Mir-605 microRNA precursor family
| mir-605 | |
|---|---|
| Identifiers | |
| Symbol | mir-605 |
| Rfam | RF01011 |
| miRBase family | MIPF0000528 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-605 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
p53 protein network
[edit]miR-605 is transcriptionally activated by the p53 protein through interaction with the promoter region of its gene. This microRNA in turn post-transcriptionally represses the oncoprotein and p53 suppressor Mdm2, which acts with p53 in a negative feedback loop in p53-wildtype cancers. Introduction of miR-605 interrupts this p53:Mdm2 interaction and instead there is a positive feedback loop in place, enabling rapid p53 accumulation in response to stress. Such p53 accumulation induces cell cycle arrest and apoptosis.[1]
See also
[edit]References
[edit]- ^ Xiao J, Lin H, Luo X, Luo X, Wang Z (2011). "miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress". EMBO J. 30 (3): 524–32. doi:10.1038/emboj.2010.347. PMC 3034018. PMID 21217645.
Further reading
[edit]- Zhang, M.; Jin, M.; Yu, Y.; Zhang, S.; Wu, Y.; Liu, H.; Liu, H.; Chen, B.; Li, Q.; Ma, X.; Chen, K. (2012). "Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population". European Journal of Cancer Care. 21 (2): 274–280. doi:10.1111/j.1365-2354.2011.01308.x. PMID 22074121.
- Zhang, M. W.; Jin, M. J.; Yu, Y. X.; Zhang, S. C.; Liu, B.; Jiang, X.; Pan, Y. F.; Li, Q. L.; Ma, X. Y.; Chen, K. (2011). "Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk". Molecular Carcinogenesis. 51: E21–E31. doi:10.1002/mc.20863. PMID 21976437. S2CID 221958071.
- Zhang, M. W.; Yu, Y. X.; Jin, M. J.; Pan, Y. F.; Jiang, X.; Li, Q. L.; Ma, X. Y.; Zhang, S. C.; Chen, K. (2011). "Association of miR-605 and miR-149 genetic polymorphisms with related risk factors of lung cancer susceptibility". Zhejiang da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 40 (3): 265–271. doi:10.3785/j.issn.1008-9292.2011.03.006. PMID 21671485.
- Nymark, P.; Guled, M.; Borze, I.; Faisal, A.; Lahti, L.; Salmenkivi, K.; Kettunen, E.; Anttila, S.; Knuutila, S. (2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer". Genes, Chromosomes and Cancer. 50 (8): 585–597. doi:10.1002/gcc.20880. PMID 21563230. S2CID 39556202.
- Scott, M. S.; Avolio, F.; Ono, M.; Lamond, A. I.; Barton, G. J. (2009). Unger, Ron (ed.). "Human miRNA Precursors with Box H/ACA snoRNA Features". PLOS Computational Biology. 5 (9): e1000507. Bibcode:2009PLSCB...5E0507S. doi:10.1371/journal.pcbi.1000507. PMC 2730528. PMID 19763159.
- Lee, I.; Ajay, S. S.; Yook, J. I.; Kim, H. S.; Hong, S. H.; Kim, N. H.; Dhanasekaran, S. M.; Chinnaiyan, A. M.; Athey, B. D. (2009). "New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites". Genome Research. 19 (7): 1175–1183. doi:10.1101/gr.089367.108. PMC 2704433. PMID 19336450.
External links
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