Talk:Streptococcus pyogenes

Virulence factors

I think under "virulence factors" it's just C5a peptidase (meaning it degrades the complement anaphylotoxin C5a released in the complement cascade) rather than anti-C5a peptidase (meaning it degrades the portion of the cell wall on S. pyogenes that degrades C5a). Just a thought.—Preceding unsigned comment added by 209.90.69.50 (talk • contribs)

Yes, that's correct. I've removed the anti-. 12:48, 15 December 2006 (UTC)

Biolevel?

What biolevel is this bacterium? Ace ofgabriel 17:09, 16 February 2007 (UTC)

• Should be a BSL-2 (i.e. same level as S. aureus, V. cholera, Proteus spp, etc.). -- MarcoTolo 01:00, 17 February 2007 (UTC)

Hyaluronic acid capsule

Doesn't S. pyogenes have a hyaluronic acid capsule that's relevant in disease? Should this be mentioned somewhere? 203.5.70.1 14:28, 22 March 2007 (UTC)

Yes, that's true. The composition of the capsule is now stated. NighthawkJ 03:24, 28 April 2007 (UTC)

Club foot

In the section on diagnosis, it currently includes the following: "As a precautionary measure tests are also carried out to check for illnesses including, but not limited to, Syphilis, and Avascular Necrosis, and Clubfoot." I'm a layman with no education at all in this area, but knowing how rampant vandalism is on Wikipedia, I have to ask: Clubfoot? Is that a real avenue of interest in this topic? Monkeyzpop (talk) 19:32, 29 June 2008 (UTC)

This appears to be vandalism. I removed it. NighthawkJ (talk) 17:59, 9 July 2008 (UTC)

Capitalization convention

This is nitpicky, but should it be "group A" or "Group A?" I've seen it capitalized differently in different entries. My micro text uses lower case, and I've also seen it that way in NEJM [1]. If there is no current standard, I would advocate the lower case usage. Rex Manning (talk) 22:35, 6 February 2009 (UTC)

Cocci/bacilli

How come the class is put as "bacilli?" Last time I checked, it was a coccus. Its hinting that in the name, even. 64.180.31.59 (talk) 18:53, 6 March 2009 (UTC)

That's the designated class- it doesn't mean that it is morphologically a rod. Take a look at the WP entry for class bacilli. Rex Manning (talk) 19:47, 8 March 2009 (UTC)

Yes. —Preceding unsigned comment added by 69.51.65.106 (talk) 05:37, 25 December 2009 (UTC)

Shorthand For Spec Proteins

For the shorhand column, i just assumed that it is SpeA and SpeC, not Spe A or Spe C. If I'm wrong, fix.174.3.111.148 (talk) 14:04, 30 October 2009 (UTC) Cocci are small spherical bacterium and bacillus are rod ahsped. The issue I see is that all the pictures of Group A Strep. (a Gram's poitive cocci) are evry color of the rainbow except blue. All Gram's positive bacterium stain blue and, conversely, all gram negative bacterium stain red to pink. Thus Streptococcus pyogenes it a blue staining spherical bacterium when viewed under a microscope.

The clubed foot comes into play when a fetus or neonate is untreated for the infection.

Pathogenesis - S. pyogenes and OCDs

Need to remove the bias and clean up/expand the research/debate concerning PANDAS; I simply don't know enough about the subject. juan^less 17:46, 18 June 2011 (UTC)

Agreed, this portion is very poorly organized, out of place, and reads like it was written by a marketing director for PANDAS. — Preceding unsigned comment added by 72.184.184.130 (talk) 01:22, 26 June 2011 (UTC)

See Also

What's up with the See Also with all the F's?

Strep group bacteria are Gram positive organisms

In looking at the illustrations for Streptococcus pyogenes on at least two different pages (Streptococcus pyogenes and Group A streptococcal infections), the illustration shows small, round organisms in chains that are redin color on a bluish green back ground.

Proper use of the Gram's stain technique should result in Strep. pyogenes staining dark blue to purple.

