User:Meodipt/2021 talk archive
Nomination of GSK-789,472 for deletion
[edit]
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Rhythdybiau (talk) 17:35, 31 March 2021 (UTC)
The article TC-2216 has been proposed for deletion because of the following concern:
The last publication on this was 9 years ago (doi:10.1016/j.bmcl.2012.05.108) so I'm assuming it failed. I don't believe we usually keep pages on failed therapeutics.
While all constructive contributions to Wikipedia are appreciated, pages may be deleted for any of several reasons.
You may prevent the proposed deletion by removing the {{proposed deletion/dated}} notice, but please explain why in your edit summary or on the article's talk page.
Please consider improving the page to address the issues raised. Removing {{proposed deletion/dated}} will stop the proposed deletion process, but other deletion processes exist. In particular, the speedy deletion process can result in deletion without discussion, and articles for deletion allows discussion to reach consensus for deletion. Project Osprey (talk) 15:07, 6 May 2021 (UTC)
GAR for Benzylpiperazine
[edit]Benzylpiperazine, an article that you or your project may be interested in, has been nominated for a community good article reassessment. If you are interested in the discussion, please participate by adding your comments to the reassessment page. If concerns are not addressed during the review period, the good article status may be removed from the article. Hog Farm Talk 06:07, 17 July 2021 (UTC)
CAR-302,282 etc. and the cholinergics template
[edit]I am trying to find literature on the currently redlinked compounds CAR-302,282, CAR-302,368, CAR-302,537, and CAR-302,668. I noticed that you were the user who added these to the cholinergics template. I know that was over a decade ago but do you remember any of the sources you used to add these? I have been very unsuccessful in finding any sources that don't just cite a Wikipedia template for these compounds' existence. Thanks! proton donor H+ 17:41, 1 September 2021 (UTC)
- They are from "Chemical Warfare Secrets Almost Forgotten" by James S. Ketchum, ISBN 978-1424300808. At the time I added them there was also some information available on some website with a US military address (which I found by searching the CAS numbers) but it suddenly disappeared from the open internet very shortly after I started copying the information from it and adding it to wikipedia, I guess it probably wasn't supposed to have been left open to the public! There are some old patents covering these compounds as well. "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents" by the Commission on Life Sciences also mentions some of them too. If you draw the structures and then search for them on PubChem using the SMILES code you can probably find more sources there. Most sources have them listed without the CAR- code, i.e. just as "302282" etc but I didn't think that was really sufficient for a page name so I used the CAR- code for the ones I made pages about. Meodipt (talk) 19:12, 1 September 2021 (UTC)
Upon checking Ketchum's book, these two are in there
but I'm actually not sure where 302368 and 302537 were from, they may have been listed on that military website alongside the others, or in the patents? Meodipt (talk) 20:04, 1 September 2021 (UTC)
- I think one of those other two might be OC1(CCCC1)C(O)(c1ccccc1)C(=O)OC1CN2CCC1CC2 but it is not on PubChem (that structure is shown in Ketchum's book in one place as 226086 but this is listed elsewhere with a different structure that matches the other sources) Meodipt (talk) 20:11, 1 September 2021 (UTC)
- Thanks a ton, this is helpful! I was going to write articles on CAR-302,282 and CAR-302,668, but it looks like you already beat me to it. Thanks for those as well. I'm going to do a bit more digging to see what I can find on the other two. proton donor H+ 04:51, 6 September 2021 (UTC)
- I'm sure there were other patents. I found two that I remembered seeing back in those days but I definitely remember at least 1 other with dozens of related examples. A lot of these compounds don't come up at all if you do a structure search on WIPO PATENTSCOPE and I'm certain they were patented, I think the indexing of patents pre-1990s is still a bit patchy.Meodipt (talk) 09:40, 6 September 2021 (UTC)
Etonitazene
[edit]Hi - sorry for adding here but I cannot work out where else to put it. I am trying to find the patent on the etonitazene derivative that has an (S) carboxamide moiety on the bridgine methylene-CH2- between the benzimidazole & the p-ethoxy phenyl. I think it did appear long ago and disappeared. My interests is that I overlaid it with MCOPPB. I am guessing that it's increased activity is due to nociceptin affinity which, if memory serves, makes it less abusable. I think I even noted the overlay but it was deleted.
Sorry to bother you.
- I moved all those old references to the list of benzimidazole opioids page when I created that, nothing that was there from years ago has been lost. However, while I don't have time to go through and double check right now I'm pretty sure alpha-carboxamido-etonitazene itself is not listed in either the patents or the scientific literature that I could find, I don't think it was ever made. If I remember correctly, the patent claims alpha-carboxamido-nitazene (i.e. with no ethoxy group) is slightly more potent than nitazene but there is no activity data supplied, the only one for which there is activity data in the journal articles is alpha-carboxamido-clonitazene which has the same potency as clonitazene. I reviewed all the old patents and papers as best as I was able to when I made that list of benzimidazole opioids page but I believe there were others that I missed, pretty sure I recall seeing mention of compounds where the 5-nitro was replaced by 5,6-dichloro for instance but I was not able to track down the relevant reference. Not so easy to search when the references are 60 years old and only published in the original German...Meodipt (talk) 21:43, 12 September 2021 (UTC)
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