Talk:Antimicrobial resistance/Archive 2

Archive 1

Archive 2

Over prescription of Antibiotics

It could be beneficial to discuss the over prescribing of antibiotics to patients and how it has led to an increase in antibiotic resistant infections. — Preceding unsigned comment added 18:03, 1 October 2014 (UTC)

Article title change?

There's an article title antimicrobial resistance that is pretty minimal. How about changing the title of this article to "antimicrobial resistance" (better I think) and combine the articles? juanTamad 10:58, 17 January 2015 (UTC) — Preceding unsigned comment added by Jtamad (talk • contribs)

I agree. The current title is misleading; antibiotics are not used to combat viral infections. We could rename the article as suggested and leave a redirect from Antibiotic resistance. Graham Beards (talk) 12:41, 17 January 2015 (UTC)

• Support Doc James (talk · contribs · email) 23:58, 17 January 2015 (UTC)
• Disagree strongly I totally disagree with the move, albeit 9 days late. the antibiotic article has had long existing problems that are not solved by a move. I worked on the antimicrobial resistance article a year ago, for reasons that can be discussed. It is a meta heading so to speak and needs to stay a separate article IMHO. Graham Beards's point has nothing to do with widening the title to antimicrobial resistance

Jtamad, Antibiotic resistance is what lay people know about, want to know about and and need to know about. Antifungal and antiviral, anti-protozoal resistance is for the expert. Doc James although head huncho at WP: Medicine, is clearly not a content expert on this as an ER doc. CAVEAT: This is no personal attack, but merely the facts, like the bold font sticking out. (BTW: if you guys want to rename something partout, why not rename antibiotic sensitivity to antibiotic susceptibility which is the proper term. Skin is sensitive, neither bacteria not antibiotics.) --Wuerzele (talk) 05:18, 27 January 2015 (UTC)

Antimicrobial resistance is a broader term. One does not need to be an expert to figure this out.

This is an editorial discussion rather than a content one. Do we want more articles that are narrower in scope or fewer articles that are broader in scope. I am in the later camp.

Doc James (talk · contribs · email) 15:33, 27 January 2015 (UTC)

• Re: "Antimicrobial resistance is a broader term. One does not need to be an expert to figure this out" A broader term, exactly , but it appears you didnt follow that this means more content. why would you want to pack in more content into this page? Does one need to be a content expert to figure this out?
• So, one more time, in more words: Antimicrobial resistance is a meta heading and NOT in common use by the lay audience. But antibiotic resistance is, and is WAY enough to write about in one article, as it was. You cannot cram all of antimicrobial resistance in one article on an encyclopedic level. I suggest a separate article, which was the status quo.
• Re "This is an editorial discussion rather than a content one." First, I dont see you discuss anything and why are you differentiating editorial from content?? Merging teh 2 articles (editorial decision) enormously influences the content.
• Re: "Do we want more articles that are narrower in scope or fewer articles that are broader in scope." ?? Counterquestion: Why distract from the issue on the table by generalizing the issue ad ultimo? Rhethoric? This is a talk page on one not very easy, but damn important topic, antibiotic resistance. why are you even posing this loaded question? for me to getsecond thoughts? I clearly answered your question for this, antibiotic resistance, and said Do NOT throw in antiviral and antifungal etc. so there was no need to ask. First, there is no wild abundance of WP articles in the area of clinical microbiology and infectious diseases anyway, -correct me if I am wrong, with stats- to justify a merger of this kind. Second by comparison, consider all the kinds of overlapping pages, eg for Meningococcus and its diseases 3 or even 4, and you make a fuss about this one mega topic of antimicrobial resistance, that permeates all fields of medicine incl. veterinary medicine, soil biology and what not.
• You merely allow antibiotic resistance to be a redirect, but not to have its own page? You don't need to be a content expert to realize that that is undue.
• Procedural comment: It is unheard of on WP, that only two editors establish a consensus, when numerous other editors work on a page. after waiting only like, what? one day, and on a decision of such a huge topic. Have a good one. --Wuerzele (talk) 08:04, 29 January 2015 (UTC)

Moved Jan 26th [1] after more than one week. Doc James (talk · contribs · email) 13:53, 29 January 2015 (UTC)

Doc James striking out the minor error I made, after having written IN THE BEGINNING if you look up: 9 days. It appears you use that error as a distraction and excuse to not engage in a discussion. And again, if its not too much for you , please have the courtesy to ping me if you communicate. --Wuerzele (talk) 08:13, 31 January 2015 (UTC)

It is totally obvious that you dodge discussions, but that is no remedy.--Wuerzele (talk) 05:27, 7 March 2015 (UTC)

image and caption

as of this version, image and caption were as in the top image.

Antibiotic resistance tests: The bacteria in the culture on the left are susceptible to the antibiotics contained in the white paper discs. The bacteria in the culture on the right are resistant to most of the antibiotics.

Was changed, per the bottom version.

Antibiotic resistance tests: The bacteria in the culture on the left are susceptible (dark, clear rings) to the antibiotics contained in the white paper discs. Those on the right are fully susceptible to only three of the seven antibiotics tested.

There is no source for this caption. Both versions of the captions are wrong. The dark rings are growth which means resistance. No ring = no growth = susceptible. Both of those are relative, not absolute. See the caption here. I would be happy to see the image restored with a correct and sourced caption. To explain, the dish is covered with the antibiotic. The white disks have different strains of bacteria on them. If the bacteria are resistant to the drug, they live and divide and expand, creating the dark circle. The amount of expansion is important - if the drug slows down growth, that is useful to know. If the bacteria are either killed or are prevented from dividing (in other words, the drug is a bacteriostatic agent), nothing happens, there is no growth, and no dark ring appears, and this shows that the bacteria are susceptible to the drug. OK with everybody? Jytdog (talk) 13:54, 26 January 2015 (UTC)

This is my image from cultures I made. The dark rings are not growth; they are areas where no colonies of bacteria can be seen, that is no growth. The dishes are not covered in antibiotic. The antibiotics are in the white discs. There is a different antibiotic in each one. The discs do not have strains of bacteria on them. The whole of the plates where covered with one strain of bacteria; a resistant strain and a sensitive strain. This is an example of a standard antibiotic sensitivity screen. I don't know where you have got the idea that the dark rings are growth and that each disc contains bacteria. Graham Beards (talk) 15:59, 26 January 2015 (UTC)

I restored the image with its caption and added a reference. Here is a relevant quote from the reference "The pathogenic organism is grown on Mueller-Hinton agar in the presence of various antimicrobial impregnated filter paper disks.  The presence or absence of growth around the disks is an indirect measure of the ability of that compound to inhibit that organism."--agr (talk) 16:13, 26 January 2015 (UTC)

Thanks, i was wrong! We had an edit conflict where we were each adding a source. I added content to the caption to better clarify the experiment. Sorry for my mistake. Duh and a big self-trout for me. Jytdog (talk) 16:15, 26 January 2015 (UTC)

just want to apologize again for this. amazing example for me of how one can find a source and cite it and fail to read it clearly. oy. sorry again. Jytdog (talk) 17:09, 26 January 2015 (UTC)

Thanks for the apology. But I don't think your caption edit is quite right. As i understand the procedure (Graham can correct me), the agar in the dish is streaked with a solution that contains the bacteria to be tested. At that point they are invisible. The antibiotic disks are then placed on the agar and the dish is incubated for a day or two. The bacteria grow out producing the "lawn" of bacteria you see in the image, except where antibiotic has defused from the disks in high enough concentration. It is not that the disk are added to grown bacteria and then kill them. The clear areas are where bacteria never grew.--agr (talk) 17:16, 26 January 2015 (UTC)

