Talk:Acetyl-CoA

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Nphi.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 13:19, 16 January 2022 (UTC)

Fatty Acid Metabolism

The article on ketone bodies (http://en.wikipedia.org/wiki/Ketone_bodies) states that the "heart gets little energy from ketone bodies; it uses mainly fatty acids." This is contrary to the current article's "both the skeletal and cardiac muscles satisfy their energy requirement mainly through oxidation of ketone bodies." I don't know which one is right (did look in PubMed and found some articles suggesting limited ketone body usage by skeletal muscle). Clarify. 76.21.142.29 (talk) 04:44, 4 December 2009 (UTC)

Vandalising

Some people are vandilizing it

- guest

Why is there no IUPAC name?

- another guest —Preceding unsigned comment added by 121.73.19.225 (talk) 08:53, 3 April 2008 (UTC)

I don't know, but chemspider says that the IUPAC name is: S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tet​ rahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphor​ yl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl​] ethanethioate.

75.4.21.69 (talk) 05:58, 6 May 2009 (UTC)

Bold text[[File:--62.231.244.75 (talk) 10:19, 1 July 2012 (UTC)Example.jpg--62.231.244.75 (talk) 10:19, 1 July 2012 (UTC)]]== missing H ==

three of the nitrogens are missing hydrogens (the two amides and the amino group on the aromatic ring). Northfox (talk) 13:24, 15 February 2009 (UTC)

I guess this has been solved. --Dirk Beetstra ^{T C} 10:28, 1 December 2009 (UTC)

InChI

28 Nov 2009 removed a tag from chembox that was messing up the display of the page. The tag contained: | InChI = 1/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1 I have no idea what this means or how to fix it, but someone may want to. —Preceding unsigned comment added by 76.119.18.244 (talk) 03:52, 29 November 2009 (UTC)

The InChI is a code that identifies the compound. It is for the untrained person unreadable (and this one probably also for trained people), but it can be machine read. Having this code on the page results that you can find this compound using internet search engines (i.e., for sure find THIS compound, other searches may find for many compounds many mismatches, e.g. the name can be written in different ways, the formula can be sorted in a different way, but some of these codes are always leading to the right compound). It is hidden behind a 'show' button so it does not mess up the page in normal view, but is still there so it can be read. It may mess up the display in show-mode, but that is easily repaired by clicking hide again, or refreshing the page. I hope this explains. --Dirk Beetstra ^{T C} 10:27, 1 December 2009 (UTC)

Diagram of the structure of acetyl CoA

Hi @DMacks:, I replaced the introductory diagram of the structure of acetyl-CoA <File:Acetyl-CoA-2D.svg> with one showing the acetyl group in blue. You improved on this diagram, creating <Acetyl-CoA-2D_colored.svg> which appears in the Ketone bodies article. However, you reverted the one here with the original <File:Acetyl-CoA-2D.svg> which does not make it clear which part of the molecule is the acetyl group in the very complex acetyl-CoA molecule (except to those who have a very extensive grounding in organic chemistry and its many and varied symbolisms).

The very name "acetyl-CoA" emphasizes the central importance of the acetyl group, a fact that is further emphasized in the introduction to the article. I therefore think it is only fair to the general reader that the appropriate diagram here is <Acetyl-CoA-2D_colored.svg>. I wonder whether you would consider using the colored version of the diagram here - it would save a lot of unnecessary bafflement. Cruithne9 (talk) 08:00, 23 February 2016 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Acetyl-CoA/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

rated High as high school/SAT biology topic, part of cell metabolism - tameeria 14:47, 18 February 2007 (UTC) This article has no references/sources. - tameeria 20:43, 18 February 2007 (UTC)

Last edited at 20:43, 18 February 2007 (UTC). Substituted at 06:35, 29 April 2016 (UTC)

Edits on Acetyl-CoA article

Hello everyone, I have been reading up on Acetyl-CoA and come across various papers that I think would be helpful to our Acetyl-CoA article. As such, I hope to make some edits to the current page so that anyone who is interested can know more about it. Here is an outline of the improvement I hope to make to the page:

