Talk:Chiral switch

Metabolite switches

37.200.16.127 talk‎; dated 6 August, 2021; 11.07

This has reference to your recent edit (6 August, 2021, 11.07) on metabolite switch, under Chiral Switch. Here the content on Metabolite Switches is basically as an extension of chiral switching approach. The focus is on chiral drugs. In this context, how do you justify the inclusion of acetanilide/phenacetin and risperidone? All the three are achiral drugs. It is not appropriate for inclusion in that table. It appears you have edited the table, heading changed from ‘racemic drugs’ to ‘original drug’.

In this context, I would appreciate if you could justify this edit of yours, else I may be constrained to remove this. Valliappan Kannappan (talk) 15:19, 18 August 2021 (UTC)[reply]

The original version of your table (before I added of acetanilide, phenacetin and risperidone) contained Astemizole and Loratadine, both of which are achiral as well - as such, I assumed that your inclusion criteria for that table didn't have a hard requirement for chirality. If you wish to remove all 5 of these drugs from the table, or split the "Metabolite switch" concept out to a separate article, then go ahead. 37.200.16.127 (talk) 08:11, 10 September 2021 (UTC)[reply]

Thanks for the insight. You are correct in pointing out the achiral nature of Astemizole and Loratadine. This has inadvertently escaped my attention during the drafting. Thanks for calling me out on this. To conserve the theme of the article, it is fair to feature only the metabolic switch of chiral drugs in the table and remove the five achiral drugs and edit the content accordingly, thereby keeping the focus on chirality aspect. Valliappan Kannappan (talk) 07:27, 11 September 2021 (UTC)[reply]