Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 18:14, 4 November 2007 (UTC)
[edit]Proteins without matches (21)
[edit]Proteins with a High Potential Match (5)
[edit]Redirected Proteins (1)
[edit]Manual Inspection (Page not found) (19)
[edit]
Protein Status Grid - Date: 18:14, 4 November 2007 (UTC)
[edit]Vebose Log - Date: 18:14, 4 November 2007 (UTC)
[edit]- INFO: Beginning work on AURKA... {November 4, 2007 10:01:15 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AURKA image.jpg {November 4, 2007 10:02:08 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 10:02:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AURKA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mq4.
| PDB = {{PDB2|1mq4}}, {{PDB2|1muo}}, {{PDB2|1ol5}}, {{PDB2|1ol6}}, {{PDB2|1ol7}}, {{PDB2|2bmc}}, {{PDB2|2c6d}}, {{PDB2|2c6e}}, {{PDB2|2j4z}}, {{PDB2|2j50}}, {{PDB2|2np8}}
| Name = Aurora kinase A
| HGNCid = 11393
| Symbol = AURKA
| AltSymbols =; AIK; ARK1; AURA; AURORA2; BTAK; MGC34538; STK15; STK6; STK7
| OMIM = 603072
| ECnumber =
| Homologene = 2670
| MGIid = 894678
| GeneAtlas_image1 = PBB_GE_AURKA_204092_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AURKA_208079_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005819 |text = spindle}}
| Process = {{GNF_GO|id=GO:0000278 |text = mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007051 |text = spindle organization and biogenesis}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0031647 |text = regulation of protein stability}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6790
| Hs_Ensembl = ENSG00000087586
| Hs_RefseqProtein = NP_003591
| Hs_RefseqmRNA = NM_003600
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 54377852
| Hs_GenLoc_end = 54400758
| Hs_Uniprot = O14965
| Mm_EntrezGene = 20878
| Mm_Ensembl = ENSMUSG00000027496
| Mm_RefseqmRNA = NM_011497
| Mm_RefseqProtein = NP_035627
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 172047401
| Mm_GenLoc_end = 172061711
| Mm_Uniprot = Q3TEY6
}}
}}
'''Aurora kinase A''', also known as '''AURKA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: AURKA aurora kinase A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6790| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nigg EA |title=Mitotic kinases as regulators of cell division and its checkpoints. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 1 |pages= 21-32 |year= 2001 |pmid= 11413462 |doi= 10.1038/35048096 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BCL6... {November 4, 2007 9:32:48 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 9:33:46 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 9:34:04 AM PST}
- CREATED: Created new protein page: BCL6 {November 4, 2007 9:34:17 AM PST}
- INFO: Beginning work on CALR... {November 4, 2007 9:34:17 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CALR image.jpg {November 4, 2007 9:36:33 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:36:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CALR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hhn.
| PDB = {{PDB2|1hhn}}, {{PDB2|1k91}}, {{PDB2|1k9c}}
| Name = Calreticulin
| HGNCid = 1455
| Symbol = CALR
| AltSymbols =; FLJ26680; RO; SSA; cC1qR
| OMIM = 109091
| ECnumber =
| Homologene = 37911
| MGIid = 88252
| GeneAtlas_image1 = PBB_GE_CALR_200935_at_tn.png
| GeneAtlas_image2 = PBB_GE_CALR_212953_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CALR_214315_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006611 |text = protein export from nucleus}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0030866 |text = cortical actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0040020 |text = regulation of meiosis}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 811
| Hs_Ensembl = ENSG00000179218
| Hs_RefseqProtein = NP_004334
| Hs_RefseqmRNA = NM_004343
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 12910392
| Hs_GenLoc_end = 12916274
| Hs_Uniprot = P27797
| Mm_EntrezGene = 12317
| Mm_Ensembl = ENSMUSG00000003814
| Mm_RefseqmRNA = NM_007591
| Mm_RefseqProtein = NP_031617
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 87731955
| Mm_GenLoc_end = 87736972
| Mm_Uniprot = Q3TVD2
}}
}}
'''Calreticulin''', also known as '''CALR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.<ref>{{cite web | title = Entrez Gene: CALR calreticulin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=811| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coppolino MG, Dedhar S |title=Calreticulin. |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 5 |pages= 553-8 |year= 1998 |pmid= 9693955 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CASP1... {November 4, 2007 9:36:50 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CASP1 image.jpg {November 4, 2007 9:37:11 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:37:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CASP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bmq.
| PDB = {{PDB2|1bmq}}, {{PDB2|1ibc}}, {{PDB2|1ice}}, {{PDB2|1rwk}}, {{PDB2|1rwm}}, {{PDB2|1rwn}}, {{PDB2|1rwo}}, {{PDB2|1rwp}}, {{PDB2|1rwv}}, {{PDB2|1rww}}, {{PDB2|1rwx}}, {{PDB2|1sc1}}, {{PDB2|1sc3}}, {{PDB2|1sc4}}, {{PDB2|2fqq}}, {{PDB2|2h48}}, {{PDB2|2hbq}}, {{PDB2|2hbr}}, {{PDB2|2hby}}, {{PDB2|2hbz}}
| Name = Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
| HGNCid = 1499
| Symbol = CASP1
| AltSymbols =; ICE; IL1BC; P45
| OMIM = 147678
| ECnumber =
| Homologene = 7653
| MGIid = 96544
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} {{GNF_GO|id=GO:0008656 |text = caspase activator activity}} {{GNF_GO|id=GO:0030693 |text = caspase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 834
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001214
| Hs_RefseqmRNA = NM_001223
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12362
| Mm_Ensembl = ENSMUSG00000025888
| Mm_RefseqmRNA = NM_009807
| Mm_RefseqProtein = NP_033937
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 5298517
| Mm_GenLoc_end = 5307285
| Mm_Uniprot = P29452
}}
}}
'''Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)''', also known as '''CASP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.<ref>{{cite web | title = Entrez Gene: CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=834| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCL3... {November 4, 2007 9:55:27 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCL3 image.jpg {November 4, 2007 9:56:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:56:23 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b50.
