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GSK-2849466

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GSK-2849466
Clinical data
Drug classSelective androgen receptor modulator
Identifiers
  • 2,3-dichloro-4-[[(2S)-3-hydroxy-3-methylbutan-2-yl]amino]benzonitrile
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC12H14Cl2N2O
Molar mass273.16 g·mol−1
3D model (JSmol)
  • C[C@@H](C(C)(C)O)NC1=C(C(=C(C=C1)C#N)Cl)Cl
  • InChI=InChI=1S/C12H14Cl2N2O/c1-7(12(2,3)17)16-9-5-4-8(6-15)10(13)11(9)14/h4-5,7,16-17H,1-3H3/t7-/m0/s1
  • Key:KYBPRVBQMUAOFG-ZETCQYMHSA-N

GSK-2849466 is an investigational new drug that is a selective androgen receptor modulator (SARM) that was being developed by GlaxoSmithKline (GSK). This experimental compound reached Phase I clinical trials for the treatment of cachexia and heart failure.[1][2][3] However, as of February 2014, GSK discontinued the development of GSK-2849466 for both indications after completing Phase I studies.[2]

References

[edit]
  1. ^ "GSK-2849466". PatSnap.
  2. ^ a b "GSK 2849466". AdisInsight. Springer Nature Switzerland AG. Archived from the original on 2024-01-14. Retrieved 2024-01-14.
  3. ^ Fonseca GW, Dworatzek E, Ebner N, Von Haehling S (August 2020). "Selective androgen receptor modulators (SARMs) as pharmacological treatment for muscle wasting in ongoing clinical trials". Expert Opinion on Investigational Drugs. 29 (8): 881–891. doi:10.1080/13543784.2020.1777275. PMID 32476495.