I'm not sure how this happened, and don't happen to have a better illustration to hand, but this really needs to be changed. ck DocKrin (talk) 12:57, 25 June 2011 (UTC)

Coming back to review this problem, the caption of the photomicrograph indicates the staining method used was "Pappenheim's Stain," most likely similar to the Giemsa stain. The use of this stain is rare enough here in the US that I have never run into it before. I will do some further research and see if a: I can find a more conventional (Gram's Stained) photomicrograph, and b: find enough about the panoptic stain of Pappenheim to add at least a stub on the matter. DocKrin (talk) 12:34, 28 November 2016 (UTC)

SpyCatcher

I removed the following section from spycatcher (disambiguation), but it sounds like good information that could be worked into this article by someone more familiar with the topic than I. Hoof Hearted (talk) 16:03, 4 April 2013 (UTC)

• SpyCatcher is a protein engineered from Streptococcus pyogenes which forms a spontaneous covalent bond to the peptide SpyTag.

Group A redundancy

There's some redundancy about S. pyogenes being group A strep in the beginning. Maybe this should be merged with that page? — Preceding unsigned comment added by Jobonki (talk • contribs) 02:49, 9 April 2015 (UTC)

Group A redundancy

There's redundancy in the intro. Also, merge with group A strep page? — Preceding unsigned comment added by Jobonki (talk • contribs) 02:50, 9 April 2015 (UTC)

Sentence about mortality doesn't make sense

The article currently says: "An estimated 700 million GAS infections occur worldwide each year. While the overall mortality rate for these infections is 0.1%, over 650,000 of the cases are severe and invasive, with these cases having a mortality rate of 25%." The citation for that claim is https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854683/, which in turn cites https://pubmed.ncbi.nlm.nih.gov/16253886/ for their claim. The problem is that the claim doesn't seem to add up: If "the overall mortality rate for these infections is 0.1%", then 700,000 die from them each year. But if there are only 650.000 cases that are severe, and that 25% of these lead to death, then there are 162,500 deaths from severe cases. As I assume only severe cases lead to death (how can an "insevere" case cause death?), that would mean that there are "only" 162,500 deaths per year in total. So something is not right. I am not able to figure out what is right, partly because I don't have full access to what seems to be the proper end-source https://pubmed.ncbi.nlm.nih.gov/16253886/; I only have access to the abstract which does not explicitly mention a 0.1% mortality rate. Something is off, and at least the sentence should be clarified so it actually makes sense. --Jhertel (talk) 10:04, 8 September 2021 (UTC)

Wiki Education assignment: Journal Club

This article was the subject of a Wiki Education Foundation-supported course assignment, between 27 August 2022 and 9 December 2022. Further details are available on the course page. Student editor(s): DogMama2 (article contribs).

— Assignment last updated by Madi oule (talk) 18:15, 23 September 2022 (UTC)

Balancing Thoroughness with Relevance

In evaluating the article, it’s very thorough. However, it also could benefit from more recent statistics and research. Maybe the sections about SpyCatcher and PANDAS whose removal was mentioned earlier could be improved and replaced with some work. Adding such items would help to enhance the article's current relevancy.Mchristensen8 (talk) 19:29, 5 December 2023 (UTC)

We already have an article on PANDAS and a link to it will suffice. Same goes for SpyCatcher. With regard to "earlier", that was a decade or so ago! Knowledge of these subjects has advanced. Graham Beards (talk) 20:37, 5 December 2023 (UTC)

Error with link in the Serotyping subsection?

There is an internal link to a page for T-antigen in the Serotyping subsection, but it appears to be an article about the SV40 viral tumor antigen. I don't think this is the same molecule as the T-antigen mentioned in this article. Is there simply no WP article about this particular molecule? Is it under a different name? Lumberjane Lilly (talk) 13:58, 21 December 2023 (UTC)

There doesn't seem to be so have changed the sentence to "Later, in 1946, Lancefield described the serologic classification of S. pyogenes isolates based on components of their surface pili (known as the T-antigen) which are used by bacteria to attach to host cells." Graham Beards (talk) 18:55, 21 December 2023 (UTC)