Draft:Arylacetamide deacetylase like 2
Submission declined on 9 October 2024 by Bluethricecreamman (talk). The proposed article does not have sufficient content to require an article of its own, but it could be merged into the existing article at AADACL2. Since anyone can edit Wikipedia, you are welcome to add that information yourself. Thank you.
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Submission declined on 19 September 2024 by Dr vulpes (talk). The proposed article does not have sufficient content to require an article of its own, but it could be merged into the existing article at AADACL2. Since anyone can edit Wikipedia, you are welcome to add that information yourself. Thank you. Declined by Dr vulpes 2 months ago. |
Submission declined on 30 July 2024 by CFA (talk). Please see Bobby Cohn's comment. The images should be removed. Please also see "Wikipedia is not a database". Large tables of values providing insufficient context to readers are not encyclopedic. Declined by CFA 3 months ago. |
- Comment: Pictures showing the full sequence length are not encyclopedic and not necessary in the article. See MOS:IMAGES for more information. Bobby Cohn (talk) 22:01, 29 July 2024 (UTC)
Arylacetamide Deacetylase Like 2, also known as AADACL2, is a protein which in humans is encoded by the AADACL2 gene.
Gene
[edit]The AADACL2 gene consists of 27413 nucleotides..[1] with an mRNA of approximately 5060 base pairs.[2] There are five exons found in the AADACL2 gene.[2] AADACL2 is found to function in catalytic activity, hydrolase activity, and found to enable carboxylic ester hydrolase activity.[3]
mRNA
[edit]The chromosomal band location of AADACL2 is 3q25.1[4] and is located on the plus strand of the DNA.
Protein
[edit]AADACL2 in humans is 401 amino acids long.[5] with a predicted molecular weight of 46 kDa.[6] The isoelectric point of AADACL2 is 7.2.[7] The AADACL2 protein contains two domains, Abhydrolase_3, that spans nearly the entire protein. Along with an intermediate domain which is Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole.[5] Both of which are found to be conserved amongst orthologs.
Localization
[edit]Human AADACL2 is predicted to be localized in the endoplasmic reticulum.[8]
Expression
[edit]AADACL2 is tissue specific. AADACL2 is expressed at a very high level in skin tissues.[4] It is found to express at low levels in placenta, esophagus, small intestine and colon[4]. It is also found in circular RNA induction during fetal development at higher levels at the intestines at 10 weeks and 20 weeks.[4]
Tertiary structure
[edit]The protein AADACL2 was found to be composed of both alpha helices along with beta barrels.[9]
Evolution
[edit]The protein encoded by AADACL2[5] evolves slower than the fibrinogen alpha[10] protein but faster than the protein cytochrome c.[11]
Paralogs
[edit]Paralogs of AADACL2 include: AADAC (Arylacetamide Deacetylase), NCEH1 (Neutral Cholesterol Ester Hydrolase 1), AADACL3 (Arylacetamide Deacetylase Like 3), AADACL4 (Arylacetamide Deacetylase Like 4), and AFMID (Arylformamidase).[3]
Orthologs
[edit]Arylacetamide Deacetylase like 2 is found only in mammals. AADACL2 is not found in fish, birds, reptiles, and amphibians. Arylacetamide Deacetylase like 2 is found in the following mammals: primates, flying lemurs, bats, rabbits & hares, rodents, insectivores, afrotheria, carnivores, even-toed ungulates, and odd-toed ungulates. Arylacetamide Deacetylase like 2 was approximately found to have first appeared in afrotheria 99 million years ago.
