Talk:Chlorphenamine/Archive 1

This is an archive of past discussions about Chlorphenamine. Do not edit the contents of this page. If you wish to start a new discussion or revive an old one, please do so on the current talk page.

Archive 1

SSRI potency

Is this potent enough that people taking SSRIs or MAOIs etc. should avoid it?

Unlikely. It's main effect is antagonism of histamine H₁ (see antihistamine). Also, I'm about to update the image from png to svg. Note that the CH₃ (methyl) groups about the nitrogen are implied in the skeletal formula and need not be written as such. Fuzzform 22:59, 31 October 2007 (UTC)

Packaging indicates those taking MAOIs should avoid it.

This was plagarised

A straight copy-paste from http://www.answers.com/topic/chlorphenamine

Actually, moron, if you read the page, answers.com copied and pasted from Wikipedia! It's very clearly cited at the bottom. —Preceding unsigned comment added by 198.108.140.10 (talk) 05:45, 11 September 2007 (UTC)

Now now, insulting people isn't nice. Please be polite. An uninformed individual might think that answers.com is more official and reliable than Wikipedia, but Wikipedians know better. Fuzzform 23:09, 31 October 2007 (UTC)

Which was the model for zimelidine?

The articles diphenhydramine and zimelidine claim that diphenhydramine, not chlorpheniramine, was used as a model for zimelidine. However, googling returns 146 matches for chlorpheniramine zimelidine, or 21 for chlorphenamine zimelidine (Swedish 12 for klorfeniramin zimelidin) but only 119 for diphenhydramine zimelidine (Swedish 13 for difenhydramin zimelidin). Which should it be? On Wpedia diphenhydramine is the one most mentioned.

Where next Columbus? 00:29, 17 December 2005 (UTC).

As I understand it, zimelidine was synthesized from chlorpheniramine. But, as diphenhydramine is by far the most common antihistamine (and probably also the basis for the synthesis of chlorpheniramine, although I haven't seen any papers confirming that), it may as well be said that zimelidine was based off of diphenhydramine. In other words, chlorpheniramine was an intermediate between diphenhydramine and zimelidine. Fuzzform 23:07, 31 October 2007 (UTC)

Actually, it was brompheniramine that was the basis for zimelidine. See (circa) page 50 in Baronde's book "Better Than Prozac". 24.218.74.249 (talk) 04:31, 19 April 2008 (UTC)

First-generation?

In the first paragraph which says that Chlorphenamine is a first-generation antihistamine, what does "first-generation" mean? Cat Dancer WS (talk) 00:36, 28 January 2008 (UTC)

1st generation antihistamines usually have sedative effects, aside from that, I cannot define them any more, but usually 1st generation antihistamines (this being the exception) aren't used for allergies any more. —Preceding unsigned comment added by 89.241.171.89 (talk) 18:32, 3 March 2008 (UTC)

Not used for allergies anymore?!?, are you crazy??? Ever heard of Benadryl??? You said this drug is the exeption but Benadryl is first generation and it is far more common and is still very widely used for allergies.--206.28.43.6 (talk) 20:37, 16 August 2008 (UTC)

I linked first-generation to the relevant article and section. These drugs are still widely used. They include Benadryl, OTC sleep aids, and Dramamine. Hopefully this will answer your questions. --Jmcclare (talk) 03:21, 10 April 2008 (UTC)

P450 Contradiction

Okay, I'm a little puzzled. Chlorphenamine says it potentiates certain opioid analgesics (including codeine), but according to CYP2D6 chlorphenamine is an inhibitor of this P450 isozyme, while codeine is a substrate. Codeine states that it is a prodrug, being converted (via CYP2D6) into the active metabolites. How can chlorphenamine potentiate codeine when it inhibits the enzyme responsible for codeine's activity? --Jmcclare (talk) 03:30, 10 April 2008 (UTC)

Antihistamines are certainly potentiators of opiods - no question about that. Either there is mistake in the CYP2D6 article, or there is some other (stronger/more important) mechanism to explain antihistamines' potentiation of opiods. 24.218.74.249 (talk) 04:36, 19 April 2008 (UTC)

Not all anti-histamines are potentiators of opioid based drugs, in other words chemically, the opioid will have no greater effect whether taken with or without anti-histamines. The reason many people beleive anti-histamines potentiate opioids is due to their sedative effect, both opioids and anti-histamines are sedatives, together they produce stronger sedation. Also remember, codeine is only 1 type of an opioid drug, whilst many opioids do not need the liver to become active as they are active in their current form. There are only a few anti-histamines that potentiate codeine (& other metabolite based opioids) directly, the rest appear to potentiate due to the combined stronger sedation, when infact, chemically, no potentiation takes place. --93.97.181.187 (talk) 21:17, 19 October 2008 (UTC)

Citation for half-life?

