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DEFA6

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DEFA6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDEFA6, DEF6, HD-6, defensin alpha 6
External IDsOMIM: 600471; MGI: 3711900; HomoloGene: 130499; GeneCards: DEFA6; OMA:DEFA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001926

NM_001177481

RefSeq (protein)

NP_001917

NP_001170952

Location (UCSC)Chr 8: 6.92 – 6.93 MbChr 8: 21.56 – 21.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene.[5][6] DEFA6 is expressed in the Paneth cells of the ileum.[7]

Function

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The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 has poor antibacterial potency.[8] However, HD6 affords protection against invasion by enteric bacterial pathogens by self-assembly to form fibrils and nanonets that surround and entangle bacteria.[9]

Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.[5]

References

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  1. ^ a b c ENSG00000285136 GRCh38: Ensembl release 89: ENSG00000164822, ENSG00000285136Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061845Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: DEFA6 defensin, alpha 6, Paneth cell-specific (Homo sapiens)".
  6. ^ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Letters. 315 (2): 187–92. doi:10.1016/0014-5793(93)81160-2. PMID 8417977. S2CID 45099115.
  7. ^ Zhao C, Wang I, Lehrer RI (November 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Letters. 396 (2–3): 319–22. doi:10.1016/0014-5793(96)01123-4. PMID 8915011. S2CID 22367037.
  8. ^ Ericksen B, Wu Z, Lu W, Lehrer RI (January 2005). "Antibacterial activity and specificity of the six human {alpha}-defensins". Antimicrobial Agents and Chemotherapy. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305.
  9. ^ Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, et al. (July 2012). "Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets". Science. 337 (6093): 477–81. Bibcode:2012Sci...337..477C. doi:10.1126/science.1218831. PMC 4332406. PMID 22722251.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Defensin-6