That's correct. This technique does not differentiate bactericidal and bacteriostatic antibiotics, i.e. those that kill and those that just inhibit reproduction. The potency of antibiotics is expressed as the minimum inhibitory concentration – it's all about the lack of bacterial growth, not killing them. "The clear rings where bacteria have died" is not correct, the bacteria have not grown in these zones. Graham Beards (talk) 18:43, 26 January 2015 (UTC)

thanks for the correction. fixed it.

missing talk page after page move

Doc James please move talk from antibiotic resistance here. I did not agree with the page move and am awaiting your reply.--Wuerzele (talk) 07:15, 28 January 2015 (UTC)

Wuerzele Agree - please, let's have missing Talk page restored. I will go to WP:chat for advice on how to do this. Regards, IiKkEe (talk) 12:29, 28 January 2015 (UTC)

Moving and merging. Please note I was not the one who did the original move. Doc James (talk · contribs · email) 18:25, 28 January 2015 (UTC)

false information in lede

"In medical therapy AMR is most problematic, but viruses, fungi and parasites can also occasionally become resistant."

This is an embarrassingly false sentence on 2 levels.

• First, AMR ≠ antibiotic resistance

AMR =antibiotic resistance + antiviral drug resistance + antifungal drug resistance + antiprotozoal drug resistance

So, the sentence should be "In medical therapy antibiotic resistance is most problematic, but viruses, fungi and parasites can also occasionally become resistant."

• Second, "In medical therapy antibiotic resistance is most problematic"? according to whom? An HIV doc doesnt say that The person with MDR Malaria or a MDRfungal infection doesnt. Imagine a soil biologist reading this, must think these medical folks cant look beyond their plate. So: "Most problematic" is in the eye of the beholder, unless qualified "for the healthcare system, for public health etc. I think what you want to say is "most common", not most problematic.
• Third, whats occasionally? defined by whom and how ? For me influenza doesnt occasionally become drug resistant, it is regularly amantadine resistant, and Tamiflu resistance is common depending on the strain. The sentence may be correct for Herpes simplex virus, but in an immunosuppressed patient not so. therefore, this is weasely, vague and not very thoughtful( it honestly sounds like a student wrote this) and not encyclopedic. This is way too sloppy for a lede sentence.

I also think, that AMR shouldnt be equated with drug resistance, as in the first sentence, since there is a separate WP page on. Cancer cells certainly become drug resistant to cancer drugs, but that's not AMR.--Wuerzele (talk) 09:29, 29 January 2015 (UTC)

Causes section a mess

Just starting to read article - Causes section is a mess. Here's how I might organize it:

Causes: Widespread use. Causes of Widespread use:

 low cost of generics, 
 uncontrolled access  
 (does globally widely available have to be mentioned as well? is it separate from the previous two?),  
 perception that antibiotics are a harmless panacea
 ubiquitous use in the meat industry to increase yields
 ? convenience of dosing (development of potent, qd po drugs)
 ...

Broadspectrum antibiotics

Lower and less frequent dosing - this area requires some research as to the dosing patterns that are more likely to create antibiotic resistance. See doi: 10.1097/CCM.0b013e318180fe62, doi: 10.1128/AAC.01053-05, doi: 10.1093/jac/dkm511, doi: 10.1128/AAC.01486-06, DOI: 10.1007/978-1-4614-1400-1_14

dissemination of resistance - ? in-patient-community links, agriculture-community links, high-risk patients. again, this area requires some research (see DOI: 10.1111/j.1469-0691.2008.02081.x) — Preceding unsigned comment added by Levydav (talk • contribs) 13:24, 8 February 2015 (UTC)

Edit

User replaced "Antibacterials in soaps and other products may contribute to antibiotic resistance" will "Antibacterials in soaps and other products do not contribute to antibiotic resistance, but are discouraged for other reasons" [2]

Ref says "A link between antibacterial chemicals used in personal cleaning products and bacterial resistance has been shown in vitro studies (in a controlled environment)." Thoughts? Doc James (talk · contribs · email) 05:36, 7 March 2015 (UTC)

I replaced the incorrect (above) sentence with the status quo which is correct. YOu, inserted a maybe which is uncited or original research. Read the reference again. --Wuerzele (talk) 05:50, 7 March 2015 (UTC)

I removed the link to microevolution as this has nothing specific to do with the mechanism of AMR. — Preceding unsigned comment added by 128.243.180.82 (talk) 11:41, 15 February 2016 (UTC)

Revert

In this edit [3] this material was restored to the lead

"Resistance may take the form of a spontaneous or induced genetic mutation, or the acquisition of resistance genes from other bacterial species by horizontal gene transfer via conjugation, transduction, or transformation. Many antibiotic resistance genes reside on transmissible plasmids, facilitating their transfer. Antibiotic-resistance plasmids frequently contain genes conferring resistance to several different antibiotics."

For one it was covered in the second sentence. Two it is overly complicated for the lead. Doc James (talk · contribs · email) 05:39, 7 March 2015 (UTC)

(edit conflict)why picking and choosing? you made much more massive changes than just that, which I reverted per WP:BRD, you ll have to discuss way more than the above- or make each edit separately.--Wuerzele (talk) 05:57, 7 March 2015 (UTC)

new topic: lede in general

Without getting too involved in the specifics of the reverts I need to mention I did some work on this article in November, and one of the major things I worked on was simplifying the lede. This is very important because this article is an excellent candidate for translation of the lede through the Medical Translation Project.

This means we need something that can be read by as many as possible, as it will be translated into 108+ different languages, many spoken where schooling is very limited. Discussing the ways in which resistance can occur is overly complicated for the lede and even so that paragraph is complicated even for a native English reader. That isn't as much of a problem down in the article, but remember the lede is supposed to be written for high-school reading level or below WP:LEDE. We have to remember the goal of the article – to inform people (not only college educated people) about antibiotic resistance. -- CFCF 🍌 (email) 10:55, 7 March 2015 (UTC)

• I came here because of a notice at WikiProject Medicine. The information seems a bit technical for the lead as compared to the kind of language which I think is common. Almost every term here is a jargon term. This may be warranted or may not be. If the article focuses on health, then typically less jargon is used, but if it is science focused, then more is acceptable. If this content is to be included then the proposer should talk through why it is important to include. It might be, but an argument should be made. Blue Rasberry (talk) 15:39, 10 March 2015 (UTC)
• the lede is absolutely horrible. it's the only thing we IiKkEe and I havent touched in our day long work over. I will take a stab at it doing it gradually and not 40 changes in one. I want to remind everybody that this article is a mongrel of a recent move that docJames refuses to discuss ( see above). I think it should be moved back to antibiotic resistance for reasons outlined above. please supply link of notice in wikiproject medicine on this talkpage for transparency.--06:23, 11 March 2015 (UTC)

Length of therapy

I modified the paragraph about length of therapy under human medicine because to me it seemed to conflate discussion of best length of therapy based on studies of effectiveness vs a patient deciding to shorten a prescribed length of therapy on the belief that it might increase probability of resistance developing. I see the editorial in BMJ that recommends ignoring advice about taking complete course of recommended therapy, stopping 72 hours after symptoms subside, but is this generally accepted? If not, seems there should be a statement that generally accepted recommendation is to continue the prescribed course of therapy (based on guidelines from Stuart Levy and others. juanTamad 05:51, 7 March 2015 (UTC) — Preceding unsigned comment added by Jtamad (talk • contribs)