| PDB = {{PDB2|1b50}}, {{PDB2|1b53}}
| Name = Chemokine (C-C motif) ligand 3
| HGNCid = 10627
| Symbol = CCL3
| AltSymbols =; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
| OMIM = 182283
| ECnumber =
| Homologene = 88430
| MGIid =
| GeneAtlas_image1 = PBB_GE_CCL3_205114_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0008009 |text = chemokine activity}} {{GNF_GO|id=GO:0042056 |text = chemoattractant activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0045069 |text = regulation of viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6348
| Hs_Ensembl = ENSG00000006075
| Hs_RefseqProtein = NP_002974
| Hs_RefseqmRNA = NM_002983
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 31439737
| Hs_GenLoc_end = 31441517
| Hs_Uniprot = P10147
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chemokine (C-C motif) ligand 3''', also known as '''CCL3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Macrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CCL3 chemokine (C-C motif) ligand 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6348| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Menten P, Wuyts A, Van Damme J |title=Macrophage inflammatory protein-1. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 6 |pages= 455-81 |year= 2003 |pmid= 12401480 |doi= }}
*{{cite journal | author=Muthumani K, Desai BM, Hwang DS, ''et al.'' |title=HIV-1 Vpr and anti-inflammatory activity. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 239-47 |year= 2004 |pmid= 15142381 |doi= 10.1089/104454904773819824 }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi= }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRYAB... {November 4, 2007 9:37:25 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:38:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Crystallin, alpha B
| HGNCid = 2389
| Symbol = CRYAB
| AltSymbols =; CRYA2; CTPP2; HSPB5
| OMIM = 123590
| ECnumber =
| Homologene = 68209
| MGIid = 88516
| GeneAtlas_image1 = PBB_GE_CRYAB_209283_at_tn.png
| Function = {{GNF_GO|id=GO:0005212 |text = structural constituent of eye lens}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005626 |text = insoluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0030018 |text = Z disc}} {{GNF_GO|id=GO:0043292 |text = contractile fiber}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007601 |text = visual perception}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1410
| Hs_Ensembl = ENSG00000109846
| Hs_RefseqProtein = NP_001876
| Hs_RefseqmRNA = NM_001885
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 111284560
| Hs_GenLoc_end = 111287704
| Hs_Uniprot = P02511
| Mm_EntrezGene = 12955
| Mm_Ensembl = ENSMUSG00000032060
| Mm_RefseqmRNA = NM_009964
| Mm_RefseqProtein = NP_034094
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 50503555
| Mm_GenLoc_end = 50508863
| Mm_Uniprot = Q52L78
}}
}}
'''Crystallin, alpha B''', also known as '''CRYAB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.<ref>{{cite web | title = Entrez Gene: CRYAB crystallin, alpha B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1410| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Derham BK, Harding JJ |title=Alpha-crystallin as a molecular chaperone. |journal=Progress in retinal and eye research |volume=18 |issue= 4 |pages= 463-509 |year= 1999 |pmid= 10217480 |doi= }}
*{{cite journal | author=Calinisan V, Gravem D, Chen RP, ''et al.'' |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646-66 |year= 2006 |pmid= 16368544 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DLG4... {November 4, 2007 9:38:16 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DLG4 image.jpg {November 4, 2007 9:39:09 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 9:39:22 AM PST}
- CREATED: Created new protein page: DLG4 {November 4, 2007 9:39:30 AM PST}
- INFO: Beginning work on EIF4E... {November 4, 2007 9:39:30 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EIF4E image.jpg {November 4, 2007 9:40:52 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:41:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EIF4E_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ej1.
