User talk:Czeer

Welcome!

Hello, Czeer! Welcome to Wikipedia! Thank you for your contributions. You may benefit from following some of the links below, which will help you get the most out of Wikipedia. If you have any questions you can ask me on my talk page, or place {{helpme}} on your talk page and ask your question there. Please remember to sign your name on talk pages by clicking

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Czeer, you are invited to the Teahouse!

Hi Czeer! Thanks for contributing to Wikipedia. Come join experienced editors at the Teahouse! The Teahouse is a space where new editors can get help from experienced editors. These editors have been around for a long time and have extensive knowledge about how Wikipedia works. Come share your experiences, ask questions, and get advice from experts. I hope to see you there! Doctree (I'm a Teahouse host)

Visit the Teahouse

This message was delivered automatically by your robot friend, HostBot (talk) 16:28, 11 September 2014 (UTC)[reply]

Testing 123

Hello Czeer! Thank you for contacting me! I will try replying to your message asap, but wanted to try writing to your talk page first.

--Wendyxie99 (talk) 19:31, 18 September 2014 (UTC)[reply]

Good reference on Exophiala dermatitidis

Untereiner, WA; Naveau, FA. 1999. Molecular systematics of the Herpotrichiellaceae with an assessment of the phylogenetic positions of Exophiala dermatitidis and Phialophora americana. MYCOLOGIA Volume: 91 Issue: 1 Pages: 67-83 Published: JAN-FEB 1999 Medmyco (talk) 22:27, 1 October 2014 (UTC)[reply]

P. Zalar, M. Novak, G.S. de Hoog, N. Gunde-Cimerman. Dishwashers – A man-made ecological niche accommodating human opportunistic fungal pathogens. Fungal Biology, 2011; 115 (10): 997 DOI: 10.1016/j.funbio.2011.04.007 Medmyco (talk) 23:50, 1 October 2014 (UTC)[reply]

Thanks

Thanks Czeer! I look forward to your edits on bioinorganics as well.Dbzam (talk) 16:53, 15 October 2014 (UTC)[reply]

Assignment 2

You may find some additional useful information in the Untereiner and Naveau paper (doi: 10.2307/3761194) and the Zalar et al. paper (doi: 10.1016/j.funbio.2011.04.007). Great start though! Medmyco (talk) 22:29, 22 October 2014 (UTC)[reply]

Homework Feedback

Hello Czeer! Great work on your article so far, especially in the pathophysiology section. One thing you could add is how infections are identified as attributable to E. dermatitidis? Also, how can the fungus be removed form dishwashers (that was hilarious), if they impose a serious health risk? Wendyxie99 (talk) 18:06, 28 October 2014 (UTC)[reply]

Hey Wendy! Thanks for the suggestions! I still have a ways to go, and appreciate any and all recommendations. See you in class tomorrow! Czeer (talk) 03:19, 29 October 2014 (UTC)[reply]

Peer Review

Wow! great work on your paragraphs, you have a really interesting fungus to work with. It would be a good idea to add examples of clinical cases since this species commonly affects humans. KassF (talk) 02:27, 29 October 2014 (UTC)[reply]

Thanks KassF for your suggestion! It's much appreciated. Czeer (talk) 03:16, 29 October 2014 (UTC)[reply]

Feedback

Hi Czeer! Great work on your article, it's extremely detailed and very organized. I think it would be a good idea to add a section about the phylogeny of the fungus. Brendanguyen5 (talk) 22:59, 29 October 2014 (UTC)Brendanguyen5[reply]

Article Review

Hey Czeer, great job on your article, it is very descriptive and contains a lot of interesting points. Perhaps you could add more information to your introductory paragraph (just a few summarized and key points from your subsections). In addition, you could mention where E. dermatitidis could have potentially originated. This article could provide some useful points: The neurotropic black yeast Exophiala dermatitidis has a possible origin in the tropical rain forest. In addition, perhaps you could elaborate on it's occurrence in saunas (which countries did they occur in and other fungi that could have been present in these saunas and caused similar symptoms). This article could provide a few points relating to that: High prevalence of the neurotrope Exophiala dermatitidis and related oligotrophic black yeasts in sauna facilities.. I hope you find these suggestions useful and I look forward to reading your finished article. Waleed Shahid1 (talk) 19:28, 30 October 2014 (UTC)[reply]

Thank you! Excellent references, I will definitely include information from them. All the best, Czeer (talk) 02:39, 3 November 2014 (UTC)[reply]

Interesting reference

I encountered an interesting paper on your fungus starting on pg 145 of this: http://www.cbs.knaw.nl/publications/sim61.pdf Medmyco (talk) 16:29, 2 November 2014 (UTC)[reply]

...overlapping with Waleed's suggestion! Medmyco (talk) 16:32, 2 November 2014 (UTC)[reply]

I HAVE A QUESTION

How do we add pictures :( Wendyxie99 (talk) 02:32, 12 November 2014 (UTC)[reply]

Hello Fellow Nickel Researcher

I am trying to figure out how to use this wikipedia thing...Reminder:Don't spend your whole break on wikipedia! LacMJ (talk) 11:30, 19 December 2014 (UTC)[reply]

Preparing for a future, later-in-life test here. Czeer (talk) 19:27, 19 December 2014 (UTC)[reply]

Whats Up Czeer

I know how to use the talk page now. ATB Lozmeister (talk) 03:12, 22 January 2015 (UTC) I also am learning how to use the talk function. Batcheld (talk) 03:54, 23 January 2015 (UTC)[reply]

Hi

Hi Czeer.

