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Protein-coding gene in the species Homo sapiens
Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene .[ 5] [ 6] Alternative splicing results in two transcript variants encoding different isoforms.
Peroxisome biogenesis factor 10 is involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane.[ 6]
Clinical significance [ edit ]
Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome .[ 6]
PEX10 has been shown to interact with PEX12 [ 7] [ 8] and PEX19 .[ 9] [ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000157911 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029047 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Warren DS, Morrell JC, Moser HW, Valle D, Gould SJ (December 1998). "Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders" . Am J Hum Genet . 63 (2): 347–59. doi :10.1086/301963 . PMC 1377304 . PMID 9683594 .
^ a b c "Entrez Gene: PEX10 peroxisome biogenesis factor 10" .
^ Chang CC, Warren DS, Sacksteder KA, Gould SJ (November 1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import" . J. Cell Biol . 147 (4): 761–74. doi :10.1083/jcb.147.4.761 . PMC 2156163 . PMID 10562279 .
^ Okumoto K, Abe I, Fujiki Y (August 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p" . J. Biol. Chem . 275 (33): 25700–10. doi :10.1074/jbc.M003303200 . PMID 10837480 .
^ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis" . J. Cell Biol . 148 (5): 931–44. doi :10.1083/jcb.148.5.931 . PMC 2174547 . PMID 10704444 .
^ Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences" . Mol. Cell. Biol . 21 (13): 4413–24. doi :10.1128/MCB.21.13.4413-4424.2001 . PMC 87101 . PMID 11390669 .
Okumoto K, Itoh R, Shimozawa N, et al. (1998). "Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B." Hum. Mol. Genet . 7 (9): 1399–405. doi :10.1093/hmg/7.9.1399 . PMID 9700193 .
South ST, Gould SJ (1999). "Peroxisome synthesis in the absence of preexisting peroxisomes" . J. Cell Biol . 144 (2): 255–66. doi :10.1083/jcb.144.2.255 . PMC 2132891 . PMID 9922452 .
Chang CC, Warren DS, Sacksteder KA, Gould SJ (1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import" . J. Cell Biol . 147 (4): 761–74. doi :10.1083/jcb.147.4.761 . PMC 2156163 . PMID 10562279 .
Sacksteder KA, Jones JM, South ST, et al. (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis" . J. Cell Biol . 148 (5): 931–44. doi :10.1083/jcb.148.5.931 . PMC 2174547 . PMID 10704444 .
Okumoto K, Abe I, Fujiki Y (2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p" . J. Biol. Chem . 275 (33): 25700–10. doi :10.1074/jbc.M003303200 . PMID 10837480 .
Warren DS, Wolfe BD, Gould SJ (2000). "Phenotype-genotype relationships in PEX10-deficient peroxisome biogenesis disorder patients". Hum. Mutat . 15 (6): 509–21. doi :10.1002/1098-1004(200006)15:6<509::AID-HUMU3>3.0.CO;2-# . PMID 10862081 . S2CID 196604223 .
Fransen M, Wylin T, Brees C, et al. (2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences" . Mol. Cell. Biol . 21 (13): 4413–24. doi :10.1128/MCB.21.13.4413-4424.2001 . PMC 87101 . PMID 11390669 .
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay" . Mol. Cell. Proteomics . 1 (3): 243–52. doi :10.1074/mcp.M100025-MCP200 . PMID 12096124 .
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Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Shimozawa N, Nagase T, Takemoto Y, et al. (2003). "Genetic Heterogeneity in Japanese Patients with Peroxisome Biogenesis Disorders and Evidence for a Founder Haplotype for the Most Common Mutation in PEX10 Gene". Peroxisomal Disorders and Regulation of Genes . Advances in Experimental Medicine and Biology. Vol. 544. p. 71. doi :10.1007/978-1-4419-9072-3_10 . ISBN 978-1-4613-4782-8 . PMID 14713216 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
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