Talk:Trisomy 18

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Disability

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Trisomy 18.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

On 21 April 2023, it was proposed that this article be moved from Edwards syndrome to Trisomy 18. The result of the discussion was moved.

German

Maybe somebody want to translate parts of die German-language version of this article: http://de.wikipedia.org/wiki/Edwards-Syndrom

Naming conventions?

What is the proper name of this article? The title is Edward's, the article uses Edwards, and the guy's name is Edwards? Please clarify! M1ss1ontomars2k4 06:36, 11 April 2006 (UTC)[reply]

You are right, the guy's name is John H. Edwards (I just created this bio stub). Therefore the article should be titled either "Edwards syndrome" or "Edwards' syndrome"— both naming conventions for syndromes are currently in use.
—Herbee 23:03, 19 May 2006 (UTC)[reply]

Or Edwards's syndrome :-P Tristanb 07:54, 25 August 2006 (UTC)[reply]

Blog about Edwards syndrome

This is a personal story from the mother of one of the oldest living sufferers of Edwards syndrome. A story by Gaye Fish contact Gaye.Fish@orange.fr —Preceding unsigned comment added by 90.31.167.208 (talk) 11:35, 20 February 2009 (UTC)[reply]

http://18mosaic.blogspot.com/ —Preceding unsigned comment added by 90.31.167.208 (talk) 09:43, 20 February 2009 (UTC)[reply]

Requested move

The following discussion is an archived discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. No further edits should be made to this section.

The result of the move request was: page moved. Vegaswikian (talk) 06:30, 11 November 2010 (UTC)[reply]

Trisomy 18 → Edwards syndrome — To be in consistency with other articles on similar conditions, such as Patau syndrome and Down syndrome. Vanjagenije 01:33, 4 November 2010 (UTC)

Support - there seems to be some confusion about whether there should be an apostrophe and, if so, where it should be located. But as long as we pick the most correct form then WP:COMMONNAME applies here. — Amakuru (talk) 12:23, 4 November 2010 (UTC)[reply]

The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page. No further edits should be made to this section.

birth data?

The upper part of the article states "The incidence of the syndrome is estimated as one in 3,000 live births.", but under the Incidence / prevalence header the following is stated: "Edwards syndrome occurs in approximately 1 in 3,000 conceptions and approximately 1 in 6,000 live births"

1 in 3000 live births or 1 in 6000 live births, what is the correct number? —Preceding unsigned comment added by 82.170.171.241 (talk) 00:10, 10 January 2011 (UTC)[reply]

and then later it says "the total number of live births is estimated to be 37" --Richardson mcphillips (talk) 01:45, 27 January 2019 (UTC)[reply]

Rick Santorum's Daughter

Should the information that Presidential Candidate Rick Santorum's daughter suffers from this condition be added to the article? It may help to personalize the condition. — Preceding unsigned comment added by 65.83.116.10 (talk) 19:50, 1 February 2012 (UTC)[reply]

We do often have a section in medical articles about notable people who suffer from the condition. In this case, it is unlikely that there are people who are notable in their own right who have full Edwards syndrome as they do not live to adulthood. Notability is not inherited, so I think it is not appropriate to have children of notable people. I am also concerned that adding the child of a presidential candidate at this point in the US election cycle might be promoting the candidate.-gadfium 08:36, 2 February 2012 (UTC)[reply]

I agree with all of the above reasons. It was more than sufficient that it was mentioned on Rick Santorum's article, with a link to this article.Wzrd1 (talk) 23:53, 7 September 2012 (UTC)[reply]

Trisomy E

I removed the alternative name "Trisomy E" in the introduction. Trisomy E is an obsolete term and moreover, it's not a synonym. The group E chromosomes are chromosomes 16, 17 and 18. Therefore, a trisomy E can mean a trisomy 16, 17 or trisomy 18. As far as I know, it was used only when karyotyping was inconclusive as to which specific trisomy was present. With modern techniques, this no longer occurs. Jennes83 (talk) 00:58, 15 November 2012 (UTC)[reply]

increasing risk or mean risk

"the risk of conceiving a child with it increases with a woman's age. The average maternal age for conceiving a child with this disorder is 32½" This seems to me to imply 2 incompatible things: a) risk increases, b) risk decreases after 32.5. It also seems to me that someone is responsible for several articles of this type, so there might be standard medical language here that I as a layman am not familiar with. --Richardson mcphillips (talk) 15:33, 10 February 2015 (UTC)[reply]

"resulting in"

