mir-711 microRNA precursor family
| mir-711 | |
|---|---|
| Identifiers | |
| Symbol | mir-711 |
| Rfam | RF01923 |
| miRBase family | MIPF0000748 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-711 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Diagnostic use in Cutaneous T-cell Lymphoma
[edit]miR-711 is able to distinguish between malignant cutaneous T-cell lymphomas and benign skin disorders with high accuracy.[1]
Hsp70.3 and Further Regulation
[edit]miR-711 has been found to target and suppress Heat Shock Protein 70.3 in vitro at a post-transcriptional level via its 3' untranslated region.[2] Ischaemic preconditioning brings about reduced miR-711 levels, with downregulated cardiac myocyte levels further dependent upon NF-kappa B.
See also
[edit]References
[edit]- ^ Ralfkiaer U, Hagedorn PH, Bangsgaard N, Løvendorf MB, Ahler CB, Svensson L, Kopp KL, Vennegaard MT, Lauenborg B, Zibert JR, Krejsgaard T, Bonefeld CM, Søkilde R, Gjerdrum LM, Labuda T, Mathiesen AM, Grønbæk K, Wasik MA, Sokolowska-Wojdylo M, Queille-Roussel C, Gniadecki R, Ralfkiaer E, Geisler C, Litman T, Woetmann A, Glue C, Røpke MA, Skov L, Odum N (November 2011). "Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)". Blood. 118 (22): 5891–900. doi:10.1182/blood-2011-06-358382. PMC 3342856. PMID 21865341.
- ^ Tranter M, Helsley RN, Paulding WR, McGuinness M, Brokamp C, Haar L, Liu Y, Ren X, Jones WK (August 2011). "Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation". The Journal of Biological Chemistry. 286 (34): 29828–37. doi:10.1074/jbc.M111.221796. PMC 3191024. PMID 21757701.
Further reading
[edit]- Li ZY, Na HM, Peng G, Pu J, Liu P (March 2011). "Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts". Molecular BioSystems. 7 (3). Royal Society of Chemistry: 871–7. doi:10.1039/c0mb00230e. PMID 21183973.
External links
[edit]
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