Yes there are two different sources of evidence. 1) what guidelines / policy statements recommend 2) what review articles conclude. We should contain both ideally. Doc James (talk · contribs · email) 06:14, 7 March 2015 (UTC)

Current status on the topic seems to be: Need more RCTs before conservative official recommendations can change. http://hicsigwiki.asid.net.au/images/4/41/Should_you_stop_an_antibiotic_course_early_if_you_feel_better_R._Everts.pdf juanTamad 06:53, 7 March 2015 (UTC)

A powerpoint presentation is not a very good source though. But yes they can. Doc James (talk · contribs · email) 06:55, 7 March 2015 (UTC)

Right, will look for better. Someone else added that not me. The current version is good IMHO. juanTamad 07:01, 7 March 2015 (UTC)

Off topic

This content is sort of off topic and thus I propose deleting it " - the term now preferred to hospital-acquired infections or nosocomial infections {from New Latin nosocomium ("hospital"), from Ancient Greek νοσοκομείον (nosokomeíon, "hospital"), from νόσος (nósos, "disease, illness") + κομέω (koméō, "to take care of")}." Doc James (talk · contribs · email) 06:18, 7 March 2015 (UTC)

if it's just the part you indicate above, I agree.--Wuerzele (talk) 06:22, 7 March 2015 (UTC)

Trouble archiving links on the article

Hello. I am finding myself repeatedly archiving links on this page. This usually happens when the archive doesn't recognize the archive to be good.

This could be because the link is either a redirect, or I am unknowingly archiving a dead link. Please check the following links to see if it's redirecting, or in anyway bad, and fix them, if possible.

• http://therealnews.com/t2/index.php?option=com_content&task=view&id=31&Itemid=74&jumival=11872
• http://www.nytimes.com/2014/05/11/opinion/sunday/the-rise-of-antibiotic-resistance.html?ref=opinion&_r=0
• http://www.fiercebiotech.com/story/antibiotics-rd-get-critical-lift-executive-order-obama-advisory-group/2014-09-19
• http://www.technologyreview.com/news/513461/nanoparticle-disguised-as-a-blood-cell-fights-bacterial-infection/
• http://purl.fdlp.gov/GPO/gpo52306

In any event this will be the only notification in regards to these links, and I will discontinue my attempts to archive these pages.

Cheers.—^{cyberbot II}_{Talk to my owner:Online} 14:41, 13 July 2015 (UTC)

Prevention

Following a "doctor's advice" though recommended by WHO may not decrease resistance to antibiotics as we already state doctors often make bad recommendations when it comes to antibiotics. If we look at the Antimicrobial_resistance#Human_medicine a number of sources state that we should be using shorter courses of antibiotics for bacterial infections much of the time. We need to balance this. Doc James (talk · contribs · email) 22:11, 22 July 2015 (UTC)

what do you want? this looks like self talk.

and who is we? you and other docs ( me not included )?

you want to balance what with what? using shorter courses in general ?

that is an ignorant and unsourced statement.--Wuerzele (talk) 03:00, 24 July 2015 (UTC)

We as in Wikipedia needs to balance the evidence and positions of both parties in the debate. The position is neither ignorant or unsourced, but I agree it is a difficult question and my suggestion is to increasingly mention the benefit of using evidence based course lengths. -- CFCF 🍌 (email) 18:00, 24 July 2015 (UTC)

Poor compliance IS an important problem, the article sounds misleading in this aspect

"Increasing bacterial resistance is linked with the volume of antibiotic prescribed, not the lack of compliance with taking antibiotics." suggests very directly that poor compliance is a minor concern.

"Antibiotic resistance increases with duration of treatment; therefore, as long as an effective minimum is kept, shorter courses of antibiotics are likely to decrease rates of resistance, reduce cost, and have better outcomes due to fewer complications." It continues to correctly state the 72 hour idea, but the initial line suggests it to be of minor importance.

"In some situations a short course is inferior to a long course." This is extremely misleading. The cited paper refers to the effectiveness of treatment, but does not claim that antibiotic resistance growth is more limited (than long courses).

There are a few antibiotics with special properties (e.g. unusual half-time), which require different treatment, though these are rare.

I will edit the article accordingly. If you disagree, please let me know. --mafutrct (talk) 10:38, 14 August 2015 (UTC)

In this edit] you took paraphrased content and replaced it with copied and pasted content.

You added "In selected cases, it may be appropriate to stop antibiotic therapy early. However, if a person takes an inadequate course of antibiotics, they may relapse and require further treatment. This increases the risk of developing resistance, as it would expose the person to antibiotics for longer."

The source says "Therefore, in selected cases, it may be appropriate to stop antibiotic therapy early. However, if a person takes an inadequate course of antibiotics, they may relapse and require further treatment.12 This increases the risk of developing resistance, as it would expose the person to antibiotics for longer."

This is not allowed. We must paraphrase none open source content. Doc James (talk · contribs · email) 12:58, 14 August 2015 (UTC)

Agree with the issue wrt poor complience. It appears that only one type of poor compliance (using less meds than recommended rather than stopping early) generally causes problems. Exception of course exist such as TB. And have adjusted the text further.Doc James (talk · contribs · email) 13:00, 14 August 2015 (UTC)

Opening sentence seems awkward

Currently the opening sentence of the article reads, "Antimicrobial resistance (AMR) is when microbes are less treatable with one or more drugs used to treat infection." This strikes me as an bizarre and awkward first sentence, possibly stemming from being taught throughout my life to avoid ever writing, "<noun> is when...". It also misses the fact that the use of antimicrobials can be preventive rather than curative. I would propose changing the first sentence to, "Antimicrobial resistance is the resistance of a microbe to one or more drugs used to treat or prevent infection." Or something more along those lines. Someguy1221 (talk) 00:01, 24 August 2015 (UTC)

One however does not want to use a word in the definition that is part of the term you are trying to describe. Have adjusted per your other suggestions. Doc James (talk · contribs · email) 01:35, 24 August 2015 (UTC)

External links modified

Hello fellow Wikipedians,

I have just added archive links to one external link on Antimicrobial resistance. Please take a moment to review my edit. If necessary, add {{cbignore}} after the link to keep me from modifying it. Alternatively, you can add {{nobots|deny=InternetArchiveBot}} to keep me off the page altogether. I made the following changes:

• Added archive https://web.archive.org/20150414174401/https://www.wp.dh.gov.uk/publications/files/2013/03/CMO-Annual-Report-Volume-2-20111.pdf to https://www.wp.dh.gov.uk/publications/files/2013/03/CMO-Annual-Report-Volume-2-20111.pdf

When you have finished reviewing my changes, please set the —^{cyberbot II}_{Talk to my owner:Online} 08:46, 25 August 2015 (UTC)

Animal use: Claims regarding FDA announcements need editing

The article states “On April 11, 2012 the FDA announced a voluntary program to phase out unsupervised use of drugs as feed additives and convert approved over-the-counter uses for antibiotics to prescription use only, requiring veterinarian supervision of their use and a prescription. In December 2013, the FDA announced the commencement of these steps to phase out the use of antibiotics for the purposes of promoting livestock growth. “ These claims need editing to avoid misleading readers.

The FDA announcement of April 11, 2012, a news release, refers to Guidance for Industry #209 (which was published on April 13, 2012), indicating conversion from OTC to VFD status for drugs administered through feed, and from OTC to prescription status for drugs administered through water. In fact, the scope of Guidance for Industry #209 is more narrow, explicitly focused on medically important antimicrobials. The draft Veterinary Feed Directive document published on April 13, 2012 identifies requirements for VFD status. The third FDA document in the Federal Register of April 13, 2012 uses the term “prescription” only in reference to “prescription or veterinary feed directive products”, and does so only in the context of medically important antimicrobials.

