Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase
| Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.287 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase (EC 2.4.1.287, arabinogalactan galactofuranosyl transferase 1, GlfT1) is an enzyme with systematic name UDP-alpha-D-galactofuranose:alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-beta/4-beta-galactofuranosyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- 2 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 2 UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol (overall reaction)
- (1a) UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol UDP + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
- (1b) UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
This enzyme is isolated from Mycobacterium tuberculosis and M. smegmatis.
References
[edit]- ^ Mikusová K, Belánová M, Korduláková J, Honda K, McNeil MR, Mahapatra S, Crick DC, Brennan PJ (September 2006). "Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall". Journal of Bacteriology. 188 (18): 6592–8. doi:10.1128/JB.00489-06. PMC 1595490. PMID 16952951.
- ^ Belánová M, Dianisková P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusová K (February 2008). "Galactosyl transferases in mycobacterial cell wall synthesis". Journal of Bacteriology. 190 (3): 1141–5. doi:10.1128/JB.01326-07. PMC 2223555. PMID 18055597.
External links
[edit]- Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol+beta-1,3/1,4-galactofuranosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
