Talk:hERG

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The name

This sounds fake to me. Ether-a-go-go? Anyone care to explain this ridiculous-sounding name? —Keenan Pepper 10:00, 11 August 2005 (UTC)[reply]

No, its quite factual. The hERG channel was identified in Drosophila flies and named so because when they were anaesthetised with ether, their legs started shaking.

bignoter 11:20, August 16, 2005 (UTC)

D. melanogaster gene ether a go-go , abbreviated as eag, encodes a product with voltage-gated potassium channel activity involved in courtship behavior. Mutants shake their legs under ether anesthesia. HERG channel, or KCNH2, is encoded by the eag-related gene, they share some characteristic but are two distinct protein.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=32428

gentile 3:42, September 11, 2005

I am currently adding to this page; I have left some minor grammar errors due to lack of time tonight. While I understand the low priority for ion channels in general, I suspect that because of hERG's central role in virtually all drug discovery programmes for human pharmaceuticals, hERG may be somewhat more important to wikipedia than other channels. Relleh22hctac (talk) 03:09, 2 February 2009 (UTC)[reply]

We should fix the name, there is no french accent on the "a". Aytrus (talk) 15:36, 30 May 2010 (UTC)[reply]

Side helix

What is the "side helix" mentioned in the 'structure' section? I have never heard of it; does this refer to the alpha helical region in the turret or in the cyclic nucleotide binding domain? I am tempted to delete "side helix". Relleh22hctac (talk) 03:09, 2 February 2009 (UTC)[reply]

That puzzled me too. After searching PubMed and Google, I cannot find any source to document the use of the term "side helx" in the context of the hERG structure. Therefore I have deleted it. (BTW: excellent edits Relleh22hctac!). Cheers. Boghog2 (talk) 06:42, 2 February 2009 (UTC)[reply]

Perhaps what was really meant was beta subunit (minK)? That or it was a typo for slide helix. Either way, Boghog2's edits seem an appropriate fix. --Dpryan (talk) 22:27, 2 February 2009 (UTC)[reply]

Extra details that need to be added

The relationship between hERG and early afterdepolarisations
The unusual length of the turret

Suggested subject headings that may ultimately be useful for ion channels

Basic Features (why is it notable)
Biological Functions
- In the Action Potential of Excitable Cells
- In other cell types
Structure
Mechanism of Action
Gating: How the Channel
Selective Permeability
Diseases of
Location
- Cells where hERG is found: Expression profile
- Animals that have hERG
- Diversity
- Evolutionary Relationship to other Ion Channels
- Classification
History
In Art and Popular Culture (probably not so much for hERG yet)

Relleh22hctac (talk) 10:10, 13 February 2009 (UTC)[reply]

Image

Use the improved image: . — Preceding unsigned comment added by JVertrees (talk • contribs) 22:37, 19 December 2012 (UTC)[reply]

External links modified

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Structure

Full-length cryo-electron microscopy structures of hERG has been available since 2017: https://doi.org/10.1016/j.cell.2017.03.048 163.1.63.21 (talk) 19:33, 8 February 2023 (UTC)[reply]