The FDA list of medically important antimicrobials does not include such ionophores as lasalocid and monensin, which are both coccidiostatic and antibiotic. These are active ingredients in some products labeled for use in growth promotion. Also, there is no suggestion in Guidance for Industry #209 that conversion from OTC to prescription use only would apply to all uses of medically important antimicrobials, and the document recognizes that the nature of veterinary involvement in some uses must depend on circumstances. In this connection, see Part VII of the document.Schafhirt (talk) 20:20, 2 September 2015 (UTC)

Text

"The first bacteria resistant to all antibiotics was discovered in China in November 2015, before spreading to Denmark and the UK in December 2015.."

• The first source is poor.
• The BBC does not say all antibiotics just "resists the most common antibiotic of last resort". There are other antibiotics of last resort.
• Third source is not very good.

Would like to see something better. Doc James (talk · contribs · email) 03:38, 22 December 2015 (UTC)

Here is the Lancet study.[4] Basically the resistance has existed for some time but this is just the first time it has been found in a plasmid which makes transfer easier.

It is not clear they are resistant to all antibiotics just that they are resistant to polymyxin antibiotics. Doc James (talk · contribs · email) 03:44, 22 December 2015 (UTC)

This source is better [5] Doc James (talk · contribs · email) 03:54, 22 December 2015 (UTC)

agree (Nature is very good)--Ozzie10aaaa (talk) 15:08, 22 December 2015 (UTC)

References

Where next

doi:10.1016/S1473-3099(15)00466-1 - pipeline review of non-antibiotic antimicrobial treatment. JFW | T@lk 10:47, 27 January 2016 (UTC)

Adding a hyperlink and more information to another topic

As I was reading, in the introductory sentences, it mentions the concept of Horizontal Gene Transfer (HGT) and I think it would be beneficial to link the Wikipedia article about HGT to this article. Although the two topics aren't completely related, HGT isn't described in this article and I found myself looking up what it was anyway. The hyperlink would allow readers to research it as necessary and allow for a better understanding of the introductory paragraphs of this article. Also, I believe that there should be an addition to the subtopic of "Develop New Drugs" to include some of the facts about the role of pharmaceutical companies in treating antimicrobial resistance. These companies aren't creating enough drugs due to the lack of incentive (profit) involved, and I have sources to back this up. I think it's a really important issue for readers to understand about the pharmaceutical industry and it directly correlates to the creation of a treatment for antimicrobial resistance. Mckenzie1818 (talk) 16:52, 18 April 2016 (UTC)

yeah the problems with the lack of financial incentive to develop new anti-infectives are well known; not a big controversial thing, nor secret. The problem of resistance is not driven by lack of new drugs; we need new drugs b/c the existing ones have been poorly used and resistance is becoming more widespread. you have it backwards. Jytdog (talk) 18:31, 18 April 2016 (UTC)

This article has deteriorated greatly through 2016, and the previous lede explained and linked HGT while also being shorter. I will restore once I've gone through the edits properly. CFCF 💌 📧 19:40, 18 April 2016 (UTC)

I'm sorry, I'm not sure I understand your recent edit. Did you just revert all of the last 30 or so edits en masse? Seems like overkill. Looks like most of those edits were minor reference improvements which are helpful to the article and which no one wants to go back through and redo. Wouldn't it be easier to just remove those few sentences/paragraphs you have problems with? It looks like your edit removed a couple of sentences here and there (which looked ready to be trimmed out) and restructured a paragraph in the lede. Could you instead remove those extraneous sentences (see the diffs from your edit) and paste in the lead from a prior revision? Seems like that would have less collateral damage... Thoughts? Ajpolino (talk) 01:43, 19 April 2016 (UTC)

(@CFCF: pinging User:CFCF)

Just a comment: I can't believe what a battleground the lede has been and evidently still is in this article and that it is still rather inadequate.McortNGHH (talk) 13:20, 8 May 2016 (UTC)

Adding recent information/statistics

This article seems to have a lot of great information and is very informative! It does jump around a lot, however, and could use a little organizing for more clear thoughts. I also think a lot of the different subtopics have information lacking. Maybe newer, recent statistics should be added? I found an article regarding a 2016 EU Antimicrobial Resistance Conference that could be very useful with this, especially with data regarding other countries. Under the "Animal Use" European area, the conference explained that a substantial reduction in antibiotic use showed no effect of farmer's profits. This could be useful to explain that "As of 2004, several European countries established a decline of antimicrobial resistance...without jeopardizing economic costs. It also gives a graph explaining these trends. The Strategies topic has a good amount of information, but maybe adding that "Screen and treat" strategies have become cost-efficient in terms of decreasing the number of patients seen a day, because it reduces surgical infections. A couple other ideas that could be started/added after strategies, could be a subtopic for "Challenges" or "Education/Intervention." Challenges, being, what is getting in the way of solving the issue of antimicrobial resistance, and education being how physicians, healthcare, providers, or even the media can have an effect in terms of the education. Again, statistics could be inserted here. The article explains many studies, one being that a 2011 intervention (consisting of hand hygiene, well-informed staff, and separation of infected patients) showed a large decrease in the incidence of a carbabenem resistant microbe, again with more graphs. These are just some ideas!

References

-- Jessicasibal (talk) 00:36, 5 November 2016 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Antimicrobial resistance/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

rated top as important medical problem with considerable media coverage

Substituted at 01:09, 22 May 2016 (UTC)

A "disaster management" section for e.g. alternative ways of treatments such as genome editing

What do you think of adding a "disaster management"-type section that includes info on what might be done when things go bad and microbes actually develop antibiotic resistance? I'm not sure how it should be called but it could include a subsection or at least info on alternative ways of treatment that could be used in such a case such as genome editing/genetic engineering.

For this see e.g.: https://www.geneticliteracyproject.org/2016/08/22/crispr-genome-editing-game-changer-war-antibiotic-resistance/

Of course it should also state that prevention should / is considered to be the highest priority etc.

--Fixuture (talk) 01:43, 27 December 2016 (UTC)

unclear what is being suggested. many kinds of microbes are already resistant to many kinds of antimicrobials; this is a natural process and has gone on for a very long time. There is a more recent problem having to do with misuse of antibiotics but this too is not some future single apocalypse but is already happening in various ways, to various extents, in various places. Jytdog (talk) 06:51, 27 December 2016 (UTC)

@Jytdog: Not sure how to make it clearer. Many sources say that it can become a disaster (and potentially usher in a "post-antibiotic era of medicine") and this section would be about dealing with that. It would also be about alternative ways of treatment which doesn't require it to be a disaster. As said I'm unsure about the name of the section.

