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Hi, i will be working on this article and here are some sources I will be using. Please feel free to offer you suggestions! Thank you. :)

  1. ^ Altuvia, Yael; Berzofsky, Jay A.; Rosenfeld, Rakefet; Margalit, Hanah (1994-01-01). "Sequence features that correlate with MHC restriction". Molecular Immunology. 31 (1): 1–19. doi:10.1016/0161-5890(94)90133-3.
  2. ^ Baker, B. M., et al. "T Cell Receptor Specificity, Cross-Reactivity, and MHC Restriction are Inextricably Linked and Result from Cooperative Engagement of the Composite Peptide/MHC Surface." Biophysical Journal 104(2): 403a.
  3. ^ Bjorkman, P. J. (1997). "MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions." Cell 89(2): 167-170.
  4. ^ Bowen, Steven; Sun, Peter; Livak, Ferenc; Sharrow, Susan; Hodes, Richard J. (2014-01-01). "A Novel T Cell Subset with Trans-Rearranged Vγ-Cβ TCRs Shows Vβ Expression Is Dispensable for Lineage Choice and MHC Restriction". The Journal of Immunology. 192 (1): 169–177. doi:10.4049/jimmunol.1302398. ISSN 0022-1767. PMC 3872174. PMID 24307734.
  5. ^ Garboczi, David N; Biddison, William E (1999-01-01). "Shapes of MHC Restriction". Immunity. 10 (1): 1–7. doi:10.1016/S1074-7613(00)80001-1.
  6. ^ Garcia, K. Christopher (2012-09-01). "Reconciling views on T cell receptor germline bias for MHC". Trends in Immunology. 33 (9): 429–436. doi:10.1016/j.it.2012.05.005. PMC 3983780. PMID 22771140.
  7. ^ Morel, P. A.; Livingstone, A. M.; Fathman, C. G. (1987-08-01). "Correlation of T cell receptor V beta gene family with MHC restriction". The Journal of Experimental Medicine. 166 (2): 583–588. doi:10.1084/jem.166.2.583. ISSN 0022-1007. PMID 3598467.
  8. ^ Piepenbrink, Kurt H.; Blevins, Sydney J.; Scott, Daniel R.; Baker, Brian M. (2013-06-05). "The basis for limited specificity and MHC restriction in a T cell receptor interface". Nature Communications. 4: 1948. doi:10.1038/ncomms2948. PMC 3708045. PMID 23736024.
  9. ^ Rangarajan, Sneha; Mariuzza, Roy A. (2014-03-17). "T cell receptor bias for MHC: co-evolution or co-receptors?". Cellular and Molecular Life Sciences. 71 (16): 3059–3068. doi:10.1007/s00018-014-1600-9. ISSN 1420-682X.
  10. ^ Tomlinson, L. A.; Christie, J. F.; Fraser, E. M.; McLaughlin, D.; McIntosh, A. E.; Kennedy, M. W. (1989-10-01). "MHC restriction of the antibody repertoire to secretory antigens, and a major allergen, of the nematode parasite Ascaris". The Journal of Immunology. 143 (7): 2349–2356. ISSN 0022-1767. PMID 2778320.
  11. ^ Van Laethem, F., et al. (2012). "MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection."
  12. ^ Zinkernagel, R. M. and P. C. Doherty (1997). "The discovery of MHC restriction." Immunology Today 18(1): 14-17.

Immcarle8 (talk) 07:53, 30 January 2016 (UTC)[reply]

Hi, this is the revised lead section for this article. For the body of the article, I would like to first introduce the concept of MHC restriction in more detail, introduce the significance of MHC restriction, talk about the arguments regarding the two models for MHC restriction, and at last describe the process of MHC restriction development.

MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell can interact with both the self-MHC molecule and the foreign peptide that is bound to it, and will recognize the peptide antigen only when it is bound to a host body's own MHC molecule. As T cells are stimulated by peptide antigens only in the presence of self-MHC molecules, MHC restriction adds another dimension to the specificity of TCR so that an antigen is recognized only as peptide-MHC complexes.[1]

MHC restriction in T cells occurs after its development in the thymus, specifically after positive selection.[2] Only the thymocytes (developing T cells in the thymus) that are capable of binding, with an appropriate affinity, with the MHC molecules can receive a survival signal and go on to the next level of selection. MHC restriction is significant for T cells to function properly when it leaves the thymus because it allows T cell receptors to bind to MHC and detect cells that are infected by intracellular pathogens, viral proteins and bearing genetic defects. Two models explaining how restriction arose are the germline model and the selection model.

The germline model suggests that MHC restriction is a result of evolutionary pressure favoring T cell receptors that are capable of binding to MHC.[3] The selection suggests that not all T cell receptors show MHC restriction, however only the T cell receptors with MHC restriction are expressed after thyme selection.[4] In fact, both hypothesis are reflected in the determination of TCR restriction, such that both germline-encoded interactions between TCR and MHC and co-receptor interactions with CD4 or CD8 to signal T cell maturation during selection. [5] Immcarle8 (talk) 05:02, 9 February 2016 (UTC)[reply]

Wiki Education Foundation-supported course assignment

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle8.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 03:02, 17 January 2022 (UTC)[reply]

Body section

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Hi, I am an Immunology student and i just added body sections to the article page. Please let me know if you have any views or suggestions! I will really appreciate your input. :) Immcarle8 (talk) 06:30, 15 February 2016 (UTC)[reply]

  1. ^ Charles A Janeway, Jr; Travers, Paul; Walport, Mark; Shlomchik, Mark J. (2001-01-01). "Antigen Recognition by B-cell and T-cell Receptors". {{cite journal}}: Cite journal requires |journal= (help)
  2. ^ Van Laethem, François; Tikhonova, Anastasia N.; Singer, Alfred (2012-01-09). "MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection". Trends in Immunology. 33 (9): 437–441. doi:10.1016/j.it.2012.05.006. ISSN 1471-4906. PMC 3427466. PMID 22771139.
  3. ^ Christopher Garcia, K; Adams, Jarrett J; Feng, Dan; Ely, Lauren K (2009-01-16). "The molecular basis of TCR germline bias for MHC is surprisingly simple". Nature Immunology. 10 (2): 143–147. doi:10.1038/ni.f.219. PMC 3982143. PMID 19148199.
  4. ^ Collins, Edward J.; Riddle, David S. (2008-08-26). "TCR-MHC docking orientation: natural selection, or thymic selection?". Immunologic Research. 41 (3): 267–294. doi:10.1007/s12026-008-8040-2. ISSN 0257-277X.
  5. ^ Garcia, K. Christopher (2012-09-01). "Reconciling views on T cell receptor germline bias for MHC". Trends in Immunology. 33 (9): 429–436. doi:10.1016/j.it.2012.05.005. PMC 3983780. PMID 22771140.
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