| PDB = {{PDB2|1ej1}}, {{PDB2|1ej4}}, {{PDB2|1ejh}}, {{PDB2|1ipb}}, {{PDB2|1ipc}}, {{PDB2|1l8b}}, {{PDB2|1wkw}}, {{PDB2|2gpq}}
| Name = Eukaryotic translation initiation factor 4E
| HGNCid = 3287
| Symbol = EIF4E
| AltSymbols =; CBP; EIF4F; EIF4E1; EIF4EL1; MGC111573
| OMIM = 133440
| ECnumber =
| Homologene = 84699
| MGIid = 95305
| GeneAtlas_image1 = PBB_GE_EIF4E_201436_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF4E_201435_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_EIF4E_201437_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000339 |text = RNA cap binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}} {{GNF_GO|id=GO:0006417 |text = regulation of translation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1977
| Hs_Ensembl = ENSG00000151247
| Hs_RefseqProtein = NP_001959
| Hs_RefseqmRNA = NM_001968
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 100020236
| Hs_GenLoc_end = 100070139
| Hs_Uniprot = P06730
| Mm_EntrezGene = 13684
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_007917
| Mm_RefseqProtein = NP_031943
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Eukaryotic translation initiation factor 4E''', also known as '''EIF4E''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jain S, Khuri FR, Shin DM |title=Prevention of head and neck cancer: current status and future prospects. |journal=Current problems in cancer |volume=28 |issue= 5 |pages= 265-86 |year= 2004 |pmid= 15375804 |doi= }}
*{{cite journal | author=Culjkovic B, Topisirovic I, Borden KL |title=Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E. |journal=Cell Cycle |volume=6 |issue= 1 |pages= 65-9 |year= 2007 |pmid= 17245113 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL28RA... {November 4, 2007 10:05:05 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 10:05:33 AM PST}
- CREATED: Created new protein page: IL28RA {November 4, 2007 10:05:40 AM PST}
- INFO: Beginning work on IL4R... {November 4, 2007 9:41:12 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL4R image.jpg {November 4, 2007 9:41:44 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 9:41:59 AM PST}
- CREATED: Created new protein page: IL4R {November 4, 2007 9:42:07 AM PST}
- INFO: Beginning work on KPNB1... {November 4, 2007 9:42:07 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KPNB1 image.jpg {November 4, 2007 9:44:48 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 9:45:14 AM PST}
- CREATED: Created new protein page: KPNB1 {November 4, 2007 9:45:23 AM PST}
- INFO: Beginning work on LGALS3... {November 4, 2007 9:45:23 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LGALS3 image.jpg {November 4, 2007 9:45:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:46:18 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LGALS3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a3k.
| PDB = {{PDB2|1a3k}}, {{PDB2|1kjl}}, {{PDB2|1kjr}}, {{PDB2|2nmn}}, {{PDB2|2nmo}}, {{PDB2|2nn8}}
| Name = Lectin, galactoside-binding, soluble, 3
| HGNCid = 6563
| Symbol = LGALS3
| AltSymbols =; LGALS2; CBP35; GAL3; GALBP; GALIG; MAC2
| OMIM = 153619
| ECnumber =
| Homologene = 37608
| MGIid = 96778
| GeneAtlas_image1 = PBB_GE_LGALS3_208949_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0019863 |text = IgE binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3958
| Hs_Ensembl = ENSG00000131981
| Hs_RefseqProtein = NP_919308
| Hs_RefseqmRNA = NM_194327
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 54673452
| Hs_GenLoc_end = 54681879
| Hs_Uniprot = P17931
| Mm_EntrezGene = 16854
| Mm_Ensembl = ENSMUSG00000050335
| Mm_RefseqmRNA = NM_010705
| Mm_RefseqProtein = NP_034835
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 46295795
| Mm_GenLoc_end = 46308037
| Mm_Uniprot = Q3V471
}}
}}
'''Lectin, galactoside-binding, soluble, 3''', also known as '''LGALS3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Barondes SH, Cooper DN, Gitt MA, Leffler H |title=Galectins. Structure and function of a large family of animal lectins. |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 20807-10 |year= 1994 |pmid= 8063692 |doi= }}
*{{cite journal | author=Nakahara S, Oka N, Raz A |title=On the role of galectin-3 in cancer apoptosis. |journal=Apoptosis |volume=10 |issue= 2 |pages= 267-75 |year= 2005 |pmid= 15843888 |doi= 10.1007/s10495-005-0801-y }}
*{{cite journal | author=Fukumori T, Kanayama HO, Raz A |title=The role of galectin-3 in cancer drug resistance. |journal=Drug Resist. Updat. |volume=10 |issue= 3 |pages= 101-8 |year= 2007 |pmid= 17544840 |doi= 10.1016/j.drup.2007.04.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LTA... {November 4, 2007 9:46:18 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 9:47:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:47:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LTA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tnr.
| PDB = {{PDB2|1tnr}}
| Name = Lymphotoxin alpha (TNF superfamily, member 1)
| HGNCid = 6709
| Symbol = LTA
| AltSymbols =; LT; TNFB; TNFSF1
| OMIM = 153440
| ECnumber =
| Homologene = 497
| MGIid = 104797
| GeneAtlas_image1 = PBB_GE_LTA_206975_at_tn.png
| GeneAtlas_image2 = PBB_GE_LTA_gnf1h00007_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0048535 |text = lymph node development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4049
| Hs_Ensembl = ENSG00000204496
| Hs_RefseqProtein = NP_000586
| Hs_RefseqmRNA = NM_000595
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 31648042
| Hs_GenLoc_end = 31650080
| Hs_Uniprot = P01374
| Mm_EntrezGene = 16992
| Mm_Ensembl = ENSMUSG00000024402
| Mm_RefseqmRNA = NM_010735
| Mm_RefseqProtein = NP_034865
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 34811218
| Mm_GenLoc_end = 34813403
| Mm_Uniprot = Q542S2
}}
}}
'''Lymphotoxin alpha (TNF superfamily, member 1)''', also known as '''LTA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.<ref>{{cite web | title = Entrez Gene: LTA lymphotoxin alpha (TNF superfamily, member 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4049| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Körner H, Sedgwick JD |title=Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity. |journal=Immunol. Cell Biol. |volume=74 |issue= 5 |pages= 465-72 |year= 1997 |pmid= 8912010 |doi= }}
*{{cite journal | author=Wang Q |title=Molecular genetics of coronary artery disease. |journal=Curr. Opin. Cardiol. |volume=20 |issue= 3 |pages= 182-8 |year= 2005 |pmid= 15861005 |doi= }}
*{{cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093-101 |year= 2006 |pmid= 16375755 |doi= }}
*{{cite journal | author=Elewaut D, Ware CF |title=The unconventional role of LT alpha beta in T cell differentiation. |journal=Trends Immunol. |volume=28 |issue= 4 |pages= 169-75 |year= 2007 |pmid= 17336158 |doi= 10.1016/j.it.2007.02.005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MCL1... {November 4, 2007 9:47:31 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MCL1 image.jpg {November 4, 2007 9:48:53 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:49:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MCL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nl9.