--Fixuture (talk) 13:17, 27 December 2016 (UTC)

you wrote "when...microbes actually develop antibiotic resistance?" but they already have and do. you don't seem to understand this subject matter. but whatever. we can only add content about X to WP if there are reliable sources that give sufficient discussion to X. if you would bring some refs that are OK per RS or MEDRS as relevant, about whatever it is that you are suggesting, then we can discuss content based on them. Please bring refs. (the blog is not helpful) thanks Jytdog (talk) 19:06, 27 December 2016 (UTC)

@Jytdog: Alright. Here are some:

• http://www.nytimes.com/2016/09/18/magazine/could-ancient-remedies-hold-the-answer-to-the-looming-antibiotics-crisis.html
• http://www.dw.com/en/plant-magic-scientists-return-to-roots-to-fight-superbugs/a-36559926
• http://www.popsci.com/heres-how-well-fight-superbugs-antibiotic-resistance
• http://phys.org/news/2016-04-fall-antibiotic-age.html
• http://www.bbc.com/future/story/20161010-all-you-need-to-know-about-the-antibiotic-apocalypse

For the usage of genetic engineering:

• http://www.the-scientist.com/?articles.view/articleNo/42992/title/Targeting-Antibiotic-Resistant-Bacteria-with-CRISPR-and-Phages/
• https://news.mit.edu/2014/fighting-drug-resistant-bacteria-0921
• http://www.popsci.com/article/science/editing-genes-superbugs-turn-antibiotic-resistance
• http://www.nature.com/scibx/journal/v7/n41/full/scibx.2014.1198.html
• http://mbio.asm.org/content/5/1/e00928-13.full (?)
• http://arep.med.harvard.edu/pdf/Byrne_MethEnz_ch6_2014.pdf (?)

--Fixuture (talk) 04:45, 29 December 2016 (UTC)

Thanks. The first set of refs - yes, everyone knows that antibiotic resistance is a growing problem, driven mostly by inappropriate use of antibiotics. The second set of refs. You have there the mBio paper which is about killing bacteria with CRISPR, and the chapter from the Harvard people about using CRISPR to edit human stem cells (not relevant, yes). The others with the exception of the SciBx piece, are popular media or press releases (gah) covering one or more of three research papers about using CRISPR delivered via phages to remove resistance plasmids in resistant bacteria. Nothing about disaster preparation. Even the SciBx paper is poor in some ways because it makes it seem like the CRISPR alone killed the bugs, but all it does is sensitize them to the antibiotic. It is good in that it points out how far there is to, to make this anything useful. This is all very early stage and anything we would add would be very WP:CRYSTALBALL. Jytdog (talk) 06:02, 29 December 2016 (UTC)

Alternative names

Super bug (bacteria) redirects to Antimicrobial resistance. I think Superbacteria should also redirect here (at this moment it redirects to Escherichia coli). I suggest mentioning these two alternative names in the article, somewhere, since those words are used frequently. I think that would be helpful for the reader (and for those who search the terms on Google). —  Ark25  (talk) 18:17, 16 January 2017 (UTC)

Bacteriophage

Someone thinks it would be useful to include this paragraph Bacteriophage in the strategies? Assianir (talk) 16:47, 31 January 2017 (UTC)

@Assianir: Better Phage therapy PawełS (talk) 00:53, 17 May 2017 (UTC)

Cochrane review update

I added the conclusion of a new Cochrane review on antibiotic stewardship to the strategies section under prevention. This is an active task on the Cochrane Task Exchange and the WP:Cochrane Collaboration. Conclusions from the review might fit elsewhere on this page. JuanTamad (talk) 01:27, 10 April 2017 (UTC)

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BMJ review article on duration

Are you sure the BMJ review shouldn't be added in the section on treatment duration ("treatment duration" would be a better heading that 'duration of antibiotics" IMO). Seems to summarize much of the evidence on the issue and then come to an authoritative opinion. This certainly seems to be a point worth adding: 'the conventional argument of “completing the course of antibiotic “ to prevent development of antibiotic resistance is not based on scientific evidence.' The citation to NPS Australia doesn't even go a page directly on the topic and I didn't find anything that even discusses the issue of duration of treatment. Doesn't seem very good reference to me. JuanTamad (talk) 07:11, 3 August 2017 (UTC)

Adding information/links with sanitation / wastewater issues?

I think this article is lacking information and links to how antimicrobial resistance is spread through lack of sanitation, in particular wastewater discharge into the environment, e.g. in India. When I get around to it, I'll try to add some info with sources of course, as per this discussion here. EMsmile (talk) 21:43, 11 August 2017 (UTC)

actually sorry, I did now find information about wastewater in the section on causes, so that's OK; but we also need the topic of wastewater treatment in the section on prevention. EMsmile (talk) 21:51, 11 August 2017 (UTC)

Non-neutral point of view

The term “structural violence” as used in this article seems not to refer to actual violence; therefore, I put a {{POV-check}} tag next to the paragraph where it appears. To make it more neutral, I propose to re-word this paragraph thusly:

Socioeconomic factors such as discrimination and poverty can contribute to improper use of antibiotics by affecting accessibility of and adherence to drug therapy. The efficacy of treatment programs for drug-resistant strains depends on whether or not programmatic improvements take into account the effects of such factors.

That being said, however, the cited source is about “structural violence” rather than about antimicrobial resistance; because the source is an opinion piece and does not support my re-worded version, I also suggest replacing it with a more neutral source. 2600:1003:B027:8176:0:55:9359:5B01 (talk) 13:17, 30 August 2017 (UTC)

Updates needed? Yes, near end of 2014 - And continued in 2017

This is a big issue and will probably continue to be in the future for some time, so the page needs to be better, some consolidation, rewriting and updating. I've taken an interest in this and want to make some changes that I'll propose here before making. A better title might be "Antimicrobial resistance." By one definition, by the WHO, "antimicrobial" is a broader term covering all microbial organisms (viruses, fungi, parasites as well as bacteria), while antibiotic resistance refers to "resistance to antibiotics that occurs in common bacteria that cause infections." (see WHO fact sheet 194) The CDC waffles, using both.

I've written a new introductory paragraph as follows:

Antimicrobial resistance occurs when pathogenic microbes continue to grow after exposure to one or more antimicrobial agents due to genetic modifications that impart resistance. Microbes that exhibit resistance can include viruses, fungi and parasites, but antimicrobial resistance (also called antibiotic or drug resistance) is mostly a problem in the treatment of infections caused by bacterial pathogens. In a recent report, the World Health Organization states that antibiotic resistance is "a growing public health threat of broad concern... [that] threatens the achievements of modern medicine." Bacteria that are resistant to multiple antibiotics are considered multidrug resistant (MDR) or, more colloquially, superbugs. In September 2014, US president Obama issued an executive order forming a task force to tackle the threat and calling the issue one of national security.

COMMENTS?

The existing intro paragraph doesn't much stress the importance of the issue I don't think.

Other issues:

- veterinary medicine is probably not the best subheading for this section. To me that would indicate that drug resistance is a problem in the treatment of animals with infections, which is not the issue here or course. It should be something like: Inappropriate use of antibiotics in animal husbandry IMHO

- maybe create a new subheading under Prevention, called Action. Include more about the executive order, the CDC threat report of 2013, this (http://www.whitehouse.gov/sites/default/files/microsites/ostp/PCAST/pcast_carb_report_sept2014.pdf) and then keep this updated (action plan to be submitted by 15 February 2015).

I'm making my way through, wordsmithing and looking for other possible changes/additions — Preceding unsigned comment added by Jtamad (talk • contribs) 04:13, 8 December 2014‎ UTC}

please focus on improving the body of the article. per WP:LEAD, the lead paragraph should summarize what is in the body of the article. when you do that well, you don't need any sources in the lead, as everything in the lead is already in the body, and of course well sourced there per WP:VERIFY. Jytdog (talk) 05:17, 8 December 2014 (UTC)

have updated the lead with the UK govt commissioned review on AMR which was published in May 2016 (reference 9). This is the by far the most comprehensive review done thus far by several dozen specialists. Also agree with the above that the article needs some restructuring. I'll be back. ASRASR (talk) 12:27, 10 November 2017 (UTC)

Adjust section headings according to Manual of Style?

