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Nancy Hopkins (scientist)

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Nancy Hopkins
Born
Nancy Doe

(1943-06-16) June 16, 1943 (age 81)[1]
New York City, US[1]
Alma materRadcliffe College
Harvard
Spouse(s)Brooke Hopkins (1967-1973)
J. Dinsmore Adams Jr. (2007)
Scientific career
FieldsBiology
InstitutionsMIT
Websitehttps://biology.mit.edu/profile/nancy-hopkins/

Nancy Hopkins, an American molecular biologist, (née Doe, born June 16, 1943) is the Amgen, Inc. Professor of Biology at the Massachusetts Institute of Technology.[1][2] She is a member of the National Academy of Sciences, the Institute of Medicine of the National Academy, and the American Academy of Arts and Sciences. She is known for her research identifying genes required for zebrafish development, and for her earlier research on gene expression in the bacterial virus lambda, and on mouse RNA tumor viruses. She is also known for her work promoting equality of opportunity for women scientists in academia.

Early life and education

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Nancy Doe Hopkins[3] was born in 1943 in New York City.

Hopkins received her BA from Radcliffe College in 1964,[1] and earned her PhD from the Department of Molecular Biology and Biochemistry at Harvard University in 1971,[4] where she worked with Professor Mark Ptashne. With Ptashne she identified the operator sites on DNA to which the lambda repressor binds to control early gene expression and hence the viral life cycle. As a postdoctoral fellow of Nobel Laureate James D. Watson and Robert Pollack at the Cold Spring Harbor Lab she worked on DNA tumor viruses and cell biology, discovering that cells whose nucleus had been removed were able to re-establish normal morphology.

Career and research

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She joined the MIT faculty in the Center for Cancer Research in 1973[4] as an assistant professor and switched to work on RNA tumor viruses. She identified viral genes that determine host range and the type and severity of cancers mouse retroviruses cause, including importantly the capsid protein p30 and transcriptional elements that came to be known as enhancers. After a sabbatical in the lab of Nobel laureate Christiane Nusslein-Volhard in 1989, Hopkins switched fields to develop molecular technologies for working with zebrafish. With her postdoctoral fellow Shuo Lin, graduate students Adam Amsterdam and Nick Gaiano, and others in her lab she developed an efficient method for large-scale insertional mutagenesis in the fish. Using this technique her lab carried out a large genetic screen that identified and cloned 25% of the genes that are essential for a fertilized egg to develop into a free-swimming zebrafish larva. Among the genes identified was an unexpected class of genes which when mutated predispose fish to get cancer, and a set of genes that cause fish to develop cystic kidney and which overlap with genes that cause cystic kidney disease in humans.

Retroviral insertional mutagenesis in zebrafish

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In an effort to help maximize the utility of the zebrafish as a model organism, Hopkins and colleagues set out to develop a large-scale insertional mutagenesis method. Although large-scale chemical mutagenesis screens were getting underway in several zebrafish labs at the time (those of Mark Fishman in Boston, and Christiane Nusslein-Volhard in Tübingen, Germany), there were concerns in the community at the time that identifying the molecular lesions using positional cloning methods would be inefficient. Hopkins believed that insertional mutagenesis, which had been very successfully employed in invertebrate model organisms (D. melanogaster and C. elegans), would provide a valuable alternative or adjunct to the chemical screens.

A Study on the Status of Women Faculty in Science at MIT

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During the mid-90s, Hopkins felt she and other women were systematically discriminated against at MIT. In July 1994, together with 15 other women faculty in the School of Science at MIT, Hopkins drafted and co-signed a letter to the then-Dean of Science (now Chancellor of Berkeley) Robert Birgeneau, stating their evidence regarding gender discrimination.[3][5] Due to her complaints to the administration, a committee was formed (with Hopkins as the initial chair) to investigate the issue of inequalities experienced by women faculty as a result of unconscious gender bias.[4] The committee existed in two forms over the course of a four-year period and included both men and women faculty members, including men who were current or previous chairs of the departments of mathematics, chemistry, and physics.[6]

The results were bold but contentious: A summary of the committee's findings, published in 1999[7] and endorsed by then-MIT president Charles Vest and then-Dean Robert Birgeneau, is credited with launching a national re-examination of equity for women scientists. While some have questioned the rigor of the analysis performed by the MIT committee,[8][9] MIT's efforts are considered by many to be a laudable example of self-monitoring by a world-renowned institution of higher education.[10][9][11][12]

It also led 9 research universities, including MIT, to form an ongoing collaboration to study and address issues of gender equity. The group, which came to be known as “The MIT-9”, includes Harvard University, Stanford University, California Institute of Technology, Princeton University, University of Pennsylvania, University of Michigan, Yale University, and University of California, Berkeley, in addition to MIT. Hopkins involved many experts, who were researching the status of women and minorities among faculty, in these collaborations. At the MIT-9 meetings, Donna Nelson presented the Nelson Diversity Surveys to compare the representation of women among faculty at these individual universities versus the national data.