| PDB = {{PDB2|2nl9}}, {{PDB2|2nla}}
| Name = Myeloid cell leukemia sequence 1 (BCL2-related)
| HGNCid = 6943
| Symbol = MCL1
| AltSymbols =; EAT; MCL1L; MCL1S; MGC104264; MGC1839; TM
| OMIM = 159552
| ECnumber =
| Homologene = 7413
| MGIid = 101769
| GeneAtlas_image1 = PBB_GE_MCL1_200797_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MCL1_200796_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MCL1_200798_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015266 |text = protein channel activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0019725 |text = cell homeostasis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4170
| Hs_Ensembl = ENSG00000143384
| Hs_RefseqProtein = NP_068779
| Hs_RefseqmRNA = NM_021960
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 148813661
| Hs_GenLoc_end = 148818760
| Hs_Uniprot = Q07820
| Mm_EntrezGene = 17210
| Mm_Ensembl = ENSMUSG00000038612
| Mm_RefseqmRNA = XM_976767
| Mm_RefseqProtein = XP_981861
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 95744192
| Mm_GenLoc_end = 95748588
| Mm_Uniprot = P97287
}}
}}
'''Myeloid cell leukemia sequence 1 (BCL2-related)''', also known as '''MCL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.<ref>{{cite web | title = Entrez Gene: MCL1 myeloid cell leukemia sequence 1 (BCL2-related)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4170| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yang-Yen HF |title=Mcl-1: a highly regulated cell death and survival controller. |journal=J. Biomed. Sci. |volume=13 |issue= 2 |pages= 201-4 |year= 2006 |pmid= 16456709 |doi= 10.1007/s11373-005-9064-4 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYOC... {November 4, 2007 9:49:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:49:58 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myocilin, trabecular meshwork inducible glucocorticoid response
| HGNCid = 7610
| Symbol = MYOC
| AltSymbols =; GLC1A; GPOA; JOAG; JOAG1; TIGR; myocilin
| OMIM = 601652
| ECnumber =
| Homologene = 220
| MGIid = 1202864
| GeneAtlas_image1 = PBB_GE_MYOC_210155_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016524 |text = latrotoxin receptor activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005929 |text = cilium}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4653
| Hs_Ensembl = ENSG00000034971
| Hs_RefseqProtein = NP_000252
| Hs_RefseqmRNA = NM_000261
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 169871180
| Hs_GenLoc_end = 169888434
| Hs_Uniprot = Q99972
| Mm_EntrezGene = 17926
| Mm_Ensembl = ENSMUSG00000026697
| Mm_RefseqmRNA = NM_010865
| Mm_RefseqProtein = NP_034995
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 164475844
| Mm_GenLoc_end = 164486368
| Mm_Uniprot = Q05AC1
}}
}}
'''Myocilin, trabecular meshwork inducible glucocorticoid response''', also known as '''MYOC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.<ref>{{cite web | title = Entrez Gene: MYOC myocilin, trabecular meshwork inducible glucocorticoid response| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4653| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fingert JH, Stone EM, Sheffield VC, Alward WL |title=Myocilin glaucoma. |journal=Survey of ophthalmology |volume=47 |issue= 6 |pages= 547-61 |year= 2003 |pmid= 12504739 |doi= }}
*{{cite journal | author=Polansky JR |title=Current perspectives on the TIGR/MYOC gene (Myocilin) and glaucoma. |journal=Ophthalmology clinics of North America |volume=16 |issue= 4 |pages= 515-27, v-vi |year= 2004 |pmid= 14740993 |doi= }}
*{{cite journal | author=Coca-Prados M, Escribano J |title=New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland. |journal=Progress in retinal and eye research |volume=26 |issue= 3 |pages= 239-62 |year= 2007 |pmid= 17321191 |doi= 10.1016/j.preteyeres.2007.01.002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NME1... {November 4, 2007 9:49:58 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NME1 image.jpg {November 4, 2007 9:50:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:50:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NME1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1be4.
