 |year= 1993 |pmid= 8429023 |doi= }}
*{{cite journal | author=Elshourbagy NA, Korman DR, Wu HL, ''et al.'' |title=Molecular characterization and regulation of the human endothelin receptors. |journal=J. Biol. Chem. |volume=268 |issue= 6 |pages= 3873-9 |year= 1993 |pmid= 8440682 |doi= }}
*{{cite journal | author=Hofstra RM, Osinga J, Tan-Sindhunata G, ''et al.'' |title=A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome). |journal=Nat. Genet. |volume=12 |issue= 4 |pages= 445-7 |year= 1996 |pmid= 8630503 |doi= 10.1038/ng0496-445 }}
*{{cite journal | author=Attié T, Till M, Pelet A, ''et al.'' |title=Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease. |journal=Hum. Mol. Genet. |volume=4 |issue= 12 |pages= 2407-9 |year= 1996 |pmid= 8634719 |doi= }}
*{{cite journal | author=Elshourbagy NA, Adamou JE, Gagnon AW, ''et al.'' |title=Molecular characterization of a novel human endothelin receptor splice variant. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25300-7 |year= 1996 |pmid= 8810293 |doi= }}
*{{cite journal | author=Kusafuka T, Wang Y, Puri P |title=Novel mutations of the endothelin-B receptor gene in isolated patients with Hirschsprung's disease. |journal=Hum. Mol. Genet. |volume=5 |issue= 3 |pages= 347-9 |year= 1997 |pmid= 8852658 |doi= }}
*{{cite journal | author=Auricchio A, Casari G, Staiano A, Ballabio A |title=Endothelin-B receptor mutations in patients with isolated Hirschsprung disease from a non-inbred population. |journal=Hum. Mol. Genet. |volume=5 |issue= 3 |pages= 351-4 |year= 1997 |pmid= 8852659 |doi= }}
*{{cite journal | author=Amiel J, Attié T, Jan D, ''et al.'' |title=Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. |journal=Hum. Mol. Genet. |volume=5 |issue= 3 |pages= 355-7 |year= 1997 |pmid= 8852660 |doi= }}
*{{cite journal | author=Freedman NJ, Ament AS, Oppermann M, ''et al.'' |title=Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17734-43 |year= 1997 |pmid= 9211925 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EMR1... {November 24, 2007 3:22:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:23:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Egf-like module containing, mucin-like, hormone receptor-like 1
| HGNCid = 3336
| Symbol = EMR1
| AltSymbols =; TM7LN3
| OMIM = 600493
| ECnumber =
| Homologene = 1493
| MGIid = 106912
| GeneAtlas_image1 = PBB_GE_EMR1_207111_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2015
| Hs_Ensembl = ENSG00000174837
| Hs_RefseqProtein = NP_001965
| Hs_RefseqmRNA = NM_001974
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 6838577
| Hs_GenLoc_end = 6891463
| Hs_Uniprot = Q14246
| Mm_EntrezGene = 13733
| Mm_Ensembl = ENSMUSG00000004730
| Mm_RefseqmRNA = NM_010130
| Mm_RefseqProtein = NP_034260
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 57044026
| Mm_GenLoc_end = 57168862
| Mm_Uniprot = Q3S4B0
}}
}}
'''Egf-like module containing, mucin-like, hormone receptor-like 1''', also known as '''EMR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.<ref name="entrez">{{cite web | title = Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=McKnight AJ, Gordon S |title=The EGF-TM7 family: unusual structures at the leukocyte surface. |journal=J. Leukoc. Biol. |volume=63 |issue= 3 |pages= 271-80 |year= 1998 |pmid= 9500513 |doi= }}
*{{cite journal | author=Baud V, Chissoe SL, Viegas-Péquignot E, ''et al.'' |title=EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. |journal=Genomics |volume=26 |issue= 2 |pages= 334-44 |year= 1995 |pmid= 7601460 |doi= }}
*{{cite journal | author=McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S |title=Chromosome mapping of the Emr1 gene. |journal=Mamm. Genome |volume=8 |issue= 12 |pages= 946 |year= 1998 |pmid= 9383301 |doi= }}
*{{cite journal | author=Carver EA, Hamann J, Olsen AS, Stubbs L |title=Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication. |journal=Mamm. Genome |volume=10 |issue= 10 |pages= 1039-40 |year= 2000 |pmid= 10501980 |doi= }}
*{{cite journal | author=Lin HH, Stacey M, Hamann J, ''et al.'' |title=Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. |journal=Genomics |volume=67 |issue= 2 |pages= 188-200 |year= 2000 |pmid= 10903844 |doi= 10.1006/geno.2000.6238 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F2R... {November 24, 2007 3:23:18 PM PST}
- SEARCH REDIRECT: Control Box Found: Coagulation factor II receptor {November 24, 2007 3:23:45 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:23:47 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 24, 2007 3:23:47 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:23:47 PM PST}
- UPDATED: Updated protein page: Coagulation factor II receptor {November 24, 2007 3:23:53 PM PST}
- INFO: Beginning work on F2RL1... {November 24, 2007 3:23:53 PM PST}
- SEARCH REDIRECT: Control Box Found: F2RL1 {November 24, 2007 3:24:22 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 24, 2007 3:24:24 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 24, 2007 3:24:24 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 24, 2007 3:24:24 PM PST}
- UPDATED: Updated protein page: F2RL1 {November 24, 2007 3:24:30 PM PST}
- INFO: Beginning work on LTB4R... {November 24, 2007 3:09:31 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:10:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Leukotriene B4 receptor
| HGNCid = 6713
| Symbol = LTB4R
| AltSymbols =; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
| OMIM = 601531
| ECnumber =
| Homologene = 22477
| MGIid = 1309472
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004974 |text = leukotriene receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1241
| Hs_Ensembl =
| Hs_RefseqProtein = NP_858043
| Hs_RefseqmRNA = NM_181657
