Talk:Tumor suppressor gene

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Merge?

This article should NOT be merged with the tumor suppressor gene. They are NOT the same thing.

Okay, merge tag removed. Abductive (reasoning) 21:01, 6 June 2010 (UTC)[reply]

Tumor suppressive genes are recessive?

I'm wondering if this can be made a little clearer in the following way. Yes, it is true that tumor suppressor genes tend to act through a recessive mechanism in that both alleles need to be taken out to exhibit a disease. However, tumor suppressor genes overwhelmingly show a dominant pattern of inheritance. Retinoblastoma is an example. Both alleles of retinoblastoma must be mutated to show the disease. This is a recessive mechanism. However, it is listed as a dominant disease, because a child who inherits a faulty allele will almost certainly acquire a second through mutation. So when examining a pedigree of retinoblastoma or Lynch Syndrome, both of which involve mutations of tumor suppressor genes, (mismatch repair in the case of Lynch), they are dominant in transmission. Can we make that clear in this article? It is not the mechanism that determines whether or not a disease is recessive/dominant, but rather the pattern of vertical transmission, from parent to progeny. — Preceding unsigned comment added by Creightonian (talk • contribs) 01:30, 16 December 2010 (UTC)[reply]

I agree Cleverwater (talk) 17:21, 20 April 2016 (UTC)[reply]

Requested move 30 May 2018

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review. No further edits should be made to this section.

The result of the move request was: moved as requested per the discussion below. Dekimasuよ! 23:53, 7 June 2018 (UTC)[reply]

Tumor suppressor gene → Tumor suppressor – The term "tumor suppressor" can refer to a gene as well as to the corresponding gene product, which is usually a protein. Renaming the page would reflect this fact and help to avoid the wrong conclusion that tumor suppressors are only genes. Shinryuu (talk) 10:09, 30 May 2018 (UTC) --Relisting. Dreamy Jazz (talk) 14:35, 5 June 2018 (UTC)[reply]

Support, I don't see why not. Abductive (reasoning) 08:17, 5 June 2018 (UTC)[reply]
Support. Seems fine. Basie (talk) 01:35, 7 June 2018 (UTC)[reply]

The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page or in a move review. No further edits should be made to this section.

Course assessment.

Are the genes that code of checkpoints most likely to be protooncogenes or tumor suppressor genes? Explain. 41.223.117.37 (talk) 17:08, 19 January 2022 (UTC)[reply]