IL1RL2

IL1RL2
Identifiers
Aliases	IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, interleukin 1 receptor like 2
External IDs	OMIM: 604512; MGI: 1913107; HomoloGene: 2860; GeneCards: IL1RL2; OMA:IL1RL2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,240,002 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,406,722 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of abdomen; ; skin of leg; ; right lobe of thyroid gland; ; right lobe of liver; ; cartilage tissue; ; left lobe of thyroid gland; ; right uterine tube; ; minor salivary glands; ; mucosa of transverse colon;
	Top expressed in
	lip; ; conjunctival fornix; ; gastrula; ; skin of external ear; ; skin of back; ; seminal vesicula; ; esophagus; ; epidermis; ; hair follicle; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1, type I, activating receptor activity; interleukin-1 receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	positive regulation of T cell differentiation; immune system process; interleukin-1-mediated signaling pathway; cellular defense response; innate immune response; inflammatory response; signal transduction; regulation of inflammatory response; positive regulation of interleukin-6 production; cytokine-mediated signaling pathway; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8808
	107527
	ENSG00000115598
	ENSMUSG00000070942
	Q9HB29
	Q9ERS7
NM_003854; NM_001351446; NM_001351447; NM_001351448; NM_001351449;
	NM_001351450
	NM_133193; NM_001356478
NP_003845; NP_001338375; NP_001338376; NP_001338377; NP_001338378;
	NP_001338379
	NP_573456; NP_001343407
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115598 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070942 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
^ Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
^ Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
^ ^a ^b "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.
Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.
Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ozkara C, Uzan M, Tanriverdi T, et al. (2006). "Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis". Seizure: The Journal of the British Epilepsy Association. 15 (5): 288–91. doi:10.1016/j.seizure.2006.02.016. PMID 16546408.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115598 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070942 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8898719-5] Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.

[pmid10191101-6] Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.

[pmid11466363-7] Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.

[entrez-8] "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

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References

Further reading