User:Nora Stefani/sandbox
Quorum Sensing
[edit]A. fischeri uses acyl-homoserine lactone (acyl-HSL) quorum sensing, which was first discovered in that microbe.[1] Individual cells produce the autoinducer N-3-(oxohexanoyl) homoserine lactone, or 3-oxo-hexanoyl-HSL, at low quantities. This autoinducer is indirectly produced by the luxL gene.[2] When enough cells amass, autoinducer levels are high enough that they begin to bind to LuxR proteins, which acts as a kinase/phophestase in cascade to upregulate expression of the lux operon. Quorum-sensing-induced bioluminescence in A. fischeri is a positive feedback system and once it is switched on it it would take a dramatic decrease in cell density to turn it back off again.[2]
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Genome
[edit]The genome for A. fischeri was completely sequenced in 2004[3] and consists of two chromosomes, one smaller and one larger. Chromosome 1 has 2.9 million base pairs (mbp) and chromosome 2 has 1.3 mbp, bringing the total genome to to 4.2 mbp.[3]
A. fischeri has the lowest G+C content of 27 Vibrio species, but is still most closely related to the higher-pathogenicity species such as V. cholerae.[3] The genome for A. fischeri also carries mobile genetic elements.[3]
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- ^ Fuqua, Clay; Parsek, Matthew R.; Greenberg, E. Peter (2001). "Regulation of Gene Expression by Cell-to-Cell Communication: Acyl-Homoserine Lactone Quorum Sensing". Annual Review of Genetics. 35 (1): 439–468. doi:10.1146/annurev.genet.35.102401.090913. PMID 11700290.
- ^ a b Schuster, Martin; Sexton, D. Joseph; Diggle, Stephen P.; Greenberg, E. Peter (2013-09-11). "Acyl-Homoserine Lactone Quorum Sensing: From Evolution to Application". Annual Review of Microbiology. 67: 43–63. doi:10.1146/annurev-micro-092412-155635. PMID 23682605. Retrieved 2017-05-18.
- ^ a b c d Ruby, E.G; et al. (December 2004). "Complete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners". Proceedings of the National Academy of Sciences. 102 (8): 3004–2009. doi:10.1073/pnas.0409900102. PMC 549501. PMID 15703294.