Talk:Cellular extensions

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Footplate

Think that the footplate is not the same as an end foot - it is not a cellular projection ? Iztwoz (talk) 09:23, 21 September 2024 (UTC)[reply]

Hello Iztwoz, I apologise that I haven't seen your message earlier. Indeed, Dorland defines footplate as the base of stapes, but numerous PMID articles and even Gray's Anatomy use the term to describe endfeet of Müller cells, astrocytes, and even microglia. I'll send a buch of links below: PecMo (talk) 12:23, 21 September 2024 (UTC)[reply]

Here are some links, Iztwoz. For example, (P:704) of Gray's Anatomy 41st ed states, "On the inner surface of the retina, the main Müller cell process expands into a terminal foot plate that contacts those of neighbouring glial cells and forms part of the internal limiting membrane".

You can also search the term "Footplate" in these articles: (1), (2) and (3). The term footplate can be used as a cellular extension, and a quick Google Scholar search will make you assured. PecMo (talk) 12:49, 21 September 2024 (UTC)[reply]

PecMo The first sentence states that they are cellular extensions which the base of stapes is not so the Dorland's ref needs to be removed.--Iztwoz (talk) 13:06, 21 September 2024 (UTC)[reply]

Iztwoz, Do you suggest using another reference then or do you want to remove that piece of information altogether?

What I understood is that the term footplate indeed commonly refers to the base of stapes; however, it may also be synonymous with foot process, especially if the context is clear (I already sent you a bunch of links).

If you wish to remove it though, it's not the big of a deal; however, we may need to modify the rest of the section in order not to leave empty spaces, useless commas and so on. PecMo (talk) 13:38, 21 September 2024 (UTC)[reply]

PecMo I have just pointed out that Dorlands ref is unsuitable, inappropriate for citing for base of stapes. You can of course use an appropriate ref.--Iztwoz (talk) 14:14, 21 September 2024 (UTC)[reply]

@Iztwoz, I added one of the references (this one)^[1] that uses the word footplate with astrocytes; it's now:

Despite not being exclusive,^[2]^[1] ..... and the term footplate commonly refers to the base of stapes.^[3]

This way Dorland states that the term footplate is associated with the base of stapes; however, it can also be used as foot process if the context is clear like the reference I provided on the page,^[1] and the other links I sent here.

I agree with you that Dorland alone doesn't state that footplate is more common one way or another, but in conjunction with another link, it more or less does like a reference combo?! PecMo (talk) 16:19, 21 September 2024 (UTC)[reply]

I also re-apologize for reverting your edit without checking the talk page. PecMo (talk) 16:21, 21 September 2024 (UTC)[reply]

Dorland's does not support the use of footplate as a cellular extension it only supports it as a synonym for base of stapes - there is no place for it as a ref for foot process. There are other sources that use footplate as a cellular extension.--Iztwoz (talk) 16:36, 21 September 2024 (UTC) Footplate seems to have a specific meaning in anatomy as the base of the stapes.^[4]--Iztwoz (talk) 16:43, 21 September 2024 (UTC)[reply]

PecMo In reply to your message on talk page - the use of foot process on pages that have specific uses of terms such as (astrocyte - endfeet) (Podocyte - foot processes) and others is much clearer to a reader than to be redirected to generic foot process. Also I believe the page to be a misnomer - it includes cellular extensions that are not foot processes.--Iztwoz (talk) 13:27, 22 September 2024 (UTC)[reply]

@Iztwoz, After some consideration, I believe you're right. I asked for the page to be deleted. PecMo (talk) 19:33, 22 September 2024 (UTC)[reply]

PecMo thanks for the notification. It's possible that some the researched information could be added to relevant pages. Best wishes --Iztwoz (talk) 19:40, 22 September 2024 (UTC)[reply]

Terminology dispute

If you search the term "foot process" on Google, nearly all results associate these structures with only one cell type, podocytes. However, when I came across numerous references, such as those cited in the article, that used the term "foot process" with other cell types, I thought of generalizing it, and wrote an article about the concept of "foot processes" in various types of cells.