I'm learning how to communicate on Wikipedia.

Your classmate, Ryder

--Rfwh (talk) 17:43, 23 January 2015 (UTC)[reply]

Introducing myself

Hi. I work with the Wiki Education Foundation, and help support students who are editing as part of a class assignment. If there's anything I can do to help with your assignment (or, for that matter, any other aspect of Wikipedia) please feel free to drop me a note. Ian (Wiki Ed) (talk) 20:57, 5 February 2015 (UTC)[reply]

Bibliography

Dear Czeer; nice start on your page on calprotectin. There are a lot of points here, so you might need to focus a bit. For the course, the chemistry/biochemistry is much more interesting! Also, I was surprised to see your statement that manganese binds more tightly than zinc, I wonder how that works. Have a nice weekend.Dbzam (talk) 19:14, 6 February 2015 (UTC)[reply]

Hi Dbzam. I was also surprised, which is why I decided to preface the point with "remarkably." Unfortunately, I'm not totally sure the authors were correct. I double checked the textbook I referenced, and although they write, "The high affinity of Mn²⁺, even over Zn²⁺, arises from its asymmetrical heterodimer structure that allows one Mn binding site made of six histidine residues..." I don't think this is backed by the primary article they cite. Instead it seems that the site binds Mn²⁺ nearly as strongly as it does Zn²⁺... but not quite. After mutating out the low binding site, they actually found that Zn²⁺ K_d = 3.4 ± 1.2 (SD) nM and Mn²⁺ K_d = 5.8 ± 1.6 (SD) nM.^[1] This seems to be in agreement with other primary sources, as well as Brophy and Nolan's recent review article. ^[2] That being said, the book may have intended to cite an earlier paper by the same authors, where the K_d of Zn²⁺ and Mn²⁺ were found to be essentially identical, with Mn²⁺ maybe binding ever so slightly slightly stronger! Their earlier finding (using WT protein) was that Zn²⁺ K_d = 1.35 nM and Mn²⁺ K_d = 1.3 nM.^[3]

Either way, it's a remarkable complex. All the best, Czeer (talk) 20:51, 6 February 2015 (UTC)[reply]

References

^ Damo, S. M.; Kehl-Fie, T. E.; Sugitani, N.; Holt, M. E.; Rathi, S.; Murphy, W. J.; Zhang, Y.; Betz, C.; Hench, L.; Fritz, G.; Skaar, E. P.; Chazin, W. J. (19 February 2013). "Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens". Proceedings of the National Academy of Sciences. 110 (10): 3841–3846. doi:10.1073/pnas.1220341110.
^ Brophy, Megan Brunjes; Nolan, Elizabeth M. (16 January 2015). "Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms". ACS Chemical Biology: 150116125412006. doi:10.1021/cb500792b.
^ Kehl-Fie, Thomas E.; Chitayat, Seth; Hood, M. Indriati; Damo, Steven; Restrepo, Nicole; Garcia, Carlos; Munro, Kim A.; Chazin, Walter J.; Skaar, Eric P. (August 2011). "Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus". Cell Host & Microbe. 10 (2): 158–164. doi:10.1016/j.chom.2011.07.004. {{cite journal}}: no-break space character in |first1= at position 7 (help); no-break space character in |first3= at position 3 (help); no-break space character in |first7= at position 4 (help); no-break space character in |first8= at position 7 (help); no-break space character in |first9= at position 5 (help)

CHM437 Peer Editing

Hey Czeer, great work on your article so far! Here are some tips that might strengthen it a bit:

1) It might help to simplify the explanation of the antimicrobial properties in the introductory section. Maybe just mention that by sequestering Mn2+ and Zn2+ its starving any microbes of these nutrients. The way you have it now is really clear and concise, which is great for most scientific writing. However, it might not be clear for non-chemists/scientists.

2) Link some more of the very technical terms to their wikipedia articles, most wikipedia users wont know what mass spectrometry or heterotetramer mean.

3) In the structure sections, it might be nice mention something about the secondary/tertiary folded structures. From your image it looks like its very heavy in alpha-helixes.

4) Over all try to ease up on technical language, the article would be somewhat difficult to read for someone with out an education in chemistry or biochemistry.

