Talk:Semaglutide

Ad jingle's pronunciation

   For reasons irrelevant here, I noticed spontaneously what my professional singer wife had to be nagged into finally noticing: the announcer rigorously pronounces the middle vowel as a short e as in "get", while the apparently all-female chorus sings the short vowel sound that appears (at least according with my pretty-median-American accent) in "cat". My WAG is that the FDA (or some other regulatory authority) enforces limitations on written or spoken ads, but that only marketeers have any effective say when something in a non-sentential sound patter accompanying an ad just happens to sound a little like the product's name ...? Comments? ... C'mon, all you wikipedian detail men....
--JerzyA (talk) 00:57, 16 September 2019 (UTC)

What? (Walker Snarling) (talk) 11:03, 19 November 2022 (UTC)

Wikipedia Talk pages are sometimes better than the articles. This is one of those times. 72.177.8.45 (talk) 21:57, 21 January 2023 (UTC)

Contradiction in the lede ? - injectable or non-injectable

In the first paragraph of the lede, we see It is distributed as a metered subcutaneous injection in a prefilled pen. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.. The second paragraph says It is the first glucagon-like peptide receptor protein treatment approved for use in the United States that does not need to be injected.. The 1st paragraph has a reference in 2015, the 2nd has a 2019 reference specifically about approving an oral version. I think I understand what's going on, but I'd prefer someone who is more familiar with the products to comment. Tarl N. (discuss) 21:38, 11 December 2020 (UTC)

Rybelsus is a tablet that you swallow. It does not need to be injected. The Rybelsus tablet contains the Semaglutide molecule. Ozempic and Wegovy are both metered subcutaneous injection pens that you inject once per week. FalseAxiom (talk) 03:47, 23 March 2023 (UTC)

Thank you for clarifying BlueBellTree (talk) 04:47, 29 September 2024 (UTC)

obesity study

[1] Phase 3 RCT, apparently obese people given this drug in high doses usually lose weight. Actual study is in NEJM. 2602:24A:DE47:BB20:50DE:F402:42A6:A17D (talk) 22:26, 13 February 2021 (UTC)

Yes, very promising indeed. However, I wouldn't bother posting it here. Whenever I post medical breakthroughs of any kind on Wikipedia, there's almost invariably some uppity moderator, who immediately springs into action, coming down on you like a ton of bricks, because apparently it breaks some arbitrary rule about sources. Even though, in this case, the study is published in a respected and peer-reviewed journal (the New England Journal for Medicine, no less), and it's a Phase 3 study so a pretty advanced trial. That, apparently, won't be good enough, because only the ancient studies from decades ago are allowed to "count", and we mustn't "jump to conclusions" or post any new stuff that might violate "WIKI_421_ruleXYZ: NO NEWS ALLOWED". The mods' favourite pastime, it seems, is to patrol these medical articles and instantly pounce on people for daring to suggest that maybe, just maybe, some iota of progress might actually have been achieved in the medical field. Wjfox2005 (talk) 13:03, 16 February 2021 (UTC)

"Oh Oh Oh Oh Zempic" listed at Redirects for discussion

A discussion is taking place to address the redirect Oh Oh Oh Oh Zempic. The discussion will occur at Wikipedia:Redirects for discussion/Log/2021 March 19#Oh Oh Oh Oh Zempic until a consensus is reached, and readers of this page are welcome to contribute to the discussion. Seventyfiveyears (talk) 01:20, 19 March 2021 (UTC)

I looked at the redirect forum and it pointed to a page at ispot.tv which discusses the jingle for the Ozempic TV spot. It concludes "The song was created for this commercial." I disagree. The song is clearly a riff on the hook from the 1974 song Magic_(Pilot_song) by British band "Pilot." Check out the song on YouTube. (https://www.youtube.com/watch?v=MzlK0OGpIRs) You only have to listen for 15 seconds before they sing the hook ... "oh, oh, oh it's magic, you know, never believe it ain't so." It's also the same tune.