I am proposing that we adjust the section headings to align the structure with the Manual of Style (Medicine). See here. I think we could use those section headings as proposed for diseases, even though it is not a disease as such. But I think it would still work. In particular I propose:

• Adding a new section on epidemiology (or prevalance), towards the middle or end of the article
• Moving the part that is currently called "Organisms" to "Causes" or to "Mechanisms" (??)
• Moving the part that is currently called "Applications" to somewhere else - to where? It has no references, so we should perhaps also shrink it down a bit. (edit: I have deleted it now)
• Also maybe add these sections:
  • History: Early discoveries, historical figures, and outdated treatments (not patient history)
  • Research directions: Include only if addressed by significant sources. See Trivia, and avoid useless statements like "More research is needed". Wikipedia is not a directory of clinical trials or researchers.
  • Special populations, such as Geriatrics or Pregnancy or Children
  • Other animals

We should also always keep in mind the situation in developing countries, such as India. For example the section on "Antibiotic usage" does not say anything about overuse in countries like India. EMsmile (talk) 16:57, 10 November 2017 (UTC)

I've done a bit of work here but I am now confused whether the section "Mechanisms" and the section "Organisms" are in the right places. Should mechanisms and causes be merged somehow? Or is talking only about the causes based on overuse of antibiotics only? Also the section on organisms is very long and detailed. I wonder if it might be better to spin that off into a separate article perhaps? (or maybe it used to be a separate article and got merged in). For some of the articles they actually already have separate pages. In those cases, I think the content here should be culled for thos organisms and rather the reader be sent across to the other article. For example this one: Main article: Methicillin-resistant Staphylococcus aureus EMsmile (talk) 23:49, 10 November 2017 (UTC)

Causes is more the direct event that leads to some outcome

Mechanism is the underlying chemistry that ties the direct event to the outcome

The later is generally more complicated, more details, and should go after the first. Doc James (talk · contribs · email) 07:12, 11 November 2017 (UTC)

OK, I understand that now. I wonder if "mechanisms" should be made into a spin-off article as it's somehow rather different and specific whereas the rest of the article focuses more on antiobiotics use and overuse? EMsmile (talk) 23:54, 11 November 2017 (UTC)

I suggest that we move the section about "organisms" to be below "mechanisms". Do others agree? EMsmile (talk) 02:12, 12 November 2017 (UTC)

Sure to both of those. A short summary on mechanisms should remain here.Doc James (talk · contribs · email) 10:52, 12 November 2017 (UTC)

OK, I have done more work along those lines. I have moved a few paragraphs into the separate articles that already exist on those topics (e.g. for the animal use stuff). No need to lose the reader here with too much detail if a separate article already exists. I think this AMR article should be seen as an overview article that is understandable for the layperson and that gives all the links to further articles where more information is to be found. Now one large chunk of text which still needs to be moved into a spin-off article is the one about "bacteria" (currently under "Mechanisms and organisms). Only a short paragraph should remain, similar to the information about the other organisms such as viruses. I couldn't find an existing article where we could move this information to. Should we create a spin-off article and if yes, what should it be called? Something like "Bacteria with antimicrobial resistance"? What do others think? EMsmile (talk) 15:15, 13 November 2017 (UTC)

Done some work on the lead - better image?

I've done some work on the lead, hope others are OK with that. The lead in my opinion was not enticing for lay persons to read. It was actually too long and detailed in many cases. So I moved some of that content to the main body. Also, it is still not a good summary of the article so it needs further work (e.g. some information about environmental issues such as untreated hospital wastewater discharged into water bodies needs to be added to the lead, picking up on content in the article). I think the current content might still require further trimming to create space for those non-medical aspects that are not yet well covered in the lead, e.g. also the overuse in animal husbandry. - Furthermore, I am not sure if the image for the lead with the long scientifc caption is suitable if the target audience is laypersons rather than scientists? Another option could be a map showing antibiotic use per capita per country (does such a map exist?). EMsmile (talk) 02:05, 12 November 2017 (UTC)

Looks better. Simplified a bit more. Doc James (talk · contribs · email) 10:53, 12 November 2017 (UTC)

How about my other suggestion: "Furthermore, I am not sure if the image for the lead with the long scientifc caption is suitable if the target audience is laypersons rather than scientists? Another option could be a map showing antibiotic use per capita per country (does such a map exist?)"? How about taking one of these maps perhaps?: https://resistancemap.cddep.org/AntibioticResistance.php (I can contact them to ask for the maps as an open access image). EMsmile (talk) 12:22, 15 November 2017 (UTC)

Added some material in the Environment section

Added the 2016 material from London School of Economics and Political Science (Araya et al) on potential impact of increased WASH infrastructure on diarrhea disease burden and in turn on the excessive use of antibiotics. It is estimated (WHO 2011) that 40% of the diarrhea cases are treated with antibiotics - something completely unnecessary if people had access to proper sanitation instead. ASRASR (talk) 13:22, 12 November 2017 (UTC)

I wonder if that material should rather be added under prevention, not under causes? Also be careful: make sure you have a citation for each key statement even if it can be inferred logically. There is this principle that we need to adhere to:

Citation truly supports content. This means: · If Source 1 says A leads to B · And Source 2 says B leads to C · It is tempting to say A leads to C. · But this is prohibited. Need to find a source that says A leads to C.

Also you don't necessarily have to say "A study by WHO found that X is the case". We are not doing scientific writing here. Rather say "X is the case" and add as a reference to WHO study. If people want to know who made the statement, they can click on the reference. EMsmile (talk) 11:12, 13 November 2017 (UTC)

Trim/streamline section on antibiotic misuse?

I just found there is a spin-off article called Antibiotic misuse. I am wondering if either the content on "antibiotic misuse" should be culled a bit from this article and movecd to the other; or if the two articles should be merged as they are likely to overlap e.g. in terms of strategies to prevent antibiotic misuse? As if often the case with Wikipedia, some good information is scattered around several articles. I think if we streamline this then we can make it much easier for readers to find what they are looking for. It would also make it easier for editors to know where they should be added more up to date study results. EMsmile (talk) 15:23, 13 November 2017 (UTC)

Moving the section about bacteria (organisms) to spin-off article?

I've mentioned this above on the talk page but let me repeat it here so that it doesn't get lost: One large chunk of text which still needs to be moved into a spin-off article is the one about "bacteria" (currently under "Mechanisms and organisms). Only a short paragraph should remain, similar to the information about the other organisms such as viruses. I couldn't find an existing article where we could move this information to. Should we create a spin-off article and if yes, what should it be called? Something like "Bacteria with antimicrobial resistance"? What do others think? (I think this AMR article should be seen as an overview article that is understandable for the layperson and that gives all the links to further articles where more information is to be found.) EMsmile (talk) 12:23, 15 November 2017 (UTC)

I have thought further about the possible name of the spin-off article. How about "Antibiotic-resistant bacteria"? ("Antimicrobial-resistant bacteria" is another option but I guess antibiotic is more precise. If nobody gives any feedback on this, I will go ahead with it in a few days or so. EMsmile (talk) 11:38, 17 November 2017 (UTC)

