Tilmacoxib

Tilmacoxib
Pharmacokinetic data
Bioavailability	solution (64–88%) compared with capsule (22–40%).
Identifiers
	IUPAC name 4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide;
CAS Number	180200-68-4 ;
PubChem CID	159271;
ChemSpider	140082;
UNII	G6VI5P84SX;
ChEBI	CHEBI:73041 ;
ChEMBL	ChEMBL34913;
CompTox Dashboard (EPA)	DTXSID0057671 ;
Chemical and physical data
Formula	C16H19FN2O3S
Molar mass	338.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(N)c3ccc(c1oc(nc1C2CCCCC2)C)cc3F;
	InChI InChI=1S/C16H19FN2O3S/c1-10-19-15(11-5-3-2-4-6-11)16(22-10)12-7-8-14(13(17)9-12)23(18,20)21/h7-9,11H,2-6H2,1H3,(H2,18,20,21); Key:MIMJSJSRRDZIPW-UHFFFAOYSA-N;

Tilmacoxib or JTE-522 is a COX-2 inhibitor and is an effective chemopreventive agent against rat experimental liver fibrosis.^[1]

References

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