I think the page for the song ought to mention that it's being used in the ad for Ozempic, or the page for the drug ought to mention the song used in the jingle. — Preceding unsigned comment added by 2600:8806:2208:1B00:C927:DC13:70DD:4F22 (talk) 01:43, 3 August 2023 (UTC)

Medical Uses

I am no doctor, but should the Medical Uses sections talk about the drug's medical uses? — Preceding unsigned comment added by 2800:810:479:15bd:d9b9:c6cd:d2ad:44f6 (talk • contribs) 05:52, 19 April 2021 (UTC)

Good point. Can you put in some suggested changes? BlueBellTree (talk) 04:47, 29 September 2024 (UTC)

Possible use of semaglutide for weight loss (Sept 2021) - FDA approved in 2021

"The future of weight loss" by Stephan J. Guyenet 14 September 2021

- https://www.worksinprogress.co/issue/the-future-of-weight-loss/ -

- 189.122.83.78 (talk) 02:31, 15 September 2021 (UTC)

While semaglutide has been much in the news recently due to studies concerning weight loss, we need to wait until there has been a review or survey of the literature, AKA a secondary source. Please see WP:MEDRS concerning medical reliable sources. Peaceray (talk) 03:53, 15 September 2021 (UTC)

We should note that FDA had approved it for anti-obesity in June 2021, and EU/EMA later that year. - Rod57 (talk) 12:53, 6 August 2024 (UTC)

Guardian: Revealed: experts who praised new ‘skinny jab’ received payments from drug maker

There are several news outlets covering payments made by Novo Nordisk to experts and groups in relation to its new drug. I don't write medical articles so I'll let others chose how to add it to the article.

• https://www.theguardian.com/business/2023/mar/12/revealed-experts-who-praised-new-skinny-jab-received-payments-from-drug-maker

Thanks

John Cummings (talk) 13:46, 12 March 2023 (UTC)

On a related note, several media describe questionable use by non-diabetics, especially in the entertainment industry UK Standard Wall Street Journal NewsWeek CBS . TGCP (talk) 10:19, 13 March 2023 (UTC)

Wiki Education assignment: CHEM 378 - Biochemistry Lab - spring 2023

This article was the subject of a Wiki Education Foundation-supported course assignment, between 30 January 2023 and 20 May 2023. Further details are available on the course page. Student editor(s): Yl2087 (article contribs).

— Assignment last updated by Bubbstar (talk) 20:10, 15 May 2023 (UTC)

the 'Research' tab

I question the necessity of this header. It could easily be merged into History.

The content of it, being negative about the drug versus another, makes me think this header was only used to highlight the negative research more to the reader.

I hesitate to edit such a major change myself so I'm just airing my thoughts on the talk page here. Scout1011 (talk) 21:38, 8 June 2023 (UTC)

Reliable sources regarding stomach paralysis.

Over the past while I've been trying to add sources regarding Ozempic causing stomach paralysis.

Almost all of them have been removed for one reason or another.

What could be considered "reliable sources" in this instance? Urbanracer34 (talk) 15:28, 12 October 2023 (UTC)

Please have a look at Wikipedia:Identifying reliable sources (medicine).--☾Loriendrew☽ ☏(ring-ring) 22:07, 12 October 2023 (UTC)

Thanks! Urbanracer34 (talk) 14:20, 13 October 2023 (UTC)

Development - History

The article needs some help on the topic of development. It states that it was developed in 2012, but later there's a reference to a phase II trial in 2008. 65.28.75.226 (talk) 15:04, 2 November 2023 (UTC)

@65.28.75.226 I agree. Why does History not begin with development? It didn't just pop into existence at phase 2 trials. 100.33.92.44 (talk) 16:06, 30 March 2024 (UTC)

I tried adding some more background into the history section but more work is needed. {{u|Gtoffoletto}}  ^talk 22:59, 15 May 2024 (UTC)

I've tried to group time & topic related parts of History (luckily they coincide), and added sub heads. - Rod57 (talk) 12:57, 6 August 2024 (UTC)

Bioavailablity - eg of oral Rybelsus

There seems to be some misconception about bioavailability . The official FDA label information, which is linked below lists Ozempic (semaglutide) for subcutaneous injection as 89% absolute bioavailability. This means compaired to intravenous injection. My concern is readers may think that if taken orally this would be 89% absorbed. The oral formulation has a special coformulation of salcaprozate sodium . The FDA label information on Rybelsus states that absolute oral bioavailability of semaglutide is estimated to be between 0.4% and 1%. However, I myself have some confusion from this statement since it did not specifically state this as Rybelsus absolute bioavailabilty.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/209637s020s021lbl.pdf

https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/213051s012lbl.pdf Ribazole (talk) 06:45, 17 December 2023 (UTC)

Since the FDA info is on the Rybelsus label, why would we not assume it applies to Rybelsus ? (Interesting that oral bioavailability has 2:5 range) - Rod57 (talk) 13:19, 6 August 2024 (UTC)

Legal compounding in USA

The situation, re compounding in the USA, warrants more than just the current report of contamination. It is encouraged and licenced by the FDA due to a shortage of the branded products. eg. [2] Rod57 (talk) 12:31, 6 August 2024 (UTC)