However, on further reflection, I realized that all the references I found using "foot process" for other cells were clinically oriented, with none being specialized in histology or biology—at least not the majority. In clinically oriented, though peer-reviewed studies, I guess it's not always necessary to strictly adhere to specific terminology like "foot process" when "end foot" or "cellular process" might be more appropriate.

I now believe the references I used lack reliability and I think the term "foot process" should be reserved for podocytes, as this maintains clarity and consistency in the field. PecMo (talk) 11:54, 24 September 2024 (UTC)[reply]

Page name

PecMo. Perhaps you could consider renaming the page as Cellular extensions and edit accordingly which would allow a lot of material to be retained and which could be a worthwhile addition. There are lots of references to cell extension, cellular extensions, cytoplasmic processes, motile processes (and probably more that I cannot bring to mind) all of which could then have a 'home'.--Iztwoz (talk) 21:34, 24 September 2024 (UTC)[reply]

Hello PecMo I went ahead and made the change, I think you said you were going to be busy for a while. Page still needs a fair bit of work.--Iztwoz (talk) 17:10, 27 October 2024 (UTC)[reply]

Hello @Iztwoz, thank you for your edits, advice, and corrections to the mistakes I made. I have revised certain sections, replacing the "foot process" term with alternatives such as "astrocyte end-feet" and "end-processes," which I believe offer a more neutral tone. Please feel free to make any further edits or adjustments as you see fit. I agree that the article could benefit from further expansion, but I’m currently unable to commit to any additional work on it; I guess we can add a template to the page if needed. Thank you again for your support. PecMo (talk) 07:57, 1 November 2024 (UTC)[reply]

Thanks PecMo - I don't think the page needs any tags. There is a lot of interesting material that you had added and when I can I would like to spend some more time reading this and working more on the page. Best wishes Iztwoz (talk) 08:37, 1 November 2024 (UTC)[reply]

^ ^a ^b ^c Schmithorst, VJ; Vannest, J; Lee, G; Hernandez-Garcia, L; Plante, E; Rajagopal, A; Holland, SK; CMIND Authorship, Consortium (January 2015). "Evidence that neurovascular coupling underlying the BOLD effect increases with age during childhood". Human brain mapping. 36 (1): 1–15. doi:10.1002/hbm.22608. PMC 6869617. PMID 25137219. A conceivable alternative explanation for changing neuronal–astrocyte coupling with age is a changing number of "footplate" astrocytic processes contacting capillaries, as has been seen in mood disorders.
^ Ikeda, T; Nakamura, K; Sato, T; Kida, T; Oku, H (9 February 2021). "Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance". International journal of molecular sciences. 22 (4). doi:10.3390/ijms22041724. PMID 33572210. Astrocytes in the brain project foot processes (i.e., astrocytic endfeet) that envelop blood vessels, neurons, and the pia mater to form the glia limitans.
^ Dorland's illustrated medical dictionary (33rd ed.). Philadelphia, PA: Elsevier Saunders. 2020. ISBN 9781455756438.
^ "Medical Definition of FOOTPLATE". www.merriam-webster.com.

[footplate-1] Schmithorst, VJ; Vannest, J; Lee, G; Hernandez-Garcia, L; Plante, E; Rajagopal, A; Holland, SK; CMIND Authorship, Consortium (January 2015). "Evidence that neurovascular coupling underlying the BOLD effect increases with age during childhood". Human brain mapping. 36 (1): 1–15. doi:10.1002/hbm.22608. PMC 6869617. PMID 25137219. A conceivable alternative explanation for changing neuronal–astrocyte coupling with age is a changing number of "footplate" astrocytic processes contacting capillaries, as has been seen in mood disorders.

[anoikis-2] Ikeda, T; Nakamura, K; Sato, T; Kida, T; Oku, H (9 February 2021). "Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance". International journal of molecular sciences. 22 (4). doi:10.3390/ijms22041724. PMID 33572210. Astrocytes in the brain project foot processes (i.e., astrocytic endfeet) that envelop blood vessels, neurons, and the pia mater to form the glia limitans.

[Dorland-3] Dorland's illustrated medical dictionary (33rd ed.). Philadelphia, PA: Elsevier Saunders. 2020. ISBN 9781455756438.

[4] "Medical Definition of FOOTPLATE". www.merriam-webster.com.

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