I have always found the page at Wikipedia:Splitting to give good guidance on when and how to split an article. It advises that articles between 40 kB and 50 kB "may need to be divided". Antimicrobial resistance is currently 46 kB of "readable prose". It is clear however that the section Bacteria is huge (over 20 kB) compared with the other corresponding sections, so a split is indicated. A slight complicating factor is that the section already contains two sub-sections that refer to daughter articles already: the 43 kB Methicillin-resistant Staphylococcus aureus and the smaller New Delhi metallo-beta-lactamase 1. When you perform the split to Antibiotic-resistant bacteria, it might be a good idea to check whether the summary sections on MRSA and NDM-1 are still current, and update if needed. Finally, there's no reason why Antimicrobial-resistant bacteria, Antibiotic resistant bacteria and Antimicrobial resistant bacteria should not exist as redirects to the new article as they are quite plausible search terms. Cheers --RexxS (talk) 17:38, 17 November 2017 (UTC)

agree w/ RexxS--Ozzie10aaaa (talk) 19:21, 17 November 2017 (UTC)

Thanks, Ozzie10aaaa and RexxS. Putting in those redirects from similar search terms is easy and a must-do. Now I am wondering what is the best term that we should use? I had proposed Antibiotic-resistant bacteria, but is one of the other alternatives a better title? Maybe: Antimicrobial-resistant bacteria? And with or without a dash?? - Also what did you mean about those summaries exactly, when you said "it might be a good idea to check whether the summary sections on MRSA and NDM-1 are still current, and update if needed"? I might need a bit of help on that as I don't have a medical background. EMsmile (talk) 00:41, 18 November 2017 (UTC)

How do people feel about this suggestion: "List of antibiotic resistant bacteria"? It could be wise to call it a list article to ensure that it purely stays on topic and doesn't start to stray into topics of causes, prevention etc - which is all covered in the main AMR article. EMsmile (talk) 23:26, 20 November 2017 (UTC)

I am supportive of the list suggestion as there are a bunch and the number continues to grow. Doc James (talk · contribs · email) 15:32, 21 November 2017 (UTC)

I'm less certain. If the spin-off article isn't going to lose information, it will be necessary to make sure that the article for each individual bacterium already contains the information in the section that's being replaced, e.g. make sure that Streptococcus pyogenes has all the information currently in Antimicrobial resistance #Streptococcus and Enterococcus, etc. That's going to be quite a bit more work that just moving the content of Antimicrobial resistance #Bacteria into a new article and summarising it, I suspect. --RexxS (talk) 19:19, 21 November 2017 (UTC)

Maybe I misunderstood what you, RexxS, are saying: We would only be creating ONE spin-off article (with title "List of antibiotic resistant bacteria") which would contain the entire content that is currently under Antimicrobial resistance #Bacteria, and not several spin-off articles at the level of the bacterium. Links can be from e.g. Streptococcus pyogenes to this new list article and to the AMR article, if it's not already in there. Did I misunderstand your point? If I did then what exactly is your alternative suggestion? EMsmile (talk) 20:22, 21 November 2017 (UTC)

I read that you were suggesting the creation of a list article that contained a linked list of all the bacteria currently displayed in Antimicrobial resistance #Bacteria (as that is what a list article is). My point – which I re-iterate – is that the current section contains more than just a list of bacteria (because it's part of the Mechanisms and organisms section). I worried that the information presently there might be lost when Antimicrobial resistance is shortened after the creation of a list article, so I suggested you should check that the information is present in each individual bacterium article. That would at least ensure the encyclopedia doesn't lose the detail that would not be present in the list article. --RexxS (talk) 21:58, 21 November 2017 (UTC)

No, actually the idea was to create a spin-off article that is entitled "List of antibiotic resistant bacteria" but that doesn't just contain a list but the exact content that is currently under "Bacteria" in this article (I would move the whole content across, as is). It would look a bit similar to this article Waterborne diseases. So it would have "list of..." in the title but be more than a purely "list type" article. Is that feasible? If not, then what could a better title be? We want to make sure the article is purely about those bacteria, not about underlying causes or things to prevent AMR, as that should be on the AMR article and not doublicated in the spin-off article. EMsmile (talk) 22:43, 21 November 2017 (UTC)

OK, as there was no further input or objections, I have now gone ahead and created the spin-off article with the title List of antibiotic resistant bacteria. Please see what you think and help to improve it further. I think it makes the artile on AMR much more balanced and easier to handle. EMsmile (talk) 11:29, 23 November 2017 (UTC)

Link to videos - uploading videos to Wikimedia Commons

I've just added a link to a youtube video, based on suggestion by User:ASRASR. Better would be of course to have the video uploaded to Wikimedia Commons. We can ask the owners of the video to release it under CC-BY SA 4.0 licence. But before we do so: let's spend a moment identifying the most important and best videos on AMR out there at the moment. There are so many. Let's choose a really good one. - The current video in the article strikes me as too researchy. I think we should move it into the new spin-off article on "antiobitic-resistant bacteria". EMsmile (talk) 11:52, 17 November 2017 (UTC)

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This entire *article* is a mess.

And I can't figure out how in the world there's no timeline of resistance, either in this article or linked from it. To be quite frank, this entire article is actually pretty useless (and misleading), all-in-all. I'm guessing whoever wrote it has no idea what in the world they're talking about. 10 June 2019, 22:29 (UTC)

Well then help to improve it!! List here first the main problem areas that you see with this article. I've tried to improve it in the past but for sure more can and should be done! Constructive criticism please. EMsmile (talk) 04:16, 11 June 2019 (UTC)

Discovering of antimicrobial-resistance genes

Appearantly, there is a new technique to find antimicrobial-resistance genes. See here. It's called FLASH, and was developed by Emily Crawford at the Chan Zuckerberg Biohub in San Francisco, California Not sure where to place it i this article. Genetics4good (talk) 17:08, 24 August 2019 (UTC)

@Genetics4good: This is a good addition. I would cite the original paper in Nucleic Acids research, rather than the reporting of it in Nature as you have done above. I would insert it into section 8, 'further research' Fortnum (talk) 20:59, 24 August 2019 (UTC)

Ok added it to #Development_of_new_drugs. You can ref the Nucleic acids paper there too. Reason of not knowing where to put it initially is because it isn't fully described what they intent to do with this knowledge (almost without doubt improving their existing medication, but perhaps also other things; ie developing gene therapies -creating immunity against this from birth- is something that comes to mind). I doubt where anywhere near that point at this moment however, but seems to be coming at least.Genetics4good (talk) 09:13, 25 August 2019 (UTC)

There seems to be a misunderstanding of the NAR study. It has nothing to do with finding new antimicrobial-resistance genes or developing new drugs. The purpose of the study was to detect known antibiotic-resistance genes. I removed the two sentences about the study. CatPath (talk) 19:35, 26 August 2019 (UTC)

Ok, thanks for the clarification. Not sure to which article the info then needs to be added though.Genetics4good (talk) 11:19, 27 August 2019 (UTC)

Controlled prescription of antibiotics

Hi, I'm new to wikipedia and doing this for my micro class. I wanted your opinions about how to maintain a reliable antibiotics by either prescribing antibiotics a lot less or by genetically engineering certain fungal genes that secrete antibiotics that inhibit the growth that have different structures microbes will not recognize?

Your article was pretty well informed Kulneet (talk) 01:09, 14 September 2019 (UTC) Kulneet Sidhu, 9/13/2019

Sorry this page is not a discussion forum about AMR. It's about discussing how to improve the Wikipedia article on AMR... EMsmile (talk) 03:08, 23 September 2019 (UTC)

DNA-based smart antimicrobials

Can these be mentioned in the article ? Appearantly, a company called Locus BioSciences is making these. The company was started by the people behind this study: Repurposing CRISPR-Cas systems as DNA-based smart antimicrobials Genetics4good (talk) 14:27, 18 October 2019 (UTC)

Broad vs narrow-spectrum antimicrobials

What hasn't been mentioned at Antimicrobial_resistance#Limiting_antibiotic_use is that narrow-spectrum antibiotics are preferable (to prevent antimicrobial resistance) over broad-spectrum antibiotics as it only attacks those bacteria species which are actually causing the diseases and which you actually want to kill.

