OR2J2

OR2J2
Identifiers
Aliases	OR2J2, OR6-19, OR6-8, OR6.3.8, ORL684, dJ80I19.4, hs6M1-6, olfactory receptor family 2 subfamily J member 2
External IDs	MGI: 2177520; HomoloGene: 88922; GeneCards: OR2J2; OMA:OR2J2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.1 Start 29,170,907 bp End 29,175,811 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 38,614,418 bp End 38,618,461 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle uterine tube right testis left testis appendix hippocampus proper hypothalamus caudate nucleus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26707 258481 Ensembl ENSG00000204700 ENSMUSG00000054940 UniProt O76002 Q8VFC2 RefSeq (mRNA) NM_030905 NM_146488 RefSeq (protein) NP_112167 NP_666699 Location (UCSC) Chr 6: 29.17 – 29.18 Mb Chr 17: 38.61 – 38.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2J2 is a protein that in humans is encoded by the OR2J2 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

Agonists include:

• 1-Octanol
• 1-Nonanol
• 1-Decanol
• 1-Heptanol
• Coumarin

See also

• Olfactory receptor

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2J2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.