User talk:Dr.Fadi Ibrahim

Your submission at Articles for creation: Dr.Fadi Ibrahim inhibit covid-19 by zinc, azaphthalocyanin and UV (June 22)

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June 2020

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CV Dr.Fadi Ibrahim Ahmed

CURRICULUM VITAE

Personal Data Name :Dr. Fadi Ibrahim Ahmed Nationality  : Egyptian Date of Birth  : 02/06/1976 Tel  : (+965)-24738037 Mobile  : (+965)-99765549 E-mail  : fed_ooo@yahoo.com Academic Qualifications High School  : El-Rabia School, Kuwait, 1994, (94.1%). University  : Bachelors of Science, Chemistry, 1998, (very good)

                 El-Mansoura University (Egypt). 

MSc  : Masters in Chemistry, 2007, (GPA 4) (practical works

                  within  9 month). Kuwait University, (Kuwait). 

Ph.D  : Doctorate Degree in Chemistry, 2012, (GPA 3.93) Kuwait University, (Kuwait). Post D  : Related to novel polymer based hydrogen storage materials, 2013, Kuwait University, (Kuwait). ● The winner Poster of the first Kuwait France chemistry meeting 2009. ● The winner of Master graduate research award in applied sciences for postgraduate research project from Kuwait University 2007/2008. ● The winner of PhD graduate research award in applied sciences for postgraduate research project from Kuwait University 2013/2014. ● Participated in the “International Conference on Chemistry and Chemical Engineering” (ICCCE-2015) September 14-16, 2015, Dubai- United Arab Emirates. ● Participated in the 2nd Kuwait Oil & Gas Show and Conference 2015. ●The winner of Kuwait National Petroleum Company KNPC-8th CEO Annual HSE improvement performance, 2015. ●The winner of best paper award certificate from TJPRC “International Journal of Nanotechnology and Application”, 2015, with paper titled “Synthesis of Smectic and Discotic Liquid Crystals Derivatives by Flow Injection System”. ● The winner of Energy Globe National Award 2016 "Polymer for Climate Protection". ●Participated in 27th International Conference on Organometallic Chemistry ICOMC, "High surface area anthracene-based microporous polymer bridged by imide links for H2 storage", 17-22 July, 2016, Melbourne, Australia. ●Participated in ISERD- 199th International Conference on Chemical and Biochemical Engineering (ICCBE) Kuwait City, Kuwait. Paper Title: Smart Synthesis of Microporous Polymers by Flow Injection method For CO2 capture. 29th-30th June, 2017. ●Participated in7th World Congress On Biopolymers and Polymers Chemistry, June 04-06, 2018 Osaka, Japan. Instruments Handled ● Analytical: GPC, Surface area analysis, HPLC, UV/VIS absorption spectroscopy, LC-MS, Polarimeter, Flame photometer, and Refractometer. ● Pharmacy. Skills: QC-IPC Tablet, Syrup & LVP Ind., R&D works. Drying & Blinding m/c, Hardness T., Friability, Flowability, Leakage tests, Granulation & Grinding Process. Computer Skills Cambridge International Diploma in IT Skills: Windows, Microsoft Office (Word, Excel, Photo Editor, Power Point, Publisher), Adobe Photoshop, Chem. Windows, Isis Draw, ACD Labs. Master thesis Title: Towards Phthalocyanine-containing true solid solution. Supervised by: Dr. Saad Makhseed Ph. D Dissertation Title: Synthesis and characterization of nanoporous organic materials. Supervised by: Dr. Saad Makhseed Relevant Publications:

1-Fadi Ibrahim, 2020, [http://"Novel%20Inhibitor%20For%20Covid-19%20From%20Zinc%20Nano-Based%20Aza-Pc%20And%20CODs%20"International%20Journal%20Of%20Modern%20Pharmaceutical%20Research,%204(3),%2091-96,%20ISSN:%202319-5878 "Novel Inhibitor For Covid-19 From Zinc Nano-Based Aza-Pc And CODs "International Journal Of Modern Pharmaceutical Research, 4(3), 91-96, ISSN: 2319-5878].