In 2020, Hopkins appeared in the Tribeca Film Festival in the film "Picture a Scientist", presenting the MIT study.[13][14][15]

Harassment incident by Francis Crick

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Hopkins stated that when she was an undergraduate in the 1960s, Francis Crick put his hands on her breasts during a lab visit.[16] She described the incident: "Before I could rise and shake hands, he had zoomed across the room, stood behind me, put his hands on my breasts and said, 'What are you working on?'"[17]

Walk-out protest of Lawrence Summers sexist comments, the then-Harvard-President

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In January 2005, at an NBER meeting in Cambridge, MA on the topic of how to address the under-representation of women and minorities in science and engineering fields, Hopkins caused controversy by walking out in protest during a talk by then President of Harvard Lawrence Summers when he speculated that one reason for the very small number of high-achieving women in science and engineering fields might be “intrinsic aptitude” (specifically that the bell-curve of aptitude is flatter for men than women).[18] Her action became public when she replied to an e-mail from Boston Globe reporter Marcella Bombardieri inquiring about Summers’ speech.[19] Bombardieri's report of Summers’ speech set off a national discussion of gender discrimination, and academic freedom, and contributed to Summers’ resignation as the President of Harvard.[19]

Honors

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Personal life

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Hopkins has been married to J. Dinsmore Adams Jr. (known as Dinny) since 2007.[23]

Further reading

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  • Zernike, Kate (27 April 2023). The Exceptions: Sixteen Women, MIT, and the Fight for Equality in Science. Simon & Schuster. ISBN 978-1-3985-2000-4.
  • First and Second Committees on Women Faculty in the School of Science (March 1999). "A Study on the Status of Women Faculty in Science at MIT". The MIT Faculty Newsletter. 11 (4). MIT. Archived from the original on 8 May 1999.

References

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  1. ^ a b c d Brownlee, Christen (August 31, 2004). "Biography of Nancy Hopkins". Proceedings of the National Academy of Sciences of the United States of America. 101 (35): 12789–12791. doi:10.1073/pnas.0405554101. PMC 516473. PMID 15328401.
  2. ^ Appel, A. (2012). "A passion for science without barriers: Nancy Hopkins, renowned champion of gender equality, looks back over her career". Nature. 481 (7379): 13. doi:10.1038/481013a. PMID 22222731.
  3. ^ a b Zernike, Kate (2023). The Exceptions: Nancy Hopkins, MIT, and the Fight for Women in Science. New York, NY: Scribner. p. 62. ISBN 978-1-9821-3183-8.
  4. ^ a b c "Nancy H. Hopkins Profile". Koch Institute for Integrative Cancer Research at MIT. Retrieved 23 January 2015.
  5. ^ The other 15 women were: Susan Carey, Sylvia T. Ceyer, Sallie W. Chisholm, Suzanne Corkin, Mildred Dresselhaus, Ann Graybiel, Ruth Lehmann, Marcia McNutt, Terry Orr-Weaver, Mary-Lou Pardue, Mary C. Potter, Paola Malanotte Rizzoli, Leigh Royden, Lisa Steiner and JoAnne Stubbe (Zernike, pp.355-361).
  6. ^ Zernike, Kate (27 April 2023). The Exceptions: Sixteen Women, MIT, and the Fight for Equality in Science. Simon & Schuster. ISBN 978-1-3985-2000-4.
  7. ^ "A Study on the Status of Women Faculty In Science at MIT". Web.mit.edu. 1999-03-04. Retrieved 2013-08-18.
  8. ^ Goldberg, Jonah (2005-01-19). "What's sex got to do with science? Don't ask!". Townhal.com. Retrieved 2015-04-14.
  9. ^ a b Hausman, Patricia; Steiger, James H. (2001-02-04). Confession Without Guilt? M.I.T. Jumped The Gun To Avoid A Sex-Discrimination Controversy, But Shot Itself In The Foot (PDF) (Technical report). Arlington, Virginia: Independent Women's Forum.
  10. ^ Goldberg, Carey (March 23, 1999). "M.I.T. Admits Discrimination Against Female Professors". New York Times. Retrieved 2013-08-18.
  11. ^ "Rensselaer Polytechnic Institute (RPI) President's Speech: Leaders in Science and Engineering: The Women of MIT". Rpi.edu. 2011-03-28. Retrieved 2013-08-18.
  12. ^ Zernike, Kate (21 March 2011). "Gains, and Drawbacks, for Female Professors". The New York Times. Retrieved 4 December 2013.
  13. ^ "Picture a Scientist". Picture a Scientist. Retrieved 2020-06-26.
  14. ^ "Picture a Scientist - Researchers expose longstanding discrimination against women in science. (with transcript)". PBS. 2021-04-14. Archived from the original on 2021-04-16.
  15. ^ Witze, Alexandra (2020-06-24). "Three extraordinary women run the gauntlet of science — a documentary". Nature. 583 (7814): 25–26. Bibcode:2020Natur.583...25W. doi:10.1038/d41586-020-01912-6. S2CID 220050232.
  16. ^ Alicia Chen (2009-10-22). "Women in the sciences still struggle, Hopkins says". Brown Daily Herald. Retrieved 2020-06-17.
  17. ^ Laura Hoopes (2011-04-01). "Nancy Hopkins' Keynote Speech Shockers". Scitable by Nature Education. Retrieved 2020-06-17.
  18. ^ Thernstrom, Stephan. "In Defense of Academic Freedom at Harvard". History News Network, George Washington University.
  19. ^ a b * Bombardieri, Marcella (January 17, 2005). "Summers' remarks on women draw fire". The Boston Globe. Archived from the original on 2 April 2016. Retrieved 4 March 2023.
  20. ^ "Nancy Hopkins". MIT Department of Biology, Directory. Retrieved 23 January 2015.
  21. ^ "Honorary Degrees, December 2014". Trinity News and Events. 2014-12-08. Retrieved 2020-01-27.
  22. ^ "Helen Dean King Award".
  23. ^ Sipher, Devan (2007-07-29). "Nancy Hopkins and Dinny Adams". The New York Times. ISSN 0362-4331. Retrieved 2020-07-22.
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