Major vault protein

MVP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y7X
Identifiers
Aliases	MVP, LRP, VAULT1, major vault protein
External IDs	OMIM: 605088; MGI: 1925638; HomoloGene: 3752; GeneCards: MVP; OMA:MVP - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 29,820,394 bp End 29,848,039 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 126,586,032 bp End 126,613,793 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right adrenal gland left adrenal gland left adrenal cortex granulocyte right adrenal cortex epithelium of colon upper lobe of left lung stromal cell of endometrium right ovary Top expressed in ankle joint duodenum intestinal villus Ileal epithelium jejunum granulocyte colon yolk sac lip membranous bone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding protein binding protein kinase binding identical protein binding Cellular component cytoplasm perinuclear region of cytoplasm nuclear pore extracellular exosome cytoskeleton membrane nucleus extracellular region cytosol secretory granule lumen ficolin-1-rich granule lumen Biological process protein transport mRNA transport negative regulation of protein tyrosine kinase activity ERBB signaling pathway negative regulation of signaling negative regulation of protein autophosphorylation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9961 78388 Ensembl ENSG00000013364 ENSMUSG00000030681 UniProt Q14764 Q9EQK5 RefSeq (mRNA) NM_017458 NM_001293204 NM_001293205 NM_005115 NM_080638 RefSeq (protein) NP_001280133 NP_001280134 NP_005106 NP_059447 NP_001280134.1 NP_542369 Location (UCSC) Chr 16: 29.82 – 29.85 Mb Chr 7: 126.59 – 126.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Major vault protein, also known as lung resistance-related protein is a protein that in humans is encoded by the MVP gene. 78 copies of the protein assemble into the large compartments called vaults.

Function

This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. Major vault protein comprises 70% of vaults which also contain vPARP and TEP1. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

Interactions

Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases major vault protein associated with the estrogen receptor in nuclear extracts.

Major vault protein has been shown to interact with estrogen receptor alpha, PTEN and PARP4.

Further reading

• Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (June 1996). "Major vault protein LRP-related multidrug resistance". European Journal of Cancer. 32A (6): 979–984. doi:10.1016/0959-8049(96)00053-6. PMID 8763338.
• Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, et al. (October 1995). "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Research. 55 (19): 4214–4219. PMID 7671223.
• Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJ, et al. (March 1996). "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". The American Journal of Pathology. 148 (3): 877–887. PMC 1861735. PMID 8774142.
• Dingemans AM, van Ark-Otte J, van der Valk P, Apolinario RM, Scheper RJ, Postmus PE, et al. (August 1996). "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Annals of Oncology. 7 (6): 625–630. doi:10.1093/oxfordjournals.annonc.a010681. PMID 8879378.
• Sugawara I, Akiyama S, Scheper RJ, Itoyama S (January 1997). "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Letters. 112 (1): 23–31. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166.
• Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, et al. (June 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–1310. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.
• Ikeda K, Oka M, Yamada Y, Soda H, Fukuda M, Kinoshita A, et al. (August 1999). "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". International Journal of Cancer. 82 (4): 599–604. doi:10.1002/(SICI)1097-0215(19990812)82:4<599::AID-IJC21>3.0.CO;2-R. PMID 10404077. S2CID 20438112.
• Rimsza LM, Campbell K, Dalton WS, Salmon S, Willcox G, Grogan TM (July 1999). "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leukemia & Lymphoma. 34 (3–4): 315–324. doi:10.3109/10428199909050956. PMID 10439368.
• Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, et al. (September 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–928. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.
• Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (November 1999). "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry. 274 (46): 32712–32717. doi:10.1074/jbc.274.46.32712. PMID 10551828.
• Lange C, Walther W, Schwabe H, Stein U (November 2000). "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter". Biochemical and Biophysical Research Communications. 278 (1): 125–133. doi:10.1006/bbrc.2000.3782. PMID 11071864.
• Holzmann K, Ambrosch I, Elbling L, Micksche M, Berger W (April 2001). "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant". FEBS Letters. 494 (1–2): 99–104. Bibcode:2001FEBSL.494...99H. doi:10.1016/S0014-5793(01)02318-3. PMID 11297743. S2CID 9235641.
• van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, et al. (March 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications. 291 (3): 535–541. doi:10.1006/bbrc.2002.6472. PMID 11855821.
• Sakaki Y, Terashi K, Yamaguchi A, Kawamata N, Tokito Y, Mori H, et al. (April 2002). "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient". Experimental Hematology. 30 (4): 340–345. doi:10.1016/S0301-472X(02)00775-0. PMID 11937269.
• Zhao Y, Yu L, Wang Q, Lou F, Pu J (March 2002). "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi. 41 (3): 183–185. PMID 11940320.
• Scheffer GL, Pijnenborg AC, Smit EF, Müller M, Postma DS, Timens W, et al. (May 2002). "Multidrug resistance related molecules in human and murine lung". Journal of Clinical Pathology. 55 (5): 332–339. doi:10.1136/jcp.55.5.332. PMC 1769658. PMID 11986335.
• van den Heuvel-Eibrink MM, Wiemer EA, Prins A, Meijerink JP, Vossebeld PJ, van der Holt B, et al. (May 2002). "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)". Leukemia. 16 (5): 833–839. doi:10.1038/sj.leu.2402496. PMID 11986944. S2CID 24297761.
• Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, et al. (October 2002). "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry. 277 (43): 40247–40252. doi:10.1074/jbc.M207608200. PMID 12177006.