2- Fadi Ibrahim, 2019, [http://"Environmental%20Protection%20from%20Greenhouse%20CO2%20Pollutant%20Gas%20Using%20Spiro-Microporous%20Absorbent%20Network",%20World%20Conference%20on%20Teacher%20Education%20(WCTE-19),%20International%20Institute%20of%20Education,%20Research%20and%20Development%20(IIERD),%20Kuwait "Environmental Protection from Greenhouse CO2 Pollutant Gas Using Spiro-Microporous Absorbent Network", World Conference on Teacher Education (WCTE-19), International Institute of Education, Research and Development (IIERD), Kuwait].

3- Fadi Ibrahim, 2018,"Green Synthesis of Zinc-Nanoparticles Using Capillary-Furnace LED Based Reactor from Portulaca oleracea Leaf and its Applications in Antimicrobial Activity" 5th Kuwait Conference of Chemistry – KCC-5. www.kcc2018kw.com.

4-Fadi Ibrahim, 2017, ""%20Journal%20of%20Nanoscience%20&%20Nanotechnology%20Research,%20iMedPub%20Journals.%20Vol.1%20No.1:1 Novel Green-Chemistry Micro-Fluidic Synthesis of Anthracene-Based Microporous for H2 Storage by Capillary-Furnace LED Based Reactor" Journal of Nanoscience & Nanotechnology Research, iMedPub Journals. Vol.1 No.1:1.

5- Fadi Ibrahim, 2016, ""%204th%20Kuwait%20Conference%20of%20Chemistry%20KCC%202016 Novel Synthesis of Calametic Liquid Crystals Derivatives by Flow Injection System as Environment Friendly Method" 4th Kuwait Conference of Chemistry KCC 2016.

6-Fadi Ibrahim, 2016, "Synthesis of Homogeneous alignment Calametic Liquid Crystals derivatives by Flow Injection System" Kuwait Journal of Science.

7-Fadi Ibrahim, 2015, "",%20Elixir%20Organic%20Chemistry,%2086,%2034830-34833. High Surface Area Anthracene-based Microporous Polymer Bridged by Imide Links For H2 Storage", Elixir Organic Chemistry, 86, 34830-34833.

8-Fadi Ibrahim, 2015, "",%20International%20Journal%20of%20Chemical%20Science,%20Int.%20J.%20Chem.%20Sci.:%2013,%20(3),%201345-1356 Synthesis of High Surface Area Microporous Spiro-Polymer For Green Chemistry Applications", International Journal of Chemical Science, Int. J. Chem. Sci.: 13, (3), 1345-1356.

9-Fadi Ibrahim, 2015, "",%20International%20Journal%20of%20Nanotechnology%20and%20Application%20(IJNA),%20Vol.%205,%20Issue%204,%209-16.%20ISSN%20(E):2278-9391 Synthesis of Smectic and Discotic Liquid Crystals Derivatives by Flow Injection System", International Journal of Nanotechnology and Application (IJNA), Vol. 5, Issue 4, 9-16. ISSN (E):2278-9391.

10- Fadi Ibrahim, 2013, ""%20Elixir%20Applied%20Chemistry,%2064,%2019054-19059 Synthesis of linear unbranched polymers chain free of macrocyclic species and oligomers based on chloro-monomers and TTSBI" Elixir Applied Chemistry, 64, 19054-19059.

11- Fadi Ibrahim 2013, ""%20Elixir%20Nanocomposite%20Materials%2062,%2017542-17548 Synthesis and characterization of linear polyimides with intrinsic microporosity and their hydrogen adsorption studies" Elixir Nanocomposite Materials 62, 17542-17548.

12- Fadi Ibrahim,. 2013, ""%20International%20Journal%20of%20Plastic%20and%20Polymer%20Technology%20(IJPPT),%20ISSN%202249-6904,%20Vol.%203,%20Issue%201,%201-16. Synthesis of linear microporous polyimides and their hydrogen storage properties" International Journal of Plastic and Polymer Technology (IJPPT), ISSN 2249-6904, Vol. 3, Issue 1, 1-16.

13- Fadi Ibrahim, 2013, ""%20International%20Journal%20of%20Chemical%20&%20Petrochemical%20Technology%20(IJCPT),%20ISSN%202277-4807%20Vol.%203,%20Issue%203,%20Aug%2017-26. Microporus Organic framework polymers for hydrogen storage applications" International Journal of Chemical & Petrochemical Technology (IJCPT), ISSN 2277-4807 Vol. 3, Issue 3, Aug 17-26.

