Talk:Hydroxychloroquine

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April 5 to 11, 2020

Treatments for COVID-19: Current consensus

A note on WP:MEDRS: Per this Wikipedia policy, we must rely on the highest quality secondary sources and the recommendations of professional organizations and government bodies when determining the scientific consensus about medical treatments.

Ivermectin: The highest quality sources (1 2 3 4) suggest Ivermectin is not an effective treatment for COVID-19. In all likelihood, ivermectin does not reduce all-cause mortality (moderate certainty) or improve quality of life (high certainty) when used to treat COVID-19 in the outpatient setting (4). Recommendations from relevant organizations can be summarized as: Evidence of efficacy for ivermectin is inconclusive. It should not be used outside of clinical trials. (May 2021, June 2021, June 2021, July 2021, July 2021) (WHO, FDA, IDSA, ASHP, CDC, NIH)
Chloroquine & hydroxychloroquine: The highest quality sources (1 2 3 4) demonstrate that neither is effective for treating COVID-19. These analyses accounted for use both alone and in combination with azithromycin. Some data suggest their usage may worsen outcomes. Recommendations from relevant organizations can be summarized: Neither hydroxychloroquine nor chloroquine should be used, either alone or in combination with azithromycin, in inpatient or outpatient settings. (July 2020, Aug 2020, Sep 2020, May 2021) (WHO, FDA, IDSA, ASHP, NIH)
Ivmmeta.com, c19ivermectin.com, c19hcq.com, hcqmeta.com, trialsitenews.com, etc: These sites are not reliable. The authors are pseudonymous. The findings have not been subject to peer review. We must rely on expert opinion, which describes these sites as unreliable. From published criticisms (1 2 3 4 5), it is clear that these analyses violate basic methodological norms which are known to cause spurious or false conclusions. These analyses include studies which have very small sample sizes, widely different dosages of treatment, open-label designs, different incompatible outcome measures, poor-quality control groups, and ad-hoc un-published trials which themselves did not undergo peer-review. (Dec 2020, Jan 2021, Feb 2021)

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Last updated (diff) on 27 February 2023 by Sumanuil (t · c)

17.000 killed

17.000 deaths in just 6 countries attributable to hydroxychloroquine: https://www.sciencedirect.com/science/article/pii/S075333222301853X

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The article claiming 17,000 deaths was retracted on August 22, 2024 due to "Reliability of the data and choice of the data. The Belgian dataset in particular was found to be unreliable, based on estimates" and "The assumption that all patients that entered the clinic were being treated the same pharmacologically was incorrect". See retraction notice at https://doi.org/10.1016/j.biopha.2023.116055. The sentence "Researchers estimate that off-label use of hydroxychloroquine in hospitals during the first phase of the pandemic caused 17,000 deaths worldwide" should be removed from this page or amended with a notice that "This article was retracted on August 22, 2024, as the editor-in-chief of the journal lost confidence in the validity of the researchers' methodology." (edit: changed to formal edit request) (edit 2: necessary changes were made to source article) it (talk) 14:07, 13 September 2024 (UTC)[reply]

Study finds Hydroxychloroquine useful against Covid-19

A large double-blind, randomised, placebo-controlled trial found that hydroxychloroquine provides "some protection against symptomatic COVID-19". However I lack the expertise to see how to incorporate this into the text, but I will leave it here. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004428 — Preceding unsigned comment added by 65.112.8.49 (talk) 16:36, 18 September 2024 (UTC)[reply]

Not done. Would need WP:MEDRS. Bon courage (talk) 16:46, 18 September 2024 (UTC)[reply]

Isn't this the largest and most thorough study on this claim though? Why is it not regarded as a reliable source? — Preceding unsigned comment added by 65.112.8.49 (talk) 22:30, 22 September 2024 (UTC)[reply]