AADACL2 | Genus and Species | Common Name | Taxonomic Group | Median Date of Divergence (MYA) | Protein Accession # | Protein Sequence Length (aa) | Sequence Identity to Human Protein (%) | Sequence Similarity to Human Protein (%) |
Primates | Homo sapiens | Human | Primates | 0 | NP_997248.2 | 401 | 100.0 | 100.0 |
Macaca mulatta | Rhesus monkey | Primates | 28.8 | XP_001106757.2 | 401 | 98 | 99.3 | |
Rhinopithecus roxellana | Golden snub-nosed monkey | Primates | 28.8 | XP_010370407.2 | 401 | 97.3 | 99.0 | |
Sapajus apella | Tufted capuchin | Primates | 43 | XP_032118900.1 | 401 | 94 | 96.3 | |
Aotus nancymaae | Nancy Ma's monkey | Primates | 43 | XP_012292432.2 | 401 | 94.5 | 96.5 | |
Microcebus murinus | Gray mouse lemur | Primates | 74 | XP_012646764.1 | 402 | 72.1 | 81.8 | |
Flying Lemurs | Cynocephalus volans | Philippine flying lemur | Dermoptera | 74 | XP_062934601.1 | 401 | 82.5 | 89.0 |
Bats | Rhinolophus ferrumequinum | Greater Horseshoe Bat | Bats | 94 | XP_032991506.1 | 401 | 81.0 | 87.8 |
Pteropus alecto | Black flying fox | Chiroptera | 94 | XP_006926324.1 | 343 | 50.5 | 63.6 | |
Rabbits & Hares | Ochotona princeps | American Pika | Lagomorpha | 87 | XP_004598151.2 | 401 | 80.5 | 88.3 |
Rodents | Octodon degus | Degu | Rodentia | 87 | XP_004643988.1 | 401 | 80.0 | 89.0 |
Mus musculus | Mouse | Rodentia | 87 | NP_001121563 | 401 | 79.1 | 89.5 | |
Marmota monax | Woodchuck | Rodentia | 87 | XP_046287168.1 | 401 | 65.1 | 78.1 | |
Insectivores | Condylura cristata | Star-nosed Mole | Eulipotyphla | 94 | XP_004682396.1 | 401 | 78.8 | 86.3 |
Afrotheria | Trichechus manatus latirostris | Florida Manatee | Sirenia | 99 | XP_004379276.3 | 402 | 78.4 | 88.1 |
Elephas maximus indicus | Indian Elephant | Proboscideans | 99 | XP_049723395.1 | 402 | 78.1 | 86.8 | |
Carnivores | Lontra canadensis | Northern American River Otter | Carnivora | 94 | XP_032708555.1 | 401 | 75.1 | 84.0 |
Phoca vitulina | Harbor Seal | Carnivora | 94 | XP_032265082.1 | 400 | 73.8 | 82.0 | |
Ursus maritimus | Polar Bear | Carnivora | 94 | XP_008705296.2 | 401 | 73.6 | 83.3 | |
Mustela putorius furo | Domestic Ferret | Carnivora | 94 | XP_004755622.1 | 401 | 73.6 | 82.5 | |
Canis lupus dingo | Dingo | Carnivora | 94 | XP_025291970.3 | 403 | 73.4 | 81.9 | |
Ailuropoda melanoleuca | Giant Panda | Carnivora | 94 | XP_002916395.1 | 397 | 72.1 | 81.0 | |
Odobenus rosmarus divergens | Pacific Walrus | Carnivora | 94 | XP_004405057.1 | 400 | 70.3 | 80.5 | |
Even-Toed Ungulates | Hippopotamus amphibius kiboko | Common Hippopotamus | Artiodactyls | 94 | XP_057593784.1 | 416 | 70.0 | 79.4 |
Camelus dromedarius | Arabian Camel | Artiodactyls | 94 | XP_010985013.1 | 401 | 63.8 | 78.1 | |
Odd-Toed Ungulates | Equus caballus | Horse | Perissodactyla | 94 | XP_014587028.1 | 587 | 49.6 | 56.6 |
Clinical significance
[edit]Allergic contact dermatitis exposed to a nickel allergy, indicates that there is lower presence in the AADACL2 RNA when exposed to a nickel allergy versus the non-allergic control.[12] Arylacetamide deacetylase-like 2 was found to be in the top fifty skin enriched genes, and was predicted to contain a signal peptide and function as a secreted protein.[13]
References
[edit]- ^ "UCSC Genome Browser". University of California Santa Cruz: Human BLAT Search- BLAT Search Genome.
- ^ a b "Homo sapiens arylacetamide deacetylase like 2 (AADACL2), mRNA". National Library of Medicine: National Center for Biotechnology Information. June 2024.
- ^ a b "Gene - Arylacetamide Deacetylase Like 2". Gene Cards: The Human Gene Database.
- ^ a b c d "AADACL2 arylacetamide deacetylase like 2 [Homo sapiens (human)]". National Library of Medicine: National Center for Biotechnology Information.
- ^ a b c "Arylacetamide Deacetylase-like 2 precursor [Homo sapiens]". National Library of Medicine: National Center for Biotechnology Information.
- ^ "Protein Molecular Weight". Bioinformatics.org: Protein Molecular Weight.
- ^ "Compute pI/Mw". Expasy: Swiss Bioinformatics Resource Portal.
- ^ "PSORT II Prediction". PSORT WWW Server.
- ^ "NCBI Domains & Structures". National Library of Medicine: National Center for Biotechnology Information.
- ^ "Fibrinogen Alpha Chain Isoform Alpha Precursor [Homo sapiens]". National Library of Medicine: National Center for Biotechnology Information.
- ^ "Cytochrome c [Homo sapiens]". National Library of Medicine- National Center for Biotechnology Information.
- ^ Pedersen, MB; et al. (November 2007). "Gene expression time course in the human skin during elicitation of allergic contact dermatitis". The Journal of Investigative Dermatology. 127 (11): 2585–2595. doi:10.1038/sj.jid.5700902. PMID 17597826. Retrieved 25 July 2024.
- ^ Per-Henrik, D.; et al. (November 19, 2014). "Expression of Human Skin-Specific Genes Defined by Transcriptomics and Antibody-Based Profiling". Journal of Histochemistry & Cytochemistry. 63 (2): 129–141. doi:10.1369/0022155414562646. PMC 4305515. PMID 25411189. Retrieved 25 July 2024.