| PDB = {{PDB2|1be4}}, {{PDB2|1bhn}}, {{PDB2|1jxv}}, {{PDB2|1ucn}}, {{PDB2|2hvd}}, {{PDB2|2hve}}
| Name = Non-metastatic cells 1, protein (NM23A) expressed in
| HGNCid = 7849
| Symbol = NME1
| AltSymbols =; AWD; GAAD; NDPKA; NM23; NM23-H1
| OMIM = 156490
| ECnumber =
| Homologene = 56418
| MGIid = 97355
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004536 |text = deoxyribonuclease activity}} {{GNF_GO|id=GO:0004550 |text = nucleoside diphosphate kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006183 |text = GTP biosynthetic process}} {{GNF_GO|id=GO:0006228 |text = UTP biosynthetic process}} {{GNF_GO|id=GO:0006241 |text = CTP biosynthetic process}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009117 |text = nucleotide metabolic process}} {{GNF_GO|id=GO:0009142 |text = nucleoside triphosphate biosynthetic process}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4830
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000260
| Hs_RefseqmRNA = NM_000269
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 18102
| Mm_Ensembl = ENSMUSG00000037601
| Mm_RefseqmRNA = XM_982532
| Mm_RefseqProtein = XP_987626
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 93773067
| Mm_GenLoc_end = 93784347
| Mm_Uniprot = Q5NC80
}}
}}
'''Non-metastatic cells 1, protein (NM23A) expressed in''', also known as '''NME1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.<ref>{{cite web | title = Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4830| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Freije JM, MacDonald NJ, Steeg PS |title=Nm23 and tumour metastasis: basic and translational advances. |journal=Biochem. Soc. Symp. |volume=63 |issue= |pages= 261-71 |year= 1998 |pmid= 9513729 |doi= }}
*{{cite journal | author=Roymans D, Willems R, Van Blockstaele DR, Slegers H |title=Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis. |journal=Clin. Exp. Metastasis |volume=19 |issue= 6 |pages= 465-76 |year= 2002 |pmid= 12405283 |doi= }}
*{{cite journal | author=Tee YT, Chen GD, Lin LY, ''et al.'' |title=Nm23-H1: a metastasis-associated gene. |journal=Taiwanese journal of obstetrics & gynecology |volume=45 |issue= 2 |pages= 107-13 |year= 2007 |pmid= 17197349 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NOS1... {November 4, 2007 9:50:39 AM PST}
- UPLOAD: Added new Image to wiki: {November 4, 2007 9:51:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:51:45 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NOS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b8q.
| PDB = {{PDB2|1b8q}}, {{PDB2|1f20}}, {{PDB2|1k2r}}, {{PDB2|1k2s}}, {{PDB2|1k2t}}, {{PDB2|1k2u}}, {{PDB2|1lzx}}, {{PDB2|1lzz}}, {{PDB2|1m00}}, {{PDB2|1mmv}}, {{PDB2|1mmw}}, {{PDB2|1om4}}, {{PDB2|1om5}}, {{PDB2|1p6h}}, {{PDB2|1p6i}}, {{PDB2|1p6j}}, {{PDB2|1p6k}}, {{PDB2|1qau}}, {{PDB2|1qav}}, {{PDB2|1qw6}}, {{PDB2|1qwc}}, {{PDB2|1rs6}}, {{PDB2|1rs7}}, {{PDB2|1tll}}, {{PDB2|1vag}}, {{PDB2|1zvi}}, {{PDB2|1zvl}}, {{PDB2|1zzq}}, {{PDB2|1zzr}}, {{PDB2|1zzu}}, {{PDB2|2g6h}}, {{PDB2|2g6i}}, {{PDB2|2g6j}}, {{PDB2|2g6k}}, {{PDB2|2g6l}}, {{PDB2|2g6m}}, {{PDB2|2g6n}}, {{PDB2|2hx3}}, {{PDB2|2hx4}}
| Name = Nitric oxide synthase 1 (neuronal)
| HGNCid = 7872
| Symbol = NOS1
| AltSymbols =; IHPS1; NOS
| OMIM = 163731
| ECnumber =
| Homologene = 37327
| MGIid = 97360
| GeneAtlas_image1 = PBB_GE_NOS1_207309_at_tn.png
| GeneAtlas_image2 = PBB_GE_NOS1_207310_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004517 |text = nitric-oxide synthase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0010181 |text = FMN binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050660 |text = FAD binding}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006809 |text = nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4842
| Hs_Ensembl = ENSG00000089250
| Hs_RefseqProtein = NP_000611
| Hs_RefseqmRNA = NM_000620
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 116135362
| Hs_GenLoc_end = 116283965
| Hs_Uniprot = P29475
| Mm_EntrezGene = 18125
| Mm_Ensembl = ENSMUSG00000029361
| Mm_RefseqmRNA = XM_992536
| Mm_RefseqProtein = XP_997630
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 118103174
| Mm_GenLoc_end = 118219870
| Mm_Uniprot = Q9JJ30
}}
}}
'''Nitric oxide synthase 1 (neuronal)''', also known as '''NOS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Miyagoe-Suzuki Y, Takeda SI |title=Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma. |journal=Microsc. Res. Tech. |volume=55 |issue= 3 |pages= 164-70 |year= 2002 |pmid= 11747091 |doi= 10.1002/jemt.1167 }}
*{{cite journal | author=Waddington SN |title=Arginase in glomerulonephritis. |journal=Kidney Int. |volume=61 |issue= 3 |pages= 876-81 |year= 2002 |pmid= 11849441 |doi= 10.1046/j.1523-1755.2002.00236.x }}
*{{cite journal | author=Rotilio G, Aquilano K, Ciriolo MR |title=Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes. |journal=IUBMB Life |volume=55 |issue= 10-11 |pages= 629-34 |year= 2004 |pmid= 14711010 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPPB... {November 4, 2007 9:51:45 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:52:17 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Natriuretic peptide precursor B
| HGNCid = 7940
| Symbol = NPPB
| AltSymbols =; BNP
| OMIM = 600295
| ECnumber =
| Homologene = 81698
| MGIid =
| GeneAtlas_image1 = PBB_GE_NPPB_206801_at_tn.png
| Function = {{GNF_GO|id=GO:0008613 |text = diuretic hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007589 |text = fluid secretion}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0030146 |text = diuresis}} {{GNF_GO|id=GO:0030147 |text = natriuresis}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0042312 |text = regulation of vasodilation}} {{GNF_GO|id=GO:0043114 |text = regulation of vascular permeability}} {{GNF_GO|id=GO:0050880 |text = regulation of blood vessel size}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4879
| Hs_Ensembl = ENSG00000120937
| Hs_RefseqProtein = NP_002512
| Hs_RefseqmRNA = NM_002521
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 11840108
