Talk:Nalbuphine

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Comment

i have just read the nalbuphine page and was surprised to not see a section on addiction or dependancy. i have had personal experiance of this drug and it is very addictive and rally hard to come off. just a suggestion but should the article have those suggested sections.

12:14, 14 October 2010 (UTC)ProfMad12:14, 14 October 2010 (UTC)

1) Nalbuphine detoxification of a person dependant on mu opiate agonists (DHC, Morphine & Codeine). This was inspired by the following paper:-

Administration of Nalbuphine to Heroin Addicts. Feasibility and Short-Term Effects Michael Voronkov 1, Daria Ocheret 2, Svetlana Bondarenko 2, Yuriy Ivanov Yu 3, and Sergey Koren 4

Prof Mad investigation:- 52 year old person, dependant on DHC & Opium Poppies, equating to ~ 100-150 mg Morphine/daily, over several years.was detoxed using nalbuphine . Dosage ranged from 40- 200 mg /day. (Ave = 120mg/day { 1.2mg/kg}) for 10 days. (Fiscal restraints prevented further administration. This was done by both i.m & i.v routes). Withrawal (nalbuphine started 24 hrs, after last mu opiate dose ) was severe, yet apparantly tolerable. Full blown symptoms reducing within 4 days. It reduced apparent cravings to a significant degree (whether psychological, or physical), and reduced other symptoms. On stopping their was some dependency on nalbuphine, but passed within a day. It is now possible for the person to function on 120mg/ 1-2 days DHC,to control their initial pain it was prescribed for. The conclusion drawn,is that though more 'brutal' than buprenorphine' further investigations into its use as a detoxifying agent, may prove rewarding. This was done in a non-clinical setting, and had many flaws, as a scientific experiment. However, it did significantly reduce opiate use, rapidly. 12:14, 14 October 2010 (UTC)ProfMad12:14, 14 October 2010 (UTC) —Preceding unsigned comment added by Profmad (talk • contribs)