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Archive 1

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Kristy M. Ainslie
CitizenshipUSA
Alma materPennsylvania State University, Michigan State University
Scientific career
FieldsEngineering, Pharmacy
Doctoral advisorJohn Tarbell, Micheal Pishko
Websiteainslielab.web.unc.edu

Kristy M. Ainslie is a pharmaceutical science professor at University of North Carolina at Chapel Hill in the Eshelman School of Pharmacy. She is also joint in the UNC School of Medicine Department of Microbiology and Immunology and affiliated faculty in the UNC/NC State joint Biomedical Engineering department. Additionally, she is part of UNC's Biological and Biomedical Sciences Program (BBSP).

Background==

Ainslie completed her Bachelors of Science in Chemical engineering from Michigan State University in 1999. After working as a environmental engineer at Malcolm Pirnie, she began graduate school at Penn State as a fellow in the Huck Institutes of the Life Science. In 2003, she completed her Masters of Science in Chemical engineering under John Tarbell, focusing on shear stress modulation of vascular smooth muscle cell contraction.[1][2][3][4][5] Two years later in 2005, she completed her PhD in Chemical engineering under Micheal Pishko, focusing on protein adhesion and cell responses to nanomaterials.[6][7][8][9][10] After a brief post doc at the microcantilever start-up Protiveris, she worked with Lloyd Whitman at the United States Naval Research Laboratory.[11] In 2006, she began a post doc at University of San Francisco in the Department of Bioengineering and Therapeutic Sciences under the direction of Tejal Desai. The focus of Ainslie's research at UCSF was on microfabricated oral drug delivery[12][13] carriers and immune responses to planar nanomaterials.[14][15]

Ainslie began her career as a tenure track Assistant Professor at Ohio State University in the School of Pharmacy in the Division of Pharmaceutics and Pharmaceutical Chemistry. In 2014, Ainslie moved to the University of North Carolina at Chapel Hill and the UNC Eshelman School of Pharmacy Division of Pharmacoengineering and Molecular Pharmaceutics as an Associate Professor.[

Career==

Ainslie has several ares of focus for her lab including immune therapies to treat and prevent infectious diseases.[16]

Awards==
  • 2012 OSU Council of Graduate Students James M. Siddens Distinguished Faculty Advising Award
  • 2009 Controlled Release Society Outstanding Oral Drug Delivery Award
  • 2007 Controlled Release Society-Capsugel Post-Doc Award for Innovative Aspects of Oral Drug Delivery & Absorption
  • 2005 Walter R. and Aura Lee Supina Graduate Fellowship in Chemical Engineering
  • 2000 The Pennsylvania State University Life Science Consortium Graduate Fellowship
  • 1999 Commencement Speaker for Michigan State University College of Engineering Graduation Ceremony


