Piketoprofen
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Trade names | Calmatel, Picalm |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Topical (cream) |
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Chemical and physical data | |
Formula | C22H20N2O2 |
Molar mass | 344.414 g·mol−1 |
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Piketoprofen (INN; trade names Calmatel, Picalm) is a nonsteroidal anti-inflammatory drug (NSAID) for topical use in form of a cream.[1][2]
Chemically, it is the 4-picolineamide of the NSAID ketoprofen.
Synthesis
[edit]Thionyl chloride reacts with ketoprofen to form its acid chloride (2). Amide formation with 2-amino-4-methylpyridine (3) gives piketoprofen.[3][4]
References
[edit]- ^ Fabregas JL, Cucala J, Segura J, Tarrus E (May 1986). "Percutaneous absorption of piketoprofen in rabbits: effect of nonionic surface-active agents". Il Farmaco; Edizione Pratica. 41 (5): 177–83. PMID 3487466.
- ^ Burgos A, Busquier MP, Reino JG, Ferreiro JL, Navarro F, Valverde J, Moreno E (2001). "Double-Blind, Double-Dummy Comparative Study of Local Action Transcutaneous Flurbiprofen (Flurbiprofen LAT) versus Piketoprofen Cream in the Treatment of Extra-Articular Rheumatism". Clin Drug Investig. 21 (2): 95–102. doi:10.2165/00044011-200121020-00002. S2CID 56907918.
- ^ GB patent 1436502, Spickett, R.G.W; Noverola, A.V; Soto, J.P, "Amide derivatives of 3-benzoyl-phemylalkanoic acids", issued 1976-05-19, assigned to Antonio Gallardo S A
- ^ "Piketoprofen". Thieme. Retrieved 2024-07-02.