14- Saad makhseed, Fadi Ibrahim and Jacob Samuel, 2012, " ",%20Polymer,%20(14),%20%20Elsevier%2053,%202964-2972. Phthalimide based Polymers of Intrinsic Microporosity", Polymer, (14), Elsevier 53, 2964-2972.

15- Saad Makhseed, Fadi Ibrahim, Jacob Samuel, Madeleine Helliwell, John E. Warren, C. Grazia Bezzu, Neil B. McKeown, 2008, "",%20CHEMISTRY%20%20EUROPEAN%20JOURNAL,%2014,%204810-4815,%20Cover%20Picture. Clathrate Formation from Octaazaphthalocyanines Possessing Bulky Phenoxyl Substituents: A New Cubic Crystal Containing Solvent-Filled, Nanoscale Voids", CHEMISTRY EUROPEAN JOURNAL, 14, 4810-4815, Cover Picture.

16- Saad Makhseed, Jacob Samuela and Fadi Ibrahim, 2008, "",%20Tetrahedron,%2064,%208871-8877. Synthesis and characterization of non-aggregating octa-substituted azaphthalo cyanines bearing bulky phenoxy substituents", Tetrahedron, 64, 8871-8877.

17- Fadi Ibrahim and Saad Makhseed, 2008, [["",%20ARKIVOC,%2085-94. Synthesis and spectral of properties tetrapyrazinoporphyrazinato metal complexes derived from sterically hindered phenol", ARKIVOC, 85-94.]]

18-Saad Makhseed, Jacob Samuela and Fadi Ibrahim, Grazia Bezzu, and Neil B. McKeown, 2007, "",%20Tetrahedron%20letters,%2048,%207358-7361 The synthesis of metal-free octaazaphthalo-cyanine derivatives containing bulky phenoxy substituents to prevent self-association", Tetrahedron letters, 48, 7358-7361.

Novel Inhibitor for COVID-19 from Zinc Nano-Based Aza-Pc and CQDs

Novel Inhibitor for COVID-19 from Zinc Nano-Based Aza-Pc and CQDs Fadi Ibrahim*

• Department of Chemistry, Saad bin-alrabee alansari School Kuwait

http://www.ijmpronline.com/ ABSTRACT: In this article, the antiviral activity of seven different carbon quantum dots (CQDs) with Azaphthalocyanin (Az-Pcs) for the treatment of human coronavirus infections was investigated. Az-Pcs used to adsorb UV light and concentrate it to CQDs to avoid destruction of tissue and cells by high energy. The first generation Az-Pcs-CQDs antiviral with nanostructures showed a concentration-dependent virus inactivation with an expected estimated EC50 of 50±8 μ gmL-1. The underlying mechanism of action of these Az-Pcs-CQDs could be due to interaction of the functional groups of the CQDs with COVID-19 entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step. Az-Pcs with boronic acid derivatives have been proposed as low toxicity agents for inhibiting the entry various viruses. The underlying mechanism of action of these CQDs was revealed to be the CQDs interaction with the COVID-19 S-protein. The antiviral activity of Az-Pcs-CQDs with different Zn nano-size need to be evaluated on Huh-7 cell monolayers infected with COVID-19. Keywords COVID-19; antiviral activity; Zinc nanoparticles; carbon quantum dots (CQDs); UV light; Surface plasmon resonance; Atomic force microscopy; Boronic acid Aza-Pc CONCLUSION The viral infection cycle produces important biological and structural changes in the host cell, resulting in cell damage. The possibility to interfere with viral attachment to cells as well as viral replication to reduce viral infection and spreading is an appropriate antiviral approach. These CQDs were shown to interfere significantly with COVID-19 infection in a concentration-dependent manner. The presence of boronic acid functions proved to be vital for covering CQDs with antiviral activity Mechanistic studies suggest that the particles are acting at the early state of virus infection through the inhibition of entry that could be due to inhibition of protein S-receptor interaction with the host cell membrane. These results are extremely encouraging to replace currently used antiviral agents such a ribavirin and IFN known to have major side effects. such as confusion, short-term memory loss, deficits in executive functions, as well as extrapyramidal effects. Further experimental confirmations are required if this approach can be extrapolated to other coronaviruses, notably to the clinically relevant MERS- CoV, to validate the potential of these nanostructures as alternative anti-MERS therapeutics and approaches to confront this severe and life-threatening disease. Also, how such particles work in vivo has to be shown in the future.25

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