This works on two ways:

• first off, you only create resistance against antibiotics with the species you want to kill, not all bacteria species
• bacteria species also fight for space amongst themselves, so if you keep more beneficial/"good" bacteria alive, they have a better chance to kill of those bad bacteria which might not of been killed completely (and once those are destroyed, they won't pass on the resistance to new bacteria of the same species)

Please find references and add to the Antimicrobial_resistance#Limiting_antibiotic_use section Genetics4good (talk) 14:59, 18 October 2019 (UTC)

Sounds good, please help by providing the reference(s) needed, User:Genetics4good EMsmile (talk) 02:27, 4 November 2019 (UTC)

Aelin therapeutics approach

Can we also mention the approach used by Aelin Therapeutics (appearantely they use a non-conventional approach against which antibiotic resistance has little effect) See here Genetics4good (talk) 16:30, 9 November 2019 (UTC)

Adding a link for an animation in the external links section

Hello, My name is Nitai Steinberg, I am very new to the Wikipedia editing community, so I don't want to make mistakes. I recently created a short (5.5 minutes) movie that tries to address common misconceptions people have regarding antibiotic resistance (it was during my studies at the MSc in Biomedical Communications program, University of Toronto, Canada). Those misconceptions are prevalent in the public, but even among even among students of life sciences, veterinary and medicine. In part, it is because the process of evolution by natural selection goes against human intuition. At this stage, I published the final version of the movie on YouTube, and would like to promote it as much as possible to reach as many people as possible. Here is the link: https://www.youtube.com/watch?v=ePxnY41LI8Y I wondered if it is possible to add a link at the bottom of the page for the YouTube video page about this subject, I think it could really help people solidify all the knowledge that already exists in this Wikipedia page, and in general promote deeper understanding of the subject, while avoiding or correcting misconceptions people may have. Please let me know if you think it is acceptable. Thank you for your time, Nitai Steinberg, PhD --Nitaiste (talk) 18:25, 15 October 2019 (UTC)

Hi again, just wanted to make sure, is it possible add the link to the video to the external links section? I just want to make sure it's acceptable before I do it. Just would be happy to do it before World Antibiotic Awareness Week, next week (November 18). Thanks! --Nitaiste (talk) 17:15, 11 November 2019 (UTC)

Hi, I don't think the video adds anything to the article. There are also inaccuracies in that some antibiotics are bacteriostatic and are not bacteriocidal and some have toxic effects on the host. Please see WP:External links. Graham Beards (talk) 18:25, 11 November 2019 (UTC)

(ec) You may have misunderstood Wikipedia's purpose. ... and would like to promote it as much as possible to reach as many people as possible - any kind of promotional activity or advocacy is prohibited here. You are welcome to improve the article itself based on reliable 3rd-party sources (see also WP:MEDRS for health-related source requirements), but links to personal videos are generally not suitable for Wikipedia (see also WP:EL for more information). GermanJoe (talk) 18:29, 11 November 2019 (UTC)

OK, great, thank you for your responses. I'm glad that I asked, didn't want to create any issues by not adhering to Wikipedia's purposes. As I did the research for this project I found the existing resources available for the general public lacking, or containing or may cause misconceptions (as the topic of evolution by natural selection in general is very prone to misconceptions), so I created this video that would hopefully help to clarify the topic and these misconceptions to the public. The content was approved by scientific content advisors (while I agree there are many simplifications and it does not go to the level of mechanism of actions of antibiotics and the difference between bacteriocidic and bacteriostatic antibiotics, as well as other missing details, but making it short and concise was a consideration we took). But I understand now that it should add to the existing information in the Wikipedia page, and I agree that it is not necessarily the case given the amount of information it contains, so I understand why this link should not be included here. I will try to distribute this video in other means, as I think it could be still helpful. Thank you for your time explaining to me the Wikipedia etiquette. --Nitaiste (talk) 19:36, 11 November 2019 (UTC)

Reworking Causes Section

I am currently working to rewrite the causes section so I might be deleting and adding in some subsections. Feel free to let me know if you have any suggestions or questions. Kaitling (talk) 15:15, 21 February 2020 (UTC)Kaitling

This is a self-citing addition and then I ask a volunteer to review whether or not the citation should be added.

Viruses in the environment carry as-yet-unreported functional antibiotic resistance genes (ARGs), albeit in small quantities and environmental bacteriophages could be reservoirs of widely variable, unknown ARGs that could be disseminated via virus-host interactions.— Preceding unsigned comment added by Ulg07100 (talk • contribs) 18:02, 12 June 2020 (UTC)

@Ulg07100: It should not be added - the text ... as-yet-unreported functional antibiotic resistance genes (ARGs) ... implies this is recent research, that has not yet been discussed and verified by other scientists. Wikipedia is no venue to popularize recent cutting-edge research, but should focus on established widely-accepted knowledge. But if you want to get another uninvolved view on your request, please use the template Template:request edit in a new request (see linked information for more details). It would also be helpful if you could provide an additional different source, not only your own research. GermanJoe (talk) 12:49, 16 June 2020 (UTC)

@Ulg07100: - re-ping for notification, first one probably didn't work. GermanJoe (talk) 12:53, 16 June 2020 (UTC)

References

Edit request

• Information to be added or removed: After the part (“Using three or more drugs together, termed combination therapy, has helped to control this problem, but new drugs are needed because of the continuing emergence of drug-resistant HIV strains.[102]”) of the article (Antimicrobial resistance), I want to add the following and self-citing information: “Viruses in the environment carry functional antibiotic resistance genes (ARGs), albeit in small quantities and environmental bacteriophages could be reservoirs of widely variable, unknown ARGs that could be disseminated via virus-host interactions.” • Explanation of issue: This a self-citing addition and so I ask a volunteer to review whether or not the citation should be added. • References supporting change: Ulg07100 (talk) 05:34, 19 June 2020 (UTC)

References

• Declined Too soon to add, whilst viruses carry antibiotic resistance genes, that widely variable unknown ARGs can be disseminated requires an adequate secondary source.PainProf (talk) 04:50, 7 July 2020 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 14 January 2020 and 10 April 2020. Further details are available on the course page. Student editor(s): Kaitling.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:25, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 May 2019 and 2 July 2019. Further details are available on the course page. Student editor(s): Sammy521.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:29, 16 January 2022 (UTC)

First sentence

I'm not happy with the first sentence in Lead. "Antimicrobial resistance (AMR or AR) is the ability of a pathogenic microbe to evolve resistance to the effects of an antimicrobial medication." AMR is not an ability to evolve, it's already happened. The bacteria have developed, by evolution, biological mechanisms that protect them from the effects of antimicrobials. Graham Beards (talk) 17:49, 30 October 2020 (UTC)

Good point; I've tried to make it a bit less clunky. 86.152.156.140 (talk) 14:27, 4 November 2020 (UTC)

Abandoned user draft

User:570fmf/sandbox is an abandoned 2013 rewrite of the then section "Role of other animals". Please would an interested editor assess what is useful, incorporate it into the live article, blank the user page as WP:COPYARTICLE, and leave a note here when done? – Fayenatic London 11:50, 23 December 2021 (UTC)