Portal:History of science/Selected anniversaries/April 22
- 1500 – Portuguese navigator Pedro Álvares Cabral becomes the first European to sight Brazil
- 1692 – birth of James Stirling, Scottish mathematician (d. 1770)
- 1758 – death of Antoine de Jussieu, French naturalist (b. 1686)
- 1891 – birth of Harold Jeffreys, English astronomer (d. 1989)
- 1904 – birth of J. Robert Oppenheimer, American physicist (d. 1967)
- 1909 – birth of Rita Levi-Montalcini, Italian neurologist, Nobel laureate
- 1910 – birth of Norman Steenrod, American mathematician (d. 1971)
- 1919 – birth of Donald J. Cram, American chemist, Nobel laureate (d. 2001)
- 1922 – birth of Wolf V. Vishniac, American microbiologist (d. 1973)
- 1929 – birth of Michael Atiyah, mathematician
- 1945 – death of Wilhelm Cauer, German mathematician (b. 1900)
- 1951 – death of Horace Donisthorpe, British entomologist (b. 1870)
- 1980 – death of Fritz Strassmann, German physicist (b. 1902)
- 2005 – death of Philip Morrison, American physicist (b. 1915)