| Hs_GenLoc_end = 11841575
| Hs_Uniprot = P16860
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Natriuretic peptide precursor B''', also known as '''NPPB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.<ref>{{cite web | title = Entrez Gene: NPPB natriuretic peptide precursor B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4879| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cosson S |title=Usefulness of B-type natriuretic peptide (BNP) as a screen for left ventricular abnormalities in diabetes mellitus. |journal=Diabetes Metab. |volume=30 |issue= 4 |pages= 381-6 |year= 2004 |pmid= 15525883 |doi= }}
*{{cite journal | author=Cauliez B, Berthe MC, Lavoinne A |title=[Brain natriuretic peptide: physiological, biological and clinical aspects] |journal=Ann. Biol. Clin. (Paris) |volume=63 |issue= 1 |pages= 15-25 |year= 2005 |pmid= 15689309 |doi= }}
*{{cite journal | author=Buchner S, Riegger G, Luchner A |title=[Clinical utility of the cardiac markers BNP and NT-proBNP] |journal=Acta Med. Austriaca |volume=31 |issue= 4 |pages= 144-51 |year= 2005 |pmid= 15732251 |doi= }}
*{{cite journal | author=LaPointe MC |title=Molecular regulation of the brain natriuretic peptide gene. |journal=Peptides |volume=26 |issue= 6 |pages= 944-56 |year= 2005 |pmid= 15911064 |doi= 10.1016/j.peptides.2004.08.028 }}
*{{cite journal | author=Hoffmann U, Borggrefe M, Brueckmann M |title=New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit. |journal=Critical care (London, England) |volume=10 |issue= 2 |pages= 134 |year= 2006 |pmid= 16594987 |doi= 10.1186/cc4883 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PIK3CG... {November 4, 2007 9:52:17 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 9:53:14 AM PST}
- SEARCH REDIRECT: Control Box Found: PIK3R1 {November 4, 2007 9:53:38 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 4, 2007 9:53:39 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 4, 2007 9:53:39 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 4, 2007 9:53:39 AM PST}
- UPDATED: Updated protein page: PIK3R1 {November 4, 2007 9:53:45 AM PST}
- INFO: Beginning work on PSEN2... {November 4, 2007 9:53:45 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:55:06 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Presenilin 2 (Alzheimer disease 4)
| HGNCid = 9509
| Symbol = PSEN2
| AltSymbols =; AD3L; AD4; PS2; STM2
| OMIM = 600759
| ECnumber =
| Homologene = 386
| MGIid = 109284
| GeneAtlas_image1 = PBB_GE_PSEN2_204261_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSEN2_204262_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PSEN2_211373_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005639 |text = integral to nuclear inner membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001708 |text = cell fate specification}} {{GNF_GO|id=GO:0006509 |text = membrane protein ectodomain proteolysis}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007220 |text = Notch receptor processing}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008632 |text = apoptotic program}} {{GNF_GO|id=GO:0016485 |text = protein processing}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0042640 |text = anagen}} {{GNF_GO|id=GO:0042987 |text = amyloid precursor protein catabolic process}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043085 |text = positive regulation of enzyme activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5664
| Hs_Ensembl = ENSG00000143801
| Hs_RefseqProtein = NP_000438
| Hs_RefseqmRNA = NM_000447
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 225124887
| Hs_GenLoc_end = 225150422
| Hs_Uniprot = P49810
| Mm_EntrezGene = 19165
| Mm_Ensembl = ENSMUSG00000010609
| Mm_RefseqmRNA = NM_011183
| Mm_RefseqProtein = NP_035313
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 182063681
| Mm_GenLoc_end = 182082576
| Mm_Uniprot = Q3U4P5
}}
}}
'''Presenilin 2 (Alzheimer disease 4)''', also known as '''PSEN2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.<ref>{{cite web | title = Entrez Gene: PSEN2 presenilin 2 (Alzheimer disease 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5664| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cruts M, Van Broeckhoven C |title=Presenilin mutations in Alzheimer's disease. |journal=Hum. Mutat. |volume=11 |issue= 3 |pages= 183-90 |year= 1998 |pmid= 9521418 |doi= 10.1002/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.0.CO;2-J }}
*{{cite journal | author=McGeer PL, Kawamata T, McGeer EG |title=Localization and possible functions of presenilins in brain. |journal=Reviews in the neurosciences |volume=9 |issue= 1 |pages= 1-15 |year= 1998 |pmid= 9683324 |doi= }}
*{{cite journal | author=Nishimura M, Yu G, St George-Hyslop PH |title=Biology of presenilins as causative molecules for Alzheimer disease. |journal=Clin. Genet. |volume=55 |issue= 4 |pages= 219-25 |year= 1999 |pmid= 10361981 |doi= }}
*{{cite journal | author=da Costa CA |title=Recent insights on the pro-apoptotic phenotype elicited by presenilin 2 and its caspase and presenilinase-derived fragments. |journal=Current Alzheimer research |volume=2 |issue= 5 |pages= 507-14 |year= 2006 |pmid= 16375654 |doi= }}
*{{cite journal | author=Wolfe MS |title=When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease. |journal=EMBO Rep. |volume=8 |issue= 2 |pages= 136-40 |year= 2007 |pmid= 17268504 |doi= 10.1038/sj.embor.7400896 }}
*{{cite journal | author=De Strooper B |title=Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. |journal=EMBO Rep. |volume=8 |issue= 2 |pages= 141-6 |year= 2007 |pmid= 17268505 |doi= 10.1038/sj.embor.7400897 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PXN... {November 4, 2007 9:55:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:55:26 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Paxillin
| HGNCid = 9718
| Symbol = PXN
| AltSymbols =; FLJ16691
| OMIM = 602505
| ECnumber =
| Homologene = 37697
| MGIid = 108295
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017166 |text = vinculin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007172 |text = signal complex assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5829
