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Characteristics of patients who have been infected with
SARS-CoV-2, MERS-CoV, and SARS-CoV[1] ()
Virus SARS-CoV-2[a] MERS-CoV SARS-CoV H1N1, H3N2
Disease COVID-19 Middle East respiratory syndrome Severe acute respiratory syndrome Seasonal flu
Epidemiology
Detection date December 2019 June 2012 November 2002 Endemic (n.a.)
Detection place Wuhan, China Jeddah, Saudi Arabia Guangdong, China Endemic (n.a.)
Confirmed cases 88,585[b] 2494 8096 5~15,000,000/y
Case fatality rate 3,043[b] (3.44%) 858 (37%) 744 (10%) 290-650,000 (0.1%)
Basic reproduction number 2.2 (95% CI:1.4–3.9)[2][3]

2.68 (95% CI:2.47–2.86)[4]

1.3
Serial interval period 7.5±3.4 days (95% CI:5.3–19)[2]
Demographic
Age average 49 56 39.9
Age range 21–76 14–94 1–91
Male:female ratio 2.7:1 3.3:1 1:1.25
Health-care workers 16[c] 9.8% 23.1%
Symptoms
Fever 40 (98%) 98% 99–100%
Dry cough 31 (76%) 47% 29–75%
Dyspnea/short breath 22 (55%) 72% 40–42%
Diarrhea 1 (3%) 26% 20–25%
Sore throat 0 21% 13–25%
Ventilatory support 9.8% 80% 14–20%
Prognostic/Evolution
Incubation 5.5 days (1–14)[5][6] or

5.2 days (95% CI:4.1–7.0)[2]

2-4 days
Onset Day 0 Day 0
First medical visit +4.6 days (95% CI:4.1–5.1)[2]
Hospital admission +7.0 days (4.0–8.0)[7] or

+12.5 days (95% CI:10.3–14.8)[2][3]

+9.1 days (95% CI:8.6–9.7)[2][3]

Dyspnea/short breath +8.0 days (5.0–13.0)[7]
ARDS +9.0 days (8.0–14.0)[7]
Mechanical ventilation / ICU +10.5 days (7.0–14.0)[7]
Recovery +22.2 days (95% CI:18–83)[8]
Dead +14 days (6–41)[9] or

hospitalization + 12.4[10]

+22.3 days (95% CI:18–82)[8]

Notes
  1. ^ Symptoms were based on the first 41 patients.
  2. ^ a b Data: 2020-03-01.
  3. ^ Data as of 21 January 2020; other data up to 21 January 2020. Published on 24 January 2020.

See also

[edit]

References

  1. ^ Wang, Chen; Horby, Peter W.; Hayden, Frederick G.; Gao, George F. (24 January 2020). "A novel outbreak of global health concern". The Lancet. 395 (10223): 470–473. doi:10.1016/S0140-6736(20)30185-9. PMC 7135038. PMID 31986257.
  2. ^ a b c d e f Li, Qun; Guan, Xuhua; Wu, Peng; Wang, Xiaoye; Zhou, Lei; Tong, Yeqing; Ren, Ruiqi; Leung, Kathy S.M.; Lau, Eric H.Y.; Wong, Jessica Y.; Xing, Xuesen (2020-01-29). "Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia". New England Journal of Medicine. 382 (13): 1199–1207. doi:10.1056/NEJMoa2001316. ISSN 0028-4793. PMC 7121484. PMID 31995857.
  3. ^ a b c Fauci, Anthony S.; Lane, H. Clifford; Redfield, Robert R. (2020-02-28). "Covid-19 — Navigating the Uncharted". New England Journal of Medicine. 382 (13): 1268–1269. doi:10.1056/NEJMe2002387. ISSN 0028-4793. PMC 7121221. PMID 32109011.
  4. ^ Wu, Joseph T.; Leung, Kathy; Leung, Gabriel M. (2020-02-29). "Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study". The Lancet. 395 (10225): 689–697. doi:10.1016/S0140-6736(20)30260-9. ISSN 0140-6736. PMC 7159271. PMID 32014114.
  5. ^ "Q&A on coronaviruses (COVID-19) : How long is the incubation period for COVID-19?". www.who.int. Retrieved 2020-03-02.
  6. ^ "Coronavirus disease 2019 (COVID-19) Situation Report – 29" (PDF). World Health Organization. 2020-02-19.
  7. ^ a b c d Ronco, Claudio; Navalesi, Paolo; Vincent, Jean Louis (2020-02-06). "Coronavirus epidemic: preparing for extracorporeal organ support in intensive care". The Lancet Respiratory Medicine. 8 (3): 240–241. doi:10.1016/S2213-2600(20)30060-6. ISSN 2213-2600. PMC 7154507. PMID 32035509.
  8. ^ a b "Report 4: Severity of 2019-novel coronavirus (nCoV)" (PDF). WHO Collaborating Centre for Infectious Disease Modelling MRC Centre for Global Infectious Disease Analysis. 2020-02-10.
  9. ^ W, Wang; J, Tang; F, Wei (April 2020). "Updated Understanding of the Outbreak of 2019 Novel Coronavirus (2019-nCoV) in Wuhan, China". Journal of Medical Virology. 92 (4): 441–447. doi:10.1002/jmv.25689. PMC 7167192. PMID 31994742.
  10. ^ Famulare, Mike (2020-02-19). "2019-nCoV: preliminary estimates of the confirmed-case-fatality-ratio and infection-fatality-ratio, and initial pandemic risk assessment". institutefordiseasemodeling.github.io. Retrieved 2020-03-02.