Nrf2 internal ribosome entry site (IRES)
In molecular biology, the Nrf2 internal ribosome entry site (IRES) is an RNA element present in the 5′ UTR of the mRNA encoding the transcription factor Nrf2. It contains a stem-loop structure upstream of a ribosome binding site. This stem loop inhibits ribosome binding and translation of Nrf2 under normal conditions, but allows translation under oxidative stress conditions.[1][2][3]
See also
[edit]References
[edit]- ^ Li, W; Thakor, N; Xu, EY; Huang, Y; Chen, C; Yu, R; Holcik, M; Kong, AN (January 2010). "An internal ribosomal entry site mediates redox-sensitive translation of Nrf2". Nucleic Acids Research. 38 (3): 778–788. doi:10.1093/nar/gkp1048. PMC 2817467. PMID 19934254.
- ^ Zhang, J; Dinh, TN; Kappeler, K; Tsaprailis, G; Chen, QM (June 2012). "La autoantigen mediates oxidant induced de novo Nrf2 protein translation". Molecular & Cellular Proteomics. 11 (6): M111.015032. doi:10.1074/mcp.m111.015032. PMC 3433904. PMID 22207702.
- ^ Shay, KP; Michels, AJ; Li, W; Kong, AN; Hagen, TM (June 2012). "Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823 (6): 1102–1109. doi:10.1016/j.bbamcr.2012.04.002. PMC 4012555. PMID 22521877.