In the pharmacokinetic data, chlorphenamine has a stated half-life of 21-27 hours. However, standard Chlor-Trimeton and generics state that they are effective for 4 hours. There are 8 and 12-hour versions, but these are a sustained relief formulation. If it takes 21-27 hours for the body to metabolize and excrete 50% of a chlorphenamine dose, how can it no longer be effective after 4 hours? I don't see a citation on the article which would cover this half-life claim, so I wonder if it could be incorrect.

Can anyone clarify this or add a citation? Thanks. Josh274 (talk) 00:38, 10 June 2008 (UTC)

Generally such info held by DrugBank link provided in the infobox, except DrugBank site currently seems temporarily down :-( David Ruben ^Talk 13:22, 10 June 2008 (UTC)

A belated answer:Firstly, biological half-life is the result of a complex set of processes and there is no guarantee (at the outset) of a direct relationship between half-life and duration of action. The consumer medical information provided by the distributor with the drug can usually be relied upon as a correct example for most individuals as the testing and research wil verify what the consumer needs to know, which is usually "How long will it relieve the symptoms?" and "How soon can I take more?". In differing individuals the outcome will not always be the same. To get some background look at Biological half-life as it will help. The DrugBank card confirms 21-27 hours for chlorphenamine. The complex process of metabolism is influenced by things such as the combination of chemicals in the formulation, other medicines an individual way be taking, whether a metabolite is lipophilic or otherwise (this is just a few examples). Solubility in a lipid may result in a slower elimination from the body but reduce the availability of the drug to perform its intended function. It also depends on which half-life is being measured and of which drug metabolite. The half-life in blood-plasma may be short but the duration of empirically known action much longer. For an example see [1]Celsius100 (talk) 03:10, 3 July 2009 (UTC)

SSRI template/category?

Should this be on the antidepressant template under SSRIs? It's already in the SSRI category, but it seems a little strange since it isn't used as an antidepressant. Thoughts? --Galaxiaad 18:47, 6 November 2006 (UTC)

I don't think so. As you say, it isn't used as an antidepressant. It's main use is as an antihistamine, and that's the template it belongs in. Fuzzform 23:00, 31 October 2007 (UTC)

Plus it's not an SSRI. The first S in SSRI is for selective. Reub2000 (talk) 02:51, 19 May 2011 (UTC)

Deconamine

I propose an addition to the combo-drug subsection. Deconamine, a combo-drug consisting of Chlorpheniramine and Pseudoephedrine.

Bullmoosebell (talk) 00:04, 5 January 2012 (UTC)

Legal status in the UK

I know for a fact that Chlorphenamine is a Pharmacy only medication in the UK, so I changed it from GSL to P in the infobox. If the "P" term is not common Wikipedia practise, feel free to modify it to the appropriate term. — Preceding unsigned comment added by Tomf60 (talk • contribs) 19:18, 7 September 2012 (UTC)

This is inaccurate. Piriton, a branded version of Chlorphenamine, is available in all pharmacies and supermarkets without prescription. — Preceding unsigned comment added by 87.194.154.84 (talk) 15:58, 9 February 2013 (UTC)

There is no such thing as 'chlorphenamine'

I think the correct spelling is chlorpheniramine. Can we get a correction? LVehko (talk) 19:47, 26 April 2010 (UTC)

Chlorpheniramine is a former name, it's now known as chlorphenamine. Chlorphenamine is internationally known (INN), and is a former BAN name. — Preceding unsigned comment added by 2a02:c7d:7608:e700:3cb8:8763:2ec5:44b4 (talk • contribs) 16:52, 16 June 2016 (UTC)

Maleate - formula vs structure diagram

The formula C16H19ClN2 in the infobox does not seem to match the structure shown top right which only seems to have 14 C. The maleate ion has 4 C so is it possible that maleate is divalent and the formula is for half of the salt, ie chlorphenamine ion + half of shared maleate ion ? - Rod57 (talk) 14:11, 14 September 2015 (UTC)

C16H19ClN2 is the correct formula and it does match the structure shown in the infobox which also has 16 carbons. ChemNerd (talk) 16:54, 16 June 2016 (UTC)