Mir-615 microRNA precursor family
| mir-615 | |
|---|---|
| Identifiers | |
| Symbol | mir-615 |
| Rfam | RF00879 |
| miRBase family | MIPF0000342 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota |
| PDB structures | PDBe |
mir-615 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma.
miR-615 and NGX6
[edit]Nasopharyngeal carcinoma-associated gene 6 (NGX6) acts as a tumour suppressor gene in colon cancer. miR-615 has been found to be downregulated in NGX6-transfected cells, although identification of its target genes has not yet been achieved.[1]
Hox cluster conservation
[edit]miR-615 has been found to reside within Hox gene clusters, alongside Hox genes other miRNAs. Hox genes are involved in anterior-posterior axis patterning. miR-615 is located at the HOXC5 (encdoing the HOXC5 homeobox protein) intron in mammals.[2]
See also
[edit]References
[edit]- ^ Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, et al. (2010). "Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells". Mol Cell Biochem. 345 (1–2): 283–90. doi:10.1007/s11010-010-0582-7. PMID 20859756. S2CID 27292546.
- ^ Woltering JM, Durston AJ (2008). "MiR-10 represses HoxB1a and HoxB3a in zebrafish". PLOS ONE. 3 (1): e1396. Bibcode:2008PLoSO...3.1396W. doi:10.1371/journal.pone.0001396. PMC 2148072. PMID 18167555.
Further reading
[edit]- Yang, Y.; Wang, L. L.; Li, Y. H.; Gao, X. N.; Liu, Y.; Yu, L. (2011). "Effect of CpG Island Methylation on MicroRNA Expression in the k-562 Cell Line". Biochemical Genetics. 50 (1–2): 122–134. doi:10.1007/s10528-011-9478-9. PMID 22089542. S2CID 16736093.
- Hulf, T.; Sibbritt, T.; Wiklund, E. D.; Bert, S.; Strbenac, D.; Statham, A. L.; Robinson, M. D.; Clark, S. J. (2011). "Discovery pipeline for epigenetically deregulated miRNAs in cancer: Integration of primary miRNA transcription". BMC Genomics. 12: 54. doi:10.1186/1471-2164-12-54. PMC 3037319. PMID 21255435.
External links
[edit]
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