Jump to content

OR1B1

From Wikipedia, the free encyclopedia
(Redirected from OR1B1 (gene))
OR1B1
Identifiers
AliasesOR1B1, OR9-26, OR9-B, olfactory receptor family 1 subfamily B member 1 (gene/pseudogene), olfactory receptor family 1 subfamily B member 1
External IDsMGI: 3030196; HomoloGene: 17479; GeneCards: OR1B1; OMA:OR1B1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004450

NM_147051

RefSeq (protein)

NP_001004450

NP_667262

Location (UCSC)Chr 9: 122.63 – 122.63 MbChr 2: 36.99 – 37.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1B1 is a protein that in humans is encoded by the OR1B1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

[edit]

As of 2024, OR1B1 was an orphan receptor, meaning that no odorants have been identified which bind to it.[6][7]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000280094Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075377Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".
  6. ^ de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.
  7. ^ "OR1B1". M2OR. ChemSenSim lab, Université Côte d’Azur, Institut de Chimie de Nice. 2024-03-23. Retrieved 2024-07-04.

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.