Three locomotives were built; they were manufactured at Progress Rail's Mayfield, Kentucky factory.[1] Two operated in revenue freight service on Norfolk Southern, while a third operated as a demonstrator unit for Progress Rail.[2] At one time Norfolk Southern had four more PR43Cs on order.[3] The locomotives operated by Norfolk Southern worked on freight trains in central Illinois, leading to speculation that they were being tested, as Caterpillar's headquarters are located in Peoria, Illinois.[1]
The process of converting an SD50 to a PR43C altered the external appearance of the locomotive; the original radiator section was replaced with a larger one similar in appearance to that of an EMD SD70ACe or SD70M-2.[1]
As a result of repeated failures, the locomotives were retired in 2017, and all were cut up for scrap in 2018.[citation needed]