I really like the images you put together and the article is very well researched. Great job! Eprince93 (talk) 23:48, 28 February 2015 (UTC)[reply]

Thank you so much for your comments!! I'll make sure to introduce all of the changes that you suggest. Hope you had a fine weekend, Czeer (talk) 00:18, 2 March 2015 (UTC)[reply]

Disambiguation link notification for March 7

Hi. Thank you for your recent edits. Wikipedia appreciates your help. We noticed though that when you edited 2-Mercaptoethanol, you added a link pointing to the disambiguation page Dimers. Such links are almost always unintended, since a disambiguation page is merely a list of "Did you mean..." article titles. Read the FAQ • Join us at the DPL WikiProject.

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Chatting about your experience editing Wikipedia for classes?

Hi Czeer, I'm with the Wiki Education Foundation, and our content expert in one of your classes mentioned that you're taking your second Wikipedia-based class. Thought you'd be interesting to talk to for a blog post over at wikiedu.org/blog -- let me know if you'd be interested in talking about your experiences and editing. You can respond here or reach me at eryk at wikiedu.org. Looking forward to hearing from you! Eryk (Wiki Ed) (talk) 18:25, 10 March 2015 (UTC)[reply]

Thank you

Dear Czeer, Thank you for all your comments, and I really appreciate your feedback. Good luck with your assignment. It looks great! Anavimadumim15 (talk) 20:09, 13 March 2015 (UTC)[reply]

Comments on sandbox

Dear Czeer; here are a few suggestions on some final editing that you can do on your page before going live. Overall it is an excellent article. You might want to reduce some of the technical language if you can, and avoid language like 'it has been suggested'. I was a big confused as to how many metals bind to the protein, I think the number of sites vs quaternary structure was hard to follow. The picture shows 2 manganese ions in a tetramer (?) but I had thought that it binds 4 per tetramer. Is it possible to say how tightly the metals are bound or do you think this is extra information not required here? You might want to mention that bacteria have a nutritional requirement for zinc, so sequestration makes them sick. In a few cases I was not sure if you were discussing the bacteria or the host cells, e.g. when discussing the plasma membrane, and I did not understand the comment about cell death. Dbzam (talk) 15:47, 19 March 2015 (UTC)[reply]

Reference errors on 13 April

Hello, I'm ReferenceBot. I have automatically detected that an edit performed by you may have introduced errors in referencing. It is as follows:

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Please check this page and fix the errors highlighted. If you think this is a false positive, you can report it to my operator. Thanks, ReferenceBot (talk) 00:18, 14 April 2015 (UTC)[reply]

Disambiguation link notification for April 14

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A brownie for you!

Not a barnstar, but thanks for coming to the Art+Fem meetup! Artchivist1 (talk) 23:37, 23 September 2015 (UTC)[reply]

Disambiguation link notification for October 26

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Calprotectin suitable for WikiJournal of Medicine

Hello Czeer!

I like your contribution of the Calprotectin article! In fact, you could submit at least the version you contributed to WikiJournal of Medicine. WikiJournal of Medicine is an open-access journal with no publication charges of any kind. We aim to provide accurate information on complex topics to the general public as well as to academics and medical professionals. We've discussed it in the editorial board of the journal, and we think it would be a great addition to our most recent issue. It would also give the article/image a standard reference format (including a DOI code) which will make it easier for scholars to cite your work in external sources.

If you are interested, you may send an email to submissions@wijoumed.org with an adapted copy-paste of the submission letter. The link to the page may then be your sandbox version of the article.

Best regards,

Mikael Häggström (talk) 19:13, 21 August 2017 (UTC),[reply]
Editor-in-chief, WikiJournal of Medicine

[1] Damo, S. M.; Kehl-Fie, T. E.; Sugitani, N.; Holt, M. E.; Rathi, S.; Murphy, W. J.; Zhang, Y.; Betz, C.; Hench, L.; Fritz, G.; Skaar, E. P.; Chazin, W. J. (19 February 2013). "Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens". Proceedings of the National Academy of Sciences. 110 (10): 3841–3846. doi:10.1073/pnas.1220341110.

[2] Brophy, Megan Brunjes; Nolan, Elizabeth M. (16 January 2015). "Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms". ACS Chemical Biology: 150116125412006. doi:10.1021/cb500792b.

[3] Kehl-Fie, Thomas E.; Chitayat, Seth; Hood, M. Indriati; Damo, Steven; Restrepo, Nicole; Garcia, Carlos; Munro, Kim A.; Chazin, Walter J.; Skaar, Eric P. (August 2011). "Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus". Cell Host & Microbe. 10 (2): 158–164. doi:10.1016/j.chom.2011.07.004. {{cite journal}}: no-break space character in |first1= at position 7 (help); no-break space character in |first3= at position 3 (help); no-break space character in |first7= at position 4 (help); no-break space character in |first8= at position 7 (help); no-break space character in |first9= at position 5 (help)

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