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16995
| Mm_Ensembl = ENSMUSG00000046908
| Mm_RefseqmRNA = NM_008519
| Mm_RefseqProtein = NP_032545
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 54720038
| Mm_GenLoc_end = 54722563
| Mm_Uniprot = Q3U2P2
}}
}}
'''Leukotriene B4 receptor''', also known as '''LTB4R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LTB4R leukotriene B4 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1241| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Raport CJ, Schweickart VL, Chantry D, ''et al.'' |title=New members of the chemokine receptor gene family. |journal=J. Leukoc. Biol. |volume=59 |issue= 1 |pages= 18-23 |year= 1996 |pmid= 8558062 |doi= }}
*{{cite journal | author=Tager AM, Luster AD |title=BLT1 and BLT2: the leukotriene B(4) receptors. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2-3 |pages= 123-34 |year= 2004 |pmid= 12895595 |doi= }}
*{{cite journal | author=Miyahara N, Miyahara S, Takeda K, Gelfand EW |title=Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation. |journal=Allergology international : official journal of the Japanese Society of Allergology |volume=55 |issue= 2 |pages= 91-7 |year= 2006 |pmid= 17075244 |doi= 10.2332/allergolint.55.91 }}
*{{cite journal | author=Akbar GK, Dasari VR, Webb TE, ''et al.'' |title=Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18363-7 |year= 1996 |pmid= 8702478 |doi= }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi= }}
*{{cite journal | author=Owman C, Nilsson C, Lolait SJ |title=Cloning of cDNA encoding a putative chemoattractant receptor. |journal=Genomics |volume=37 |issue= 2 |pages= 187-94 |year= 1997 |pmid= 8921391 |doi= 10.1006/geno.1996.0541 }}
*{{cite journal | author=Yokomizo T, Izumi T, Chang K, ''et al.'' |title=A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. |journal=Nature |volume=387 |issue= 6633 |pages= 620-4 |year= 1997 |pmid= 9177352 |doi= 10.1038/42506 }}
*{{cite journal | author=Maier R, Glatz A, Mosbacher J, Bilbe G |title=Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 297-302 |year= 1997 |pmid= 9268704 |doi= 10.1006/bbrc.1997.7135 }}
*{{cite journal | author=Gaudreau R, Le Gouill C, Métaoui S, ''et al.'' |title=Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits. |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 15-8 |year= 1998 |pmid= 9742207 |doi= }}
*{{cite journal | author=Kato K, Yokomizo T, Izumi T, Shimizu T |title=Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 413-20 |year= 2000 |pmid= 10934229 |doi= }}
*{{cite journal | author=Yokomizo T, Kato K, Terawaki K, ''et al.'' |title=A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 421-32 |year= 2000 |pmid= 10934230 |doi= }}
*{{cite journal | author=Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M |title=Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3570-6 |year= 2002 |pmid= 11907121 |doi= }}
*{{cite journal | author=Gaudreau R, Le Gouill C, Venne MH, ''et al.'' |title=Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31567-76 |year= 2002 |pmid= 12077128 |doi= 10.1074/jbc.M202723200 }}
*{{cite journal | author=Hennig R, Ding XZ, Tong WG, ''et al.'' |title=5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue. |journal=Am. J. Pathol. |volume=161 |issue= 2 |pages= 421-8 |year= 2002 |pmid= 12163367 |doi= }}
*{{cite journal | author=Ito N, Yokomizo T, Sasaki T, ''et al.'' |title=Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 44898-904 |year= 2003 |pmid= 12244116 |doi= 10.1074/jbc.M208051200 }}
*{{cite journal | author=Tong WG, Ding XZ, Hennig R, ''et al.'' |title=Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. |journal=Clin. Cancer Res. |volume=8 |issue= 10 |pages= 3232-42 |year= 2003 |pmid= 12374694 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Yokomizo T, Noiri E, Izumi T, Shimizu T |title=In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor. |journal=Adv. Exp. Med. Biol. |volume=507 |issue= |pages= 357-61 |year= 2003 |pmid= 12664610 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC31A2... {November 24, 2007 3:11:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 24, 2007 3:12:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 31 (copper transporters), member 2
| HGNCid = 11017
| Symbol = SLC31A2
| AltSymbols =; COPT2; CTR2; hCTR2
| OMIM = 603088
| ECnumber =
| Homologene = 37536
| MGIid = 1333844
| GeneAtlas_image1 = PBB_GE_SLC31A2_204204_at_tn.png
| Function = {{GNF_GO|id=GO:0005375 |text = copper ion transmembrane transporter activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006825 |text = copper ion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1318
| Hs_Ensembl = ENSG00000136867
| Hs_RefseqProtein = NP_001851
| Hs_RefseqmRNA = NM_001860
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 114953108
| Hs_GenLoc_end = 114966241
| Hs_Uniprot = O15432
| Mm_EntrezGene = 20530
| Mm_Ensembl = ENSMUSG00000066152
| Mm_RefseqmRNA = XM_981201
| Mm_RefseqProtein = XP_986295
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 61772806
| Mm_GenLoc_end = 61784772
| Mm_Uniprot = Q3U9W6
}}
}}
'''Solute carrier family 31 (copper transporters), member 2''', also known as '''SLC31A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC31A2 solute carrier family 31 (copper transporters), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1318| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zhou B, Gitschier J |title=hCTR1: a human gene for copper uptake identified by complementation in yeast. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7481-6 |year= 1997 |pmid= 9207117 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
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}}
{{refend}}
{{protein-stub}}
end log.