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002850
| Hs_RefseqmRNA = NM_002859
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 19303
| Mm_Ensembl = ENSMUSG00000029528
| Mm_RefseqmRNA = NM_011223
| Mm_RefseqProtein = NP_035353
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 115767727
| Mm_GenLoc_end = 115816985
| Mm_Uniprot = O88294
}}
}}
'''Paxillin''', also known as '''PXN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Turner CE |title=Paxillin. |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 9 |pages= 955-9 |year= 1998 |pmid= 9785458 |doi= }}
*{{cite journal | author=Panetti TS |title=Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. |journal=Front. Biosci. |volume=7 |issue= |pages= d143-50 |year= 2002 |pmid= 11779709 |doi= }}
*{{cite journal | author=Rose DM, Han J, Ginsberg MH |title=Alpha4 integrins and the immune response. |journal=Immunol. Rev. |volume=186 |issue= |pages= 118-24 |year= 2003 |pmid= 12234367 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SERPINA3... {November 4, 2007 9:30:13 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 9:32:27 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:32:48 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINA3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1as4.
| PDB = {{PDB2|1as4}}, {{PDB2|1qmn}}, {{PDB2|2ach}}, {{PDB2|3caa}}, {{PDB2|4caa}}
| Name = Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
| HGNCid = 16
| Symbol = SERPINA3
| AltSymbols =; AACT; ACT; GIG24; GIG25; MGC88254
| OMIM = 107280
| ECnumber =
| Homologene = 40658
| MGIid = 105045
| GeneAtlas_image1 = PBB_GE_SERPINA3_202376_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030569 |text = chymotrypsin inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0019216 |text = regulation of lipid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 12
| Hs_Ensembl = ENSG00000196136
| Hs_RefseqProtein = NP_001076
| Hs_RefseqmRNA = NM_001085
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 94148467
| Hs_GenLoc_end = 94160142
| Hs_Uniprot = P01011
| Mm_EntrezGene = 20716
| Mm_Ensembl = ENSMUSG00000021091
| Mm_RefseqmRNA = NM_009252
| Mm_RefseqProtein = NP_033278
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 104807779
| Mm_GenLoc_end = 104815378
| Mm_Uniprot = Q91WP6
}}
}}
'''Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3''', also known as '''SERPINA3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.<ref>{{cite web | title = Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Janciauskiene S, Wright HT |title=Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease. |journal=Bioessays |volume=20 |issue= 12 |pages= 1039-46 |year= 1999 |pmid= 10048303 |doi= 10.1002/(SICI)1521-1878(199812)20:12<1039::AID-BIES10>3.0.CO;2-Z }}
*{{cite journal | author=Kalsheker N, Morley S, Morgan K |title=Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. |journal=Biochem. Soc. Trans. |volume=30 |issue= 2 |pages= 93-8 |year= 2002 |pmid= 12023832 |doi= 10.1042/ }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC2A1... {November 4, 2007 9:56:23 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 9:57:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 2 (facilitated glucose transporter), member 1
| HGNCid = 11005
| Symbol = SLC2A1
| AltSymbols =; GLUT; GLUT1; MGC141895; MGC141896
| OMIM = 138140
| ECnumber =
| Homologene = 68520
| MGIid = 95755
| GeneAtlas_image1 = PBB_GE_SLC2A1_201250_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC2A1_201249_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005351 |text = sugar:hydrogen ion symporter activity}} {{GNF_GO|id=GO:0005355 |text = glucose transmembrane transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}}
| Process = {{GNF_GO|id=GO:0008643 |text = carbohydrate transport}} {{GNF_GO|id=GO:0015758 |text = glucose transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6513
| Hs_Ensembl = ENSG00000117394
| Hs_RefseqProtein = NP_006507
| Hs_RefseqmRNA = NM_006516
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 43164106
| Hs_GenLoc_end = 43197117
| Hs_Uniprot = P11166
| Mm_EntrezGene = 20525
| Mm_Ensembl = ENSMUSG00000028645
| Mm_RefseqmRNA = NM_011400
| Mm_RefseqProtein = NP_035530
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 118606700
| Mm_GenLoc_end = 118635259
| Mm_Uniprot = Q3TD17
}}
}}
'''Solute carrier family 2 (facilitated glucose transporter), member 1''', also known as '''SLC2A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. GLUT1 is a major glucose transporter in the mammalian blood-brain barrier. It is present at high levels in primate erythrocytes and brain endothelial cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6513| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hruz PW, Mueckler MM |title=Structural analysis of the GLUT1 facilitative glucose transporter (review). |journal=Mol. Membr. Biol. |volume=18 |issue= 3 |pages= 183-93 |year= 2002 |pmid= 11681785 |doi= }}
*{{cite journal | author=Baumann MU, Deborde S, Illsley NP |title=Placental glucose transfer and fetal growth. |journal=Endocrine |volume=19 |issue= 1 |pages= 13-22 |year= 2003 |pmid= 12583599 |doi= }}
*{{cite journal | author=Mobasheri A, Richardson S, Mobasheri R, ''et al.'' |title=Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1327-38 |year= 2006 |pmid= 16136514 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMARCA4... {November 4, 2007 9:57:25 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SMARCA4 image.jpg {November 4, 2007 9:59:36 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 10:00:10 AM PST}
- CREATED: Created new protein page: SMARCA4 {November 4, 2007 10:00:18 AM PST}
- INFO: Beginning work on SP3... {November 4, 2007 10:00:18 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SP3 image.jpg {November 4, 2007 10:00:58 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 10:01:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1va1.