I wonder about this sentence: "In 2008/2009, 495 diagnoses of Edwards syndrome (trisomy 18) were made in England and Wales, 92% of which were made prenatally, resulting in 339 abortions, 49 stillbirths/miscarriages/fetal deaths, 72 unknown outcomes, and 35 live births." The "resulting in" makes sense for the abortions, I suppose, but not for the rest, especially since not all the diagnoses were prenatal. I've tried rewriting it several times but can't make it smooth. --Richardson mcphillips (talk) 22:22, 27 May 2015 (UTC)[reply]

External links modified

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Obsolete External Links

It appears that external link #10 is obsolete. www.iscn1995.org is now a Japanese site devoted to tires for cars. I did some searching, and it seems that the 1995 edition of International System for human Cytogenetic Nomenclature (ISCN) is no longer in print. It is available for sale on Amazon.com and can be borrowed from a handful of libraries according to http://trove.nla.gov.au. It is also available online from onlinelibrary.wiley.com, but requires a subscription to access.

I am not sure what the normal course of action in this situation is, I made an account just a few minutes ago to bring this to the community's attention. I think that unless someone has the paper lying around or has a subscription to Wiley's Online Library, maybe we should use a newer and more accessible edition? The explanation in the wiki page that was cited seems pretty current, so I don't think that the wording will need to be changed, just the citation. I'm sure each edition has content that can be summarized by the existing text.

I think the other links need to be examined as well, especially the pre-2013 links. A lot of major advances in genetics have occurred in the past few years according to my professors, and some of the information may need to be changed. I am only an undergrad biology student, and do not yet understand all the scientific jargon in the journals and articles that are cited. So, I think others with more experience in genetics should be the ones who examine the links. Deducted (talk) 00:17, 20 December 2016 (UTC)[reply]

The first and easiest action is to add an archive link to the page. I've done this for the reference you mentioned. It would be better to re-evaluate the value of each reference in light of major advances as you suggest, but this takes more experience and time.-gadfium 05:50, 20 December 2016 (UTC)[reply]

NIH

The GHR is a perfectly reasonable source per WP:MEDRS. Doc James (talk · contribs · email) 22:50, 25 April 2018 (UTC)[reply]

"Edwards syndrome occurs in all human populations, but is more prevalent in female offspring"

Unfortunately the reference is not accessible. My question is this: articles about this condition say that more girls survive to birth and beyond than boys. Is that what the line quoted above means? If it means that there are absolutely more females than males altogether, then it might be good to provide an accessible source.--Richardson mcphillips (talk) 01:41, 27 January 2019 (UTC)[reply]

Oldest living persons

Elaine Fagan's name Has been remouved from the Wikipedia page ? Why ? Was she the first person with full trisomy 18 to reach the aduldhood ? I read somewhere that there where other people that made it since. And who is/was the oldest person living with mosaic trisomy 18 then ? How old is he/she ? — Preceding unsigned comment added by 93.22.36.81 (talk) 22:52, 14 November 2019 (UTC)[reply]

Clarification Needed

The article says: "Trisomy 18 (47,XX,+18) is caused by a meiotic nondisjunction event." What about (47,XY,+18)? Is this caused by a different mechanism?209.93.42.139 (talk) 08:02, 29 April 2021 (UTC)[reply]

Requested move 21 April 2023

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion.

The result of the move request was: moved. (closed by non-admin page mover) -- Maddy from Celeste (WAVEDASH) 21:45, 28 April 2023 (UTC)[reply]

Edwards syndrome → Trisomy 18 – The most common name in reliable sources. See NGRAM or Google Scholar results since 2010: 3700 for "Edwards syndrome", 16,500 for Trisomy 18. Additionally the proposed name is consonant with some other article titles for trisomies, such as Trisomy X. (t · c) buidhe 19:41, 21 April 2023 (UTC)[reply]

Comment. This would reverse the 2010 (mini-)consensus move above, which @Vanjagenije proposed "[t]o be in consistency with other articles on similar conditions, such as Patau syndrome and Down syndrome." SilverLocust (talk) 20:40, 21 April 2023 (UTC)[reply]

Of the autosomal trisomies, three others (Down syndrome, Emanuel syndrome, and Patau syndrome) are currently under non-descriptive names, while four (Trisomy 8, Trisomy 9, Trisomy 16, and Trisomy 22) are under descriptive names. (t · c) buidhe 22:35, 21 April 2023 (UTC)[reply]

Pinging people involved in the 2010 move request: Amakuru, Vanjagenije (t · c) buidhe 22:38, 21 April 2023 (UTC)[reply]

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Confusing Prognosis Section

"One percent of children live to age 10." Then the following sentence states, "a retrospective Canadian study... demonstrated ten-year survival of 9.8%"

So is it 1% or 9.8%?

Happy to dig into the citations and rewrite this section if others agree it's confusingly written. Glen newell (talk) 20:16, 3 January 2024 (UTC)[reply]