References==
  1. ^ Sharma, Ritu; Yellowley, Claire; Civelek, Mete; Ainslie, Kristy; Hodgson, Louis; Tarbell, John; Donahue, Hennry (2002). "Intracellular Calcium Changes in Rat Aortic Smooth Muscle Cells in Response to Fluid Flow". Ann Biomed Eng. 30 (3): 371. PMC 4472337. PMID 12051621.
  2. ^ Civelek, Mete; Ainslie, Kristy; Garanich, Jeffery; Tarbell, John (2002). "Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism". J Appl Physiol. 93 (6): 1907. PMID 12391063. Retrieved 25 June 2018.
  3. ^ Florian, Jeffery; Kosky, Jason; Ainslie, Kristy; Pang, Zhang; Dull, Randall; Tarbell, John (2003). "Heparan sulfate proteoglycan is a mechanosensor on endothelial cells". Circulation. 93 (10): 136. PMID 14563712. Retrieved 25 June 2018.
  4. ^ Ainslie, Kristy; Shi, Z; Garanich, Jeffery; Tarbell, John (2004). "Rat aortic smooth muscle cells contract in response to serum and its components in a calcium independent manner". Ann Biomed Eng. 32 (12): 1667. PMID 15675680.
  5. ^ Ainslie, Kristy; Garanich, Jeffery; Dull, Randall; Tarbell, John (2005). "Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response". J Appl Physiol. 98 (1): 242. PMID 15322072. Retrieved 25 June 2018.
  6. ^ Dyer, Maureen; Ainslie, Kristy; Pishko, Micheal (2007). "Protein adhesion on silicon-supported hyperbranched poly(ethylene glycol) and poly(allylamine) thin films". Langmuir. 23 (13): 7018. PMID 17506587. Retrieved 25 June 2018.
  7. ^ Ainslie, Kristy; Sharma, Gurav; Dyer, Maureen; Grimes, Craig; Pishko, Micheal (2005). "Attenuation of protein adsorption on static and oscillating magnetostrictive nanowires". Nano Letters. 5 (9): 1852. PMID 16159237. Retrieved 25 June 2018.
  8. ^ Ainslie, Kristy; Bachelder, Eric; Borka, Sachin; Zahr, Alisar; Sen, Ayusman; Badding, John; Pishko, Micheal (2007). "Cell adhesion on nanofibrous polytetrafluoroethylene (nPTFE)". Langmuir. 23 (2): 747. PMID 17209629. Retrieved 25 June 2018.
  9. ^ Kristy, Ainslie; Bachelder, Eric; Sharma, Gurav; Grimes, Craig; Pishko, Micheal (2009). "Macrophage cell adhesion and inflammation cytokines on magnetostrictive nanowires". Nanotoxicology. 1 (4): 279. Retrieved 25 June 2018.
  10. ^ Bachelder, Eric; Ainslie, Kristy; Pishko, Micheal (2005). "Utilizing a quartz crystal microbalance for quantifying CD4+ T cell counts". Sensor Letters. 3 (3): 211. Retrieved 25 June 2018.
  11. ^ Stine, Rory; Cole, Christina; Ainslie, Kristy; Mulvaney, Shawn; Whitman, Lloyd (2007). "Formation of primary amines on silicon nitride surfaces: a direct, plasma-based pathway to functionalization". Langmuir. 23 (8): 4400. PMID 17323989. Retrieved 25 June 2018.
  12. ^ Ainslie, Kristy; Kraning, Casey; Desai, Tejal (2008). "Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics". Lab Chip. 8 (7): 1042. PMC 2969854. PMID 18584077.
  13. ^ Ainslie, Kristy; Lowe, Rachel; Beaudette, Tristan; Petty, Lamar; Bachelder, Eric; Desai, Tejal (2009). "Microfabricated devices for enhanced bioadhesive drug delivery: attachment to and small-molecule release through a cell monolayer under flow". Small. 5 (24): 2857. PMID 19787677. Retrieved 25 June 2018.
  14. ^ Kristy, Ainslie; Tao, Sarah; Popat, Ketul; Daniels, Hugh; Hardev, Veeral; Grimes, Craig; Desai, Tejal (2009). "In vitro inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone". J Biomed Mater Res A. 91 (3): 647. PMID 18988278. Retrieved 25 June 2018.
  15. ^ Ainslie, Kristy; Tao, Sarah; Popat, Ketul; Desai, Tejal (2008). "In vitro immunogenicity of silicon-based micro- and nanostructured surfaces". ASC Nano. 2 (5): 1076. PMID 19206506. Retrieved 25 June 2018.
  16. ^ Faulkner, Julia. "Young Innovators Program opens up pharmacy school to high school students". Daily Tarheel. Retrieved 27 July 2018.