1.Move the Direct Synthesis out of Function and put it as a stand-alone section. I plan to add these categories to it:

• Oxidative decarboxylation of pyruvate through pyruvate dehydrogenase complex
• Beta-oxidation of fatty acids
• ATP-citrate lysase catalysed conversion of citrate from cytoplasm to oxaloacetate and acetyl CoA in cytosol
• Degradation of ketogenic branched-chain amino acids (valine, leucine, and isoleucine)
• Ethanol coversion to acetaldehyde (by alcohol dehydrogenase), then to acetate and eventually to acetyl coA.

2.Add to the Function section:

• Subsection: Acetyl CoA as an intermediate

 a.Fatty acid production (move the available information in the current article to here)
 b.Mevalonate pathway (MVA) - isoprenoids an sterols production 
 c.Ketone bodies production

• Subsection: Acetylation

 a. Role in mitosis and cell growth through histone acetylation
 b. Role in apoptosis

3.Add a small section on History of Acetyl CoA discovery.

4.I also hope to reorganize some of the ideas into the relevant subsections such that the introduction of Acetyl CoA only covers the basic details of what it is, its overall structure and a brief mention of its role in metabolism pathways.

I would really appreciate any feedback/suggestion on the outline and if there is anything I can do to further improve the depth and quality of our current article. Thank you!:)

Nphi (talk) 21:40, 30 October 2016 (UTC)nphi

As a new editor to Wikipedia, you are to be congratulated for getting this far and for requesting feedback. Here it is: 1) keep the information general, 2) cite general sources (textbooks, monographs, major reviews), avoiding journal article, 3) make your edits incrementally, not one big revision, 4) post additional questions or ask for help. With best wishes for a successful project.

Thank you so much for your advice! I truly appreciate it and would keep it in mind as I make my edits :) Nphi (talk) 22:53, 1 November 2016 (UTC)nphi

Remove

It is not good form to leave invisible text in the current versions of the article. I found a block of text, surrounded by the Wikipedia comment markers, so that it did not show. Some editor "removed" it my "commenting it out". The correct editing technique it to actually delete it, and let other editors use the saved previous versions to restore it or do what ever they want with the removed text. For instance you can see what I removed by looking at the version immediately before my change, using my name and time appended here. Nick Beeson (talk) 21:02, 15 November 2016 (UTC)

Wiki Education assignment: CHEM 300

This article was the subject of a Wiki Education Foundation-supported course assignment, between 9 January 2023 and 28 April 2023. Further details are available on the course page. Student editor(s): Acrchan (article contribs). Peer reviewers: Dvnyn.

— Assignment last updated by RS UBC800 (talk) 21:13, 2 April 2023 (UTC)

Edits to article

Hello. I wanted to make additional edits on this article. Here are my proposed edits below:

Edit the bullet points into paragraphs for the “Functions” section and add information

- Expand on Acetyl-CoA’s role in melatonin synthesis

- Change the lead bullet points into headings

Add more pictures to the “Functions” section and “Extramitochondrial” subsection

- Insert images for synthesis pathways for the examples mentioned in the “Functions” section

Find more recent sources for “Intramitochondrial” synthesis

Feel free to let me know your opinions and if you have any feedback ˙ᵕ˙ Acrchan (talk) 20:47, 29 March 2023 (UTC)

@Acrchan: Some suggestions:

only reviews or books, no primary literature, please. WP:SECONDARY, WP:TERTIARY. Do not include words in the art. Words go into captions. Acetyl-CoA is involved in many processes, so why pick melatonin? --Smokefoot (talk) 21:46, 29 March 2023 (UTC)

Thanks for the tips! I picked melatonin since it was the only section that didn't have any description and there's been really interesting developments in research regarding the relationship between melatonin synthesis and Acetyl-CoA. I also wanted to ask if you knew why journal articles were discouraged from being sources in the discussion above? Acrchan (talk) 22:07, 29 March 2023 (UTC)