| PDB = {{PDB2|1va1}}
| Name = Sp3 transcription factor
| HGNCid = 11208
| Symbol = SP3
| AltSymbols =; DKFZp686O1631; SPR-2
| OMIM = 601804
| ECnumber =
| Homologene = 7952
| MGIid = 1277166
| GeneAtlas_image1 = PBB_GE_SP3_213168_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001779 |text = natural killer cell differentiation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}} {{GNF_GO|id=GO:0030224 |text = monocyte differentiation}} {{GNF_GO|id=GO:0030851 |text = granulocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6670
| Hs_Ensembl = ENSG00000172845
| Hs_RefseqProtein = NP_001017371
| Hs_RefseqmRNA = NM_001017371
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 174481505
| Hs_GenLoc_end = 174538676
| Hs_Uniprot = Q02447
| Mm_EntrezGene = 20687
| Mm_Ensembl = ENSMUSG00000027109
| Mm_RefseqmRNA = NM_011450
| Mm_RefseqProtein = NP_035580
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 72737266
| Mm_GenLoc_end = 72781285
| Mm_Uniprot = Q2M4I5
}}
}}
'''Sp3 transcription factor''', also known as '''SP3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.<ref>{{cite web | title = Entrez Gene: SP3 Sp3 transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6670| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tseng L, Gao J, Mazella J, ''et al.'' |title=Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium. |journal=Ann. N. Y. Acad. Sci. |volume=828 |issue= |pages= 27-37 |year= 1997 |pmid= 9329821 |doi= }}
*{{cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401-14 |year= 2003 |pmid= 12943729 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WRN... {November 4, 2007 10:02:41 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein WRN image.jpg {November 4, 2007 10:03:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 10:03:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_WRN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2axl.
| PDB = {{PDB2|2axl}}, {{PDB2|2dgz}}, {{PDB2|2e1e}}, {{PDB2|2e1f}}, {{PDB2|2fbt}}, {{PDB2|2fbv}}, {{PDB2|2fbx}}, {{PDB2|2fby}}, {{PDB2|2fc0}}
| Name = Werner syndrome
| HGNCid = 12791
| Symbol = WRN
| AltSymbols =; RECQL2; RECQL3; DKFZp686C2056; RECQ3
| OMIM = 604611
| ECnumber =
| Homologene = 6659
| MGIid = 109635
| GeneAtlas_image1 = PBB_GE_WRN_205667_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003678 |text = DNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0008408 |text = 3'-5' exonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000723 |text = telomere maintenance}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0007568 |text = aging}} {{GNF_GO|id=GO:0040009 |text = regulation of growth rate}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7486
| Hs_Ensembl = ENSG00000165392
| Hs_RefseqProtein = NP_000544
| Hs_RefseqmRNA = NM_000553
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 31010320
| Hs_GenLoc_end = 31150818
| Hs_Uniprot = Q14191
| Mm_EntrezGene = 22427
| Mm_Ensembl = ENSMUSG00000031583
| Mm_RefseqmRNA = XM_986059
| Mm_RefseqProtein = XP_991153
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 34701594
| Mm_GenLoc_end = 34851407
| Mm_Uniprot = Q3TB25
}}
}}
'''Werner syndrome''', also known as '''WRN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of werner syndrome, an autosomal recessive disorder characterized by premature aging.<ref>{{cite web | title = Entrez Gene: WRN Werner syndrome| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7486| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Moser MJ, Oshima J, Monnat RJ |title=WRN mutations in Werner syndrome. |journal=Hum. Mutat. |volume=13 |issue= 4 |pages= 271-9 |year= 1999 |pmid= 10220139 |doi= 10.1002/(SICI)1098-1004(1999)13:4<271::AID-HUMU2>3.0.CO;2-Q }}
*{{cite journal | author=Kastan MB, Lim DS |title=The many substrates and functions of ATM. |journal=Nat. Rev. Mol. Cell Biol. |volume=1 |issue= 3 |pages= 179-86 |year= 2001 |pmid= 11252893 |doi= 10.1038/35043058 }}
*{{cite journal | author=Comai L, Li B |title=The Werner syndrome protein at the crossroads of DNA repair and apoptosis. |journal=Mech. Ageing Dev. |volume=125 |issue= 8 |pages= 521-8 |year= 2005 |pmid= 15336909 |doi= 10.1016/j.mad.2004.06.004 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ZNF3... {November 4, 2007 10:03:32 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 10:04:58 AM PST}
- CREATED: Created new protein page: ZNF3 {November 4, 2007 10:05:05 AM PST}
end log.
