PEX19

PEX19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W85, 2WL8, 3AJB, 3MK4
Identifiers
Aliases	PEX19, D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1, peroxisomal biogenesis factor 19
External IDs	OMIM: 600279; MGI: 1334458; HomoloGene: 134253; GeneCards: PEX19; OMA:PEX19 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,286,348 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,964,060 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; ventricular zone; ; epithelium of colon; ; abdominal fat; ; thoracic diaphragm; ; subcutaneous adipose tissue; ; islet of Langerhans; ; right lobe of liver;
	Top expressed in
	yolk sac; ; tail of embryo; ; lip; ; muscle of thigh; ; right kidney; ; ventricular zone; ; digastric muscle; ; temporal muscle; ; brown adipose tissue; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peroxisome membrane class-1 targeting sequence binding; protein N-terminus binding; ATPase binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; cytosol; membrane; peroxisomal membrane; peroxisome; nucleoplasm; brush border membrane; nucleus; protein-containing complex;
Biological process	protein targeting to peroxisome; peroxisome organization; protein stabilization; peroxisome membrane biogenesis; peroxisome fission; protein import into peroxisome membrane; transmembrane transport; establishment of protein localization to peroxisome; negative regulation of lipid binding; chaperone-mediated protein folding;
	Sources:Amigo / QuickGO
Orthologs
	5824
	19298
	ENSG00000162735
	ENSMUSG00000003464
	P40855
	Q8VCI5
	NM_001131039; NM_001193644; NM_002857
	NM_001159525; NM_023041; NM_001356513; NM_001356514
	NP_001180573; NP_002848
	NP_001152997; NP_075528; NP_001343442; NP_001343443
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.^[5]^[6]^[7]

Interactions

PEX19 has been shown to interact with:

ABCD1,^[8]^[9]
ABCD2,^[8]^[9]
ABCD3,^[8]^[9]^[10]^[11]
PEX10,^[10]^[12]
PEX11B,^[10]^[12]
PEX12,^[10]^[12]
PEX13,^[10]^[12]
PEX16,^[12] and
PEX3.^[8]^[10]^[12]^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162735 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003464 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Höfler G, Roscher AA, Braun A (November 1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein". Genomics. 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID 9339377.
^ Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y (April 1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly". Proc Natl Acad Sci U S A. 96 (5): 2116–21. Bibcode:1999PNAS...96.2116M. doi:10.1073/pnas.96.5.2116. PMC 26746. PMID 10051604.
^ "Entrez Gene: PEX19 peroxisomal biogenesis factor 19".
^ ^a ^b ^c ^d Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (March 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
^ ^a ^b ^c Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (April 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.
^ ^a ^b ^c ^d ^e ^f Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
^ Biermanns M, Gärtner J (July 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.
^ ^a ^b ^c ^d ^e ^f Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
Overview of all the structural information available in the PDB for UniProt: P40855 (Peroxisomal biogenesis factor 19) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162735 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003464 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9339377-5] Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Höfler G, Roscher AA, Braun A (November 1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein". Genomics. 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID 9339377.

[pmid10051604-6] Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y (April 1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly". Proc Natl Acad Sci U S A. 96 (5): 2116–21. Bibcode:1999PNAS...96.2116M. doi:10.1073/pnas.96.5.2116. PMC 26746. PMID 10051604.

[entrez-7] "Entrez Gene: PEX19 peroxisomal biogenesis factor 19".

[pmid11883941-8] Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (March 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.

[pmid10777694-9] Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (April 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.

[pmid10704444-10] ^ ^a ^b ^c ^d ^e ^f Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.

[pmid11453642-11] Biermanns M, Gärtner J (July 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.

[pmid11390669-12] ^ ^a ^b ^c ^d ^e ^f Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

[pmid16189514-13] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Interactions

References

Further reading

External links