  17. ^ Kauffman, KJ; Do, C; Sharma, S; Gallovic, MD; Bachelder, EM; Ainslie, KM (Aug 2012). "Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product". ACS Appl Mater Interfaces. 4 (8): 4149. doi:10.1021/am3008888. PMID 22833690.
  18. ^ Bachelder, EM; Beaudette, TT; Broaders, KE; Dashe, J; Fréchet, JM (Aug 2008). "Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications". JACS. 130 (32): 10494–5. doi:10.1021/ja803947s. PMC 2673804. PMID 18630909.
  19. ^ Frechet, JM; Bachelder, EM; Beaudette, TT; Broaders, KE. "Acid-Degradable and Bioerodible Modified Polyhydroxylated Materials". Google Patent.
  20. ^ Chen, Naihan; Johnson, Monica; Collier, Micheal; Gallovic, Matthew; Johnson, Monica; Ainslie, Kristy (2018). "Tunable degradation of acetalated dextran microparticles enables controlled vaccine adjuvant and antigen delivery to modulate adaptive immune responses". Journal of Controlled Release. 273. PMID 29407676. Retrieved 26 June 2018.
  21. ^ Ainslie, Kristy. "ENCAPSULATED ACTIVE VITAMIN D VACCINE FOR THE TREATMENT OF MULTIPLE SCLEROSIS". NIH RePORTER. National Institutes of Health. {{cite web}}: Missing or empty |url= (help)
  22. ^ Collier, MA; Peine, KJ; Gautum, S; Oghumu, S; Varikuti, S; Borteh, H; Papenfuss, TL; Satoskar, AR; Bachelder, EM; Ainslie, KM (Feb 29, 2016). "Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles". International Journal of Pharmaceutics. 499 (1–2): 186–94. doi:10.1016/j.ijpharm.2016.01.004. PMID 26768723.
  23. ^ Ainslie; et al. "COMPOSITIONS AND METHODS FOR INHIBITING LEISHMANIA". Free Patents Online. {{cite web}}: Explicit use of et al. in: |first1= (help)
  24. ^ Hoang, KV; Borteh, HM; Rajaram, MV; Peine, KJ; Curry, H; Collier, MA; Homsy, ML; Bachelder, EM; Gunn, JS; Schlesinger, LS; Ainslie, KM (Dec 2014). "Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection". Int J Pharm. 477 (1–2): 334. doi:10.1016/j.ijpharm.2014.10.022. PMC 4267924. PMID 25447826.
  25. ^ Hoang, KV; Curry, H; Collier, MA; Borteh, H; Bachelder, EM; Schlesinger, LS; Gunn, JS; Ainslie, KM (Mar 25, 2016). "Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge". Antimicrob Agents Chemother. 60 (4): 2052–62. doi:10.1128/AAC.02228-15. PMC 4808193. PMID 26787696.
  26. ^ Gallovic, Matthew; Schully, Kevin; Bell, Matthew; Elberson, Margret; Palmer, John; Darko, Christen; Bachelder, Eric; Keane-Myers, Andrea; Ainslie, Kristy (2016). "Acetalated Dextran Microparticulate Vaccine Formulated via Coaxial Electrospray Preserves Toxin Neutralization and Enhances Murine Survival Following Inhalational Bacillus Anthracis Exposure". Adv Healthc Mater. 5 (20). PMID 27594343. Retrieved 25 June 2018.
  27. ^ Junkins, Robert; Gallovic, Matthew; Johnson, Brandon; Collier, Micheal; Watkins-Schulz, Rebekah; Cheng, Ning; David, Clement; McGee, Charles; Sempowski, Greg; Shterev, Ivo; McKinnon, Karen; Bachelder, Eric; Ainslie, Kristy; Ting, Jenny (2018). "A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination". J Control Release. 270: 1. PMID 29170142.
  28. ^ Graham-Gurysh, Elizabeth; Moore, Kathryn; Satterlee, Andrew; Sheetz, Kevin; Lin; Bachelder, Eric; Miller, C. Ryan; Hingtgen, Shawn; Ainslie, Kristy (2018). "Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection". Mol Pharm. 15 (3): 1309. PMC 5999333. PMID 29342360.
External links==

--— Preceding unsigned comment added by SithLordSparklePants (talk • contribs) 14:25, 27 July 2018 (UTC)

It isn't helpful to post the entire re-written article here, I can't work out what you have changed, added or edited, please post just your specific change with the relevant reference instead. Thank you. Theroadislong (talk) 15:16, 27 July 2018 (UTC)
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